{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T04:21:52Z","timestamp":1667535712750},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2006,5,16]],"date-time":"2006-05-16T00:00:00Z","timestamp":1147737600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2006,5,16]],"date-time":"2006-05-16T00:00:00Z","timestamp":1147737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Protein J"],"published-print":{"date-parts":[[2006,6]]},"DOI":"10.1007\/s10930-006-9009-4","type":"journal-article","created":{"date-parts":[[2006,5,15]],"date-time":"2006-05-15T15:21:20Z","timestamp":1147706480000},"page":"257-262","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Mutagenesis Studies on the N-terminus and Thr54 of Naja naja atra (Taiwan cobra) Chymotrypsin Inhibitor"],"prefix":"10.1007","volume":"25","author":[{"given":"Fang-Jiun","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Ping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Ching","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long-Sen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,5,16]]},"reference":[{"key":"9009_CR1","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1110\/ps.4460102","volume":"11","author":"O. Buczek","year":"2002","unstructured":"Buczek O., Krowarsch D., Otlewski J. (2002). Protein Sci. 11: 924\u2013932","journal-title":"Protein Sci."},{"key":"9009_CR2","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1093\/protein\/10.2.131","volume":"10","author":"L. Cardle","year":"1997","unstructured":"Cardle L., Dufton M. J. (1997). Protein Eng. 10: 131\u2013136","journal-title":"Protein Eng."},{"key":"9009_CR3","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1006\/bbrc.1996.1283","volume":"225","author":"L. S. Chang","year":"1996","unstructured":"Chang L. S., Wu P. F., Chang C. C. (1996). Biochem. Biophys. Res. Commun. 225: 990\u2013996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"9009_CR4","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1006\/bbrc.2001.4878","volume":"283","author":"L. S. Chang","year":"2001","unstructured":"Chang L. S., Chung C., Huang S. B., Lin S. R. (2001). Biochem. Biophys. Res. Commun. 283: 862\u2013867","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"9009_CR6","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.bbapap.2004.11.006","volume":"1747","author":"Y. C. Cheng","year":"2005","unstructured":"Cheng Y. C., Yan F. J., Chang L. S. (2005). Biochim. Biophys. Acta 1747: 213\u2013220","journal-title":"Biochim. Biophys. Acta"},{"key":"9009_CR7","doi-asserted-by":"publisher","first-page":"33346","DOI":"10.1074\/jbc.M006085200","volume":"275","author":"A. Crzesiak","year":"2000a","unstructured":"Crzesiak A., Krokoszynska I., Krowarsch D., Buczek O., Dadlez M., Otlewski J. (2000a). J. Biol. Chem. 275: 33346\u201333352","journal-title":"J. Biol. Chem."},{"key":"9009_CR8","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1006\/jmbi.2000.3935","volume":"301","author":"A. Crzesiak","year":"2000b","unstructured":"Crzesiak A., Helland R., Smalas A.O., Krowarsch D., Dadlez M., Otlewski J. (2000b). J. Mol. Biol. 301: 205\u2013217","journal-title":"J. Mol. Biol."},{"key":"9009_CR9","doi-asserted-by":"publisher","first-page":"3645","DOI":"10.1021\/bi972282u","volume":"37","author":"P. E. Hansen","year":"1998","unstructured":"Hansen P. E., Zhang W., Lauritzen C., Bjorn S., Petersen L. C., Norris K., Olsen O. H., Betzel C. (1998). Biochemstry 37: 3645\u20133653","journal-title":"Biochemstry"},{"key":"9009_CR10","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1093\/oxfordjournals.jbchem.a131100","volume":"79","author":"Y. Hokama","year":"1976","unstructured":"Hokama Y., Iwanaga S., Tatsuki T., Suzuki T. (1976). J. Biochem. 79: 559\u2013578","journal-title":"J. Biochem."},{"key":"9009_CR11","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1006\/jmbi.1997.1460","volume":"275","author":"I. Krokoszynska","year":"1998","unstructured":"Krokoszynska I., Dadlez M., Otlewski J. (1998). J. Mol. Biol. 275: 503\u2013513","journal-title":"J. Mol. Biol."},{"key":"9009_CR12","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1006\/jmbi.1999.2757","volume":"289","author":"D. Krowarsch","year":"1999","unstructured":"Krowarsch D., Dadlez M., Buczek O., Krokoszynska I., Smalas A. O., Otlewski J. (1999). J. Mol. Biol. 289: 175\u2013186","journal-title":"J. Mol. Biol."},{"key":"9009_CR13","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/S0141-8130(05)80073-X","volume":"14","author":"C. Lauritzen","year":"1992","unstructured":"Lauritzen C., Skovgaard O., Hansen P. E., Tuchsen E. (1992). Int. J. Biol. Macromol. 14: 326\u2013332","journal-title":"Int. J. Biol. Macromol."},{"key":"9009_CR14","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1111\/j.1399-3011.1983.tb03095.x","volume":"21","author":"C. S. Liu","year":"1983","unstructured":"Liu C. S., Wu T. C., Lo T. B. (1983). Int. J. Peptide Protein Res. 21: 209\u2013215","journal-title":"Int. J. Peptide Protein Res."},{"key":"9009_CR15","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1006\/jmbi.1996.0781","volume":"266","author":"W. Lu","year":"1997","unstructured":"Lu W., Apostol I., Qasim M. A., Warne N., Wynn R., Zhang W. L., Anderson S., Chiang Y. W., Ogin E., Rothberg I., Ryan K., Laskowski M. Jr. (1997). J. Mol. Biol. 266: 441\u2013461","journal-title":"J. Mol. Biol."},{"key":"9009_CR17","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1111\/j.1432-1033.1983.tb07481.x","volume":"133","author":"A. Ritonja","year":"1983a","unstructured":"Ritonja A., Turk V., Gubensek F. (1983a). Eur. J. Biochem. 133: 427\u2013432","journal-title":"Eur. J. Biochem."},{"key":"9009_CR18","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/0167-4838(83)90067-5","volume":"746","author":"A. Ritonja","year":"1983b","unstructured":"Ritonja A., Meloun B., Gubensek F. (1983b). Biochim. Biophys. Acta 746: 138\u2013145","journal-title":"Biochim. Biophys. Acta"},{"key":"9009_CR19","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1111\/j.1432-1033.1990.tb15622.x","volume":"194","author":"J. Shafqat","year":"1990a","unstructured":"Shafqat J., Beg O. U., Yin S. J., Zaidi Z. H., Jornvall H. (1990a). Eur. J. Biochem. 194: 337\u2013341","journal-title":"Eur. J. Biochem."},{"key":"9009_CR20","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/0014-5793(90)81426-O","volume":"275","author":"J. Shafqat","year":"1990b","unstructured":"Shafqat J., Zaidi Z. H., Jornvall H. (1990b). FEBS Lett. 275: 6\u20138","journal-title":"FEBS Lett."},{"key":"9009_CR21","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/0014-5793(91)81361-B","volume":"294","author":"A. R. Siddigi","year":"1991","unstructured":"Siddigi A. R., Zaidi Z. H., Jornvall H. (1991). FEBS Lett. 294: 141\u2013143","journal-title":"FEBS Lett."},{"key":"9009_CR22","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1007\/BF01024879","volume":"7","author":"J. Siekman","year":"1988","unstructured":"Siekman J., Wenzel H. R., Matuszak E., Goldammer E., Tschesche H. (1988). J. Protein Chem. 7: 633\u2013640","journal-title":"J. Protein Chem."},{"key":"9009_CR23","first-page":"721","volume":"76","author":"H. Takahashi","year":"1974","unstructured":"Takahashi H., Iwanaga S., Kitagawa T., Hokama Y., Suzuki T. (1974). J. Biochem. 76: 721\u2013733","journal-title":"J. Biochem."},{"key":"9009_CR24","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.cbpc.2003.11.007","volume":"B317","author":"X. D. Zhou","year":"2004","unstructured":"Zhou X. D., Jin Y., Lu Q. M., Li D. S., Zhu S. W., Wang W. Y., Xiong Y. L. (2004). Comparative Biochem. Physiol. B317: 219\u2013224","journal-title":"Comparative Biochem. Physiol."}],"container-title":["The Protein Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10930-006-9009-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10930-006-9009-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10930-006-9009-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10930-006-9009-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T23:48:02Z","timestamp":1667519282000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10930-006-9009-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,16]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["9009"],"URL":"https:\/\/doi.org\/10.1007\/s10930-006-9009-4","relation":{},"ISSN":["1572-3887","1875-8355"],"issn-type":[{"value":"1572-3887","type":"print"},{"value":"1875-8355","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5,16]]},"assertion":[{"value":"16 May 2006","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}