{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T12:46:45Z","timestamp":1778849205909,"version":"3.51.4"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T00:00:00Z","timestamp":1558483200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T00:00:00Z","timestamp":1558483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Protein J"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1007\/s10930-019-09840-9","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T05:23:14Z","timestamp":1558588994000},"page":"506-514","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["New Synthetic Peptides Conjugated to Gold Nanoclusters: Antibiotic Activity Against Escherichia coli O157:H7 and Methicillin-Resistant Staphylococcus aureus (MRSA)"],"prefix":"10.1007","volume":"38","author":[{"given":"Y. A.","family":"Prada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanny","family":"Guzm\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Ort\u00edz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Cabanzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Mej\u00eda-Ospino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,5,22]]},"reference":[{"key":"9840_CR1","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.addr.2012.05.004","volume":"65","author":"L Vigderman","year":"2013","unstructured":"Vigderman L, Zubarev ER (2013) Therapeutic platforms based on gold nanoparticles and their covalent conjugates with drug molecules. Adv Drug Deliv Rev 65:663\u2013676","journal-title":"Adv Drug Deliv Rev"},{"key":"9840_CR2","doi-asserted-by":"publisher","first-page":"287","DOI":"10.2217\/17435889.2.3.287","volume":"2","author":"MJ Kogan","year":"2007","unstructured":"Kogan MJ, Olmedo I, Hosta L, Guerrero AR, Cruz LJ, Albericio F (2007) Peptides and metallic nanoparticles for biomedical applications. Nanomedicine 2:287\u2013306","journal-title":"Nanomedicine"},{"key":"9840_CR3","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.1021\/ac061578f","volume":"79","author":"Y Liu","year":"2007","unstructured":"Liu Y, Shipton MK, Ryan J, Kaufman ED, Franzen S, Feldheim DL (2007) Synthesis, stability, and cellular internalization of gold nanoparticles containing mixed peptide\u2013poly(ethylene glycol) monolayers. Anal Chem 79:2221\u20132229","journal-title":"Anal Chem"},{"key":"9840_CR4","volume-title":"Perspectives and peptides of the next generation\u201d, in Prokaryotic antimicrobial peptides: genes to applications","author":"KA Brogden","year":"2011","unstructured":"Brogden KA (2011) In: Drider D, Rebaffat S (eds) Perspectives and peptides of the next generation\u201d, in Prokaryotic antimicrobial peptides: genes to applications. Springer, New York"},{"key":"9840_CR5","first-page":"435","volume":"84","author":"NY Yount","year":"2006","unstructured":"Yount NY, Bayer AS, Xiong YQ (2006) Advances in antimicrobial peptide immunobiology 84:435\u2013458","journal-title":"Advances in antimicrobial peptide immunobiology"},{"key":"9840_CR6","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.1016\/j.addr.2013.09.019","volume":"65","author":"JL Markman","year":"2013","unstructured":"Markman JL, Rekechenetskiy A, Holler E, Ljubimova JY (2013) Nanomedicine therapeutic approaches to overcome cancer drug resistance. Adv Drug Deliv Rev 65:1866\u20131879","journal-title":"Adv Drug Deliv Rev"},{"key":"9840_CR7","doi-asserted-by":"publisher","first-page":"731","DOI":"10.2174\/138955712801264774","volume":"12","author":"A Brandelli","year":"2012","unstructured":"Brandelli A (2012) Nanostructures as promising tools for delivery of antimicrobial peptides. Mini Rev Med Chem 12:731\u2013741","journal-title":"Mini Rev Med Chem"},{"key":"9840_CR8","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.bbrc.2013.12.006","volume":"443","author":"SN Narla","year":"2014","unstructured":"Narla SN, Pinnamaneni P, Nie H, Li Y, Sun XL (2014) BSA-boronic acid conjugate as lectin mimetics. Biochem Biophys Res Commun 443:562\u2013567","journal-title":"Biochem Biophys Res Commun"},{"key":"9840_CR9","first-page":"639","volume":"117","author":"M Zhang","year":"2013","unstructured":"Zhang M, Dang YQ, Liu TY, Li HW, Wu Y, Li Q, Wang K, Zou B (2013) Pressure-induced fluorescence enhancement of the BSA-protected gold nanoclusters and the corresponding conformational changes of protein. J Phys Chem 117:639\u2013647","journal-title":"J Phys Chem"},{"key":"9840_CR10","doi-asserted-by":"publisher","first-page":"7939","DOI":"10.1016\/j.biomaterials.2013.06.066","volume":"34","author":"X Ming","year":"2013","unstructured":"Ming X, Carver K, Wu L (2013) Albumin-based nanoconjugates for targeted delivery of therapeutic oligonucleotides. Biomaterials 34:7939\u20137949","journal-title":"Biomaterials"},{"key":"9840_CR11","doi-asserted-by":"publisher","first-page":"585","DOI":"10.2174\/092986710790416290","volume":"17","author":"L Zhang","year":"2010","unstructured":"Zhang L, Pornpattananangkul D, Hu CJ, Huang C (2010) Development of nanoparticles for antimicrobial drug delivery. Curr Med Chem 17:585\u2013594","journal-title":"Curr Med Chem"},{"key":"9840_CR12","doi-asserted-by":"publisher","first-page":"4713","DOI":"10.1021\/am5083733","volume":"7","author":"H Ding","year":"2015","unstructured":"Ding H, Yang D, Zhao C, Song Z, Liu P, Wang Y, Chen Z, Shen J (2015) Protein-gold hybrid nanocubes for cell imaging and drug delivery. ACS Appl Mater Interfaces 7:4713\u20134719","journal-title":"ACS Appl Mater Interfaces"},{"key":"9840_CR13","doi-asserted-by":"publisher","first-page":"5111","DOI":"10.1021\/nn300768d","volume":"6","author":"CAJ Lin","year":"2012","unstructured":"Lin CAJ, Chuang WK, Huang ZY, Kang ST, Chang CY, Chen CT, Li JL, Li JK, Wang HH, Kung FC, Shen JL, Chan WH, Yeh CK, Yeh HI, Lai WFT, Chang WH (2012) Rapid transformation of protein-caged nanomaterials into microbubbles as bimodal imaging agents. ACS Nano 6:5111\u20135121","journal-title":"ACS Nano"},{"key":"9840_CR14","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1007\/s12602-016-9219-9","volume":"8","author":"YA Prada","year":"2016","unstructured":"Prada YA, Guzm\u00e1n F, Rond\u00f3n R, Escobar P, Ortiz C, Sierra DA, Torres R, Mej\u00eda-Ospino E (2016) A new synthetic peptide with in vitro antibacterial potential against Escherichia coli O157: H7 and methicillin-resistant Staphylococcus aureus (MRSA). Probiotics Antimicrob Proteins 8:134\u2013140","journal-title":"Probiotics Antimicrob Proteins"},{"key":"9840_CR15","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1016\/j.peptides.2011.01.026","volume":"32","author":"C Jofr\u00e9","year":"2011","unstructured":"Jofr\u00e9 C, Guzm\u00e1n F, C\u00e1rdenas C, Albericio F, Marshall SH (2011) A natural peptide and its variants derived from the processing of infectious pancreatic necrosis virus (IPNV) displaying enhanced antimicrobial activity: a novel alternative for the control of bacterial diseases. Peptides 32:852\u2013858","journal-title":"Peptides"},{"key":"9840_CR16","doi-asserted-by":"publisher","first-page":"3229","DOI":"10.3390\/ijms13033229","volume":"13","author":"R Gopal","year":"2012","unstructured":"Gopal R, Park JS, Seo CH, Park Y (2012) Applications of circular dichroism for structural analysis of gelatin and antimicrobial peptides. Int J Mol Sci 13:3229\u20133244","journal-title":"Int J Mol Sci"},{"key":"9840_CR17","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1021\/ja806804u","volume":"131","author":"J Xie","year":"2009","unstructured":"Xie J, Zheng Y, Ying JY (2009) Protein-directed synthesis of highly fluorescent gold nanoclusters. J Am Chem Soc 131:888\u2013889","journal-title":"J Am Chem Soc"},{"key":"9840_CR18","doi-asserted-by":"publisher","first-page":"8800","DOI":"10.1021\/nn202860s","volume":"5","author":"X Yuan","year":"2011","unstructured":"Yuan X, Luo Z, Zhang Q, Zhang X, Zheng Y, Lee JY, Xie J (2011) Synthesis of highly fluorescent metal (Ag, Au, Pt, and Cu) nanoclusters by electrostatically induced reversible phase transfer. ACS Nano 5:8800\u20138808","journal-title":"ACS Nano"},{"key":"9840_CR19","doi-asserted-by":"publisher","first-page":"2563","DOI":"10.1128\/AEM.00184-16","volume":"82","author":"N Ojeda","year":"2016","unstructured":"Ojeda N, C\u00e1rdenas C, Guzm\u00e1n F, Marshall H (2016) Chemical synthesis and in vitro evaluation of a phage display derived peptide active against infectious salmon anemia virus. Appl Environ Microbiol 82:2563\u20132571","journal-title":"Appl Environ Microbiol"},{"key":"9840_CR20","doi-asserted-by":"publisher","first-page":"2299","DOI":"10.2174\/0929867321666140217110155","volume":"21","author":"J Cruz","year":"2014","unstructured":"Cruz J, Ortiz C, Guzm\u00e1n F, Torres R (2014) Antimicrobial peptides: promising compounds against pathogenic microorganisms. Curr Med Chem 21:2299\u20132321","journal-title":"Curr Med Chem"},{"key":"9840_CR21","doi-asserted-by":"publisher","first-page":"2591","DOI":"10.1021\/acsnano.5b07596","volume":"10","author":"A Yahia-ammar","year":"2016","unstructured":"Yahia-ammar A, Sierra D, Me F (2016) Self-assembled gold nanoclusters for bright fluorescence imaging and enhanced drug delivery. ACS Nano 10:2591\u20132599","journal-title":"ACS Nano"},{"key":"9840_CR22","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.aca.2015.02.031","volume":"871","author":"X Cao","year":"2015","unstructured":"Cao X, Li H, Lian L, Xu N, Lou D, Wu Y (2015) A dual-responsive fluorescence method for the detection of clenbuterol based on BSA-protected gold nanoclusters. Anal Chim Acta 871:43\u201350","journal-title":"Anal Chim Acta"},{"key":"9840_CR23","unstructured":"Protein cross-linkers: handook & selection guide (2018) G-Biosciences, USA"},{"key":"9840_CR24","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.jconrel.2017.03.392","volume":"254","author":"M Gaber","year":"2017","unstructured":"Gaber M, Medhat W, Hany M, Saher N (2017) Protein-lipid nanohybrids as emerging platforms for drug and gene delivery: challenges and outcomes. J Control Release 254:75\u201391","journal-title":"J Control Release"},{"key":"9840_CR25","doi-asserted-by":"publisher","first-page":"3667","DOI":"10.7150\/thno.19365","volume":"7","author":"FF An","year":"2017","unstructured":"An FF, Zhang XH (2017) Strategies for preparing albumin-based nanoparticles for multifunctional bioimaging and drug delivery. Theranostics 7:3667\u20133689","journal-title":"Theranostics"},{"key":"9840_CR26","doi-asserted-by":"publisher","first-page":"2588","DOI":"10.1007\/s00018-005-5373-z","volume":"62","author":"JL Gifford","year":"2005","unstructured":"Gifford JL, Hunter HN, Vogel HJ (2005) Lactoferricin: a lactoferrin-derived peptide with antimicrobial, antiviral, antitumor and immunological properties. Cell Mol Life Sci 62:2588\u20132598","journal-title":"Cell Mol Life Sci"},{"key":"9840_CR27","doi-asserted-by":"publisher","first-page":"5777","DOI":"10.1021\/bi0100384","volume":"40","author":"SA Muhle","year":"2001","unstructured":"Muhle SA, Tam JP (2001) Design of Gram-negative selective antimicrobial peptides. Biochemistry 40:5777\u20135785","journal-title":"Biochemistry"},{"key":"9840_CR28","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1016\/j.bbamem.2006.02.030","volume":"1758","author":"SK Kandasamy","year":"2006","unstructured":"Kandasamy SK, Larson RG (2006) Effect of salt on the interactions of antimicrobial peptides with zwitterionic lipid bilayers. Biochim Biophys Acta\u2014Biomembr 1758:1274\u20131284","journal-title":"Biochim Biophys Acta\u2014Biomembr"},{"key":"9840_CR29","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1002\/jcc.21365","volume":"31","author":"J Maupetit","year":"2010","unstructured":"Maupetit J, Derreumaux P, Tuff\u00e9ry P (2010) A fast method for large-scale de novo peptide and mini protein structure prediction. J Comput Chem 31:726\u2013738","journal-title":"J Comput Chem"},{"key":"9840_CR30","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/0014-5793(95)00687-5","volume":"368","author":"KW Bensch","year":"1995","unstructured":"Bensch KW, Raida M, M\u00e4gert H-J, Schulz-Knappe P, Forssmann W-G (1995) hBD-1: a novel \u03b2-defensin from human plasma. FEBS Lett 368:331\u2013335","journal-title":"FEBS Lett"},{"key":"9840_CR31","doi-asserted-by":"publisher","first-page":"50450","DOI":"10.1074\/jbc.M208429200","volume":"277","author":"JP Tam","year":"2008","unstructured":"Tam JP, Lu YA, Yang JL (2008) Correlations of cationic charges with salt sensitivity and microbial specificity of cystine-stabilized \u03b2-strand antimicrobial peptides. J Biol Chem 277:50450\u201350456","journal-title":"J Biol Chem"},{"key":"9840_CR32","doi-asserted-by":"publisher","first-page":"2002","DOI":"10.1016\/S0006-3495(00)76448-4","volume":"79","author":"L Yang","year":"2000","unstructured":"Yang L, Weiss TM, Lehrer RI, Huang HW (2000) Crystallization of antimicrobial pores in membranes: magainin and protegrin. Biophys J 79:2002\u20132009","journal-title":"Biophys J"},{"key":"9840_CR33","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1128\/AAC.44.7.1803-1808.2000","volume":"44","author":"D Mosca","year":"2000","unstructured":"Mosca D, Hurst MA, Beverly W, Fujii C, Falla T (2000) IB-367, a protegrin peptide with in vivo and in vivo activities against the microflora associated with oral mucositis. Antimicrob Agents Chemother 44:1803\u20131808","journal-title":"Antimicrob Agents Chemother"},{"key":"9840_CR34","first-page":"5","volume-title":"Handbook of biologically active peptides","author":"N Antcheva","year":"2006","unstructured":"Antcheva N, Zelezetsky I, Tossi A (2006) Cationic antimicrobial peptides\u2014the defensins. Handbook of biologically active peptides. Academic Press, Amsterdam, pp 5\u201367"},{"key":"9840_CR35","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1111\/j.1742-4658.2009.07544.x","volume":"5","author":"S Rodziewicz-motowid\u0142o","year":"2010","unstructured":"Rodziewicz-motowid\u0142o S, Mickiewicz B, Greber K, Sikorska E (2010) Antimicrobial and conformational studies of the active and inactive analogs of the protegrin-1 peptide. FEBS J 5:1010\u20131022","journal-title":"FEBS J"},{"key":"9840_CR36","doi-asserted-by":"publisher","first-page":"3928","DOI":"10.1096\/fj.09-137588","volume":"23","author":"MJ Oudhoff","year":"2009","unstructured":"Oudhoff MJ, Kroeze KL, Nazmi K, Van Den Keijbus PAM, Van Hof W, Fernandez-Borja M, Hordijk PL, Gibbs S, Bolscher JGM, Veerman ECI (2009) Structure-activity analysis of histatin, a potent wound healing peptide from human saliva: cyclization of histatin potentiates molar activity 1000-fold. FASEB J 23:3928\u20133935","journal-title":"FASEB J"},{"key":"9840_CR37","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1021\/bc1002295","volume":"22","author":"R Xu","year":"2011","unstructured":"Xu R, Fisher M, Juliano RL (2011) Targeted albumin-based nanoparticles for delivery of amphipathic drugs. Bioconjug Chem 22:870\u2013878","journal-title":"Bioconjug Chem"},{"key":"9840_CR38","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1021\/nl034396z","volume":"3","author":"H Gu","year":"2003","unstructured":"Gu H, Ho PL, Tong E, Wang L, Xu B (2003) Presenting vancomycin on nanoparticles to enhance antimicrobial activities. Nano Lett 3:1261\u20131263","journal-title":"Nano Lett"},{"issue":"12","key":"9840_CR39","first-page":"1","volume":"9","author":"E Lee","year":"2014","unstructured":"Lee E, Shin A, Jeong KW, Jin B, Jnawali HN, Shin S, Shin SY, Kim Y (2014) Role of phenylalanine and valine10 residues in the antimicrobial activity and cytotoxicity of piscidin-1. PLoS ONE 9(12):1\u201330","journal-title":"PLoS ONE"}],"container-title":["The Protein Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10930-019-09840-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10930-019-09840-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10930-019-09840-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T12:31:51Z","timestamp":1721305911000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10930-019-09840-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,22]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["9840"],"URL":"https:\/\/doi.org\/10.1007\/s10930-019-09840-9","relation":{},"ISSN":["1572-3887","1875-8355"],"issn-type":[{"value":"1572-3887","type":"print"},{"value":"1875-8355","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,22]]},"assertion":[{"value":"22 May 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"We express our consent to the publication of results declaring no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}