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The aim of the present study is therefore to investigate the work ability benefits of a structured postoperative treatment (SPT) over a standard care approach (SA) in patients who underwent anterior cervical decompression and fusion (ACDF) for cervical radiculopathy and factors important to the 2-year outcome. <jats:italic>Methods<\/jats:italic> Secondary outcome and prediction model of a prospective randomized controlled multi-centre study with a 2-year follow-up (clinicaltrials.gov NCT01547611). The Work Ability Index (WAI) and Work Ability Score (WAS) were measured at baseline and up to 2\u00a0years after ACDF in 154 patients of working age who underwent SPT or SA after surgery. Predictive factors for the WAI at 2\u00a0years were analysed. <jats:italic>Results<\/jats:italic> Both WAI and WAS significantly improved with SPT and SA (p\u2009&lt;\u20090.001), without any between-group differences. Thoughts of being able to work within the next 6\u00a0months, Neck Disability Index (NDI), and work-related neck load explained 59% of the variance in WAI at the 2-year follow-up after ACDF. <jats:italic>Conclusions<\/jats:italic> Patients improved over time without group differences, suggesting the improvement to be surgery related. Expectation to work within the next 6\u00a0months, self-reported neck functioning and work-related neck load were important to work ability and are central factors to ask early after ACDF, to identifying further interventions promoting return to work.<\/jats:p>","DOI":"10.1007\/s10926-021-10015-6","type":"journal-article","created":{"date-parts":[[2021,12,11]],"date-time":"2021-12-11T11:04:40Z","timestamp":1639220680000},"page":"473-482","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Work Ability After Anterior Cervical Decompression and Fusion Followed by a Structured Postoperative Rehabilitation: Secondary Outcomes of a Prospective Randomized Controlled Multi-Centre Trial with a 2-year Follow-up"],"prefix":"10.1007","volume":"32","clinical-trial-number":[{"clinical-trial-number":"nct01547611","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6075-4432","authenticated-orcid":false,"given":"Anneli","family":"Peolsson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Wibault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e5kan","family":"L\u00f6fgren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c5sa","family":"Dedering","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitta","family":"\u00d6berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Zsigmond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"W\u00e5hlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,12,11]]},"reference":[{"key":"10015_CR1","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1093\/brain\/117.2.325","volume":"117","author":"K Radhakrishnan","year":"1994","unstructured":"Radhakrishnan K, Litchy WJ, O\u2019Fallon MV, et al. 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