{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T02:30:37Z","timestamp":1772764237173,"version":"3.50.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2007,1,3]],"date-time":"2007-01-03T00:00:00Z","timestamp":1167782400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2007,1,3]],"date-time":"2007-01-03T00:00:00Z","timestamp":1167782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Protein J"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1007\/s10930-006-9063-y","type":"journal-article","created":{"date-parts":[[2007,1,2]],"date-time":"2007-01-02T20:02:40Z","timestamp":1167768160000},"page":"221-230","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Biological and Structural Characterization of Crotoxin and New Isoform of Crotoxin B PLA2 (F6a) from Crotalus durissus collilineatus Snake Venom"],"prefix":"10.1007","volume":"26","author":[{"given":"Luis Alberto","family":"Ponce-Soto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Lomonte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lea","family":"Rodrigues-Simioni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Camillo","family":"Novello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Marangoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,1,3]]},"reference":[{"key":"9063_CR1","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/S1357-2725(02)00060-2","volume":"34","author":"Y. Angulo","year":"2002","unstructured":"Angulo Y., Olamendi-Portugal T., Alape-Gir\u00f3n A., Possani L. D., Lomonte B. (2002) Int. J. Biochem. 34: 1268\u20131278","journal-title":"Int. J. Biochem."},{"key":"9063_CR2","unstructured":"Ara\u00fajo, F. A. A., SantaL\u00facia, M., and Cabral, R. F. (2003). In: Cardoso, J. L. C., Fran\u00e7a, F. O. S., Fan, H. W., M\u00e1laque, C. M. S., and Haddad Jr., V. (eds.), Sarvier\/FAPESP, S\u00e3o Paulo, pp 6\u201312"},{"key":"9063_CR3","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/0041-0101(85)90367-8","volume":"23","author":"M. M. Azevedo-Marques","year":"1982","unstructured":"Azevedo-Marques M. M., Cupo P., Coimbra T. M., Hering S. E., Rossi M. A., Laure C. J. (1982) Toxicon 23: 631\u2013636","journal-title":"Toxicon"},{"key":"9063_CR4","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1023\/A:1007123329817","volume":"19","author":"D. G. Beghini","year":"2000","unstructured":"Beghini D. G., Toyama M. H., Hyslop S., Sodek L., Novello J. C.,Marangoni S. (2000) J. Protein Chem. 19: 603\u2013607","journal-title":"J. Protein Chem."},{"issue":"4","key":"9063_CR5","first-page":"439","volume":"39","author":"C. Bon","year":"1989","unstructured":"Bon C., Bouchier C., Choumet V., Faure G., Jiang M. S., Lambezat M. P., Radvanyi F., Saliou B. (1989) Acta Physiol. Pharmacol. Latinoam. 39(4): 439\u2013448","journal-title":"Acta Physiol. Pharmacol. Latinoam."},{"key":"9063_CR6","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1111\/j.1432-1033.1979.tb13278.x","volume":"99","author":"C. Bon","year":"1979","unstructured":"Bon C., Changeux J. P., Jeng T. W., Fraenkel-Conrat H. (1979) Eur. J. Biochem. 99: 471\u2013481","journal-title":"Eur. J. Biochem."},{"issue":"2","key":"9063_CR7","first-page":"34P","volume":"212","author":"O. V. Brazil","year":"1971","unstructured":"Brazil O. V., Excell B. J. (1971) J Physiol. 212(2): 34P\u201335P","journal-title":"J Physiol."},{"key":"9063_CR8","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/0041-0101(76)90010-6","volume":"14","author":"H. Breithaupt","year":"1976","unstructured":"Breithaupt H. (1976) Toxicon 14: 221\u2013233.","journal-title":"Toxicon"},{"key":"9063_CR9","first-page":"38","volume":"1","author":"E. B\u00fclbring","year":"1946","unstructured":"B\u00fclbring E. (1946) Br. J. Pharmacol. 1: 38\u201361","journal-title":"Br. J. Pharmacol."},{"issue":"Pt 3","key":"9063_CR10","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1042\/bj20020092","volume":"366","author":"L. Chioato","year":"2002","unstructured":"Chioato L., De Oliveira A. H., Ruller R., Sa J. M., Ward R.J. (2002) Biochem. J. 366(Pt 3): 971\u2013976","journal-title":"Biochem. J."},{"key":"9063_CR42","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/0076-6879(91)97134-K","volume":"197","author":"W. Cho","year":"1991","unstructured":"Cho W., K\u00e9zdy F. J. (1991) Methods Enzymol. 197: 75\u201379","journal-title":"Methods Enzymol."},{"issue":"1","key":"9063_CR11","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/0014-5793(91)80231-Q","volume":"280","author":"V. Curin-Serbec","year":"1991","unstructured":"Curin-Serbec V., Novak D., Babnik J., Turk D., Gubensek F. (1991) A. FEBS Lett. 280(1): 175\u2013178","journal-title":"A. FEBS Lett."},{"issue":"2","key":"9063_CR12","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/0041-0101(87)90246-7","volume":"25","author":"G. Faure","year":"1987","unstructured":"Faure G., Bon C. (1987) Taxicon 25(2): 229\u2013234","journal-title":"Taxicon"},{"key":"9063_CR13","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1021\/bi00402a036","volume":"27","author":"G. Faure","year":"1988","unstructured":"Faure G., Bon C. (1988) Biochemistry 27: 730\u2013738","journal-title":"Biochemistry"},{"key":"9063_CR14","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1111\/j.1432-1033.1994.tb18978.x","volume":"223","author":"G. Faure","year":"1994","unstructured":"Faure G., Choumet V., Bouchier C., Camoin L., Guillaume J. L., Monegier B., Vuilhorgne M., Bon C. (1994) Eur. J. Biochem. 223: 161\u2013164","journal-title":"Eur. J. Biochem."},{"key":"9063_CR15","doi-asserted-by":"publisher","first-page":"8074","DOI":"10.1021\/bi00246a028","volume":"30","author":"G. Faure","year":"1991","unstructured":"Faure G., Guillaume J. L., Camoin L., Saliou B., Bon C. (1991) Biochemistry 30: 8074\u20138083","journal-title":"Biochemistry"},{"issue":"2","key":"9063_CR16","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1111\/j.1432-1033.1993.tb17946.x","volume":"214","author":"G. Faure","year":"1993","unstructured":"Faure G., Harvey A. L., Thomson E., Saliou B., Radvanyi F., Bon C. (1993) Eur. J. Biochem. 214(2): 491\u2013496","journal-title":"Eur. J. Biochem."},{"key":"9063_CR17","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1113\/jphysiol.1960.sp006413","volume":"150","author":"B. L. Ginsborg","year":"1960","unstructured":"Ginsborg B. L., Warriner J. (1960) Brit. J. Physiol. 150: 707\u2013717","journal-title":"Brit. J. Physiol."},{"issue":"1","key":"9063_CR18","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/0041-0101(84)90141-7","volume":"22","author":"P. Gopalakrishnakone","year":"1984","unstructured":"Gopalakrishnakone P., Dempster D. W., Hawgood B. J., Elder H. Y. (1984) Toxicon. 22(1): 85\u201398","journal-title":"Toxicon."},{"issue":"11","key":"9063_CR19","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1016\/0041-0101(95)00085-Z","volume":"33","author":"J. M. Gutierrez","year":"1995","unstructured":"Gutierrez J. M., Lomonte B. (1995) Toxicon 33(11): 1405\u20131424","journal-title":"Toxicon"},{"issue":"8","key":"9063_CR20","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/j.toxicon.2003.11.005","volume":"42","author":"J. M. Gutierrez","year":"2003","unstructured":"Gutierrez J. M., Ownby C. L. (2003) Toxicon 42(8): 915\u2013931","journal-title":"Toxicon"},{"key":"9063_CR21","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/0041-0101(78)90056-9","volume":"16","author":"E. Habermann","year":"1978","unstructured":"Habermann E., Breithaupt H. (1978) Toxicon 16: 19\u201330","journal-title":"Toxicon"},{"key":"9063_CR22","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/0041-0101(94)90078-7","volume":"32","author":"A. L. Harvey","year":"1994","unstructured":"Harvey A. L., Barfaraz A., Thompson E., Faiz A., Preston S., Harris J. B. (1994) Toxicon. 32: 257\u2013265","journal-title":"Toxicon."},{"issue":"2","key":"9063_CR23","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/0306-4522(79)90090-3","volume":"4","author":"B. J. Hawgood","year":"1979","unstructured":"Hawgood B. J., Santana de Sa S. (1979) Neuroscience 4(2): 293\u2013303","journal-title":"Neuroscience"},{"issue":"1","key":"9063_CR24","doi-asserted-by":"crossref","first-page":"91P","DOI":"10.1113\/jphysiol.1977.sp011757","volume":"266","author":"B. J. Hawgood","year":"1977","unstructured":"Hawgood B. J., Smith J. (1977) J Physiol. 266(1): 91P-92P","journal-title":"J Physiol."},{"key":"9063_CR25","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/0003-2697(84)90307-5","volume":"13","author":"R. L. Heinrikson","year":"1984","unstructured":"Heinrikson R. L., Meredith S. C. (1984) Anal. Biochem. 13: 65\u201372","journal-title":"Anal. Biochem."},{"key":"9063_CR41","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1016\/0041-0101(96)00057-8","volume":"34","author":"M. Holzer","year":"1996","unstructured":"Holzer M., Mackessy S. P. (1996) Toxicon 34: 1149\u20131155","journal-title":"Toxicon"},{"issue":"6","key":"9063_CR26","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/0041-0101(89)90013-5","volume":"27","author":"R. M. Kini","year":"1989","unstructured":"Kini R. M., Evans H. J. (1989) Toxicon 27(6): 613\u2013635","journal-title":"Toxicon"},{"issue":"8","key":"9063_CR27","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.toxicon.2003.11.002","volume":"42","author":"R. M. Kini","year":"2003","unstructured":"Kini R. M., (2003) Toxicon 42(8): 827\u2013840","journal-title":"Toxicon"},{"issue":"2","key":"9063_CR28","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/0167-4838(89)90218-5","volume":"30","author":"I. Krizaj","year":"1989","unstructured":"Krizaj I., Turk D., Ritonja A., Gubensek F. (1989) Biochim. Biophys. Acta. 30(2): 198\u2013202","journal-title":"Biochim. Biophys. Acta."},{"issue":"4","key":"9063_CR29","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/S0165-6147(99)01300-0","volume":"20","author":"G. Lambeau","year":"1999","unstructured":"Lambeau G., Lazdunski M. (1999) Trends Pharmacol. Sci. 20(4): 162\u2013170","journal-title":"Trends Pharmacol. Sci."},{"issue":"4","key":"9063_CR30","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/0305-0491(90)90109-7","volume":"97","author":"B. W. Lennon","year":"1990","unstructured":"Lennon B. W., Kaiser II (1990) Comp. Biochem. Physiol. B. 97(4): 695\u2013699","journal-title":"Comp. Biochem. Physiol. B."},{"issue":"3","key":"9063_CR31","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/S0041-0101(03)00149-1","volume":"42","author":"B. Lomonte","year":"2003","unstructured":"Lomonte B., Angulo Y., Santamar\u00eda C. (2003) Toxicon 42(3): 307\u2013312","journal-title":"Toxicon"},{"issue":"1","key":"9063_CR32","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/S0005-2736(99)00143-1","volume":"1461","author":"B. Lomonte","year":"1999","unstructured":"Lomonte B., Pizarro-Cerda J., Angulo Y., Gorvel J. P., Moreno E. (1999) Biochim. Biophys. Acta. 1461(1): 19\u201326","journal-title":"Biochim. Biophys. Acta."},{"issue":"11","key":"9063_CR33","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1016\/0041-0101(94)90408-1","volume":"32","author":"B. Lomonte","year":"1994","unstructured":"Lomonte B., Tarkowski A., Hanson L. A. (1994) Toxicon 32(11): 1359\u20131369","journal-title":"Toxicon"},{"issue":"3","key":"9063_CR34","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1023\/A:1015320616206","volume":"21","author":"D. G. Oliveira","year":"2002","unstructured":"Oliveira D. G., Toyama M. H., Novello J. C., Beriam L. O., Marangoni S. (2002) J. Protein Chem. 21(3): 161\u2013168","journal-title":"J. Protein Chem."},{"issue":"3","key":"9063_CR35","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1023\/A:1015332314389","volume":"21","author":"L. A Ponce-Soto","year":"2002","unstructured":"Ponce-Soto L. A, Toyama M. H., Hyslop S., Novello J. C., Marangoni S. (2002) J Protein Chem. 21(3): 131\u2013136","journal-title":"J Protein Chem."},{"issue":"2","key":"9063_CR43","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s10930-006-0006-4","volume":"25","author":"L. A. Ponce-Soto","year":"2006","unstructured":"Ponce-Soto L. A., Bonfim V. L., Rodrigues-Simioni L., Novello J. C., Marangoni S. (2006) Protein J. 25(2): 147\u2013155","journal-title":"Protein J."},{"issue":"14","key":"9063_CR36","doi-asserted-by":"publisher","first-page":"3018","DOI":"10.1046\/j.1432-1033.2003.03679.x","volume":"270","author":"P. Prijatelj","year":"2003","unstructured":"Prijatelj P., Sribar J., Ivanovski G., Krizaj I., Gubensek F., Pungercar J. (2003) Eur. J. Biochem. 270(14): 3018\u20133025","journal-title":"Eur. J. Biochem."},{"issue":"7","key":"9063_CR37","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/j.toxicon.2004.03.011","volume":"43","author":"A. Rangel-Santos","year":"2004","unstructured":"Rangel-Santos A., Dos-Santos E. C., Lopes-Ferreira M., Lima C., Cardoso D. F., Motam I. (2004) Toxicon. 43(7): 801\u2013810","journal-title":"Toxicon."},{"key":"9063_CR38","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/BF00997027","volume":"270","author":"K. Rubsamen","year":"1971","unstructured":"Rubsamen K., Breithaupt H., Habermann E. (1971) Arch. Pharmacol. 270: 274\u2013288","journal-title":"Arch. Pharmacol."},{"issue":"1","key":"9063_CR39","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1006\/abbi.1996.0042","volume":"326","author":"H. S. de Selistre Araujo","year":"1996","unstructured":"Selistre de Araujo H. S., White S. P., Ownby C. L. (1996) Arch. Biochem. Biophys. 326(1):21\u201330","journal-title":"Arch. Biochem. Biophys."},{"issue":"1","key":"9063_CR40","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1006\/abio.2001.5318","volume":"297","author":"M. B. Smolka","year":"2001","unstructured":"Smolka M. B., Zhou H., Purkayastha S., Aebersold R. (2001) Anal. Biochem. 297(1): 25\u201331","journal-title":"Anal. Biochem."}],"container-title":["The Protein Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10930-006-9063-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10930-006-9063-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10930-006-9063-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10930-006-9063-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T23:50:25Z","timestamp":1667519425000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10930-006-9063-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,3]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["9063"],"URL":"https:\/\/doi.org\/10.1007\/s10930-006-9063-y","relation":{},"ISSN":["1572-3887","1875-8355"],"issn-type":[{"value":"1572-3887","type":"print"},{"value":"1875-8355","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,3]]},"assertion":[{"value":"3 January 2007","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}