{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:53:26Z","timestamp":1782780806540,"version":"3.54.5"},"reference-count":74,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T00:00:00Z","timestamp":1537920000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T00:00:00Z","timestamp":1537920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["SC3GM099637"],"award-info":[{"award-number":["SC3GM099637"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R25GM083755"],"award-info":[{"award-number":["R25GM083755"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000181","name":"AFOSR","doi-asserted-by":"crossref","award":["F49620-99-1-0327"],"award-info":[{"award-number":["F49620-99-1-0327"]}],"id":[{"id":"10.13039\/100000181","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000181","name":"AFOSR","doi-asserted-by":"crossref","award":["FA 9550-05-1-0472"],"award-info":[{"award-number":["FA 9550-05-1-0472"]}],"id":[{"id":"10.13039\/100000181","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Protein J"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1007\/s10930-018-9792-8","type":"journal-article","created":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T10:55:45Z","timestamp":1537959345000},"page":"548-571","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Identification of Receptor Ligands in Apo B100 Reveals Potential Functional Domains"],"prefix":"10.1007","volume":"37","author":[{"suffix":"Jr.","given":"Juan","family":"Guevara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Jamie","family":"Romo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5244-6691","authenticated-orcid":false,"given":"Natalia Valentinova","family":"Guevara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,9,26]]},"reference":[{"key":"9792_CR1","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S0022-2275(20)34780-5","volume":"21","author":"MJ Chapman","year":"1980","unstructured":"Chapman MJ (1980) Review. Animal lipoproteins: chemistry, structure, and comparative aspects. J Lipid Res 21:789\u2013853","journal-title":"J Lipid Res"},{"key":"9792_CR2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.5772\/48145","volume-title":"Lipoproteins\u2014role in health and diseases","author":"R Prassl","year":"2012","unstructured":"Prassl R, Laggner P (2012) Lipoprotein structure and dynamics: low density lipoprotein viewed as a highly dynamic and flexible nanoparticle, Chap. 1. In: Frank S, Kostner G (eds) Lipoproteins\u2014role in health and diseases. Intech, London, pp\u00a03\u201320. https:\/\/doi.org\/10.5772\/48145"},{"key":"9792_CR3","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0022-2275(20)35376-1","volume":"22","author":"MJ Chapman","year":"1981","unstructured":"Chapman MJ, Goldstein S, Lagrange D, Laplaud PM (1981) A density gradient ultracentrifugal procedure for the isolation of the major lipoprotein classes from human serum. J Lipid Res 22:339\u2013358","journal-title":"J Lipid Res"},{"key":"9792_CR4","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1002\/pmic.200300938","volume":"5","author":"H Karlsson","year":"2005","unstructured":"Karlsson H, Leanderson P, Tagesson C, Lindahl M (2005) Lipoproteomics I: mapping of proteins in low-density lipoprotein using two-dimensional gel electrophoresis and mass spectrometry. Proteomics 5:551\u2013565","journal-title":"Proteomics"},{"key":"9792_CR5","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.cca.2009.11.023","volume":"411","author":"H-Y Sun","year":"2010","unstructured":"Sun H-Y, Chen S-F, Lai M-D, Chang T-T, Li P-Y, Shieh D-B, Young KC (2010) Comparative proteomic profiling of plasma very-low-density and low-density lipoproteins. Clin Chim Acta 411:336\u2013344","journal-title":"Clin Chim Acta"},{"key":"9792_CR6","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/279679a0","volume":"279","author":"JL Goldstein","year":"1979","unstructured":"Goldstein JL, Anderson RGW, Brown MS (1979) Coated pits, coated vesicles, and receptor-mediated endocytosis. Nature 279:679\u2013685","journal-title":"Nature"},{"key":"9792_CR7","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1038\/323734a0","volume":"323","author":"TJ Knott","year":"1986","unstructured":"Knott TJ, Pease RJ, Powell LM, Wallis SC, Rall SC Jr, Innerarity TL, Blackhart B, Taylor WH, Marcel Y, Milne R, Johnson D, Fuller M, Lusis AJ, McCarthy BJ, Mahley RW, Levy-Wilson B, Scott J (1986) Complete protein sequence and identification of structural domains of human apolipoprotein B. Nature 323:734\u2013738","journal-title":"Nature"},{"key":"9792_CR8","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1038\/323738a0","volume":"323","author":"C-Y Yang","year":"1986","unstructured":"Yang C-Y, Chen S-H, Gianturco SH, Bradley WA, Sparrow JT, Tanimura M, Li W-H, Sparrow DA, DeLoof H, Rosseneu M, Lee F-S, Gu Z-W, Gotto AM Jr, Chan L (1986) Sequence, structure, receptor-binding domains and internal repeats of human apolipoprotein B-100. Nature 323:738\u2013742","journal-title":"Nature"},{"key":"9792_CR9","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1007\/PL00006528","volume":"49","author":"PJ Babin","year":"1999","unstructured":"Babin PJ, Bogerd J, Kooiman FP, Van Marrewijk WJA, Van der Host DJ (1999) Apolipophorin II\/I, apolipoprotein B, vitellogenin, and microsomal triglyceride transfer protein genes are derived from a common ancestor. J Mol Evol 49:150\u2013160","journal-title":"J Mol Evol"},{"key":"9792_CR10","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1194\/jlr.R600028-JLR200","volume":"48","author":"MMW Smolenaars","year":"2007","unstructured":"Smolenaars MMW, Madsen O, Rodenburg KW, Van der Host DJ (2007) Molecular diversity and evolution of the large lipid transfer protein superfamily review. J Lipid Res 48:489\u2013502","journal-title":"J Lipid Res"},{"key":"9792_CR11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1471-2148-7-3","volume":"7","author":"J-C Avarre","year":"2007","unstructured":"Avarre J-C, Lubzens E, Babin PJ (2007) Apolipocrustacein, formerly vitellogenin, is the major egg yolk precursor protein in decapod crustaceans and is homologous to insect apolipophorin II\/I and vertebrate apolipoprotein B. BMC Evol Biol 7:3. https:\/\/doi.org\/10.1186\/1471-2148-7-3","journal-title":"BMC Evol Biol"},{"key":"9792_CR12","first-page":"58","volume":"10","author":"A Zdybicka-Barabas","year":"2013","unstructured":"Zdybicka-Barabas A, Cytrynska M (2013) Apolipophorins and insects immune response. Invertebr Surviv J 10:58\u201368","journal-title":"Invertebr Surviv J"},{"key":"9792_CR13","doi-asserted-by":"publisher","first-page":"3232","DOI":"10.1016\/j.molimm.2009.08.006","volume":"46","author":"Z Li","year":"2009","unstructured":"Li Z, Zhang S, Zhang J, Liu M, Liu Z (2009) Vitellogenin is a cidal factor capable of killing bacteria via interaction with lipopolysaccharide and lipoteichoic acid. Mol Immunol 46:3232\u20133239","journal-title":"Mol Immunol"},{"key":"9792_CR14","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.biocel.2010.11.003","volume":"43","author":"S Zhang","year":"2011","unstructured":"Zhang S, Wang S, Li H, Li L (2011) Vitellogenin, a multivalent sensor and an antimicrobial effector. Int J Biochem Cell Biol 43:303\u2013305","journal-title":"Int J Biochem Cell Biol"},{"key":"9792_CR15","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.cub.2005.01.046","volume":"15","author":"Q Wang","year":"2005","unstructured":"Wang Q, Zhang Z, Blackwell K, Carmichael GG (2005) Vigilins bind to promiscuously A-to-I-edited RNAs and are involved in the formation of heterochromatin. Curr Biol 15:384\u2013391","journal-title":"Curr Biol"},{"key":"9792_CR16","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1261\/rna.1036308","volume":"14","author":"J Zhou","year":"2008","unstructured":"Zhou J, Wang Q, Chen L-L, Carmichael GG (2008) On the mechanism of induction of heterochromatin by the RNA-binding protein vigilin. RNA 14:1773\u20131781","journal-title":"RNA"},{"key":"9792_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12848","author":"MB Mobin","year":"2016","unstructured":"Mobin MB, Gerstberger S, Teupser D, Campana B, Charisse K, Heim MH, Manoharan M, Tuschi T, Stoffel M (2016) The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation. Nat Commun. https:\/\/doi.org\/10.1038\/ncomms12848","journal-title":"Nat Commun"},{"issue":"4721","key":"9792_CR18","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1126\/science.2994225","volume":"230","author":"TJ Knott","year":"1985","unstructured":"Knott TJ, Rall SC Jr, Innerarity TL, Jacobson SF, Urdea MS, Levy-Wilson B, Powell LM, Pease RJ, Eddy R, Nakai H, Byers M, Priestley LM, Robertson E, Rall LB, Betsholtz C, Shows TB, Mahley RW, Scott J (1985) Human apolipoprotein B: structure of carboxyl-terminal domains, sites of gene expression, and chromosomal localization. Science 230(4721):37\u201343","journal-title":"Science"},{"key":"9792_CR19","doi-asserted-by":"publisher","first-page":"8142","DOI":"10.1073\/pnas.83.21.8142","volume":"83","author":"SW Law","year":"1986","unstructured":"Law SW, Grant SM, Higuchi K, Hospattankar A, Lackner K, Lee N, Brewer HB (1986) Human liver apolipoprotein B-100: complete nucleic acid and derived amino acid sequence. Proc Natl Acad Sci USA 83:8142\u20138146","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7","key":"9792_CR20","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1007\/BF01886889","volume":"14","author":"J Guevara Jr","year":"1995","unstructured":"Guevara J Jr, Walch ET, Epstein HF, Sparrow JT, Valentinova NV (1995) Evidence that Apo B-100 of low density lipoprotein is a novel Src-related protein kinase. J Protein Chem 14(7):627\u2013631","journal-title":"J Protein Chem"},{"issue":"6","key":"9792_CR21","doi-asserted-by":"publisher","first-page":"440","DOI":"10.4158\/EP.1.6.440","volume":"1","author":"JG Guevara Jr","year":"1995","unstructured":"Guevara JG Jr, Valentinova NV, Yang C-y, Davison D, Morrisett JD (1995) Human lipoprotein[a]: regions in sequences of apolipoproteins similar to domains in signal transduction proteins. J Endocr Pract 1(6):440\u2013448","journal-title":"J Endocr Pract"},{"key":"9792_CR22","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1161\/01.ATV.18.3.473","volume":"18","author":"Y Zhu","year":"1998","unstructured":"Zhu Y, Lin JH-C, Liao H-L, Friedli O Jr, Verna L et al (1998) LDL induces transcription factor activator protein-1 in human endothelial cells. Arterioscler Thromb Vasc Biol 18:473\u2013480","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"9792_CR23","doi-asserted-by":"publisher","first-page":"4256","DOI":"10.1073\/pnas.90.9.4256","volume":"90","author":"TA Voyno-Yasenetskaya","year":"1993","unstructured":"Voyno-Yasenetskaya TA, Dobbs LG, Erickson SK, Hamiltorn RL (1993) Proc Natl Acad Sci USA 90:4256\u20134260","journal-title":"Proc Natl Acad Sci USA"},{"key":"9792_CR24","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1042\/bj20020410","volume":"369","author":"IAM Relou","year":"2003","unstructured":"Relou IAM, Bax LAB, van Rijn HJM, Akkerman J-WN (2003) Site-specific phosphorylation of platelet focal adhesion kinase by low-density lipoprotein. Biochem J 369:407\u2013416","journal-title":"Biochem J"},{"issue":"18","key":"9792_CR25","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1023\/A:1020627212272","volume":"8","author":"JG Guevara Jr","year":"1999","unstructured":"Guevara JG Jr, Kang D-c, Moore JP (1999) Nucleic acid-binding properties of low-density lipoproteins: LDL as a natural gene vector. J Protein Chem 8(18):845\u2013857","journal-title":"J Protein Chem"},{"key":"9792_CR26","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1194\/jlr.M003277","volume":"51","author":"JG Guevara Jr","year":"2010","unstructured":"Guevara JG Jr, Prashad N, Ermolinsky B, Gaubatz JW, Kang D-c, Schwarzbach AE, Loose DS, Guevara NV (2010) Apo B100 similarities to viral proteins suggest basis for LDL-DNA binding and transfection capacity. J Lipid Res 51:1704\u20131718","journal-title":"J Lipid Res"},{"key":"9792_CR27","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S0969-2126(99)80025-2","volume":"7","author":"HA Lewis","year":"1999","unstructured":"Lewis HA, Chen H, Edo C, Buckanovich RJ, Yang YYL, Musunuru K, Zhong R, Darnell RB, Burley SK (1999) Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding domains. Structure 7:191\u2013203","journal-title":"Structure"},{"issue":"3","key":"9792_CR28","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1093\/nar\/29.3.638","volume":"29","author":"NV Grishin","year":"2001","unstructured":"Grishin NV (2001) KH domain: one motif, two folds. Nucleic Acids Res 29(3):638\u2013643","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"9792_CR29","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1385\/MN:23:1:53","volume":"23","author":"Y Li","year":"2001","unstructured":"Li Y, Cam J, Bu G (2001) Low-density lipoprotein receptor family; endocytosis and signal transduction. Mol Neurobiol 23(1):53\u201367","journal-title":"Mol Neurobiol"},{"key":"9792_CR30","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.1007\/s00018-004-4090-3","volume":"61","author":"J Gent","year":"2004","unstructured":"Gent J, Braakman I (2004) Low-density lipoprotein receptor structure and folding. Cell Mol Life Sci 61:2461\u20132470","journal-title":"Cell Mol Life Sci"},{"key":"9792_CR31","first-page":"1341","volume":"11","author":"M Dieckmann","year":"2010","unstructured":"Dieckmann M, Dietrich MF, Herz J (2010) Lipoprotein receptors\u2014an evolutionarily ancient multi-functional receptor family. Biol Chem 11:1341\u20131363","journal-title":"Biol Chem"},{"issue":"2","key":"9792_CR32","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/S0006-291X(86)80489-2","volume":"134","author":"AD Cardin","year":"1986","unstructured":"Cardin AD, Hirose N, Blankenship DT, Jackson RL, Harmony JAK (1986) Binding of high reactive heparin to human apolipoprotein E: identification of two heparin-binding domains. Biochem Biophys Res Commun 134(2):783\u2013789","journal-title":"Biochem Biophys Res Commun"},{"key":"9792_CR33","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1161\/01.ATV.9.1.21","volume":"9","author":"AD Cardin","year":"1989","unstructured":"Cardin AD, Weintraub HJR (1989) Molecular modeling of protein-glycosaminoglycan interactions. Arteriosclerosis 9:21\u201332","journal-title":"Arteriosclerosis"},{"key":"9792_CR34","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1002\/(SICI)1521-1878(199802)20:2<156::AID-BIES8>3.0.CO;2-R","volume":"20","author":"RE Hileman","year":"1998","unstructured":"Hileman RE, Fromm JR, Weiler JM, Linhardt RJ (1998) Glycosaminoglycan-protein interactions: definition of consensus sites in glycosaminoglycan binding proteins review. BioEssays 20:156\u2013167","journal-title":"BioEssays"},{"key":"9792_CR35","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/S0022-2275(20)32014-9","volume":"41","author":"M Zaiou","year":"2000","unstructured":"Zaiou M, Arnold KS, Newhouse YM, Innerarity TL, Weisgraber KH, Segall ML, Phillips MC, Lund-Katz S (2000) Apolipoprotein E\u2014low density lipoprotein receptor interaction: influences of basic residue and amphipathic \u03b1-helix organization in the ligand. J Lipid Res 41:1087\u20131095","journal-title":"J Lipid Res"},{"issue":"8","key":"9792_CR36","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.1016\/S0021-9258(18)68957-4","volume":"263","author":"A Lalazar","year":"1988","unstructured":"Lalazar A, Weisgraber KH, Rall SC Jr, Giladi H, Innerarity TL, Levanon AZ, Boyles JK, Amit B, Gorecki M, Mahley RW, Vogel T (1988) Site-specific mutagenesis of human apolipoprotein E. J Biol Chem 263(8):3542\u20133545","journal-title":"J Biol Chem"},{"key":"9792_CR37","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1110\/ps.072865407","volume":"16","author":"D Lee","year":"2007","unstructured":"Lee D, Walsh JD, Migliorini M, Yu P, Cai T, Schwieters CD, Krueger S, Strickland DD, Wang Y-X (2007) The structure of receptor-associated protein (RAP). Protein Sci 16:1628\u20131640","journal-title":"Protein Sci"},{"key":"9792_CR38","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1146\/annurev.biochem.72.121801.161800","volume":"72","author":"JS Bonifacino","year":"2003","unstructured":"Bonifacino JS, Traub LM (2003) Signal for sorting of trans-membrane proteins to endosomes and lysosomes. Annu Rev Biochem 72:395\u2013447","journal-title":"Annu Rev Biochem"},{"key":"9792_CR39","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1111\/j.1600-0854.2010.01056.x","volume":"11","author":"P Kozik","year":"2010","unstructured":"Kozik P, Francis RW, Seaman MNJ, Robinson MS (2010) A screen for endocytic motifs. Traffic 11:843\u2013855","journal-title":"Traffic"},{"issue":"2","key":"9792_CR40","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/S1043-2760(01)00526-4","volume":"13","author":"DK Strickland","year":"2002","unstructured":"Strickland DK, Gonias SL, Argraves WS (2002) Diverse roles for the LDL receptor family. Trends Endocrin Metab 13(2):66\u201374","journal-title":"Trends Endocrin Metab"},{"key":"9792_CR41","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.atherosclerosis.2009.06.010","volume":"208","author":"GR Thompson","year":"2010","unstructured":"Thompson GR et al (2010) Efficacy criteria and cholesterol targets for LDL apheresis. Arteriosclerosis 208:317\u2013321","journal-title":"Arteriosclerosis"},{"issue":"3","key":"9792_CR42","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1016\/S0006-291X(86)80287-X","volume":"139","author":"AV Hospattankar","year":"1986","unstructured":"Hospattankar AV, Law SW, Lackner K, Brewer HB Jr (1986) Identification of low density lipoprotein receptor binding domains of human apolipoprotein B-100: a proposed consensus LDL receptor binding sequence of Apo B-100. Biochem Biophys Res Comm 139(3):1078\u20131085","journal-title":"Biochem Biophys Res Comm"},{"issue":"23","key":"9792_CR43","doi-asserted-by":"crossref","first-page":"11097","DOI":"10.1016\/S0021-9258(18)60931-7","volume":"262","author":"KH Weisgraber","year":"1987","unstructured":"Weisgraber KH, Rall SC Jr (1987) Human apolipoprotein B-100 heparin-binding sites. J Biol Chem 262(23):11097\u201311103","journal-title":"J Biol Chem"},{"key":"9792_CR44","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S0022-2275(20)40763-1","volume":"33","author":"S Fantappi\u00e8","year":"1992","unstructured":"Fantappi\u00e8 S, Corsini A, Sidoli A, Uboldi P, Granata A, Zanelli T, Rossi P, Marcovina S, Fumagalli R, Catapano AL (1992) Monoclonal antibodies to human low density lipoprotein identify distinct areas on apolipoprotein B-100 relevant to the low density lipoprotein-receptor interaction. J Lipid Res 33:1111\u20131121","journal-title":"J Lipid Res"},{"key":"9792_CR45","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.bbrc.2010.05.045","volume":"397","author":"BR Ali","year":"2010","unstructured":"Ali BR, Nouvel I, Leung KF, Hume AN, Seabra MC (2010) A novel statin-mediated \u201cprenylation block-and-release\u201d assay provides insight into the membrane targeting mechanisms of small GTPases. Biochem Biophys Res Commun 397:34\u201341","journal-title":"Biochem Biophys Res Commun"},{"key":"9792_CR46","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.ygeno.2005.08.012","volume":"86","author":"B Chen","year":"2005","unstructured":"Chen B, Piel WH, Gui L, Bruford E, Monteiro A (2005) The HSP90 family of genes in the human genome: insights into their divergence and evolution. Genomics 86:627\u2013637","journal-title":"Genomics"},{"key":"9792_CR47","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1476-5926-9-3","volume":"9","author":"YK Bashmakov","year":"2010","unstructured":"Bashmakov YK, Zigangirova NA, Pashko YP, Kapotina LN, Petyaev IM (2010) Chlamydia trachomatis inhibition and restoration of LDL-receptor level in HepG2 cells treated with mevastatin. Comp Hepatol 9:3\u20138","journal-title":"Comp Hepatol"},{"key":"9792_CR48","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1111\/j.1476-5381.2012.02103.x","volume":"167","author":"ML Pinson-Daza","year":"2012","unstructured":"Pinson-Daza ML, Garzon R, Couraud PO, Romero IA, Weksler B, Ghigo D, Bosia A, Riganti C (2012) The association of statins plus LDL receptor-targeted liposome-encapsulated doxorubicin increases in vitro drug delivery across blood-brain barrier cells. Br J Pharm 167:1431\u20131447","journal-title":"Br J Pharm"},{"key":"9792_CR49","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1002\/mrd.22489","volume":"82","author":"J Schindelin","year":"2015","unstructured":"Schindelin J, Rueden CT, Hiner MC, Eliceiri KW (2015) The ImageJ ecosystem: an open platform for biomedical image analysis. Mol Reprod Dev 82:518\u2013529","journal-title":"Mol Reprod Dev"},{"key":"9792_CR50","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1042\/BJ20090175","volume":"421","author":"JK Jensen","year":"2009","unstructured":"Jensen JK, Dolmer K, Schar C, Gettins PGW (2009) Receptor-associated protein (RAP) has two high-affinity binding sites for the low-density lipoprotein receptor-related protein (LRP): consequences for the chaperone functions of RAP. Biochem J 421:273\u2013282","journal-title":"Biochem J"},{"issue":"35","key":"9792_CR51","doi-asserted-by":"publisher","first-page":"18430","DOI":"10.1074\/jbc.M116.744904","volume":"291","author":"JM Prasad","year":"2016","unstructured":"Prasad JM, Young PA, Strickland DK (2016) High affinity binding of the receptor-associated protein D1D2 domains with the low density lipoprotein receptor-related protein (LRP1) involves bivalent complex formation. Critical roles of lysine 60 and 191. J Biol Chem 291(35):18430\u201318439","journal-title":"J Biol Chem"},{"key":"9792_CR52","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.molcel.2006.02.021","volume":"22","author":"C Fisher","year":"2006","unstructured":"Fisher C, Beglova N, Blacklow SC (2006) Structure of an LDL-R-RAP complex reveals a general mode for ligand recognition by lipoprotein receptors. Mol Cell 22:277\u2013283","journal-title":"Mol Cell"},{"key":"9792_CR53","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1042\/BJ20140977","volume":"468","author":"E Bloem","year":"2015","unstructured":"Bloem E, Ebberink EHTM, van den Biggelaar M, van der Zwaan C, Mertens K, Meijer AB (2015) A novel chemical footprinting approach identifies critical lysine residues involved in the binding of receptor-associated protein to cluster II of LDL receptor-related protein. Biochem J 468:65\u201372","journal-title":"Biochem J"},{"key":"9792_CR54","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.str.2010.12.022","volume":"19","author":"C Kohler","year":"2011","unstructured":"Kohler C, Lighthouse JK, Werther T, Andersen O, Diehl A, Schmieder P et al (2011) The structure of MESD45-184 brings light into the mechanism of LDLR family folding. Structure 19:337\u2013348","journal-title":"Structure"},{"issue":"11","key":"9792_CR55","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1093\/molbev\/msn179","volume":"25","author":"P Juarez","year":"2008","unstructured":"Juarez P, Comas I, Gonzalez-Candelas F, Calvete JJ (2008) Evolution of snake venom disintegrins by positive Darwinian selection. Mol Biol Evol 25(11):2391\u20132407","journal-title":"Mol Biol Evol"},{"issue":"4","key":"9792_CR56","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1124\/pr.110.002733","volume":"62","author":"B Korkmaz","year":"2010","unstructured":"Korkmaz B, Horwitz MS, Jenne DE, Gauthier F (2010) Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases. Pharma Rev 62(4):726\u2013759","journal-title":"Pharma Rev"},{"issue":"18","key":"9792_CR57","doi-asserted-by":"publisher","first-page":"5028","DOI":"10.1093\/emboj\/18.18.5028","volume":"18","author":"Y Fujii","year":"1999","unstructured":"Fujii Y, Shimizu T, Kusumoto M, Kyogoku Y, Taniguchi T, Hakoshima T (1999) Crystal structure of an IRF-DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequences. EMBO J 18(18):5028\u20135041","journal-title":"EMBO J"},{"key":"9792_CR58","doi-asserted-by":"publisher","first-page":"16506","DOI":"10.1021\/bi9816599","volume":"37","author":"Y Luo","year":"1998","unstructured":"Luo Y, Lu W, Mohamedali KA, Jang J-H, Jones RB, Gabriel JL, Kan M, McKeehan WL (1998) The glycine box: a determinant of specificity for fibroblast growth factor. Biochemistry 37:16506\u201316515","journal-title":"Biochemistry"},{"issue":"49","key":"9792_CR59","doi-asserted-by":"publisher","first-page":"46386","DOI":"10.1074\/jbc.M107654200","volume":"276","author":"V Blanc","year":"2001","unstructured":"Blanc V, Henderson JO, Kennedy S, Davidson NO (2001) Mutagenesis of Apobec-1 complementation factor reveals distinct domains that modulate RNA binding protein-protein interaction with Apobec-1 and complementation of C to U RNA-editing activity. J Biol Chem 276(49):46386\u201346393","journal-title":"J Biol Chem"},{"key":"9792_CR60","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1017\/S1355838202015649","volume":"8","author":"A Mehta","year":"2002","unstructured":"Mehta A, Driscoll DM (2002) Identification of domains in apobec-1 complementation factor required for RNA binding and apolipoprotein-B mRNA editing. RNA 8:69\u201382","journal-title":"RNA"},{"key":"9792_CR61","doi-asserted-by":"publisher","first-page":"10678","DOI":"10.1021\/bi990967j","volume":"38","author":"EP Newberry","year":"1999","unstructured":"Newberry EP, Latifi T, Towler DA (1999) The RRM domain of MINT, a Novel Msx2 binding protein, recognizes and regulates the rat osteocalcin promoter. Biochemistry 38:10678\u201310690","journal-title":"Biochemistry"},{"issue":"31","key":"9792_CR62","doi-asserted-by":"publisher","first-page":"32913","DOI":"10.1074\/jbc.M314098200","volume":"279","author":"OL Sierra","year":"2004","unstructured":"Sierra OL, Cheng S-L, Loewy AP, Charlton-Kachigian N, Towler DA (2004) MINT, the Msx2 interacting nuclear matrix target, enhances Runx2-dependent activation of the osteocalcin fibroblast growth factor response element. J Biol Chem 279(31):32913\u201332923","journal-title":"J Biol Chem"},{"key":"9792_CR63","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1042\/bj3330433","volume":"333","author":"C Ettelaie","year":"1998","unstructured":"Ettelaie C, James NJ, Adam JM, Nicola KP, Wilbourn BR, Bruckdorfer KR (1998) Identification of a domain in apolipoprotein B-100 that inhibits the procoagulant activity of tissue factor. Biochem J 333:433\u2013438","journal-title":"Biochem J"},{"key":"9792_CR64","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1161\/01.ATV.19.7.1784","volume":"19","author":"C Ettelaie","year":"1999","unstructured":"Ettelaie C, Wibourn BR, Adam JM, James NJ, Bruckdorfer KR (1999) Comparison of the inhibitory effects of ApoB100 and tissue factor pathway inhibitor on tissue factor and the influence of lipoprotein oxidation. Arterioscler Thromb Vasc Biol 19:1784\u20131790","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"9792_CR65","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.bbapap.2011.04.009","volume":"1824","author":"S Takeda","year":"2012","unstructured":"Takeda S, Takeya H, Iwanaga S (2012) Snake venom metalloproteinases: structure, function and relevance to the mammalian ADAM\/ADAMTS family proteins. Biochim Biophys Acta 1824:164\u2013176","journal-title":"Biochim Biophys Acta"},{"key":"9792_CR66","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1016\/j.toxicon.2005.02.024","volume":"45","author":"JJ Calvete","year":"2005","unstructured":"Calvete JJ, Marcinkiewicz C, Monleon D, Esteve V, Celda B, Juarez P, Sanz L (2005) Snake venom disintegrins: evolution of structure and function. Toxicon 45:1063\u20131074","journal-title":"Toxicon"},{"key":"9792_CR67","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1021\/bi9017208","volume":"49","author":"M Guttman","year":"2010","unstructured":"Guttman M, Prieto JH, Croy JE, Komives EA (2010) Decoding of lipoprotein-receptor interactions: properties of ligand binding modules governing interactions with apolipoprotein E. Biochemistry 49:1207\u20131216","journal-title":"Biochemistry"},{"issue":"36","key":"9792_CR68","doi-asserted-by":"crossref","first-page":"21682","DOI":"10.1016\/S0021-9258(20)88240-4","volume":"264","author":"DW Russell","year":"1989","unstructured":"Russell DW, Brown MS, Goldstein JL (1989) Different combinations of cysteine-rich repeats mediate binding of low density lipoprotein receptor to two different proteins. J Biol Chem 264(36):21682\u201321688","journal-title":"J Biol Chem"},{"issue":"10","key":"9792_CR69","doi-asserted-by":"publisher","first-page":"2269","DOI":"10.1002\/j.1460-2075.1995.tb07221.x","volume":"14","author":"G Bu","year":"1995","unstructured":"Bu G, Geuze HJ, Strous GJ, Schwartz AL (1995) 39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein. EMBO J 14(10):2269\u20132280","journal-title":"EMBO J"},{"issue":"1","key":"9792_CR70","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1128\/JVI.01788-07","volume":"82","author":"D Luo","year":"2008","unstructured":"Luo D, Xu T, Hunke C, Gruber G, Vasudevan SG, Lescar J (2008) Crystal structure of the NS3 protease-helicase from dengue virus. J Virol 82(1):173\u2013183","journal-title":"J Virol"},{"issue":"2","key":"9792_CR71","doi-asserted-by":"publisher","first-page":"80","DOI":"10.4161\/chan.3999","volume":"1","author":"HM Jones","year":"2007","unstructured":"Jones HM, Bailey MA, Baty CJ, MacGrego GG, Syme CA, Hamilton KL, Devor DC (2007) An NH2-terminal multi-basic RKR motif is required for the ATP-dependent regulation of hIK1. Channels 1(2): 80\u201391","journal-title":"Channels"},{"key":"9792_CR72","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/S0960-9822(03)00208-2","volume":"13","author":"H Yuan","year":"2003","unstructured":"Yuan H, Michelsen K, Schwappach B (2003) 14-3-3 Dimers probe the assembly status of multimeric membrane proteins. Curr Biol 13:638\u2013646","journal-title":"Curr Biol"},{"issue":"10","key":"9792_CR73","doi-asserted-by":"publisher","first-page":"5783","DOI":"10.1073\/pnas.1031748100","volume":"100","author":"S Shikano","year":"2003","unstructured":"Shikano S, Li M (2003) Membrane receptor trafficking: Evidence of proximal and distal zones conferred by two independent endoplasmic reticulum localization signals. Proc Natl Acad Sci USA 100(10):5783\u20135788","journal-title":"Proc Natl Acad Sci USA"},{"issue":"10","key":"9792_CR74","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1038\/ncb1297","volume":"7","author":"S Shikano","year":"2005","unstructured":"Shikano S, Boblitz B, Sun H, Li M (2005) Genetic isolation of transport signals directing cell surface expression. Nat Cell Biol 7(10):985\u2013992","journal-title":"Nat Cell Biol"}],"container-title":["The Protein Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10930-018-9792-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10930-018-9792-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10930-018-9792-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T00:22:01Z","timestamp":1667521321000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10930-018-9792-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,26]]},"references-count":74,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["9792"],"URL":"https:\/\/doi.org\/10.1007\/s10930-018-9792-8","relation":{},"ISSN":["1572-3887","1875-8355"],"issn-type":[{"value":"1572-3887","type":"print"},{"value":"1875-8355","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,26]]},"assertion":[{"value":"26 September 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}