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Furthermore, to analyze whether these predictors are generic, i.e., apply to healthy people as well, or are disease specific.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>TEMPRANO and MS@Work data were combined resulting in a dataset of 135 recently diagnosed PwMS (\u2264\u20091\u00a0year) and 172 healthy people. We analyzed the associations of baseline predictors that fit within the international classification of functioning and health (ICF) framework using a mixed-effect negative-binomial model with log link for work difficulties and number of working hours after one year, and fitted each model using a fully Bayesian approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Slower information processing speed was a disease-specific predictor for more work difficulties after one year (posterior mean ratio (PMR)\u2009=\u20090.82, 95% confidence interval (CI)\u2009=\u2009[0.69, 0.97]). Higher conscientiousness was a generic predictor for more working hours after one year (PMR\u2009=\u20091.02, 95%CI\u2009=\u2009[1.01, 1.03] for PwMS and PMR\u2009=\u20091.01, 95% CI\u2009=\u2009[1.00, 1.02] for healthy people). Being male (PMR\u2009=\u20090.75, 95% CI\u2009=\u2009[0.58, 0.96]), being younger (PMR\u2009=\u20090.99, 95% CI\u2009=\u2009[0.98, 1.00]), higher information processing speed (PMR\u2009=\u20091.08, 95% CI\u2009=\u2009[1.04, 1.13]), better learning and memory (PMR\u2009=\u20091.09, 95% CI\u2009=\u2009[1.03, 1.15]), and mentally burdensome job tasks (PMR\u2009=\u20091.36, 95% CI\u2009=\u2009[1.22, 1.52]) were disease-specific predictors for more working hours after one year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>For recently diagnosed PwMS, disease-specific predictors that fit within the ICF framework associate with perceived work difficulties and working hours after one year.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10926-025-10279-2","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T08:52:25Z","timestamp":1740732745000},"page":"426-436","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["What Predicts Changes in the Work Situation of Recently Diagnosed People with Multiple Sclerosis and do these Predictors also Apply to Healthy People?"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7824-2796","authenticated-orcid":false,"given":"Shalina R. 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Work. 2018;60(2):263\u201370.","journal-title":"Work"}],"container-title":["Journal of Occupational Rehabilitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10926-025-10279-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10926-025-10279-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10926-025-10279-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T06:01:43Z","timestamp":1776751303000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10926-025-10279-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,27]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10279"],"URL":"https:\/\/doi.org\/10.1007\/s10926-025-10279-2","relation":{},"ISSN":["1053-0487","1573-3688"],"issn-type":[{"value":"1053-0487","type":"print"},{"value":"1573-3688","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,27]]},"assertion":[{"value":"11 February 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"S.R.D. Saddal, K. van der Hiele, E. Motazedi, E.E.A. van Egmond, L.H. Visser, A. van der Kruit, M.M. Schoonheim, V. de Groot & F.G. Schaafsma declare no conflicts of interest. P.T. Waskowiak has served as a speaker for and received research support from Biogen. M.v.D. was supported by a research grant from BMS. H. E. Hulst is an editor of the Multiple Sclerosis Journal controversies sections, receives research support from the Dutch MS Research Foundation and the Dutch Research Council. She has served as a consultant for or received research support from Atara Biotherapeutics, Biogen, Novartis, Celgene\/Bristol Meyers Squibb, Sanofi Genzyme, MedDay and Merck BV.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Temprano was approved by the Medical Ethics Committee of Amsterdam UMC (Register CCMO: NL72064.029.20). The MS@Work study was approved by the Medical Ethical Committee Brabant (Register CCMO: NL43098.008.12 1307).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"All included participants from the Temprano study signed informed consent agreeing to use of their data to research what happens early after MS diagnosis. All included participants from the MS@Work study signed informed consent agreeing to use their data for the purpose of investigating which (possibly treatable) factors lead to decreased work or job loss in pwMS.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000. Informed consent was obtained from all patients for being included in the study.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}}]}}