{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T01:50:09Z","timestamp":1772502609419,"version":"3.50.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T00:00:00Z","timestamp":1531699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T00:00:00Z","timestamp":1531699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Science Foundation of Education Department of Fujian Province, China","award":["JAT160247"],"award-info":[{"award-number":["JAT160247"]}]},{"name":"the Young talent project of Health Department of Fujian Province, China","award":["2017-1-69"],"award-info":[{"award-number":["2017-1-69"]}]},{"name":"the Joint Funds for the innovation of science and Technology","award":["2016Y9048"],"award-info":[{"award-number":["2016Y9048"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Protein J"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s10930-018-9781-y","type":"journal-article","created":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T10:47:26Z","timestamp":1531738046000},"page":"353-360","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Comparative Profiling of Three Atheris Snake Venoms: A. squamigera, A. nitschei and A. chlorechis"],"prefix":"10.1007","volume":"37","author":[{"given":"He","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaole","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"K\u00f6nig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianbao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,7,16]]},"reference":[{"key":"9781_CR1","first-page":"1","volume":"7","author":"DP Pandey","year":"2016","unstructured":"Pandey DP, Vohra R, Stalcup P, Shrestha BR (2016) A season of snakebite envenomation: presentation patterns, timing of care, anti-venom use, and case fatality rates from a hospital of southcentral nepal. J Venom Res 7:1\u20139","journal-title":"J Venom Res"},{"issue":"8","key":"9781_CR2","doi-asserted-by":"publisher","first-page":"3556","DOI":"10.1021\/pr800332p","volume":"7","author":"A Alapegir\u00f3n","year":"2008","unstructured":"Alapegir\u00f3n A, Sanz L, Escolano J, Floresd\u00edaz M, Madrigal M, Sasa M et al (2008) Snake venomics of the lancehead pitviper bothrops asper: geographic, individual, and ontogenetic variations. J Proteome Res 7(8):3556","journal-title":"J Proteome Res"},{"issue":"6","key":"9781_CR3","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1074\/mcp.M600419-MCP200","volume":"6","author":"GW Birrell","year":"2007","unstructured":"Birrell GW, Earl ST, Wallis TP, Masci PP, De JJ, Gorman JJ et al (2007) The diversity of bioactive proteins in australian snake venoms. Mol Cell Proteom 6(6):973","journal-title":"Mol Cell Proteom"},{"issue":"3","key":"9781_CR4","doi-asserted-by":"publisher","first-page":"e622","DOI":"10.1371\/journal.pntd.0000622","volume":"4","author":"GD Tanaka","year":"2010","unstructured":"Tanaka GD, Furtado MDFD., Portaro FCV, Sant\u2019Anna OA, Tambourgi DV (2010) Diversity of micrurus snake species related to their venom toxic effects and the prospective of antivenom neutralization. PLoS Negl Trop Dis 4(3):e622","journal-title":"PLoS Negl Trop Dis"},{"key":"9781_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bcp.2016.03.006","volume":"115","author":"RP Samy","year":"2016","unstructured":"Samy RP, Sethi G, Lim LH (2016) A brief update on potential molecular mechanisms underlying antimicrobial and wound-healing potency of snake venom molecules. Biochem Pharmacol 115:1\u20139","journal-title":"Biochem Pharmacol"},{"key":"9781_CR6","volume-title":"The dangerous snakes of Africa: natural history, species directory: venoms and snakebite","author":"S Spawls","year":"1995","unstructured":"Spawls S, Branch WR (1995) The dangerous snakes of Africa: natural history, species directory: venoms and snakebite. Blandford, London"},{"issue":"4","key":"9781_CR7","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/0041-0101(65)90025-5","volume":"2","author":"LP Knoepffler","year":"1965","unstructured":"Knoepffler LP (1965) Autoobservation d\u2019envenimation par morsure d\u2019Atheris sp. Toxicon 2(4):275\u2013276","journal-title":"Toxicon"},{"issue":"10","key":"9781_CR8","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1016\/S0041-0101(98)00008-7","volume":"36","author":"D Mebs","year":"1998","unstructured":"Mebs D, Holada K, Kornal\u00edk F, Sim\u00e1k J, Vankov\u00e1 H, M\u00fcller D et al (1998) Severe coagulopathy after a bite of a green bush viper (Atheris squamiger): case report and biochemical analysis of the venom. Toxicon 36(10):1333","journal-title":"Toxicon"},{"issue":"5","key":"9781_CR9","first-page":"153","volume":"64","author":"LJ Top","year":"2006","unstructured":"Top LJ, Tulleken JE, Ligtenberg JJ, Meertens JH, Ts VDW, Zijlstra JG (2006) Serious envenomation after a snakebite by a western bush viper (Atheris chlorechis) in the netherlands: a case report. Neth J Med 64(5):153\u2013156","journal-title":"Neth J Med"},{"issue":"2","key":"9781_CR10","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.toxicon.2008.05.021","volume":"52","author":"J Valenta","year":"2008","unstructured":"Valenta J, Stach Z, Fricova D, Zak J, Balik M (2008) Envenoming by the viperid snake proatheris superciliaris: a case report. Toxicon 52(2):392\u2013394","journal-title":"Toxicon"},{"issue":"3","key":"9781_CR11","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1002\/rcm.2853","volume":"21","author":"P Favreau","year":"2007","unstructured":"Favreau P, Cheneval O, Menin L, Michalet S, Gaertner H, Principaud F et al (2007) The venom of the snake genus atheris contains a new class of peptides with clusters of histidine and glycine residues. Rapid Commun Mass Spectrom 21(3):406\u2013412","journal-title":"Rapid Commun Mass Spectrom"},{"key":"9781_CR12","volume-title":"True vipers: natural history and toxinology of old world vipers","author":"D Mallow","year":"2003","unstructured":"Mallow D, Ludwig D, Nilson G, Mallow D, Ludwig D, Nilson G (2003) True vipers: natural history and toxinology of old world vipers. Krieger, Malabar"},{"issue":"1","key":"9781_CR13","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1042\/BJ20040354","volume":"384","author":"S Li","year":"2004","unstructured":"Li S, Wang JX, Ren Y, Wang N, Zhao K, Chen X et al (2004) Proteomic characterization of two snake venoms: naja naja atra and agkistrodon halys. Biochem J 384(1):119\u2013127","journal-title":"Biochem J"},{"issue":"1","key":"9781_CR14","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s40409-017-0116-9","volume":"23","author":"JJ Calvete","year":"2017","unstructured":"Calvete JJ, Petras D, Calder\u00f3ncelis F, Lomonte B, Encinar JR, Sanzmedel A (2017) Protein-species quantitative venomics: looking through a crystal ball. J Venom Anim Toxins Incl Trop Dis 23(1):27","journal-title":"J Venom Anim Toxins Incl Trop Dis"},{"key":"9781_CR15","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.toxicon.2013.05.012","volume":"71","author":"H Wang","year":"2013","unstructured":"Wang H, Chen X, Wang L, Chen W, Zhou M, Chen T et al (2013) Cloning and characterisation of three novel disintegrin precursors from the venoms of three atheris species: Atheris chlorechis, Atheris nitschei and Atheris squamigera. Toxicon 71:31\u201340","journal-title":"Toxicon"},{"issue":"6","key":"9781_CR16","doi-asserted-by":"publisher","first-page":"168","DOI":"10.3390\/toxins8060168","volume":"8","author":"H Wang","year":"2016","unstructured":"Wang H, Chen X, Zhou M, Wang L, Chen T, Shaw C (2016) Molecular characterization of three novel phospholipase a2proteins from the venom ofatheris chlorechis, Atheris nitschei and Atheris squamigera. Toxins 8(6):168","journal-title":"Toxins"},{"issue":"248","key":"9781_CR17","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/0076-6879(95)48015-3","volume":"248","author":"ND Rawlings","year":"1995","unstructured":"Rawlings ND, Barrett AJ (1995) Evolutionary families of metallopeptidases. Methods Enzymol 248(248):183","journal-title":"Methods Enzymol"},{"key":"9781_CR18","first-page":"53","volume":"197","author":"V Cipriani","year":"2017","unstructured":"Cipriani V, Debono J, Goldenberg J, Tnw J, Arbuckle K, Dobson J et al (2017) Correlation between ontogenetic dietary shifts and venom variation in Australian brown snakes (pseudonaja). Comp Biochem Physiol C 197:53\u201360","journal-title":"Comp Biochem Physiol C"},{"issue":"1","key":"9781_CR19","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.regpep.2010.07.086","volume":"164","author":"H Wang","year":"2010","unstructured":"Wang H, Wang L, Zhou M, Chen T, Shaw C (2010) Molecular cloning and deduced organization of the phpg\/cnp precursor from the venom of the african forest viper, Atheris squamigera. Regul Pept 164(1):35\u201335","journal-title":"Regul Pept"},{"issue":"4","key":"9781_CR20","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.bbrc.2007.11.027","volume":"365","author":"SC Wagstaff","year":"2008","unstructured":"Wagstaff SC, Favreau P, Cheneval O, Laing GD, Wilkinson MC, Miller RL et al (2008) Molecular characterisation of endogenous snake venom metalloproteinase inhibitors. Biochem Biophys Res Commun 365(4):650\u2013656","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"9781_CR21","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1086\/594380","volume":"82","author":"D Cundall","year":"2009","unstructured":"Cundall D (2009) Viper fangs: functional limitations of extreme teeth. Physiol Biochem Zool 82(1):63","journal-title":"Physiol Biochem Zool"},{"issue":"8","key":"9781_CR22","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1016\/j.toxicon.2010.02.028","volume":"55","author":"SP Mackessy","year":"2010","unstructured":"Mackessy SP (2010) Evolutionary trends in venom composition in the Western Rattlesnakes (Crotalus viridis, sensu lato): Toxicity vs. tenderizers. Toxicon 55(8):1463\u20131474","journal-title":"Toxicon"},{"issue":"1666","key":"9781_CR23","doi-asserted-by":"publisher","first-page":"2443","DOI":"10.1098\/rspb.2009.0048","volume":"276","author":"A Barlow","year":"2009","unstructured":"Barlow A, Pook CE, Harrison RA, W\u00fcster W (2009) Coevolution of diet and prey-specific venom activity supports the role of selection in snake venom evolution. Proc Biol Sci 276(1666):2443\u20132449","journal-title":"Proc Biol Sci"},{"issue":"6","key":"9781_CR24","doi-asserted-by":"publisher","first-page":"183","DOI":"10.3390\/toxins8060183","volume":"8","author":"AM Moura-Da-Silva","year":"2016","unstructured":"Moura-Da-Silva AM, Almeida MT, Portes-Junior JA, Nicolau CA, Francisco GN, Valente RH (2016) Processing of snake venom metalloproteinases: generation of toxin diversity and enzyme inactivation. Toxins 8(6):183","journal-title":"Toxins"},{"issue":"11","key":"9781_CR25","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1016\/j.febslet.2009.03.029","volume":"583","author":"JJ Calvete","year":"2009","unstructured":"Calvete JJ, Sanz L, Angulo Y, Lomonte B, Guti\u00e9rrez JM (2009) Venoms, venomics, antivenomics. FEBS Lett 583(11):1736\u20131743","journal-title":"FEBS Lett"},{"issue":"5","key":"9781_CR26","doi-asserted-by":"publisher","first-page":"163","DOI":"10.3390\/toxins9050163","volume":"9","author":"JM Guti\u00e9rrez","year":"2017","unstructured":"Guti\u00e9rrez JM, Solano G, Pla D, Herrera M, Segura \u00c1, Vargas M et al (2017) Preclinical evaluation of the efficacy of antivenoms for snakebite envenoming: state-of-the-art and challenges ahead:. Toxins 9(5):163","journal-title":"Toxins"}],"container-title":["The Protein Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10930-018-9781-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10930-018-9781-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10930-018-9781-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T00:21:15Z","timestamp":1667521275000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10930-018-9781-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,16]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["9781"],"URL":"https:\/\/doi.org\/10.1007\/s10930-018-9781-y","relation":{},"ISSN":["1572-3887","1875-8355"],"issn-type":[{"value":"1572-3887","type":"print"},{"value":"1875-8355","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,16]]},"assertion":[{"value":"16 July 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All applicable international, national, and\/or institutional guidelines for the care and use of animals were followed.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}