{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T23:02:50Z","timestamp":1752102170825,"version":"3.37.3"},"reference-count":105,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,1,2]],"date-time":"2021-01-02T00:00:00Z","timestamp":1609545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,2]],"date-time":"2021-01-02T00:00:00Z","timestamp":1609545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["6793","PDF"],"award-info":[{"award-number":["6793","PDF"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Protein J"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1007\/s10930-020-09944-7","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T20:14:20Z","timestamp":1610741660000},"page":"87-107","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Oxidative Damage? Not a Problem! The Characterization of Humanin-like Mitochondrial Peptide in Anoxia Tolerant Freshwater Turtles"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6129-6253","authenticated-orcid":false,"given":"Sanoji","family":"Wijenayake","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7363-1853","authenticated-orcid":false,"given":"Kenneth B.","family":"Storey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,2]]},"reference":[{"key":"9944_CR1","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/S1096-4959(01)00408-0","volume":"130","author":"P Hochachka","year":"2001","unstructured":"Hochachka P, Lutz P (2001) Mechanism, origin, and evolution of anoxia tolerance in animals. Comp Biochem Physiol B Biochem Mol Biol 130:435\u2013459","journal-title":"Comp Biochem Physiol B Biochem Mol Biol"},{"key":"9944_CR2","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1002\/047167558X","volume-title":"Functional Metabolism","author":"K Storey","year":"2004","unstructured":"Storey K, Storey J (2004) Oxygen limitation and metabolic rate depression. In: Storey KB (ed) Functional Metabolism. John Wiley & Sons Inc, Hoboken, NJ, USA, pp 415\u2013442"},{"issue":"231","key":"9944_CR3","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1126\/science.2417316","volume":"80","author":"P Hochachka","year":"1986","unstructured":"Hochachka P (1986) Defense strategies against hypoxia and hypothermia. Science 80(231):234\u2013241. https:\/\/doi.org\/10.1126\/science.2417316","journal-title":"Science"},{"key":"9944_CR4","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.1242\/jeb.02716","volume":"210","author":"K Storey","year":"2007","unstructured":"Storey K, Storey J (2007) Tribute to P. L. Lutz: putting life on `pause\u2019 \u2013 molecular regulation of hypometabolism. J Exp Biol 210:1700\u20131714. https:\/\/doi.org\/10.1242\/jeb.02716","journal-title":"J Exp Biol"},{"key":"9944_CR5","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.cbpa.2006.03.019","volume":"147","author":"K Storey","year":"2007","unstructured":"Storey K (2007) Anoxia tolerance in turtles: Metabolic regulation and gene expression. Comp Biochem Physiol Part A Mol Integr Physiol 147:263\u2013276. https:\/\/doi.org\/10.1016\/j.cbpa.2006.03.019","journal-title":"Comp Biochem Physiol Part A Mol Integr Physiol"},{"key":"9944_CR6","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/0305-0491(95)02043-8","volume":"113","author":"K Storey","year":"1996","unstructured":"Storey K (1996) Metabolic adaptations supporting anoxia tolerance in reptiles: recent advances. Comp Biochem Physiol Part B Comp Biochem 113:23\u201335. https:\/\/doi.org\/10.1016\/0305-0491(95)02043-8","journal-title":"Comp Biochem Physiol Part B Comp Biochem"},{"key":"9944_CR7","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1139\/z88-021","volume":"66","author":"P Hochachka","year":"1988","unstructured":"Hochachka P (1988) Metabolic suppression and oxygen availability. Can J Zool 66:152\u2013158. https:\/\/doi.org\/10.1139\/z88-021","journal-title":"Can J Zool"},{"key":"9944_CR8","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1242\/jeb.200.17.2295","volume":"200","author":"D Jackson","year":"1997","unstructured":"Jackson D (1997) Lactate accumulation in the shell of the turtle, Chrysemys picta bellii, during anoxia at 3 and 10\u00b0C. J Exp Biol 200:2295\u20132300","journal-title":"J Exp Biol"},{"key":"9944_CR9","doi-asserted-by":"publisher","first-page":"R1564","DOI":"10.1152\/ajpregu.2000.278.6.R1564","volume":"278","author":"D Jackson","year":"2000","unstructured":"Jackson D, Crocker C, Ultsch G (2000) Bone and shell contribution to lactic acid buffering of submerged turtles Chrysemys picta bellii at 3\u00b0C. Am J Physiol - Regul Integr Comp Physiol 278:R1564-1571","journal-title":"Am J Physiol - Regul Integr Comp Physiol"},{"key":"9944_CR10","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1152\/jappl.1968.24.4.503","volume":"24","author":"D Jackson","year":"1968","unstructured":"Jackson D (1968) Metabolic depression and oxygen depletion in the diving turtle. J Appl Physiol 24:503\u2013509","journal-title":"J Appl Physiol"},{"key":"9944_CR11","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s11010-012-1508-3","volume":"374","author":"A Krivoruchko","year":"2013","unstructured":"Krivoruchko A, Storey K (2013) Activation of the unfolded protein response during anoxia exposure in the turtle Trachemys scripta elegans. Mol Cell Biochem 374:91\u2013103. https:\/\/doi.org\/10.1007\/s11010-012-1508-3","journal-title":"Mol Cell Biochem"},{"key":"9944_CR12","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s00360-009-0414-9","volume":"180","author":"A Krivoruchko","year":"2010","unstructured":"Krivoruchko A, Storey K (2010) Regulation of the heat shock response under anoxia in the turtle, Trachemys scripta elegans. J Comp Physiol B 180:403\u2013414. https:\/\/doi.org\/10.1007\/s00360-009-0414-9","journal-title":"J Comp Physiol B"},{"key":"9944_CR13","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.bbagen.2010.03.015","volume":"1800","author":"A Krivoruchko","year":"2010","unstructured":"Krivoruchko A, Storey K (2010) Activation of antioxidant defenses in response to freezing in freeze-tolerant painted turtle hatchlings. Biochim Biophys Acta - Gen Subj 1800:662\u2013668. https:\/\/doi.org\/10.1016\/j.bbagen.2010.03.015","journal-title":"Biochim Biophys Acta - Gen Subj"},{"key":"9944_CR14","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1023\/A:1006817806010","volume":"170","author":"W Willmore","year":"1997","unstructured":"Willmore W, Storey KB (1997) Antioxidant systems and anoxia tolerance in a freshwater turtle Trachemys scripta elegans. Mol Cell Biochem 170:177\u2013185. https:\/\/doi.org\/10.1023\/A:1006817806010","journal-title":"Mol Cell Biochem"},{"key":"9944_CR15","first-page":"263","volume-title":"Cell and Molecular Responses to Stress","author":"M Hermes-Lima","year":"2001","unstructured":"Hermes-Lima M, Storey JM, Storey KB (2001) Antioxidant defenses and animal adaptation to oxygen availability during environmental stress. In: Storey K, Storey J (eds) Cell and Molecular Responses to Stress, vol 2. Elsevier Press, Amesterdam, pp 263\u2013287"},{"key":"9944_CR16","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/S1095-6433(00)00160-4","volume":"125","author":"DC Jackson","year":"2000","unstructured":"Jackson DC (2000) Living without oxygen: Lessons from the freshwater turtle. Comp Biochem Physiol Part A Mol Integr Physiol 125:299\u2013315. https:\/\/doi.org\/10.1016\/S1095-6433(00)00160-4","journal-title":"Comp Biochem Physiol Part A Mol Integr Physiol"},{"key":"9944_CR17","doi-asserted-by":"publisher","first-page":"145","DOI":"10.4172\/2157-7625.1000224","volume":"65","author":"K Storey","year":"1990","unstructured":"Storey K, Storey J (1990) Metabolic rate depression and biochemical adaptation in anaerobiosis, hibernation and estivation. Q Rev Biol 65:145\u2013174. https:\/\/doi.org\/10.4172\/2157-7625.1000224","journal-title":"Q Rev Biol"},{"key":"9944_CR18","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/J.GENE.2018.01.086","volume":"649","author":"S Wijenayake","year":"2018","unstructured":"Wijenayake S, Hawkins L, Storey K (2018) Dynamic regulation of six histone H3 lysine (K) methyltransferases in response to prolonged anoxia exposure in a freshwater turtle. Gene 649:50\u201357. https:\/\/doi.org\/10.1016\/J.GENE.2018.01.086","journal-title":"Gene"},{"key":"9944_CR19","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s11010-020-03848-x","volume":"1","author":"S Wijenayake","year":"2020","unstructured":"Wijenayake S, Storey K (2020) Dynamic regulation of histone H3 lysine (K) acetylation and deacetylation during prolonged oxygen deprivation in a champion anaerobe. Mol Cell Biochem 1:3. https:\/\/doi.org\/10.1007\/s11010-020-03848-x","journal-title":"Mol Cell Biochem"},{"key":"9944_CR20","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s00360-016-0960-x","volume":"186","author":"S Wijenayake","year":"2016","unstructured":"Wijenayake S, Storey K (2016) The role of DNA methylation during anoxia tolerance in a freshwater turtle (<i>Trachemys scripta elegans<i\/>). J Comp Physiol B 186:333\u2013342. https:\/\/doi.org\/10.1007\/s00360-016-0960-x","journal-title":"J Comp Physiol B"},{"key":"9944_CR21","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.gene.2012.10.049","volume":"513","author":"J Zhang","year":"2013","unstructured":"Zhang J, Biggar K, Storey K (2013) Regulation of p53 by reversible post-transcriptional and post-translational mechanisms in liver and skeletal muscle of an anoxia tolerant turtle, Trachemys scripta elegans. Gene 513:147\u2013155. https:\/\/doi.org\/10.1016\/j.gene.2012.10.049","journal-title":"Gene"},{"key":"9944_CR22","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s11010-010-0479-5","volume":"342","author":"A Krivoruchko","year":"2010","unstructured":"Krivoruchko A, Storey K (2010) Epigenetics in anoxia tolerance: A role for histone deacetylases. Mol Cell Biochem 342:151\u2013161. https:\/\/doi.org\/10.1007\/s11010-010-0479-5","journal-title":"Mol Cell Biochem"},{"key":"9944_CR23","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.cryobiol.2014.08.008","volume":"69","author":"Y Biggar","year":"2014","unstructured":"Biggar Y, Storey KB (2014) Global DNA modifications suppress transcription in brown adipose tissue during hibernation. Cryobiology 69:333\u2013338. https:\/\/doi.org\/10.1016\/j.cryobiol.2014.08.008","journal-title":"Cryobiology"},{"key":"9944_CR24","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1242\/jeb.104828","volume":"218","author":"K Biggar","year":"2015","unstructured":"Biggar K, Storey K (2015) Insight into post-transcriptional gene regulation: stress-responsive microRNAs and their role in the environmental stress survival of tolerant animals. J Exp Biol 218:1281\u20131289. https:\/\/doi.org\/10.1242\/jeb.104828","journal-title":"J Exp Biol"},{"key":"9944_CR25","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.4161\/cc.19790","volume":"11","author":"KK Biggar","year":"2012","unstructured":"Biggar KK, Storey KB (2012) Evidence for cell cycle suppression and microRNA regulation of cyclin D1 during anoxia exposure in turtles. Cell Cycle 11:1705\u20131713. https:\/\/doi.org\/10.4161\/cc.19790","journal-title":"Cell Cycle"},{"key":"9944_CR26","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1093\/jmcb\/mjq045","volume":"3","author":"K Biggar","year":"2011","unstructured":"Biggar K, Storey K (2011) The emerging roles of microRNAs in the molecular responses of metabolic rate depression. J Mol Cell Biol 3:167\u2013175. https:\/\/doi.org\/10.1093\/jmcb\/mjq045","journal-title":"J Mol Cell Biol"},{"key":"9944_CR27","doi-asserted-by":"publisher","first-page":"R278","DOI":"10.1152\/ajpregu.1989.257.2.R278","volume":"257","author":"S Brooks","year":"1989","unstructured":"Brooks S, Storey K (1989) Regulation of glycolytic enzymes during anoxia in the turtle Pseudemys scripta. Am J Physiol 257:R278\u2013R283. https:\/\/doi.org\/10.1152\/ajpregu.1989.257.2.R278","journal-title":"Am J Physiol"},{"key":"9944_CR28","doi-asserted-by":"publisher","first-page":"R517","DOI":"10.1152\/ajpcell.1992.262.2.C517","volume":"262","author":"J Duncan","year":"1992","unstructured":"Duncan J, Storey K (1992) Subcellular enzyme binding and the regulation of glycolysis in anoxic turtle brain. Am J Physiol 262:R517\u2013R523","journal-title":"Am J Physiol"},{"key":"9944_CR29","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1002\/1097-010X(20001201)287:7<477::AID-JEZ3>3.0.CO;2-4","volume":"287","author":"SC Greenway","year":"2000","unstructured":"Greenway SC, Storey KB (2000) Mitogen-activated protein kinases and anoxia tolerance in turtles. J Exp Zool Part A Ecol Genet Physiol 287:477\u2013484. https:\/\/doi.org\/10.1002\/1097-010X(20001201)287:7%3c477::AID-JEZ3%3e3.0.CO;2-4","journal-title":"J Exp Zool Part A Ecol Genet Physiol"},{"key":"9944_CR30","doi-asserted-by":"publisher","first-page":"3141","DOI":"10.1242\/jeb.01056","volume":"207","author":"PL Lutz","year":"2004","unstructured":"Lutz PL, Milton SL (2004) Negotiating brain anoxia survival in the turtle. J Exp Biol 207:3141\u20133147","journal-title":"J Exp Biol"},{"key":"9944_CR31","unstructured":"Lutz P, Nilsson G, Prentice H (2003) The Brain Without Oxygen: Causes of Failure - Physiological and Molecular . P.L. Lutz, G.E. Nilsson, H.M. Prentice - Google Books, 3rd ed. Kluwer Academic Publishers, Dordrecht"},{"key":"9944_CR32","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1097\/00004647-200405000-00001","volume":"24","author":"GE Nilsson","year":"2004","unstructured":"Nilsson GE, Lutz PL (2004) Anoxia Tolerant Brains. J Cereb Blood Flow Metab 24:475\u2013486. https:\/\/doi.org\/10.1097\/00004647-200405000-00001","journal-title":"J Cereb Blood Flow Metab"},{"key":"9944_CR33","doi-asserted-by":"publisher","first-page":"20150797","DOI":"10.1098\/rsbl.2015.0797","volume":"12","author":"ME Pamenter","year":"2016","unstructured":"Pamenter ME, Gomez CR, Richards JG, Milsom WK (2016) Mitochondrial responses to prolonged anoxia in brain of red-eared slider turtles. Biol Lett 12:20150797. https:\/\/doi.org\/10.1098\/rsbl.2015.0797","journal-title":"Biol Lett"},{"key":"9944_CR34","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00261.2003","author":"HM Prentice","year":"2003","unstructured":"Prentice HM, Milton SL, Scheurle D, Lutz PL (2003) Gene transcription of brain voltage-gated potassium channels is reversibly regulated by oxygen supply. Am J Physiol - Regul Integr Comp Physiol. https:\/\/doi.org\/10.1152\/ajpregu.00261.2003","journal-title":"Am J Physiol - Regul Integr Comp Physiol"},{"key":"9944_CR35","doi-asserted-by":"publisher","first-page":"3522","DOI":"10.1523\/jneurosci.20-10-03522.2000","volume":"20","author":"PE Bickler","year":"2000","unstructured":"Bickler PE, Donohoe PH, Buck LT (2000) Hypoxia-induced silencing of NMDA receptors in turtle neurons. J Neurosci 20:3522\u20133528. https:\/\/doi.org\/10.1523\/jneurosci.20-10-03522.2000","journal-title":"J Neurosci"},{"key":"9944_CR36","doi-asserted-by":"publisher","first-page":"R32","DOI":"10.1152\/ajpcell.1991.261.1.C32","volume":"261","author":"GE Nilsson","year":"1991","unstructured":"Nilsson GE, Lutz PL (1991) Release of inhibitory neurotransmitters in response to anoxia in turtle brain. Am J Physiol 261:R32\u2013R37","journal-title":"Am J Physiol"},{"key":"9944_CR37","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1097\/00004647-199807000-00010","volume":"18","author":"SL Milton","year":"1998","unstructured":"Milton SL, Lutz PL (1998) Low Extracellular Dopamine Levels Are Maintained in the Anoxic Turtle (Trachemys scripta) Striatum. J Cereb Blood Flow Metab 18:803\u2013807","journal-title":"J Cereb Blood Flow Metab"},{"key":"9944_CR38","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1111\/j.1471-4159.2009.06068.x","volume":"109","author":"S Kesaraju","year":"2009","unstructured":"Kesaraju S, Schmidt-Kastner R, Prentice HM, Milton SL (2009) Modulation of stress proteins and apoptotic regulators in the anoxia tolerant turtle brain. J Neurochem 109:1413\u20131426. https:\/\/doi.org\/10.1111\/j.1471-4159.2009.06068.x","journal-title":"J Neurochem"},{"key":"9944_CR39","doi-asserted-by":"publisher","first-page":"186","DOI":"10.4161\/OXIM.3.3.4","volume":"3","author":"A Krivoruchko","year":"2010","unstructured":"Krivoruchko A, Storey K (2010) Forever young: Mechanisms of natural anoxia tolerance and potential links to longevity. Oxid Med Cell Longev 3:186. https:\/\/doi.org\/10.4161\/OXIM.3.3.4","journal-title":"Oxid Med Cell Longev"},{"key":"9944_CR40","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1242\/jeb.085381","volume":"217","author":"J Larson","year":"2014","unstructured":"Larson J, Drew KL, Folkow LP et al (2014) No oxygen? No problem! intrinsic brain tolerance to hypoxia in vertebrates. J Exp Biol 217:1024\u20131039","journal-title":"J Exp Biol"},{"key":"9944_CR41","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1097\/01.WCB.0000126565.27130.79","volume":"24","author":"HM Prentice","year":"2004","unstructured":"Prentice HM, Milton SL, Scheurle D, Lutz PL (2004) The upregulation of cognate and inducible heat shock proteins in the anoxic turtle brain. J Cereb Blood Flow Metab 24:826\u2013828. https:\/\/doi.org\/10.1097\/01.WCB.0000126565.27130.79","journal-title":"J Cereb Blood Flow Metab"},{"key":"9944_CR42","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1007\/s11373-006-9084-8","volume":"13","author":"SL Milton","year":"2006","unstructured":"Milton SL, Nayak G, Lutz PL, Prentice HM (2006) Gene transcription of neuroglobin is upregulated by hypoxia and anoxia in the brain of the anoxia-tolerant turtle Trachemys scripta. J Biomed Sci 13:509\u2013514. https:\/\/doi.org\/10.1007\/s11373-006-9084-8","journal-title":"J Biomed Sci"},{"key":"9944_CR43","first-page":"110","volume":"19","author":"T Burmester","year":"2004","unstructured":"Burmester T, Hankeln T (2004) Neuroglobin: A respiratory protein of the nervous system. News Physiol Sci 19:110\u2013113","journal-title":"News Physiol Sci"},{"key":"9944_CR44","doi-asserted-by":"publisher","first-page":"7992","DOI":"10.1073\/pnas.082244399","volume":"99","author":"JM Kriegl","year":"2002","unstructured":"Kriegl JM, Bhattacharyya AJ, Nienhaus K et al (2002) Ligand binding and protein dynamics in neuroglobin. Proc Natl Acad Sci U S A 99:7992\u20137997. https:\/\/doi.org\/10.1073\/pnas.082244399","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9944_CR45","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1152\/physrev.2001.81.2.569","volume":"81","author":"RE Weber","year":"2001","unstructured":"Weber RE, Vinogradov SN (2001) Nonvertebrate Hemoglobins: Functions and Molecular Adaptations. Physiol Rev 81:569\u2013628. https:\/\/doi.org\/10.1152\/physrev.2001.81.2.569","journal-title":"Physiol Rev"},{"key":"9944_CR46","doi-asserted-by":"publisher","first-page":"13042","DOI":"10.1073\/pnas.2135111100","volume":"100","author":"M Ikonen","year":"2003","unstructured":"Ikonen M, Liu B, Hashimoto Y et al (2003) Interaction between the Alzheimer\u2019s survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis. Proc Natl Acad Sci U S A 100:13042\u201313047. https:\/\/doi.org\/10.1073\/pnas.2135111100","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9944_CR47","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1038\/nature01627","volume":"423","author":"B Guo","year":"2003","unstructured":"Guo B, Zhai D, Cabezas E et al (2003) Humanin peptide suppresses apoptosis by interfering with Bax activation. Nature 423:456\u2013461. https:\/\/doi.org\/10.1038\/nature01627","journal-title":"Nature"},{"key":"9944_CR48","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1006\/bbrc.2001.4765","volume":"283","author":"Y Hashimoto","year":"2001","unstructured":"Hashimoto Y, Ito Y, Niikura T et al (2001) Mechanisms of neuroprotection by a novel rescue factor humanin from swedish mutant amyloid precursor protein. Biochem Biophys Res Commun 283:460\u2013468. https:\/\/doi.org\/10.1006\/bbrc.2001.4765","journal-title":"Biochem Biophys Res Commun"},{"key":"9944_CR49","doi-asserted-by":"publisher","first-page":"6336","DOI":"10.1073\/pnas.101133498","volume":"98","author":"Y Hashimoto","year":"2001","unstructured":"Hashimoto Y, Niikura T, Tajima H et al (2001) A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer\u2019s disease genes and A\u03b2. Proc Natl Acad Sci U S A 98:6336\u20136341. https:\/\/doi.org\/10.1073\/pnas.101133498","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9944_CR50","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-019-1549-7","author":"HH Mehta","year":"2019","unstructured":"Mehta HH, Xiao J, Ramirez R et al (2019) Metabolomic profile of diet-induced obesity mice in response to humanin and small humanin-like peptide 2 treatment. Metabolomics. https:\/\/doi.org\/10.1007\/s11306-019-1549-7","journal-title":"Metabolomics"},{"key":"9944_CR51","doi-asserted-by":"crossref","unstructured":"Miller B, Kim SJ, Kumagai H, et al (2020) Peptides derived from small mitochondrial open reading frames: Genomic, biological, and therapeutic implications. Exp. Cell Res. 393","DOI":"10.1016\/j.yexcr.2020.112056"},{"key":"9944_CR52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-65381-7","volume":"10","author":"MA Moreno Ayala","year":"2020","unstructured":"Moreno Ayala MA, Gottardo MF, Zuccato CF et al (2020) Humanin Promotes Tumor Progression in Experimental Triple Negative Breast Cancer. Sci Rep 10:1\u201312. https:\/\/doi.org\/10.1038\/s41598-020-65381-7","journal-title":"Sci Rep"},{"key":"9944_CR53","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1167\/iovs.15-17053","volume":"57","author":"PG Sreekumar","year":"2016","unstructured":"Sreekumar PG, Ishikawa K, Spee C et al (2016) The mitochondrial-derived peptide humanin protects RPE cells from oxidative stress, senescence, and mitochondrial dysfunction. Investig Ophthalmol Vis Sci 57:1238\u20131253. https:\/\/doi.org\/10.1167\/iovs.15-17053","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"9944_CR54","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1530\/JME-12-0203","volume":"50","author":"K Yen","year":"2012","unstructured":"Yen K, Lee C, Mehta H, Cohen P (2012) The emerging role of the mitochondrial-derived peptide humanin in stress resistance. J Mol Endocrinol 50:11\u201319","journal-title":"J Mol Endocrinol"},{"key":"9944_CR55","doi-asserted-by":"publisher","first-page":"11185","DOI":"10.18632\/aging.103534","volume":"12","author":"K Yen","year":"2020","unstructured":"Yen K, Mehta HH, Kim SJ et al (2020) The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan. Aging (Albany NY) 12:11185\u201311199. https:\/\/doi.org\/10.18632\/aging.103534","journal-title":"Aging (Albany NY)"},{"key":"9944_CR56","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-32616-7","author":"K Yen","year":"2018","unstructured":"Yen K, Wan J, Mehta HH et al (2018) Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-018-32616-7","journal-title":"Sci Rep"},{"key":"9944_CR57","doi-asserted-by":"publisher","first-page":"4962","DOI":"10.1096\/fj.201801741R","volume":"33","author":"F Zaman","year":"2019","unstructured":"Zaman F, Zhao Y, Celvin B et al (2019) Humanin is a novel regulator of Hedgehog signaling and prevents glucocorticoid-induced bone growth impairment. FASEB J 33:4962\u20134974. https:\/\/doi.org\/10.1096\/fj.201801741R","journal-title":"FASEB J"},{"key":"9944_CR58","doi-asserted-by":"publisher","first-page":"123","DOI":"10.3389\/fnagi.2019.00123","volume":"11","author":"SC Z\u00e1rate","year":"2019","unstructured":"Z\u00e1rate SC, Traetta ME, Codagnone MG et al (2019) Humanin, a mitochondrial-derived peptide released by astrocytes, prevents synapse loss in hippocampal neurons. Front Aging Neurosci 11:123. https:\/\/doi.org\/10.3389\/fnagi.2019.00123","journal-title":"Front Aging Neurosci"},{"key":"9944_CR59","doi-asserted-by":"publisher","first-page":"2276","DOI":"10.3109\/19401736.2014.984178","volume":"27","author":"D Yu","year":"2016","unstructured":"Yu D, Fang X, Storey KB et al (2016) Complete mitochondrial genomes of the yellow-bellied slider turtle Trachemys scripta scripta and anoxia tolerant red-eared slider Trachemys scripta elegans. Mitochondrial DNA Part A DNA Mapping, Seq Anal 27:2276\u20132277. https:\/\/doi.org\/10.3109\/19401736.2014.984178","journal-title":"Mitochondrial DNA Part A DNA Mapping, Seq Anal"},{"key":"9944_CR60","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1038\/msb.2011.75","volume":"7","author":"F Sievers","year":"2011","unstructured":"Sievers F, Wilm A, Dineen D et al (2011) Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega. Mol Syst Biol 7:539. https:\/\/doi.org\/10.1038\/msb.2011.75","journal-title":"Mol Syst Biol"},{"key":"9944_CR61","doi-asserted-by":"publisher","first-page":"3784","DOI":"10.1093\/nar\/gkg563","volume":"31","author":"E Gasteiger","year":"2003","unstructured":"Gasteiger E, Gattiker A, Hoogland C et al (2003) ExPASy: the proteomics server for in-depth protein knowledge and analysis. Nucleic Acids Res 31:3784\u20133788. https:\/\/doi.org\/10.1093\/nar\/gkg563","journal-title":"Nucleic Acids Res"},{"key":"9944_CR62","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.tem.2013.01.005","volume":"24","author":"C Lee","year":"2013","unstructured":"Lee C, Yen K, Cohen P (2013) Humanin: A harbinger of mitochondrial-derived peptides? Trends Endocrinol Metab 24:222\u2013228. https:\/\/doi.org\/10.1016\/j.tem.2013.01.005","journal-title":"Trends Endocrinol Metab"},{"key":"9944_CR63","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1002\/prot.24065","volume":"80","author":"D Xu","year":"2012","unstructured":"Xu D, Zhang Y (2012) Ab initio protein structure assembly using continuous structure fragments and optimized knowledge-based force field. Proteins Struct Funct Bioinforma 80:1715\u20131735. https:\/\/doi.org\/10.1002\/prot.24065","journal-title":"Proteins Struct Funct Bioinforma"},{"key":"9944_CR64","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1002\/prot.24179","volume":"81","author":"D Xu","year":"2013","unstructured":"Xu D, Zhang Y (2013) Toward optimal fragment generations for ab initio protein structure assembly. Proteins Struct Funct Bioinforma 81:229\u2013239. https:\/\/doi.org\/10.1002\/prot.24179","journal-title":"Proteins Struct Funct Bioinforma"},{"key":"9944_CR65","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1110\/ps.0236803","volume":"12","author":"B Wallner","year":"2003","unstructured":"Wallner B, Elofsson A (2003) Can correct protein models be identified? Protein Sci 12:1073\u20131086. https:\/\/doi.org\/10.1110\/ps.0236803","journal-title":"Protein Sci"},{"key":"9944_CR66","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.bbrc.2005.01.100","volume":"329","author":"D Benaki","year":"2005","unstructured":"Benaki D, Zikos C, Evangelou A et al (2005) Solution structure of humanin, a peptide against Alzheimer\u2019s disease-related neurotoxicity. Biochem Biophys Res Commun 329:152\u2013160. https:\/\/doi.org\/10.1016\/j.bbrc.2005.01.100","journal-title":"Biochem Biophys Res Commun"},{"key":"9944_CR67","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1471-2105-2-5","volume":"2","author":"S Cristobal","year":"2001","unstructured":"Cristobal S, Zemla A, Fischer D et al (2001) A study of quality measures for protein threading models. BMC Bioinformatics 2:5. https:\/\/doi.org\/10.1186\/1471-2105-2-5","journal-title":"BMC Bioinformatics"},{"key":"9944_CR68","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1038\/nprot.2010.5","volume":"5","author":"A Roy","year":"2010","unstructured":"Roy A, Kucukural A, Zhang Y (2010) I-TASSER: A unified platform for automated protein structure and function prediction. Nat Protoc 5:725\u2013738. https:\/\/doi.org\/10.1038\/nprot.2010.5","journal-title":"Nat Protoc"},{"key":"9944_CR69","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1002\/prot.22588","volume":"77","author":"Y Zhang","year":"2009","unstructured":"Zhang Y (2009) I-TASSER: Fully automated protein structure prediction in CASP8. Proteins Struct Funct Bioinforma 77:100\u2013113. https:\/\/doi.org\/10.1002\/prot.22588","journal-title":"Proteins Struct Funct Bioinforma"},{"key":"9944_CR70","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1741-7007-5-17","volume":"5","author":"S Wu","year":"2007","unstructured":"Wu S, Skolnick J, Zhang Y (2007) Ab initio modeling of small proteins by iterative TASSER simulations. BMC Biol 5:17. https:\/\/doi.org\/10.1186\/1741-7007-5-17","journal-title":"BMC Biol"},{"key":"9944_CR71","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1093\/bioinformatics\/bti770","volume":"22","author":"A Konstantin","year":"2005","unstructured":"Konstantin A, Bordoli L, \u00dcrgen K, Torsten S (2005) The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. Bioinformatics 22:195\u2013201. https:\/\/doi.org\/10.1093\/bioinformatics\/bti770","journal-title":"Bioinformatics"},{"key":"9944_CR72","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1038\/nprot.2015.053","volume":"10","author":"LA Kelley","year":"2015","unstructured":"Kelley LA, Mezulis S, Yates CM et al (2015) The Phyre2 web portal for protein modeling, prediction and analysis. Nat Protoc 10:845\u2013858. https:\/\/doi.org\/10.1038\/nprot.2015.053","journal-title":"Nat Protoc"},{"key":"9944_CR73","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1093\/bioinformatics\/bti125","volume":"21","author":"J S\u00f6ding","year":"2005","unstructured":"S\u00f6ding J (2005) Protein homology detection by HMM\u2013HMM comparison. Bioinformatics 21:951\u2013960. https:\/\/doi.org\/10.1093\/bioinformatics\/bti125","journal-title":"Bioinformatics"},{"key":"9944_CR74","doi-asserted-by":"crossref","unstructured":"Jackson D, Ultsch G (1982) Long-term submergence at 3\u00b0C of the turtle, Chrysemys picta bellii, in normoxic and severely hypoxic water: II. Extracellular ionic responses to extreme lactic acidosis. J Exp Biol 29\u201343","DOI":"10.1242\/jeb.96.1.29"},{"key":"9944_CR75","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/0034-5687(83)90066-X","volume":"53","author":"D Jackson","year":"1983","unstructured":"Jackson D, Heisler N (1983) Intracellular and extracellular acid\u2013base and electrolyte status of submerged anoxic turtles at 3\u00b0C. Respir Physiol 53:187\u2013201","journal-title":"Respir Physiol"},{"key":"9944_CR76","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s00360-016-0960-x","volume":"186","author":"S Wijenayake","year":"2016","unstructured":"Wijenayake S, Storey K (2016) The role of DNA methylation during anoxia tolerance in a freshwater turtle (Trachemys scripta elegans). J Comp Physiol B 186:333\u2013342. https:\/\/doi.org\/10.1007\/s00360-016-0960-x","journal-title":"J Comp Physiol B"},{"key":"9944_CR77","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1021\/pr1011476","volume":"10","author":"C Welinder","year":"2011","unstructured":"Welinder C, Ekblad L (2011) Coomassie staining as loading control in western blot analysis. J Proteome Res 10:1416\u20131419. https:\/\/doi.org\/10.1021\/pr1011476","journal-title":"J Proteome Res"},{"key":"9944_CR78","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2017.07.026","author":"SN Tessier","year":"2017","unstructured":"Tessier SN, Zhang Y, Wijenayake S, Storey KB (2017) MAP kinase signaling and Elk1 transcriptional activity in hibernating thirteen-lined ground squirrels. Biochim Biophys Acta - Gen Subj. https:\/\/doi.org\/10.1016\/j.bbagen.2017.07.026","journal-title":"Biochim Biophys Acta - Gen Subj"},{"key":"9944_CR79","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.8144","author":"KK Biggar","year":"2019","unstructured":"Biggar KK, Zhang J, Storey KB (2019) Navigating oxygen deprivation: Liver transcriptomic responses of the red eared slider turtle to environmental anoxia. PeerJ. https:\/\/doi.org\/10.7717\/peerj.8144","journal-title":"PeerJ"},{"key":"9944_CR80","first-page":"R1380","volume":"265","author":"S Brooks","year":"1993","unstructured":"Brooks S, Storey K (1993) De novo protein synthesis and protein phosphorylation during anoxia and recovery in the red-eared turtle. Am J Physiol 265:R1380\u2013R1386","journal-title":"Am J Physiol"},{"key":"9944_CR81","first-page":"57","volume-title":"Hypometabolism: strategies of survival in vertebrates and invertebrates","author":"K Biggar","year":"2011","unstructured":"Biggar K, Groom A, Storey K (2011) Hypometabolism and turtles: Physiological and molecular strategies of anoxic survival. In: Nowakowska A, Caputa M (eds) Hypometabolism: strategies of survival in vertebrates and invertebrates. Research Signpost, Kerala, pp 57\u201394"},{"key":"9944_CR82","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1002\/cbf.3422","volume":"37","author":"KE Szereszewski","year":"2019","unstructured":"Szereszewski KE, Storey KB (2019) Identification of a prosurvival neuroprotective mitochondrial peptide in a mammalian hibernator. Cell Biochem Funct 37:494\u2013503. https:\/\/doi.org\/10.1002\/cbf.3422","journal-title":"Cell Biochem Funct"},{"key":"9944_CR83","doi-asserted-by":"publisher","DOI":"10.1002\/0471250953.bi0301s42","author":"WR Pearson","year":"2013","unstructured":"Pearson WR (2013) An introduction to sequence similarity (\u201chomology\u201d) searching. Curr Protoc Bioinforma. https:\/\/doi.org\/10.1002\/0471250953.bi0301s42","journal-title":"Curr Protoc Bioinforma"},{"key":"9944_CR84","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1038\/sj.bjp.0704429","volume":"134","author":"T Mamiya","year":"2001","unstructured":"Mamiya T, Ukai M (2001) [Gly14]-Humanin improved the learning and memory impairment induced by scopolamine in vivo. Br J Pharmacol 134:1597\u20131599. https:\/\/doi.org\/10.1038\/sj.bjp.0704429","journal-title":"Br J Pharmacol"},{"key":"9944_CR85","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ghir.2016.03.005","volume":"29","author":"J Xiao","year":"2016","unstructured":"Xiao J, Kim SJ, Cohen P, Yen K (2016) Humanin: Functional Interfaces with IGF-I. Growth Horm IGF Res 29:21\u201327. https:\/\/doi.org\/10.1016\/j.ghir.2016.03.005","journal-title":"Growth Horm IGF Res"},{"key":"9944_CR86","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.ygeno.2009.05.006","volume":"94","author":"M Bodzioch","year":"2009","unstructured":"Bodzioch M, Lapicka-Bodzioch K, Zapala B et al (2009) Evidence for potential functionality of nuclearly-encoded humanin isoforms. Genomics 94:247\u2013256. https:\/\/doi.org\/10.1016\/j.ygeno.2009.05.006","journal-title":"Genomics"},{"key":"9944_CR87","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.jmb.2009.07.063","volume":"393","author":"DE Kim","year":"2009","unstructured":"Kim DE, Blum B, Bradley P, Baker D (2009) Sampling Bottlenecks in De novo Protein Structure Prediction. J Mol Biol 393:249\u2013260. https:\/\/doi.org\/10.1016\/j.jmb.2009.07.063","journal-title":"J Mol Biol"},{"issue":"355","key":"9944_CR88","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1126\/science.aal4512","volume":"80","author":"J S\u00f6ding","year":"2017","unstructured":"S\u00f6ding J (2017) Big-data approaches to protein structure prediction. Science 80(355):248\u2013249","journal-title":"Science"},{"key":"9944_CR89","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/nmeth.3437","volume":"12","author":"Y Shen","year":"2015","unstructured":"Shen Y, Bax A (2015) Homology modeling of larger proteins guided by chemical shifts. Nat Methods 12:747\u2013750. https:\/\/doi.org\/10.1038\/nmeth.3437","journal-title":"Nat Methods"},{"key":"9944_CR90","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0205819","author":"NJ Cheung","year":"2018","unstructured":"Cheung NJ, Yu W (2018) De novo protein structure prediction using ultra-fast molecular dynamics simulation. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0205819","journal-title":"PLoS ONE"},{"key":"9944_CR91","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s11064-011-0593-0","volume":"37","author":"ST Zhao","year":"2012","unstructured":"Zhao ST, Huang XT, Zhang C, Ke Y (2012) Humanin protects cortical neurons from ischemia and reperfusion injury by the increased activity of superoxide dismutase. Neurochem Res 37:153\u2013160. https:\/\/doi.org\/10.1007\/s11064-011-0593-0","journal-title":"Neurochem Res"},{"key":"9944_CR92","doi-asserted-by":"publisher","first-page":"2613","DOI":"10.1161\/01.STR.0000242772.94277.1f","volume":"37","author":"X Xu","year":"2006","unstructured":"Xu X, Chua CC, Gao J et al (2006) Humanin is a novel neuroprotective agent against stroke. Stroke 37:2613\u20132619. https:\/\/doi.org\/10.1161\/01.STR.0000242772.94277.1f","journal-title":"Stroke"},{"key":"9944_CR93","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.brainres.2008.06.018","volume":"1227","author":"X Xu","year":"2008","unstructured":"Xu X, Chua CC, Gao J et al (2008) Neuroprotective effect of humanin on cerebral ischemia\/reperfusion injury is mediated by a PI3K\/Akt pathway. Brain Res 1227:12\u201318. https:\/\/doi.org\/10.1016\/j.brainres.2008.06.018","journal-title":"Brain Res"},{"key":"9944_CR94","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.brainres.2006.03.060","volume":"1090","author":"Q Wang","year":"2006","unstructured":"Wang Q, Tompkins KD, Simonyi A et al (2006) Apocynin protects against global cerebral ischemia-reperfusion-induced oxidative stress and injury in the gerbil hippocampus. Brain Res 1090:182\u2013189. https:\/\/doi.org\/10.1016\/j.brainres.2006.03.060","journal-title":"Brain Res"},{"key":"9944_CR95","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1007\/s10495-005-1191-x","volume":"10","author":"D Wang","year":"2005","unstructured":"Wang D, Li H, Yuan H et al (2005) Humanin delays apoptosis in K562 cells by downregulation of P38 MAP kinase. Apoptosis 10:963\u2013971. https:\/\/doi.org\/10.1007\/s10495-005-1191-x","journal-title":"Apoptosis"},{"key":"9944_CR96","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.cbpa.2006.08.041","volume":"147","author":"SL Milton","year":"2007","unstructured":"Milton SL, Prentice HM (2007) Beyond anoxia: The physiology of metabolic downregulation and recovery in the anoxia-tolerant turtle. Comp. Biochem Physiol - A Mol Integr Physiol 147:277\u2013290","journal-title":"Biochem Physiol - A Mol Integr Physiol"},{"key":"9944_CR97","doi-asserted-by":"publisher","first-page":"15825","DOI":"10.1074\/jbc.M413062200","volume":"280","author":"F Luciano","year":"2005","unstructured":"Luciano F, Zhai D, Zhu X et al (2005) Cytoprotective peptide humanin binds and inhibits proapoptotic Bcl-2\/Bax family protein BimEL. J Biol Chem 280:15825\u201315835. https:\/\/doi.org\/10.1074\/jbc.M413062200","journal-title":"J Biol Chem"},{"key":"9944_CR98","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0193583","author":"C Janzen","year":"2018","unstructured":"Janzen C, Lei MYY, Jeong ISD et al (2018) Humanin (HN) and glucose transporter 8 (GLUT8) in pregnancies complicated by intrauterine growth restriction. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0193583","journal-title":"PLoS ONE"},{"key":"9944_CR99","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1993.265.1.r49","author":"LT Buck","year":"1993","unstructured":"Buck LT, Land SC, Hochachka PW (1993) Anoxia-tolerant hepatocytes: Model system for study of reversible metabolic suppression. Am J Physiol - Regul Integr Comp Physiol. https:\/\/doi.org\/10.1152\/ajpregu.1993.265.1.r49","journal-title":"Am J Physiol - Regul Integr Comp Physiol"},{"key":"9944_CR100","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.gene.2009.10.005","volume":"450","author":"A Krivoruchko","year":"2010","unstructured":"Krivoruchko A, Storey K (2010) Molecular mechanisms of turtle anoxia tolerance: A role for NF-\u03baB. Gene 450:63\u201369. https:\/\/doi.org\/10.1016\/j.gene.2009.10.005","journal-title":"Gene"},{"key":"9944_CR101","doi-asserted-by":"publisher","first-page":"4990","DOI":"10.1016\/j.bbagen.2013.06.034","volume":"1830","author":"A Krivoruchko","year":"2013","unstructured":"Krivoruchko A, Storey K (2013) Anoxia-responsive regulation of the FoxO transcription factors in freshwater turtles, Trachemys scripta elegans. Biochim Biophys Acta - Gen Subj 1830:4990\u20134998. https:\/\/doi.org\/10.1016\/j.bbagen.2013.06.034","journal-title":"Biochim Biophys Acta - Gen Subj"},{"key":"9944_CR102","doi-asserted-by":"publisher","first-page":"e6334","DOI":"10.1371\/journal.pone.0006334","volume":"4","author":"RH Muzumdar","year":"2009","unstructured":"Muzumdar RH, Huffman DM, Atzmon G et al (2009) Humanin: A Novel Central Regulator of Peripheral Insulin Action. PLoS ONE 4:e6334. https:\/\/doi.org\/10.1371\/journal.pone.0006334","journal-title":"PLoS ONE"},{"key":"9944_CR103","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1002\/1097-010X(20001201)287:7<477::AID-JEZ3>3.0.CO;2-4","volume":"287","author":"SC Greenway","year":"2000","unstructured":"Greenway SC, Storey KB (2000) Mitogen-activated protein kinases and anoxia tolerance in turtles. J Exp Zool 287:477\u2013484. https:\/\/doi.org\/10.1002\/1097-010X(20001201)287:7%3c477::AID-JEZ3%3e3.0.CO;2-4","journal-title":"J Exp Zool"},{"key":"9944_CR104","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1007\/s10038-006-0397-2","volume":"51","author":"T Kin","year":"2006","unstructured":"Kin T, Sugie K, Hirano M et al (2006) Humanin expression in skeletal muscles of patients with chronic progressive external ophthalmoplegia. J Hum Genet 51:555\u2013558. https:\/\/doi.org\/10.1007\/s10038-006-0397-2","journal-title":"J Hum Genet"},{"key":"9944_CR105","doi-asserted-by":"publisher","first-page":"e13063","DOI":"10.14814\/phy2.13063","volume":"4","author":"E-K Gidlund","year":"2016","unstructured":"Gidlund E-K, von Walden F, Venoj\u00e4rvi M et al (2016) Humanin skeletal muscle protein levels increase after resistance training in men with impaired glucose metabolism. Physiol Rep 4:e13063. https:\/\/doi.org\/10.14814\/phy2.13063","journal-title":"Physiol Rep"}],"container-title":["The Protein Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10930-020-09944-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10930-020-09944-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10930-020-09944-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T00:30:46Z","timestamp":1667521846000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10930-020-09944-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,2]]},"references-count":105,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["9944"],"URL":"https:\/\/doi.org\/10.1007\/s10930-020-09944-7","relation":{},"ISSN":["1572-3887","1875-8355"],"issn-type":[{"type":"print","value":"1572-3887"},{"type":"electronic","value":"1875-8355"}],"subject":[],"published":{"date-parts":[[2021,1,2]]},"assertion":[{"value":"25 November 2020","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"Authors declare no competing financial or non-financial interests. All authors read and approve the final version of the manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The approved animal care committee protocol (ID: 13683) was used for all animal treatments and handling.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}