{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T22:31:10Z","timestamp":1781735470881,"version":"3.54.5"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2011,8,17]],"date-time":"2011-08-17T00:00:00Z","timestamp":1313539200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2011,8,17]],"date-time":"2011-08-17T00:00:00Z","timestamp":1313539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Pharmacokinet Pharmacodyn"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1007\/s10928-011-9211-7","type":"journal-article","created":{"date-parts":[[2011,8,17]],"date-time":"2011-08-17T15:30:05Z","timestamp":1313595005000},"page":"613-636","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A Bayesian hierarchical nonlinear mixture model in the presence of artifactual outliers in a population pharmacokinetic study"],"prefix":"10.1007","volume":"38","author":[{"given":"Leena","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian S.","family":"Caffo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utkarsh","family":"Kohli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratik","family":"Pandharipande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Kurnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Wesley","family":"Ely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Michael","family":"Stein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,8,17]]},"reference":[{"key":"9211_CR1","volume-title":"Outliers in statistical data, 3rd edn","author":"V Barnett","year":"1994","unstructured":"Barnett V, Lewis T (1994) Outliers in statistical data, 3rd edn. Wiley, New York"},{"issue":"2","key":"9211_CR2","doi-asserted-by":"publisher","first-page":"119","DOI":"10.2307\/1268541","volume":"25","author":"RJ Beckman","year":"1983","unstructured":"Beckman RJ, Cook RD (1983) Outliers..........s. Technometrics 25(2):119\u2013149","journal-title":"Technometrics"},{"key":"9211_CR3","doi-asserted-by":"crossref","DOI":"10.1007\/978-94-015-3994-4","volume-title":"Identification of outliers","author":"DM Hawkins","year":"1980","unstructured":"Hawkins DM (1980) Identification of outliers. Chapman and Hall, London"},{"key":"9211_CR4","doi-asserted-by":"publisher","DOI":"10.1002\/0471725250","volume-title":"Robust statistics","author":"PJ Huber","year":"1981","unstructured":"Huber PJ (1981) Robust statistics. Wiley, New York"},{"issue":"2","key":"9211_CR5","doi-asserted-by":"publisher","first-page":"123","DOI":"10.2307\/1266540","volume":"2","author":"FJ Anscombe","year":"1960","unstructured":"Anscombe FJ, Guttman I (1960) Rejection of outliers. Technometrics 2(2):123\u2013147","journal-title":"Technometrics"},{"issue":"3","key":"9211_CR6","doi-asserted-by":"publisher","first-page":"527","DOI":"10.2307\/1267023","volume":"11","author":"I Guttman","year":"1969","unstructured":"Guttman I, Smith DE (1969) Investigation of rules for dealing with outliers in small samples from the normal distribution: I: Estimation of the mean. Technometrics 11(3):527\u2013550","journal-title":"Technometrics"},{"issue":"316","key":"9211_CR7","doi-asserted-by":"publisher","first-page":"929","DOI":"10.2307\/2283190","volume":"61","author":"JL Gastwirth","year":"1966","unstructured":"Gastwirth JL (1966) On robust procedures. J Am Stat Assoc 61(316):929\u2013948","journal-title":"J Am Stat Assoc"},{"key":"9211_CR8","volume-title":"Robust estimates of location: survey and advances","author":"DF Andrews","year":"1972","unstructured":"Andrews DF, Bickel PJ, Hampel FR, Huber PJ, Rogers WH, Tukey JW (1972) Robust estimates of location: survey and advances. Princeton University Press, Princeton"},{"issue":"1","key":"9211_CR9","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1214\/aoms\/1177703732","volume":"35","author":"PJ Huber","year":"1964","unstructured":"Huber PJ (1964) Robust estimation of a location parameter. Ann Math Stat 35(1):73\u2013101","journal-title":"Ann Math Stat"},{"issue":"1","key":"9211_CR10","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1214\/aos\/1176343347","volume":"4","author":"RA Maronna","year":"1976","unstructured":"Maronna RA (1976) Robust M-estimators of multivariate location and scatter. Ann Stat 4(1):51\u201367","journal-title":"Ann Stat"},{"issue":"372","key":"9211_CR11","doi-asserted-by":"publisher","first-page":"828","DOI":"10.2307\/2287169","volume":"75","author":"D Ruppert","year":"1980","unstructured":"Ruppert D, Carroll RJ (1980) Trimmed least squares estimation in the linear model. J Am Stat Assoc 75(372):828\u2013838","journal-title":"J Am Stat Assoc"},{"issue":"388","key":"9211_CR12","doi-asserted-by":"publisher","first-page":"871","DOI":"10.2307\/2288718","volume":"79","author":"PJ Rousseeuw","year":"1984","unstructured":"Rousseeuw PJ (1984) Least median of squares regression. J Am Stat Assoc 79(388):871\u2013880","journal-title":"J Am Stat Assoc"},{"issue":"3","key":"9211_CR13","doi-asserted-by":"publisher","first-page":"325","DOI":"10.2307\/1268316","volume":"22","author":"M Aitkin","year":"1980","unstructured":"Aitkin M, Wilson GT (1980) Mixture models, outliers and the EM algorithm. Technometrics 22(3):325\u2013331","journal-title":"Technometrics"},{"issue":"1","key":"9211_CR14","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1093\/biomet\/55.1.119","volume":"55","author":"GE Box","year":"1968","unstructured":"Box GE, Tiao GC (1968) A Bayesian approach to some outlier problems. Biometrika 55(1):119\u2013129","journal-title":"Biometrika"},{"issue":"2","key":"9211_CR15","doi-asserted-by":"publisher","first-page":"131","DOI":"10.2307\/2346940","volume":"27","author":"B Abraham","year":"1978","unstructured":"Abraham B, Box GEP (1978) Linear models and spurious observations. Appl Stat 27(2):131\u2013138","journal-title":"Appl Stat"},{"key":"9211_CR16","unstructured":"de Finetti B (1961) The Bayesian approach to the rejection of outliers. In: Proceedings of the fourth Berkeley symposium on mathematical statistics and probability, vol 1, pp 199\u2013210"},{"issue":"4","key":"9211_CR17","doi-asserted-by":"publisher","first-page":"723","DOI":"10.2307\/1267384","volume":"15","author":"I Guttman","year":"1973","unstructured":"Guttman I (1973) Care and handling of univariate or multivariate outliers in detecting spuriosity: a Bayesian approach. Technometrics 15(4):723\u2013738","journal-title":"Technometrics"},{"issue":"3","key":"9211_CR18","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.2517-6161.1984.tb01317.x","volume":"46","author":"M West","year":"1984","unstructured":"West M (1984) Outlier models and prior distributions in Bayesian linear regression. J R Stat Soc B 46(3):431\u2013439","journal-title":"J R Stat Soc B"},{"issue":"6","key":"9211_CR19","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/BF02353466","volume":"23","author":"M Karlsson","year":"1995","unstructured":"Karlsson M, Beal SL, Sheiner LB (1995) Three new residual error models for population PK\/PD analyses. J Pharmacokinet Pharmacodyn 23(6):651\u2013672","journal-title":"J Pharmacokinet Pharmacodyn"},{"issue":"1","key":"9211_CR20","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1111\/j.0006-341X.2000.00081.x","volume":"56","author":"JK Lindsey","year":"2000","unstructured":"Lindsey JK, Byrom WD, Wang J, Jarvis P, Jones B (2000) Generalized nonlinear models for pharmacokinetic data. Biometrics 56(1):81\u201388","journal-title":"Biometrics"},{"issue":"3","key":"9211_CR21","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1081\/BIP-100102500","volume":"10","author":"JK Lindsey","year":"2000","unstructured":"Lindsey JK, Jones B (2000) Modeling pharmacokinetic data using heavy-tailed multivariate distributions. J Biopharm Stat 10(3):369\u2013381","journal-title":"J Biopharm Stat"},{"issue":"1","key":"9211_CR22","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s10928-009-9112-1","volume":"36","author":"HE Silber","year":"2009","unstructured":"Silber HE, Kjellsson MC, Karlsson MO (2009) The impact of misspecification of residual error or correlation structure on the type I error rate for covariate inclusion. J Pharmacokinet Pharmacodyn 36(1):81\u201399","journal-title":"J Pharmacokinet Pharmacodyn"},{"issue":"3","key":"9211_CR23","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1093\/biomet\/73.3.645","volume":"73","author":"A Mallet","year":"1986","unstructured":"Mallet A (1986) A maximum likelihood estimation method for random coefficient regression models. Biometrika 73(3):645\u2013656","journal-title":"Biometrika"},{"issue":"3","key":"9211_CR24","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/BF01062140","volume":"16","author":"A Mallet","year":"1988","unstructured":"Mallet A, Mentre F, Steimer JL, Lokiec F (1988) Nonparametric maximum likelihood estimation for population pharmacokinetics, with application to cyclosporine. J Pharmacokinet Biopharm 16(3):311\u2013327","journal-title":"J Pharmacokinet Biopharm"},{"issue":"5","key":"9211_CR25","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1007\/BF01061470","volume":"20","author":"M Davidian","year":"1992","unstructured":"Davidian M, Gallant AR (1992) Smooth nonparametric maximum likelihood estimation for population pharmacokinetics, with application to quinidine. J Pharmacokinet Biopharm 20(5):529\u2013556","journal-title":"J Pharmacokinet Biopharm"},{"issue":"3","key":"9211_CR26","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1093\/biomet\/80.3.475","volume":"80","author":"M Davidian","year":"1993","unstructured":"Davidian M, Gallant AR (1993) The nonlinear mixed effects model with a smooth random effects density. Biometrika 80(3):475\u2013488","journal-title":"Biometrika"},{"issue":"440","key":"9211_CR27","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.2307\/2965398","volume":"92","author":"P Muller","year":"1997","unstructured":"Muller P, Rosner GL (1997) A Bayesian population model with hierarchical mixture priors applied to blood count data. J Am Stat Assoc 92(440):1279\u20131292","journal-title":"J Am Stat Assoc"},{"issue":"433","key":"9211_CR28","doi-asserted-by":"publisher","first-page":"62","DOI":"10.2307\/2291383","volume":"91","author":"J Wakefield","year":"1996","unstructured":"Wakefield J (1996) The Bayesian analysis of population pharmacokinetic models. J Am Stat Assoc 91(433):62\u201375","journal-title":"J Am Stat Assoc"},{"issue":"3","key":"9211_CR29","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/j.2517-6161.1982.tb01215.x","volume":"44","author":"RD Cook","year":"1982","unstructured":"Cook RD, Holschuh N, Weisberg S (1982) A note on an alternative outlier model. J R Stat Soc B 44(3):370\u2013376","journal-title":"J R Stat Soc B"},{"key":"9211_CR30","volume-title":"A survey of sampling from contaminated distributions","author":"JW Tukey","year":"1960","unstructured":"Tukey JW (1960) A survey of sampling from contaminated distributions. Standford University Press, Stanford"},{"issue":"22","key":"9211_CR31","doi-asserted-by":"publisher","first-page":"2644","DOI":"10.1001\/jama.298.22.2644","volume":"298","author":"PP Pandharipande","year":"2007","unstructured":"Pandharipande PP, Pun BT, Herr DL, Maze M, Girard TD, Miller RR, Shintani AK, Thompson JL, Jackson JC, Deppen SA, Stiles RA, Dittus RS, Bernard GR, Ely EW (2007) Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the mends randomized controlled trial. J Am Med Assoc 298(22):2644\u20132653","journal-title":"J Am Med Assoc"},{"key":"9211_CR32","unstructured":"Beal SL, Sheiner LB, Boeckmann AJ (eds) (1989\u20132006) NONMEM users guides. ICON Development Solutions, Ellicott City"},{"issue":"3","key":"9211_CR33","first-page":"195","volume":"8","author":"SL Beal","year":"1982","unstructured":"Beal SL, Sheiner LB (1982) Estimating population kinetics. Crit Rev Biomed Eng 8(3):195\u2013222","journal-title":"Crit Rev Biomed Eng"},{"key":"9211_CR34","volume-title":"Pharmacokinetics","author":"M Gibaldi","year":"1975","unstructured":"Gibaldi M, Perrier D (1975) Pharmacokinetics. Marcel Dekker, New York"},{"issue":"5","key":"9211_CR35","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1093\/bja\/88.5.669","volume":"88","author":"RM Venn","year":"2002","unstructured":"Venn RM, Karol MD, Grounds RM (2002) Pharmacokinetics of dexmedetomidine infusions for sedation of postoperative patients requiring intensive care. Br J Anaesth 88(5):669\u2013675","journal-title":"Br J Anaesth"},{"issue":"6","key":"9211_CR36","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1097\/00000542-200612000-00009","volume":"105","author":"GC Petroz","year":"2006","unstructured":"Petroz GC, Sikich N, James M, van Dyk H, Shafer SL, Schily M, Lerman J (2006) A phase I, two-center study of the pharmacokinetics and pharmacodynamics of dexmedetomidine in children. Anesthesiology 105(6):1098\u20131110","journal-title":"Anesthesiology"},{"issue":"4","key":"9211_CR37","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1002\/(SICI)1520-6017(200004)89:4<519::AID-JPS9>3.0.CO;2-U","volume":"89","author":"S Dutta","year":"2000","unstructured":"Dutta S, Lal R, Karol MD, Cohen T, Ebert T (2000) Influence of cardiac output on dexmedetomidine pharmacokinetics. J Pharm Sci 89(4):519\u2013527","journal-title":"J Pharm Sci"},{"issue":"5","key":"9211_CR38","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1097\/00000542-199305000-00002","volume":"78","author":"JB Dyck","year":"1993","unstructured":"Dyck JB, Maze M, Haack C, Vuorilehto L, Shafer SL (1993) The pharmacokinetics and hemodynamic effects of intravenous and intramuscular dexmedetomidine hydrochloride in adult human volunteers. Anesthesiology 78(5):813\u2013820","journal-title":"Anesthesiology"},{"issue":"2","key":"9211_CR39","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1161\/HYPERTENSIONAHA.107.098939","volume":"51","author":"D Kurnik","year":"2008","unstructured":"Kurnik D, Muszkat M, Sofowora GG, Friedman EA, Dupont WD, Scheinin M, Wood AJ, Stein CM (2008) Ethnic and genetic determinants of cardiovascular response to the selective alpha 2-adrenoceptor agonist dexmedetomidine. Hypertension 51(2):406\u2013411","journal-title":"Hypertension"},{"issue":"2","key":"9211_CR40","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.ejpain.2009.04.003","volume":"14","author":"U Kohli","year":"2010","unstructured":"Kohli U, Muszkat M, Sofowora GG, Harris PA, Friedman EA, Dupont WD, Scheinin M, Wood AJ, Stein CM, Kurnik D (2010) Effects of variation in the human alpha2a- and alpha2c-adrenoceptor genes on cognitive tasks and pain perception. Eur J Pain 14(2):154\u2013159","journal-title":"Eur J Pain"},{"issue":"435","key":"9211_CR41","doi-asserted-by":"publisher","first-page":"917","DOI":"10.2307\/2291710","volume":"91","author":"J Wakefield","year":"1996","unstructured":"Wakefield J, Bennett J (1996) The Bayesian modeling of covariates for population pharmacokinetic models. J Am Stat Assoc 91(435):917\u2013927","journal-title":"J Am Stat Assoc"},{"issue":"9\u201310","key":"9211_CR42","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1002\/sim.4780140917","volume":"14","author":"J Wakefield","year":"1995","unstructured":"Wakefield J, Racine-Poon A (1995) An application of Bayesian population pharmacokinetic\/pharmacodynamic models to dose recommendation. Stat Med 14(9\u201310):971\u2013986","journal-title":"Stat Med"},{"issue":"1","key":"9211_CR43","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1191\/096228098670696372","volume":"7","author":"A Racine-Poon","year":"1998","unstructured":"Racine-Poon A, Wakefield J (1998) Statistical methods for population pharmacokinetic modelling. Stat Methods Med Res 7(1):63\u201384","journal-title":"Stat Methods Med Res"},{"key":"9211_CR44","unstructured":"Spiegelhalter D, Thomas A, Best N, Lunn D (2004) WinBUGS 1.4 user manual. Technical report, MRC Biostatistics Unit, Institute of Public Health and Department of Epidemiology and Public Health, Imperial College School of Medicine"},{"key":"9211_CR45","unstructured":"Lunn DJ, Wakefield J, Thomas A, Best N, Spiegelhalter D (1999) PKBugs user guide. Technical report, Department of Epidemiology & Public Health, Imperial College School of Medicine"},{"issue":"3","key":"9211_CR46","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1023\/A:1020206907668","volume":"29","author":"DJ Lunn","year":"2002","unstructured":"Lunn DJ, Best N, Thomas A, Wakefield J, Spiegelhalter D (2002) Bayesian analysis of population PK\/PD models: general concepts and software. J Pharmacokinet Pharmacodyn 29(3):271\u2013307","journal-title":"J Pharmacokinet Pharmacodyn"},{"issue":"1","key":"9211_CR47","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.2517-6161.1985.tb01331.x","volume":"47","author":"M Aitkin","year":"1985","unstructured":"Aitkin M, Rubin DB (1985) Estimation and hypothesis testing in finite mixture models. J R Stat Soc B 47(1):67\u201375","journal-title":"J R Stat Soc B"},{"key":"9211_CR48","doi-asserted-by":"publisher","DOI":"10.1002\/0471721182","volume-title":"Finite mixture models","author":"G McLachlan","year":"2000","unstructured":"McLachlan G, Peel D (2000) Finite mixture models. Wiley-Interscience, New York"},{"key":"9211_CR49","first-page":"733","volume":"6","author":"A Gelman","year":"1996","unstructured":"Gelman A, Meng X-L, Stern H (1996) Posterior predictive assessment of model fitness via realized discrepancies. Stat Sin 6:733\u2013807","journal-title":"Stat Sin"},{"key":"9211_CR50","doi-asserted-by":"crossref","DOI":"10.1201\/9780429258480","volume-title":"Bayesian data analysis, 2nd edn","author":"A Gelman","year":"2003","unstructured":"Gelman A, Carlin JB, Stern HS, Rubin DB (2003) Bayesian data analysis, 2nd edn. Chapman & Hall\/CRC, Boca Raton"},{"issue":"4","key":"9211_CR51","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1111\/1467-9868.00353","volume":"64","author":"DJ Spiegelhalter","year":"2002","unstructured":"Spiegelhalter DJ, Best NG, Carlin BP, Van Der Linde A (2002) Bayesian measures of model complexity and fit. J R Stat Soc B 64(4):629\u2013630","journal-title":"J R Stat Soc B"},{"issue":"4","key":"9211_CR52","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1111\/1467-9868.00353","volume":"64","author":"M DeIorio","year":"2002","unstructured":"DeIorio M, Robert CP (2002) Discussion of spiegelhalter et\u00a0al. J R Stat Soc B 64(4):583\u2013639","journal-title":"J R Stat Soc B"},{"issue":"1","key":"9211_CR53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/biomet\/85.1.1","volume":"85","author":"AE Gelfand","year":"1998","unstructured":"Gelfand AE, Ghosh SK (1998) Model choice: a minimum posterior predictive loss approach. Biometrika 85(1):1\u201311","journal-title":"Biometrika"},{"issue":"1","key":"9211_CR54","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.2517-6161.1995.tb02028.x","volume":"57","author":"PW Laud","year":"1995","unstructured":"Laud PW, Ibrahim JG (1995) Predictive model selection. J R Stat Soc B 57(1):247\u2013262","journal-title":"J R Stat Soc B"}],"container-title":["Journal of Pharmacokinetics and Pharmacodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10928-011-9211-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10928-011-9211-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10928-011-9211-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10928-011-9211-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T03:36:00Z","timestamp":1744169760000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10928-011-9211-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,17]]},"references-count":54,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["9211"],"URL":"https:\/\/doi.org\/10.1007\/s10928-011-9211-7","relation":{},"ISSN":["1567-567X","1573-8744"],"issn-type":[{"value":"1567-567X","type":"print"},{"value":"1573-8744","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,17]]},"assertion":[{"value":"18 January 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2011","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2011","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}