{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T02:08:16Z","timestamp":1746756496267},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,2,12]],"date-time":"2016-02-12T00:00:00Z","timestamp":1455235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Pharmacokinet Pharmacodyn"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1007\/s10928-016-9465-1","type":"journal-article","created":{"date-parts":[[2016,2,12]],"date-time":"2016-02-12T15:26:17Z","timestamp":1455290777000},"page":"191-206","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Model-based meta-analysis for development of a population-pharmacokinetic (PPK) model for Vitamin D3 and its 25OHD3 metabolite using both individual and arm-level data"],"prefix":"10.1007","volume":"43","author":[{"given":"Alanna S.","family":"Ocampo-Pelland","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc R.","family":"Gastonguay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan F.","family":"French","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew M.","family":"Riggs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,2,12]]},"reference":[{"key":"9465_CR1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00198-008-0626-y","volume":"20","author":"T Hagenau","year":"2009","unstructured":"Hagenau T, Vest R, Gissel TN, Poulsen CS, Erlandsen M, Mosekilde L, Vestergaard P (2009) Global vitamin D levels in relation to age, gender, skin pigmentation and latitude: an ecologic meta-regression analysis. Osteoporos Int 20:133\u2013140","journal-title":"Osteoporos Int"},{"issue":"4","key":"9465_CR2","first-page":"273","volume":"65","author":"D Wranicz","year":"2014","unstructured":"Wranicz D, Szostak-W\u0119gierek J (2014) Health outcomes of vitamin D. Part II. Role in prevention of diseases. Rocz Panstw Zakl Hig 65(4):273\u2013279","journal-title":"Rocz Panstw Zakl Hig"},{"key":"9465_CR3","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3109\/00365518209168118","volume":"42","author":"C Christiansen","year":"1982","unstructured":"Christiansen C, Christensen MS, McNair P, Nielsen B, Madsbad S (1982) Vitamin D metabolites in diabetic patients: decreased serum concentration of 24,25-dihydroxyvitamin D. Scand J Clin Lab Investig 42:487\u2013491","journal-title":"Scand J Clin Lab Investig"},{"issue":"1","key":"9465_CR4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.2174\/1573399811666141210153503","volume":"11","author":"T Issa","year":"2015","unstructured":"Issa T, Zantout C, Azar S (2015) Vitamin d replacement and type 2 diabetes mellitus. Curr Diabetes Rev 11(1):7\u201316","journal-title":"Curr Diabetes Rev"},{"issue":"April","key":"9465_CR5","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1158\/1940-6207.CAPR-13-0269","volume":"7","author":"EA Hibler","year":"2014","unstructured":"Hibler EA, Jacobs ET, Stone AD, Sardo CL, Galligan MA, Jurutka PW (2014) Associations between vitamin D-binding protein isotypes, circulating 25(OH)D levels, and vitamin D metabolite uptake in colon cancer cells. Cancer Prev Res 7(April):426\u2013434","journal-title":"Cancer Prev Res"},{"key":"9465_CR6","doi-asserted-by":"crossref","first-page":"565S","DOI":"10.1093\/ajcn\/88.2.565S","volume":"88","author":"C Davis","year":"2008","unstructured":"Davis C (2008) Vitamin D and cancer: current dilemmas and future research needs. Am J Clin Nutr 88:565S","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"9465_CR7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2261-14-1","volume":"14","author":"T Ruwanpathirana","year":"2014","unstructured":"Ruwanpathirana T, Reid CM, Owen AJ, Fong DPS, Gowda U, Renzaho AMN (2014) Assessment of vitamin D and its association with cardiovascular disease risk factors in an adult migrant population: an audit of patient records at a Community Health Centre in Kensington, Melbourne, Australia. BMC Cardiovasc Disord 14(1):1\u20138","journal-title":"BMC Cardiovasc Disord"},{"issue":"July","key":"9465_CR8","first-page":"1","volume":"5","author":"TK W\u00f6bke","year":"2014","unstructured":"W\u00f6bke TK, Sorg BL, Steinhilber D (2014) Vitamin D in inflammatory diseases. Front Physiol 5(July):1\u201320","journal-title":"Front Physiol"},{"issue":"Suppl 243","key":"9465_CR9","first-page":"154","volume":"72","author":"PM Brannon","year":"2012","unstructured":"Brannon PM (2012) Key questions in vitamin D research. Scand J Clin Lab Investig 72(Suppl 243):154\u2013162","journal-title":"Scand J Clin Lab Investig"},{"key":"9465_CR10","unstructured":"IOM (Institute of Medicine) (2011) Dietary reference intakes for calcium and vitamin D. Committee to review dietary reference intakes for vitamin D and calcium. The National Academies Press, Washington, DC"},{"issue":"3","key":"9465_CR11","doi-asserted-by":"crossref","first-page":"3846","DOI":"10.1056\/NEJMra070553","volume":"357","author":"MF Holick","year":"2007","unstructured":"Holick MF (2007) Vitamin D deficiency. N Engl J Med 357(3):3846\u20133847","journal-title":"N Engl J Med"},{"key":"9465_CR12","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s12018-009-9026-x","volume":"7","author":"MF Holick","year":"2009","unstructured":"Holick MF (2009) Vitamin D and health: evolution, biologic functions, and recommended dietary intakes for vitamin D. Clin Rev Bone Min Metab 7:2\u201319","journal-title":"Clin Rev Bone Min Metab"},{"key":"9465_CR13","doi-asserted-by":"crossref","first-page":"3605","DOI":"10.3390\/nu5093605","volume":"5","author":"F Alshahrani","year":"2013","unstructured":"Alshahrani F, Aljohani N (2013) Vitamin D: deficiency, sufficiency and toxicity. Nutrients 5:3605\u20133616","journal-title":"Nutrients"},{"key":"9465_CR14","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.pbiomolbio.2006.02.016","volume":"92","author":"P\u00c3 Lips","year":"2006","unstructured":"Lips P\u00c3 (2006) Vitamin D physiology. Prog Biophys Mol Biol 92:4\u20138","journal-title":"Prog Biophys Mol Biol"},{"issue":"Suppl 2","key":"9465_CR15","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1111\/j.1753-4887.2008.00105.x","volume":"66","author":"HF DeLuca","year":"2008","unstructured":"DeLuca HF (2008) Evolution of our understanding of vitamin D. Nutr Rev 66(Suppl 2):S73\u2013S87","journal-title":"Nutr Rev"},{"key":"9465_CR16","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1093\/ajcn\/77.1.204","volume":"77","author":"RP Heaney","year":"2003","unstructured":"Heaney RP, Davies KM, Chen TC, Holick MF, Janet Barger-Lux M (2003) Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr 77:204\u2013210","journal-title":"Am J Clin Nutr"},{"key":"9465_CR17","unstructured":"Food And Nutrition Board and Institue Of Medicine (1997) Dietary reference intakes for calcium, phosphorus, magnesium, vitamin D, and fluoride, no. 1. National Academy Press, Washington, D.C."},{"issue":"9105","key":"9465_CR18","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S0140-6736(05)78933-9","volume":"351","author":"A Malabanan","year":"1998","unstructured":"Malabanan A, Veronikis IE, Holick MF (1998) Redefining vitamin D insufficiency. Lancet 351(9105):805\u2013806","journal-title":"Lancet"},{"issue":"12","key":"9465_CR19","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1056\/NEJM199803193381201","volume":"338","author":"MK Thomas","year":"1998","unstructured":"Thomas MK, Lloyd-Jones DM, Thadhani RI, Shaw AC, Deraska DJ, Kitch BT, Vamvakas EC, Dick IM, Prince RL, Finkelstein JS (1998) Hypovitaminosis D in medical inpatients. N Engl J Med 338(12):777\u2013783","journal-title":"N Engl J Med"},{"issue":"2","key":"9465_CR20","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1080\/07315724.2003.10719287","volume":"22","author":"RP Heaney","year":"2003","unstructured":"Heaney RP, Dowell MS, Hale CA, Bendich A (2003) Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D. J Am Coll Nutr 22(2):142\u2013146","journal-title":"J Am Coll Nutr"},{"issue":"6","key":"9465_CR21","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1210\/jc.2004-2364","volume":"90","author":"MF Holick","year":"2005","unstructured":"Holick MF, Siris ES, Binkley N, Beard MK, Khan A, Katzer JT, Petruschke RA, Chen E, De Papp AE (2005) Prevalence of vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy. J Clin Endocrinol Metab 90(6):3215\u20133224","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"9465_CR22","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1093\/ajcn\/87.3.688","volume":"87","author":"M Ilahi","year":"2008","unstructured":"Ilahi M, Armas LAG, Heaney RP (2008) Pharmacokinetics of a single, large dose of cholecalciferol. Am J Clin Nutr 87(10):688\u2013691","journal-title":"Am J Clin Nutr"},{"key":"9465_CR23","volume-title":"Vitamin D","author":"R Vieth","year":"2005","unstructured":"Vieth R (2005) Vitamin D, 2nd edn. Elsevier Inc., Philadelphia","edition":"2"},{"issue":"11","key":"9465_CR24","doi-asserted-by":"crossref","first-page":"e111265","DOI":"10.1371\/journal.pone.0111265","volume":"9","author":"JP Ekwaru","year":"2014","unstructured":"Ekwaru JP, Zwicker JD, Holick MF, Giovannucci E, Veugelers PJ (2014) The importance of body weight for the dose response relationship of oral vitamin D supplementation and serum 25-hydroxyvitamin D in healthy volunteers. PLoS One 9(11):e111265","journal-title":"PLoS One"},{"issue":"4","key":"9465_CR25","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/BF02555135","volume":"43","author":"Y Liel","year":"1988","unstructured":"Liel Y, Ulmer E, Shary J, Hollis BW, Bell NH (1988) Low circulating vitamin D in obesity. Calcif Tissue Int 43(4):199\u2013201","journal-title":"Calcif Tissue Int"},{"issue":"12","key":"9465_CR26","doi-asserted-by":"crossref","first-page":"4845","DOI":"10.1210\/jc.2012-4103","volume":"98","author":"A Drincic","year":"2013","unstructured":"Drincic A, Fuller E, Heaney RP, Armas LAG (2013) 25-Hydroxyvitamin D response to graded vitamin D3 supplementation among obese adults. J Clin Endocrinol Metab 98(12):4845\u20134851","journal-title":"J Clin Endocrinol Metab"},{"issue":"15","key":"9465_CR27","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.clinbiochem.2009.07.013","volume":"42","author":"D Wagner","year":"2009","unstructured":"Wagner D, Hanwell HEC, Vieth R (2009) An evaluation of automated methods for measurement of serum 25-hydroxyvitamin D. Clin Biochem 42(15):1549\u20131556","journal-title":"Clin Biochem"},{"issue":"3","key":"9465_CR28","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1210\/jc.2011-2584","volume":"97","author":"M Barake","year":"2012","unstructured":"Barake M, Daher RT, Salti I, Cortas NK, Al-Shaar L, Habib RH, Fuleihan GE-H (2012) 25-Hydroxyvitamin D assay variations and impact on clinical decision making. J Clin Endocrinol Metab 97(3):835\u2013843","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"9465_CR29","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1210\/jc.2004-0682","volume":"89","author":"BW Hollis","year":"2004","unstructured":"Hollis BW (2004) Editorial: the determination of circulating 25-hydroxyvitamin D: no easy task. J Clin Endocrinol Metab 89(7):3149\u20133151","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"9465_CR30","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.1210\/jc.2003-031979","volume":"89","author":"N Binkley","year":"2004","unstructured":"Binkley N, Krueger D, Cowgill CS, Plum L, Lake E, Hansen KE, DeLuca HF, Drezner MK (2004) Assay variation confounds the diagnosis of hypovitaminosis D: a call for standardization. J Clin Endocrinol Metab 89(7):3152\u20133157","journal-title":"J Clin Endocrinol Metab"},{"key":"9465_CR31","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.jsbmb.2004.03.055","volume":"89\u201390","author":"GD Carter","year":"2004","unstructured":"Carter GD, Carter CR, Gunter E, Jones J, Jones G, Makin HLJ, Sufi S (2004) Measurement of Vitamin D metabolites: an international perspective on methodology and clinical interpretation. J Steroid Biochem Mol Biol 89\u201390:467\u2013471","journal-title":"J Steroid Biochem Mol Biol"},{"key":"9465_CR32","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1258\/000456306775141650","volume":"43","author":"P Glendenning","year":"2006","unstructured":"Glendenning P, Taranto M, Noble JM, Musk AA, Hammond C, Goldswain PR, Fraser WD, Vasikaran SD (2006) Current assays overestimate 25-hydroxyvitamin D3 and underestimate 25-hydroxyvitamin D2 compared with HPLC: need for assay-specific decision limits and metabolite-specific assays. Ann Clin Biochem 43:23\u201330","journal-title":"Ann Clin Biochem"},{"issue":"3","key":"9465_CR33","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1210\/jcem-33-3-554","volume":"33","author":"R Belsey","year":"1971","unstructured":"Belsey R, Deluca HF, Potts JT (1971) Competitive binding assay for vitamin D and 25-OH vitamin D. J Clin Endocrinol 33(3):554\u2013557","journal-title":"J Clin Endocrinol"},{"key":"9465_CR34","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0955-2863(90)90067-U","volume":"1","author":"TC Chen","year":"1990","unstructured":"Chen TC, Turner AK, Holick MF (1990) Methods for the determination of the circulating concentration of 25-hydroxyvitamin D. J Nutr Biochem 1:315\u2013319","journal-title":"J Nutr Biochem"},{"issue":"3","key":"9465_CR35","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/clinchem\/39.3.529","volume":"39","author":"BW Hollis","year":"1993","unstructured":"Hollis BW, Kamerud JQ, Selvaag SR, Lorenz JD, Napoli JL (1993) Determination of vitamin D status by radioimmunoassay with an 125I-labeled tracer. Clin Chem 39(3):529\u2013533","journal-title":"Clin Chem"},{"issue":"11","key":"9465_CR36","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1093\/clinchem\/31.11.1815","volume":"31","author":"BW Hollis","year":"1985","unstructured":"Hollis BW, Napoll JL (1985) Improved radioimmunoassay for vitamin D and its use in assessing vitamin D status. Clin Chem 31(11):1815\u20131819","journal-title":"Clin Chem"},{"key":"9465_CR37","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/0003-2697(77)90648-0","volume":"80","author":"JA Eisman","year":"1977","unstructured":"Eisman JA, Shepard RM, DeLuca HF (1977) Determination of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 in human plasma using high-pressure liquid chromatography. Anal Biochem 80:298\u2013305","journal-title":"Anal Biochem"},{"issue":"8","key":"9465_CR38","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1002\/jbmr.2252","volume":"29","author":"N Binkley","year":"2014","unstructured":"Binkley N, Sempos CT (2014) Standardizing vitamin D assays: the way forward. Journal of Bone and Mineral Research 29(8):1709\u20131714","journal-title":"Journal of Bone and Mineral Research"},{"issue":"9","key":"9465_CR39","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1093\/ptj\/89.9.873","volume":"89","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG, Grp P (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement (reprinted from annals of internal medicine). Phys Ther 89(9):873\u2013880","journal-title":"Phys Ther"},{"key":"9465_CR40","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s10928-010-9152-6","volume":"37","author":"JE Ahn","year":"2010","unstructured":"Ahn JE, French JL (2010) Longitudinal aggregate data model-based meta-analysis with NONMEM: approaches to handling within treatment arm correlation. J Pharmacokinet Pharmacodyn 37:179\u2013201","journal-title":"J Pharmacokinet Pharmacodyn"},{"key":"9465_CR41","unstructured":"R Development Core Team (2008) R: a language and environment for statistical computing, Vienna, Austria"},{"key":"9465_CR42","unstructured":"Baron KT, Gastonguay MR (2015) Simulation from ODE-based population PK\/PD and systems pharmacology models in R with mrgsolve. In: American Conference on Pharmacometrics"},{"issue":"6","key":"9465_CR43","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1093\/ajcn\/87.6.1738","volume":"87","author":"RP Heaney","year":"2008","unstructured":"Heaney RP, Armas LAG, Shary JR, Bell NH, Binkley N, Hollis BW (2008) 25-Hydroxylation of vitamin D3: relation to circulating vitamin D3 under various input conditions. J Am Coll Nutr 87(6):1738\u20131742","journal-title":"J Am Coll Nutr"},{"issue":"10","key":"9465_CR44","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1111\/j.1742-4658.2008.06406.x","volume":"275","author":"RC Tuckey","year":"2008","unstructured":"Tuckey RC, Li W, Zjawiony JK, Zmijewski MA, Nguyen MN, Sweatman T, Miller D, Slominski A (2008) Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc. FEBS J 275(10):2585\u20132596","journal-title":"FEBS J"},{"issue":"2","key":"9465_CR45","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/0003-9861(80)90449-X","volume":"202","author":"G Jones","year":"1980","unstructured":"Jones G, Schnoes HK, Levan L, Deluca F (1980) Isolation and identification of 24-hydroxyvitamin D2 and 24,25-dihydroxyvitamin D2. Arch Biochem Biophys 202(2):450\u2013457","journal-title":"Arch Biochem Biophys"},{"issue":"6","key":"9465_CR46","first-page":"2156","volume":"83","author":"EB Mawer","year":"1998","unstructured":"Mawer EB, Jones G, Davies M, Still PE, Byford V, Schroeder NJ, Makin HLJ, Bishop CW, Knutson JC, Infirmary MR (1998) Unique 24-hydroxylated metabolites represent a significant pathway of metabolism of vitamin D2 in humans: 24-hydroxyvitamin D2 and 1,24-dihydroxyvitamin D2 detectable in human serum. J Clin Endocrinol Metab 83(6):2156\u20132166","journal-title":"J Clin Endocrinol Metab"},{"key":"9465_CR47","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1093\/ajcn\/68.4.854","volume":"68","author":"HM Trang","year":"1998","unstructured":"Trang HM, Cole DEC, Rubin LA, Pierratos A, Siu S, Vieth R (1998) Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2. Am J Clin Nutr 68:854\u2013858","journal-title":"Am J Clin Nutr"},{"issue":"58","key":"9465_CR48","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1080\/07315724.2002.10719235","volume":"21","author":"SS Harris","year":"2002","unstructured":"Harris SS, Dawson-Hughes B (2002) Plasma vitamin D and 25OHD responses of young and old men to supplementation with vitamin D3. J Am Coll Nutr 21(58):357\u2013362","journal-title":"J Am Coll Nutr"},{"key":"9465_CR49","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1172\/JCI106538","volume":"50","author":"SJ Rosenstreich","year":"1971","unstructured":"Rosenstreich SJ, Rich C, Volwiler W (1971) Deposition in and release of vitamin D3 from body fat: evidence for a storage site in the rat. J Clin Investig 50:679\u2013687","journal-title":"J Clin Investig"},{"issue":"3","key":"9465_CR50","doi-asserted-by":"crossref","first-page":"949","DOI":"10.3390\/nu5030949","volume":"5","author":"S Vanlint","year":"2013","unstructured":"Vanlint S (2013) Vitamin D and obesity. Nutrients 5(3):949\u2013956","journal-title":"Nutrients"},{"issue":"3","key":"9465_CR51","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1093\/ajcn\/72.3.690","volume":"72","author":"J Wortsman","year":"2000","unstructured":"Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF (2000) Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 72(3):690\u2013693","journal-title":"Am J Clin Nutr"},{"key":"9465_CR52","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.3945\/ajcn.2008.27189","volume":"89","author":"SM Smith","year":"2009","unstructured":"Smith SM, Gardner KK, Locke J, Zwart SR (2009) Vitamin D supplementation during Antarctic winter. Am J Clin Nutr 89:1092\u20131098","journal-title":"Am J Clin Nutr"},{"key":"9465_CR53","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1093\/ajcn\/77.6.1478","volume":"77","author":"V Tangpricha","year":"2003","unstructured":"Tangpricha V, Koutkia P, Rieke SM, Chen TC, Perez AA, Holick MF (2003) Fortification of orange juice with vitamin D: a novel approach for enhancing vitamin D nutritional health. Am J Clin Nutr 77:1478\u20131483","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"9465_CR54","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.bone.2009.08.053","volume":"46","author":"MC Peterson","year":"2010","unstructured":"Peterson MC, Riggs MM (2010) A physiologically based mathematical model of integrated calcium homeostasis and bone remodeling. Bone 46(1):49\u201363","journal-title":"Bone"}],"container-title":["Journal of Pharmacokinetics and Pharmacodynamics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10928-016-9465-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10928-016-9465-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10928-016-9465-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T10:07:01Z","timestamp":1600164421000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10928-016-9465-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,12]]},"references-count":54,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["9465"],"URL":"https:\/\/doi.org\/10.1007\/s10928-016-9465-1","relation":{},"ISSN":["1567-567X","1573-8744"],"issn-type":[{"value":"1567-567X","type":"print"},{"value":"1573-8744","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,12]]}}}