{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T19:07:20Z","timestamp":1789412840762,"version":"build-2803163510"},"reference-count":100,"publisher":"Springer Science and Business Media LLC","issue":"4-5","license":[{"start":{"date-parts":[[2016,7,4]],"date-time":"2016-07-04T00:00:00Z","timestamp":1467590400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,7,4]],"date-time":"2016-07-04T00:00:00Z","timestamp":1467590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["14GRNT18980033"],"award-info":[{"award-number":["14GRNT18980033"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000152","name":"Division of Molecular and Cellular Biosciences","doi-asserted-by":"publisher","award":["0952736"],"award-info":[{"award-number":["0952736"]}],"id":[{"id":"10.13039\/100000152","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM093065"],"award-info":[{"award-number":["GM093065"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Muscle Res Cell Motil"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1007\/s10974-016-9447-3","type":"journal-article","created":{"date-parts":[[2016,7,4]],"date-time":"2016-07-04T08:21:31Z","timestamp":1467620491000},"page":"131-147","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Investigating the effects of tropomyosin mutations on its flexibility and interactions with filamentous actin using molecular dynamics simulation"],"prefix":"10.1007","volume":"37","author":[{"given":"Wenjun","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Hitchcock-DeGregori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bipasha","family":"Barua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,7,4]]},"reference":[{"key":"9447_CR1","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s10974-013-9343-z","volume":"34","author":"F Bai","year":"2013","unstructured":"Bai F, Wang L, Kawai M (2013) A study of tropomyosin\u2019s role in cardiac function and disease using thin-filament reconstituted myocardium. J Muscle Res Cell Motil 34:295\u2013310. doi:\n                    10.1007\/s10974-013-9343-z","journal-title":"J Muscle Res Cell Motil"},{"key":"9447_CR2","doi-asserted-by":"publisher","first-page":"10150","DOI":"10.1073\/pnas.1101221108","volume":"108","author":"B Barua","year":"2011","unstructured":"Barua B, Pamula MC, Hitchcock-DeGregori SE (2011) Evolutionarily conserved surface residues constitute actin binding sites of tropomyosin. Proc Natl Acad Sci USA 108:10150\u201310155. doi:\n                    10.1073\/pnas.1101221108","journal-title":"Proc Natl Acad Sci USA"},{"key":"9447_CR3","doi-asserted-by":"publisher","first-page":"9602","DOI":"10.1074\/jbc.M113.451161","volume":"288","author":"B Barua","year":"2013","unstructured":"Barua B, Fagnant PM, Winkelmann DA, Trybus KM, Hitchcock-Degregori SE (2013) A periodic pattern of evolutionarily-conserved basic and acidic residues constitutes the binding interface of actin\u2013tropomyosin. J Biol Chem 288:9602\u20139609. doi:\n                    10.1074\/jbc.M113.451161","journal-title":"J Biol Chem"},{"key":"9447_CR4","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.cell.2012.05.037","volume":"150","author":"E Behrmann","year":"2012","unstructured":"Behrmann E, Muller M, Penczek PA, Mannherz HG, Manstein DJ, Raunser S (2012) Structure of the rigor actin\u2013tropomyosin\u2013myosin complex. Cell 150:327\u2013338. doi:\n                    10.1016\/j.cell.2012.05.037","journal-title":"Cell"},{"key":"9447_CR5","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1006\/bbrc.1997.7045","volume":"236","author":"W Bing","year":"1997","unstructured":"Bing W, Redwood CS, Purcell IF, Esposito G, Watkins H, Marston SB (1997) Effects of two hypertrophic cardiomyopathy mutations in alpha-tropomyosin, Asp175Asn and Glu180Gly, on Ca2+ regulation of thin filament motility. Biochem Biophys Res Commun 236:760\u2013764. doi:\n                    10.1006\/bbrc.1997.7045","journal-title":"Biochem Biophys Res Commun"},{"key":"9447_CR6","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s10974-007-9103-z","volume":"28","author":"SE Boussouf","year":"2007","unstructured":"Boussouf SE, Maytum R, Jaquet K, Geeves MA (2007) Role of tropomyosin isoforms in the calcium sensitivity of striated muscle thin filaments. J Muscle Res Cell Motil 28:49\u201358. doi:\n                    10.1007\/s10974-007-9103-z","journal-title":"J Muscle Res Cell Motil"},{"key":"9447_CR7","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1002\/jcc.540040211","volume":"4","author":"BR Brooks","year":"1983","unstructured":"Brooks BR, Bruccoleri RE, Olafson BD, States DJ, Swaminathan S, Karplus M (1983) Charmm\u2014a program for macromolecular energy minimization, and dynamics calculations. J Comput Chem 4:187\u2013217","journal-title":"J Comput Chem"},{"key":"9447_CR8","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1002\/pro.415","volume":"19","author":"JH Brown","year":"2010","unstructured":"Brown JH (2010) How sequence directs bending in tropomyosin and other two-stranded alpha-helical coiled coils. Protein Sci 19:1366\u20131375. doi:\n                    10.1002\/pro.415","journal-title":"Protein Sci"},{"key":"9447_CR9","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1002\/prot.24218","volume":"81","author":"JH Brown","year":"2013","unstructured":"Brown JH (2013) Deriving how far structural information is transmitted through parallel homodimeric coiled-coils: a correlation analysis of helical staggers. Proteins 81:635\u2013643. doi:\n                    10.1002\/prot.24218","journal-title":"Proteins"},{"key":"9447_CR10","doi-asserted-by":"publisher","first-page":"8496","DOI":"10.1073\/pnas.131219198","volume":"98","author":"JH Brown","year":"2001","unstructured":"Brown JH et al (2001) Deciphering the design of the tropomyosin molecule. Proc Natl Acad Sci USA 98:8496\u20138501. doi:\n                    10.1073\/pnas.131219198","journal-title":"Proc Natl Acad Sci USA"},{"key":"9447_CR11","doi-asserted-by":"publisher","first-page":"18878","DOI":"10.1073\/pnas.0509269102","volume":"102","author":"JH Brown","year":"2005","unstructured":"Brown JH, Zhou Z, Reshetnikova L, Robinson H, Yammani RD, Tobacman LS, Cohen C (2005) Structure of the mid-region of tropomyosin: bending and binding sites for actin. Proc Natl Acad Sci USA 102:18878\u201318883. doi:\n                    10.1073\/pnas.0509269102","journal-title":"Proc Natl Acad Sci USA"},{"key":"9447_CR12","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1002\/pro.5560070314","volume":"7","author":"LS Caves","year":"1998","unstructured":"Caves LS, Evanseck JD, Karplus M (1998) Locally accessible conformations of proteins: multiple molecular dynamics simulations of crambin. Protein Sci 7:649\u2013666. doi:\n                    10.1002\/pro.5560070314","journal-title":"Protein Sci"},{"key":"9447_CR13","doi-asserted-by":"publisher","first-page":"34343","DOI":"10.1074\/jbc.M505014200","volume":"280","author":"AN Chang","year":"2005","unstructured":"Chang AN, Harada K, Ackerman MJ, Potter JD (2005) Functional consequences of hypertrophic and dilated cardiomyopathy-causing mutations in alpha-tropomyosin. J Biol Chem 280:34343\u201334349. doi:\n                    10.1074\/jbc.M505014200","journal-title":"J Biol Chem"},{"key":"9447_CR14","doi-asserted-by":"publisher","first-page":"460","DOI":"10.3389\/fphys.2014.00460","volume":"5","author":"AN Chang","year":"2014","unstructured":"Chang AN, Greenfield NJ, Singh A, Potter JD, Pinto JR (2014) Structural and protein interaction effects of hypertrophic and dilated cardiomyopathic mutations in alpha-tropomyosin. Front Physiol 5:460. doi:\n                    10.3389\/fphys.2014.00460","journal-title":"Front Physiol"},{"key":"9447_CR15","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1006\/jmbi.2001.4897","volume":"311","author":"R Craig","year":"2001","unstructured":"Craig R, Lehman W (2001) Crossbridge and tropomyosin positions observed in native, interacting thick and thin filaments. J Mol Biol 311:1027\u20131036. doi:\n                    10.1006\/jmbi.2001.4897","journal-title":"J Mol Biol"},{"key":"9447_CR16","doi-asserted-by":"publisher","first-page":"7678","DOI":"10.1063\/1.477414","volume":"109","author":"M Deserno","year":"1998","unstructured":"Deserno M, Holm C (1998) How to mesh up Ewald sums. I. A theoretical and numerical comparison of various particle mesh routines. J Chem Phys 109:7678\u20137693","journal-title":"J Chem Phys"},{"key":"9447_CR17","doi-asserted-by":"publisher","first-page":"2595","DOI":"10.1016\/S0006-3495(02)75270-3","volume":"83","author":"MA Eriksson","year":"2002","unstructured":"Eriksson MA, Roux B (2002) Modeling the structure of agitoxin in complex with the Shaker K+ channel: a computational approach based on experimental distance restraints extracted from thermodynamic mutant cycles. Biophys J 83:2595\u20132609. doi:\n                    10.1016\/S0006-3495(02)75270-3","journal-title":"Biophys J"},{"key":"9447_CR18","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s10974-014-9389-6","volume":"36","author":"MA Geeves","year":"2015","unstructured":"Geeves MA, Hitchcock-DeGregori SE, Gunning PW (2015) A systematic nomenclature for mammalian tropomyosin isoforms. J Muscle Res Cell Motil 36:147\u2013153. doi:\n                    10.1007\/s10974-014-9389-6","journal-title":"J Muscle Res Cell Motil"},{"key":"9447_CR19","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.1002\/bip.360251106","volume":"25","author":"MK Gilson","year":"1986","unstructured":"Gilson MK, Honig BH (1986) The dielectric constant of a folded protein. Biopolymers 25:2097\u20132119. doi:\n                    10.1002\/bip.360251106","journal-title":"Biopolymers"},{"key":"9447_CR20","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1002\/prot.340030104","volume":"3","author":"MK Gilson","year":"1988","unstructured":"Gilson MK, Honig BH (1988) Energetics of charge\u2013charge interactions in proteins. Proteins 3:32\u201352. doi:\n                    10.1002\/prot.340030104","journal-title":"Proteins"},{"key":"9447_CR21","doi-asserted-by":"publisher","first-page":"4637","DOI":"10.1021\/bi962970y","volume":"36","author":"N Golitsina","year":"1997","unstructured":"Golitsina N et al (1997) Effects of two familial hypertrophic cardiomyopathy-causing mutations on alpha-tropomyosin structure and function. Biochemistry 36:4637\u20134642. doi:\n                    10.1021\/bi962970y","journal-title":"Biochemistry"},{"key":"9447_CR22","doi-asserted-by":"publisher","first-page":"3850","DOI":"10.1021\/bi9950701","volume":"38","author":"N Golitsina","year":"1999","unstructured":"Golitsina N et al (1999) Effects of two familial hypertrophic cardiomyopathy-causing mutations on alpha-tropomyosin structure and function. Biochemistry 38:3850. doi:\n                    10.1021\/bi9950701","journal-title":"Biochemistry"},{"key":"9447_CR23","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/978-0-387-85766-4_22","volume":"644","author":"P Gunning","year":"2008","unstructured":"Gunning P (2008) Emerging issues for tropomyosin structure, regulation, function and pathology. Adv Exp Med Biol 644:293\u2013298","journal-title":"Adv Exp Med Biol"},{"key":"9447_CR24","doi-asserted-by":"publisher","first-page":"7003","DOI":"10.1074\/jbc.M114.596676","volume":"290","author":"TM Gupte","year":"2015","unstructured":"Gupte TM et al (2015) Mechanistic heterogeneity in contractile properties of alpha-tropomyosin (TPM1) mutants associated with inherited cardiomyopathies. J Biol Chem 290:7003\u20137015. doi:\n                    10.1074\/jbc.M114.596676","journal-title":"J Biol Chem"},{"key":"9447_CR25","doi-asserted-by":"publisher","first-page":"41742","DOI":"10.1074\/jbc.M303408200","volume":"278","author":"MJ Heller","year":"2003","unstructured":"Heller MJ, Nili M, Homsher E, Tobacman LS (2003) Cardiomyopathic tropomyosin mutations that increase thin filament Ca2+ sensitivity and tropomyosin N-domain flexibility. J Biol Chem 278:41742\u201341748. doi:\n                    10.1074\/jbc.M303408200","journal-title":"J Biol Chem"},{"key":"9447_CR26","doi-asserted-by":"publisher","first-page":"4132","DOI":"10.1111\/j.1432-1033.2004.04351.x","volume":"271","author":"E Hilario","year":"2004","unstructured":"Hilario E, da Silva SL, Ramos CH, Bertolini MC (2004) Effects of cardiomyopathic mutations on the biochemical and biophysical properties of the human alpha-tropomyosin. Eur J Biochem 271:4132\u20134140. doi:\n                    10.1111\/j.1432-1033.2004.04351.x","journal-title":"Eur J Biochem"},{"key":"9447_CR27","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.jsb.2009.12.013","volume":"170","author":"SE Hitchcock-DeGregori","year":"2010","unstructured":"Hitchcock-DeGregori SE, Singh A (2010) What makes tropomyosin an actin binding protein? A perspective. J Struct Biol 170:319\u2013324. doi:\n                    10.1016\/j.jsb.2009.12.013","journal-title":"J Struct Biol"},{"key":"9447_CR28","doi-asserted-by":"publisher","first-page":"2104","DOI":"10.1021\/bi002421z","volume":"40","author":"SE Hitchcock-DeGregori","year":"2001","unstructured":"Hitchcock-DeGregori SE, Song Y, Moraczewska J (2001) Importance of internal regions and the overall length of tropomyosin for actin binding and regulatory function. Biochemistry 40:2104\u20132112","journal-title":"Biochemistry"},{"key":"9447_CR29","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s10974-008-9157-6","volume":"29","author":"KC Holmes","year":"2008","unstructured":"Holmes KC, Lehman W (2008) Gestalt-binding of tropomyosin to actin filaments. J Muscle Res Cell Motil 29:213\u2013219. doi:\n                    10.1007\/s10974-008-9157-6","journal-title":"J Muscle Res Cell Motil"},{"key":"9447_CR30","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1103\/PhysRevA.31.1695","volume":"31","author":"WG Hoover","year":"1985","unstructured":"Hoover WG (1985) Canonical dynamics\u2014equilibrium phase-space distributions. Phys Rev A 31:1695\u20131697","journal-title":"Phys Rev A"},{"issue":"33\u201338","key":"9447_CR31","first-page":"27","volume":"14","author":"W Humphrey","year":"1996","unstructured":"Humphrey W, Dalke A, Schulten K (1996) VMD: visual molecular dynamics. J Mol Graph\u00a014(33\u201338):27\u201338","journal-title":"J Mol Graph"},{"key":"9447_CR32","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S0010-4655(98)00016-2","volume":"111","author":"W Im","year":"1998","unstructured":"Im W, Beglov D, Roux B (1998) Continuum solvation model: computation of electrostatic forces from numerical solutions to the Poisson\u2013Boltzmann equation. Comput Phys Commun 111:59\u201375","journal-title":"Comput Phys Commun"},{"key":"9447_CR33","doi-asserted-by":"publisher","first-page":"9880","DOI":"10.1021\/bi301323n","volume":"51","author":"M Janco","year":"2012","unstructured":"Janco M, Kalyva A, Scellini B, Piroddi N, Tesi C, Poggesi C, Geeves MA (2012) alpha-Tropomyosin with a D175N or E180G mutation in only one chain differs from tropomyosin with mutations in both chains. Biochemistry 51:9880\u20139890. doi:\n                    10.1021\/bi301323n","journal-title":"Biochemistry"},{"key":"9447_CR34","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1016\/S0735-1097(02)03005-X","volume":"41","author":"RJ Jongbloed","year":"2003","unstructured":"Jongbloed RJ, Marcelis CL, Doevendans PA, Schmeitz-Mulkens JM, Van Dockum WG, Geraedts JP, Smeets HJ (2003) Variable clinical manifestation of a novel missense mutation in the alpha-tropomyosin (TPM1) gene in familial hypertrophic cardiomyopathy. J Am Coll Cardiol 41:981\u2013986","journal-title":"J Am Coll Cardiol"},{"key":"9447_CR35","doi-asserted-by":"publisher","first-page":"6388","DOI":"10.1021\/bi300340r","volume":"51","author":"A Kalyva","year":"2012","unstructured":"Kalyva A, Schmidtmann A, Geeves MA (2012) In vitro formation and characterization of the skeletal muscle alpha\u00b7beta tropomyosin heterodimers. Biochemistry 51:6388\u20136399. doi:\n                    10.1021\/bi300340r","journal-title":"Biochemistry"},{"key":"9447_CR36","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1161\/01.CIR.103.1.65","volume":"103","author":"A Karibe","year":"2001","unstructured":"Karibe A et al (2001) Hypertrophic cardiomyopathy caused by a novel alpha-tropomyosin mutation (V95A) is associated with mild cardiac phenotype, abnormal calcium binding to troponin, abnormal myosin cycling, and poor prognosis. Circulation 103:65\u201371","journal-title":"Circulation"},{"key":"9447_CR37","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1038\/nsb0902-646","volume":"9","author":"M Karplus","year":"2002","unstructured":"Karplus M, McCammon JA (2002) Molecular dynamics simulations of biomolecules. Nat Struct Biol 9:646\u2013652. doi:\n                    10.1038\/nsb0902-646","journal-title":"Nat Struct Biol"},{"key":"9447_CR38","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/bs.ircmb.2015.06.002","volume":"318","author":"SY Khaitlina","year":"2015","unstructured":"Khaitlina SY (2015) Tropomyosin as a regulator of actin dynamics. Int Rev Cell Mol Biol 318:255\u2013291. doi:\n                    10.1016\/bs.ircmb.2015.06.002","journal-title":"Int Rev Cell Mol Biol"},{"key":"9447_CR39","doi-asserted-by":"publisher","first-page":"3922","DOI":"10.1529\/biophysj.104.048793","volume":"87","author":"E Kremneva","year":"2004","unstructured":"Kremneva E, Boussouf S, Nikolaeva O, Maytum R, Geeves MA, Levitsky DI (2004) Effects of two familial hypertrophic cardiomyopathy mutations in alpha-tropomyosin, Asp175Asn and Glu180Gly, on the thermal unfolding of actin-bound tropomyosin. Biophys J 87:3922\u20133933. doi:\n                    10.1529\/biophysj.104.048793","journal-title":"Biophys J"},{"key":"9447_CR40","doi-asserted-by":"publisher","first-page":"21576","DOI":"10.1074\/jbc.M401074200","volume":"279","author":"SC Kwok","year":"2004","unstructured":"Kwok SC, Hodges RS (2004) Stabilizing and destabilizing clusters in the hydrophobic core of long two-stranded alpha-helical coiled-coils. J Biol Chem 279:21576\u201321588. doi:\n                    10.1074\/jbc.M401074200","journal-title":"J Biol Chem"},{"key":"9447_CR41","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s12195-009-0050-1","volume":"2","author":"SK Lakkaraju","year":"2009","unstructured":"Lakkaraju SK, Hwang W (2009) Modulation of elasticity in functionally distinct domains of the tropomyosin coiled-coil. Cell Mol Bioeng 2:57\u201365. doi:\n                    10.1007\/s12195-009-0050-1","journal-title":"Cell Mol Bioeng"},{"key":"9447_CR42","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/978-0-387-85766-4_8","volume":"644","author":"W Lehman","year":"2008","unstructured":"Lehman W, Craig R (2008) Tropomyosin and the steric mechanism of muscle regulation. Adv Exp Med Biol 644:95\u2013109","journal-title":"Adv Exp Med Biol"},{"key":"9447_CR43","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.abb.2013.09.011","volume":"552\u2013553","author":"W Lehman","year":"2014","unstructured":"Lehman W, Li XE, Orzechowski M, Fischer S (2014) The structural dynamics of alpha-tropomyosin on F-actin shape the overlap complex between adjacent tropomyosin molecules. Arch Biochem Biophys 552\u2013553:68\u201373. doi:\n                    10.1016\/j.abb.2013.09.011","journal-title":"Arch Biochem Biophys"},{"key":"9447_CR44","doi-asserted-by":"publisher","first-page":"8645","DOI":"10.1021\/bi2008257","volume":"50","author":"MH Li","year":"2011","unstructured":"Li MH, Zheng WJ (2011) Probing the structural and energetic basis of kinesin-microtubule binding using computational alanine-scanning mutagenesis. Biochemistry 50:8645\u20138655. doi:\n                    10.1021\/Bi2008257","journal-title":"Biochemistry"},{"key":"9447_CR45","doi-asserted-by":"publisher","first-page":"5022","DOI":"10.1021\/bi300362a","volume":"51","author":"M Li","year":"2012","unstructured":"Li M, Zheng W (2012) All-atom structural investigation of kinesin\u2013microtubule complex constrained by high-quality cryo-electron-microscopy maps. Biochemistry 51:5022\u20135032. doi:\n                    10.1021\/bi300362a","journal-title":"Biochemistry"},{"key":"9447_CR46","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.jmb.2009.10.060","volume":"395","author":"XE Li","year":"2010","unstructured":"Li XE, Holmes KC, Lehman W, Jung H, Fischer S (2010a) The shape and flexibility of tropomyosin coiled coils: implications for actin filament assembly and regulation. J Mol Biol 395:327\u2013339. doi:\n                    10.1016\/j.jmb.2009.10.060","journal-title":"J Mol Biol"},{"key":"9447_CR47","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.jsb.2010.01.016","volume":"170","author":"XE Li","year":"2010","unstructured":"Li XE, Lehman W, Fischer S (2010b) The relationship between curvature, flexibility and persistence length in the tropomyosin coiled-coil. J Struct Biol 170:313\u2013318. doi:\n                    10.1016\/j.jsb.2010.01.016","journal-title":"J Struct Biol"},{"key":"9447_CR48","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.jsb.2009.12.017","volume":"170","author":"XE Li","year":"2010","unstructured":"Li XE, Lehman W, Fischer S, Holmes KC (2010c) Curvature variation along the tropomyosin molecule. J Struct Biol 170:307\u2013312. doi:\n                    10.1016\/j.jsb.2009.12.017","journal-title":"J Struct Biol"},{"key":"9447_CR49","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1016\/j.bpj.2010.12.3697","volume":"100","author":"XE Li","year":"2011","unstructured":"Li XE, Tobacman LS, Mun JY, Craig R, Fischer S, Lehman W (2011) Tropomyosin position on F-actin revealed by EM reconstruction and computational chemistry. Biophys J 100:1005\u20131013. doi:\n                    10.1016\/j.bpj.2010.12.3697","journal-title":"Biophys J"},{"key":"9447_CR50","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.bbrc.2012.06.141","volume":"424","author":"XE Li","year":"2012","unstructured":"Li XE, Suphamungmee W, Janco M, Geeves MA, Marston SB, Fischer S, Lehman W (2012) The flexibility of two tropomyosin mutants, D175N and E180G, that cause hypertrophic cardiomyopathy. Biochem Biophys Res Commun 424:493\u2013496. doi:\n                    10.1016\/j.bbrc.2012.06.141","journal-title":"Biochem Biophys Res Commun"},{"key":"9447_CR51","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.bbrc.2014.02.097","volume":"446","author":"XE Li","year":"2014","unstructured":"Li XE, Orzechowski M, Lehman W, Fischer S (2014) Structure and flexibility of the tropomyosin overlap junction. Biochem Biophys Res Commun 446:304\u2013308. doi:\n                    10.1016\/j.bbrc.2014.02.097","journal-title":"Biochem Biophys Res Commun"},{"key":"9447_CR52","doi-asserted-by":"publisher","first-page":"3503","DOI":"10.1016\/j.febslet.2012.08.005","volume":"586","author":"CK Loong","year":"2012","unstructured":"Loong CK, Zhou HX, Chase PB (2012a) Familial hypertrophic cardiomyopathy related E180G mutation increases flexibility of human cardiac alpha-tropomyosin. FEBS Lett 586:3503\u20133507. doi:\n                    10.1016\/j.febslet.2012.08.005","journal-title":"FEBS Lett"},{"key":"9447_CR53","doi-asserted-by":"publisher","first-page":"e39676","DOI":"10.1371\/journal.pone.0039676","volume":"7","author":"CK Loong","year":"2012","unstructured":"Loong CK, Zhou HX, Chase PB (2012b) Persistence length of human cardiac alpha-tropomyosin measured by single molecule direct probe microscopy. PLoS ONE 7:e39676. doi:\n                    10.1371\/journal.pone.0039676","journal-title":"PLoS ONE"},{"key":"9447_CR54","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1006\/jmbi.1994.0070","volume":"246","author":"M Lorenz","year":"1995","unstructured":"Lorenz M, Poole KJ, Popp D, Rosenbaum G, Holmes KC (1995) An atomic model of the unregulated thin filament obtained by X-ray fiber diffraction on oriented actin-tropomyosin gels. J Mol Biol 246:108\u2013119. doi:\n                    10.1006\/jmbi.1994.0070","journal-title":"J Mol Biol"},{"key":"9447_CR55","doi-asserted-by":"publisher","first-page":"6413","DOI":"10.1021\/bi3006835","volume":"51","author":"S Ly","year":"2012","unstructured":"Ly S, Lehrer SS (2012) Long-range effects of familial hypertrophic cardiomyopathy mutations E180G and D175N on the properties of tropomyosin. Biochemistry 51:6413\u20136420. doi:\n                    10.1021\/bi3006835","journal-title":"Biochemistry"},{"key":"9447_CR56","doi-asserted-by":"publisher","first-page":"3586","DOI":"10.1021\/jp973084f","volume":"102","author":"AD MacKerell","year":"1998","unstructured":"MacKerell AD et al (1998) All-atom empirical potential for molecular modeling and dynamics studies of proteins. J Phys Chem B 102:3586\u20133616","journal-title":"J Phys Chem B"},{"key":"9447_CR57","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1002\/jcc.20065","volume":"25","author":"AD Mackerell Jr","year":"2004","unstructured":"Mackerell AD Jr, Feig M, Brooks CL 3rd (2004) Extending the treatment of backbone energetics in protein force fields: limitations of gas-phase quantum mechanics in reproducing protein conformational distributions in molecular dynamics simulations. J Comput Chem 25:1400\u20131415. doi:\n                    10.1002\/jcc.20065","journal-title":"J Comput Chem"},{"key":"9447_CR58","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s12265-011-9266-2","volume":"4","author":"SB Marston","year":"2011","unstructured":"Marston SB (2011) How do mutations in contractile proteins cause the primary familial cardiomyopathies? J Cardiovasc Transl Res 4:245\u2013255. doi:\n                    10.1007\/s12265-011-9266-2","journal-title":"J Cardiovasc Transl Res"},{"key":"9447_CR59","doi-asserted-by":"publisher","first-page":"4978","DOI":"10.1093\/hmg\/ddt345","volume":"22","author":"S Marston","year":"2013","unstructured":"Marston S et al (2013) Mutations in repeating structural motifs of tropomyosin cause gain of function in skeletal muscle myopathy patients. Hum Mol Genet 22:4978\u20134987. doi:\n                    10.1093\/hmg\/ddt345","journal-title":"Hum Mol Genet"},{"key":"9447_CR60","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1042\/BJ20111030","volume":"442","author":"M Marttila","year":"2012","unstructured":"Marttila M et al (2012) Abnormal actin binding of aberrant beta-tropomyosins is a molecular cause of muscle weakness in TPM2-related nemaline and cap myopathy. Biochem J 442:231\u2013239. doi:\n                    10.1042\/BJ20111030","journal-title":"Biochem J"},{"key":"9447_CR61","doi-asserted-by":"publisher","first-page":"3275","DOI":"10.1063\/1.478193","volume":"110","author":"GJ Martyna","year":"1999","unstructured":"Martyna GJ, Hughes A, Tuckerman ME (1999) Molecular dynamics algorithms for path integrals at constant pressure. J Chem Phys 110:3275\u20133290","journal-title":"J Chem Phys"},{"key":"9447_CR62","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.bpc.2014.10.001","volume":"196","author":"AM Matyushenko","year":"2015","unstructured":"Matyushenko AM, Artemova NV, Sluchanko NN, Levitsky DI (2015) Effects of two stabilizing substitutions, D137L and G126R, in the middle part of alpha-tropomyosin on the domain structure of its molecule. Biophys Chem 196:77\u201385. doi:\n                    10.1016\/j.bpc.2014.10.001","journal-title":"Biophys Chem"},{"key":"9447_CR63","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/S0006-3495(93)81110-X","volume":"65","author":"DF McKillop","year":"1993","unstructured":"McKillop DF, Geeves MA (1993) Regulation of the interaction between actin and myosin subfragment 1: evidence for three states of the thin filament. Biophys J 65:693\u2013701. doi:\n                    10.1016\/S0006-3495(93)81110-X","journal-title":"Biophys J"},{"key":"9447_CR64","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0022-2836(75)80118-5","volume":"98","author":"AD McLachlan","year":"1975","unstructured":"McLachlan AD, Stewart M, Smillie LB (1975) Sequence repeats in alpha-tropomyosin. J Mol Biol 98:281\u2013291","journal-title":"J Mol Biol"},{"key":"9447_CR65","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1152\/physiolgenomics.00099.2001","volume":"9","author":"DE Michele","year":"2002","unstructured":"Michele DE, Coutu P, Metzger JM (2002) Divergent abnormal muscle relaxation by hypertrophic cardiomyopathy and nemaline myopathy mutant tropomyosins. Physiol Genomics 9:103\u2013111. doi:\n                    10.1152\/physiolgenomics.00099.2001","journal-title":"Physiol Genomics"},{"key":"9447_CR66","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1007\/s00249-012-0859-8","volume":"41","author":"SM Mijailovich","year":"2012","unstructured":"Mijailovich SM, Kayser-Herold O, Li X, Griffiths H, Geeves MA (2012) Cooperative regulation of myosin-S1 binding to actin filaments by a continuous flexible Tm\u2013Tn chain. Eur Biophys J EBJ 41:1015\u20131032. doi:\n                    10.1007\/s00249-012-0859-8","journal-title":"Eur Biophys J EBJ"},{"key":"9447_CR67","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1529\/biophysj.107.126144","volume":"95","author":"S Minakata","year":"2008","unstructured":"Minakata S, Maeda K, Oda N, Wakabayashi K, Nitanai Y, Maeda Y (2008) Two-crystal structures of tropomyosin C-terminal fragment 176-273: exposure of the hydrophobic core to the solvent destabilizes the tropomyosin molecule. Biophys J 95:710\u2013719. doi:\n                    10.1529\/biophysj.107.126144","journal-title":"Biophys J"},{"key":"9447_CR68","doi-asserted-by":"publisher","first-page":"13487","DOI":"10.1074\/jbc.M701071200","volume":"282","author":"M Mirza","year":"2007","unstructured":"Mirza M et al (2007) The effect of mutations in alpha-tropomyosin (E40K and E54K) that cause familial dilated cardiomyopathy on the regulatory mechanism of cardiac muscle thin filaments. J Biol Chem 282:13487\u201313497. doi:\n                    10.1074\/jbc.M701071200","journal-title":"J Biol Chem"},{"key":"9447_CR69","doi-asserted-by":"publisher","first-page":"250","DOI":"10.4161\/bioa.18117","volume":"1","author":"JR Moore","year":"2011","unstructured":"Moore JR, Li X, Nirody J, Fischer S, Lehman W (2011) Structural implications of conserved aspartate residues located in tropomyosin\u2019s coiled-coil core. Bioarchitecture 1:250\u2013255. doi:\n                    10.4161\/bioa.18117","journal-title":"Bioarchitecture"},{"key":"9447_CR70","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1161\/01.RES.85.1.47","volume":"85","author":"M Muthuchamy","year":"1999","unstructured":"Muthuchamy M et al (1999) Mouse model of a familial hypertrophic cardiomyopathy mutation in alpha-tropomyosin manifests cardiac dysfunction. Circ Res 85:47\u201356","journal-title":"Circ Res"},{"key":"9447_CR71","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1016\/0022-2828(95)90026-8","volume":"27","author":"C Nakajima-Taniguchi","year":"1995","unstructured":"Nakajima-Taniguchi C, Matsui H, Nagata S, Kishimoto T, Yamauchi-Takihara K (1995) Novel missense mutation in alpha-tropomyosin gene found in Japanese patients with hypertrophic cardiomyopathy. J Mol Cell Cardiol 27:2053\u20132058","journal-title":"J Mol Cell Cardiol"},{"key":"9447_CR72","doi-asserted-by":"publisher","first-page":"5239","DOI":"10.1021\/jp970736r","volume":"101","author":"M Nina","year":"1997","unstructured":"Nina M, Beglov D, Roux B (1997) Atomic radii for continuum electrostatics calculations based on molecular dynamics free energy simulations. J Phys Chem B 101:5239\u20135248","journal-title":"J Phys Chem B"},{"key":"9447_CR73","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1002\/(SICI)1097-0134(20000101)38:1<115::AID-PROT11>3.0.CO;2-P","volume":"38","author":"MA Olson","year":"2000","unstructured":"Olson MA, Reinke LT (2000) Modeling implicit reorganization in continuum descriptions of protein\u2013protein interactions. Proteins 38:115\u2013119. doi:\n                    10.1002\/(SICI)1097-0134(20000101)38:1<115:AID-PROT11>3.0.CO;2-P","journal-title":"Proteins"},{"key":"9447_CR74","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.abb.2014.09.007","volume":"564","author":"M Orzechowski","year":"2014","unstructured":"Orzechowski M, Fischer S, Moore JR, Lehman W, Farman GP (2014) Energy landscapes reveal the myopathic effects of tropomyosin mutations. Arch Biochem Biophys 564:89\u201399. doi:\n                    10.1016\/j.abb.2014.09.007","journal-title":"Arch Biochem Biophys"},{"key":"9447_CR75","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/0022-2836(86)90469-9","volume":"192","author":"GN Phillips Jr","year":"1986","unstructured":"Phillips GN Jr (1986) Construction of an atomic model for tropomyosin and implications for interactions with actin. J Mol Biol 192:128\u2013131","journal-title":"J Mol Biol"},{"key":"9447_CR76","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/0022-2836(86)90468-7","volume":"192","author":"GN Phillips Jr","year":"1986","unstructured":"Phillips GN Jr, Fillers JP, Cohen C (1986) Tropomyosin crystal structure and muscle regulation. J Mol Biol 192:111\u2013131","journal-title":"J Mol Biol"},{"key":"9447_CR77","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1002\/jcc.20289","volume":"26","author":"JC Phillips","year":"2005","unstructured":"Phillips JC et al (2005) Scalable molecular dynamics with NAMD. J Comput Chem 26:1781\u20131802. doi:\n                    10.1002\/jcc.20289","journal-title":"J Comput Chem"},{"key":"9447_CR78","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.jmb.2004.12.013","volume":"346","author":"A Pirani","year":"2005","unstructured":"Pirani A, Xu C, Hatch V, Craig R, Tobacman LS, Lehman W (2005) Single particle analysis of relaxed and activated muscle thin filaments. J Mol Biol 346:761\u2013772. doi:\n                    10.1016\/j.jmb.2004.12.013","journal-title":"J Mol Biol"},{"key":"9447_CR79","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.jmb.2005.12.050","volume":"357","author":"A Pirani","year":"2006","unstructured":"Pirani A et al (2006) An atomic model of the thin filament in the relaxed and Ca2+-activated states. J Mol Biol 357:707\u2013717. doi:\n                    10.1016\/j.jmb.2005.12.050","journal-title":"J Mol Biol"},{"key":"9447_CR80","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.jsb.2006.02.020","volume":"155","author":"KJ Poole","year":"2006","unstructured":"Poole KJ et al (2006) A comparison of muscle thin filament models obtained from electron microscopy reconstructions and low-angle X-ray fibre diagrams from non-overlap muscle. J Struct Biol 155:273\u2013284. doi:\n                    10.1016\/j.jsb.2006.02.020","journal-title":"J Struct Biol"},{"key":"9447_CR81","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1006\/jmcc.2001.1445","volume":"33","author":"R Prabhakar","year":"2001","unstructured":"Prabhakar R, Boivin GP, Grupp IL, Hoit B, Arteaga G, Solaro RJ, Wieczorek DF (2001) A familial hypertrophic cardiomyopathy alpha-tropomyosin mutation causes severe cardiac hypertrophy and death in mice. J Mol Cell Cardiol 33:1815\u20131828. doi:\n                    10.1006\/jmcc.2001.1445","journal-title":"J Mol Cell Cardiol"},{"key":"9447_CR82","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/s10974-013-9358-5","volume":"34","author":"C Redwood","year":"2013","unstructured":"Redwood C, Robinson P (2013) Alpha-tropomyosin mutations in inherited cardiomyopathies. J Muscle Res Cell Motil 34:285\u2013294. doi:\n                    10.1007\/s10974-013-9358-5","journal-title":"J Muscle Res Cell Motil"},{"key":"9447_CR83","doi-asserted-by":"publisher","first-page":"2980","DOI":"10.1016\/S0006-3495(97)78327-9","volume":"73","author":"B Roux","year":"1997","unstructured":"Roux B (1997) Influence of the membrane potential on the free energy of an intrinsic protein. Biophys J 73:2980\u20132989. doi:\n                    10.1016\/S0006-3495(97)78327-9","journal-title":"Biophys J"},{"key":"9447_CR84","doi-asserted-by":"publisher","DOI":"10.1007\/s10974-015-9419-z","author":"MJ Rynkiewicz","year":"2015","unstructured":"Rynkiewicz MJ, Schott V, Orzechowski M, Lehman W, Fischer S (2015) Electrostatic interaction map reveals a new binding position for tropomyosin on F-actin. J Muscle Res Cell Motil. doi:\n                    10.1007\/s10974-015-9419-z","journal-title":"J Muscle Res Cell Motil"},{"key":"9447_CR85","doi-asserted-by":"publisher","first-page":"7684","DOI":"10.1021\/j100382a068","volume":"94","author":"KA Sharp","year":"1990","unstructured":"Sharp KA, Honig B (1990a) Calculating total electrostatic energies with the nonlinear Poisson\u2013Boltzmann equation. J Phys Chem 94:7684\u20137692","journal-title":"J Phys Chem"},{"key":"9447_CR86","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1146\/annurev.bb.19.060190.001505","volume":"19","author":"KA Sharp","year":"1990","unstructured":"Sharp KA, Honig B (1990b) Electrostatic interactions in macromolecules: theory and applications. Annu Rev Biophys Biophys Chem 19:301\u2013332. doi:\n                    10.1146\/annurev.bb.19.060190.001505","journal-title":"Annu Rev Biophys Biophys Chem"},{"key":"9447_CR87","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.str.2005.09.016","volume":"14","author":"A Singh","year":"2006","unstructured":"Singh A, Hitchcock-DeGregori SE (2006) Dual requirement for flexibility and specificity for binding of the coiled-coil tropomyosin to its target, actin. Structure\u00a014:43\u201350. doi:\n                    10.1016\/j.str.2005.09.016","journal-title":"Structure"},{"key":"9447_CR88","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1016\/j.bpj.2010.05.004","volume":"99","author":"D Sousa","year":"2010","unstructured":"Sousa D, Cammarato A, Jang K, Graceffa P, Tobacman LS, Li XE, Lehman W (2010) Electron microscopy and persistence length analysis of semi-rigid smooth muscle tropomyosin strands. Biophys J 99:862\u2013868. doi:\n                    10.1016\/j.bpj.2010.05.004","journal-title":"Biophys J"},{"key":"9447_CR89","doi-asserted-by":"publisher","first-page":"4544","DOI":"10.1016\/j.jmb.2013.08.020","volume":"425","author":"DR Sousa","year":"2013","unstructured":"Sousa DR, Stagg SM, Stroupe ME (2013) Cryo-EM structures of the actin: tropomyosin filament reveal the mechanism for the transition from C- to M-state. J Mol Biol 425:4544\u20134555. doi:\n                    10.1016\/j.jmb.2013.08.020","journal-title":"J Mol Biol"},{"key":"9447_CR90","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.jmgm.2010.06.010","volume":"29","author":"JE Stone","year":"2010","unstructured":"Stone JE, Hardy DJ, Ufimtsev IS, Schulten K (2010) GPU-accelerated molecular modeling coming of age. J Mol Graph Model 29:116\u2013125. doi:\n                    10.1016\/j.jmgm.2010.06.010","journal-title":"J Mol Graph Model"},{"key":"9447_CR91","doi-asserted-by":"publisher","first-page":"6728","DOI":"10.1074\/jbc.M707485200","volume":"283","author":"JP Sumida","year":"2008","unstructured":"Sumida JP, Wu E, Lehrer SS (2008) Conserved Asp-137 imparts flexibility to tropomyosin and affects function. J Biol Chem 283:6728\u20136734. doi:\n                    10.1074\/jbc.M707485200","journal-title":"J Biol Chem"},{"key":"9447_CR92","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1016\/S0002-9149(02)02780-7","volume":"90","author":"SL Van Driest","year":"2002","unstructured":"Van Driest SL, Will ML, Atkins DL, Ackerman MJ (2002) A novel TPM1 mutation in a family with hypertrophic cardiomyopathy and sudden cardiac death in childhood. Am J Cardiol 90:1123\u20131127","journal-title":"Am J Cardiol"},{"key":"9447_CR93","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1006\/jmbi.1996.0800","volume":"266","author":"P Vibert","year":"1997","unstructured":"Vibert P, Craig R, Lehman W (1997) Steric-model for activation of muscle thin filaments. J Mol Biol 266:8\u201314. doi:\n                    10.1006\/jmbi.1996.0800","journal-title":"J Mol Biol"},{"key":"9447_CR94","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1038\/nature14033","volume":"519","author":"J von der Ecken","year":"2015","unstructured":"von der Ecken J, Muller M, Lehman W, Manstein DJ, Penczek PA, Raunser S (2015) Structure of the F-actin\u2013tropomyosin complex. Nature 519:114\u2013117. doi:\n                    10.1038\/nature14033","journal-title":"Nature"},{"key":"9447_CR95","doi-asserted-by":"publisher","first-page":"435271","DOI":"10.1155\/2011\/435271","volume":"2011","author":"F Wang","year":"2011","unstructured":"Wang F et al (2011) Facilitated cross-bridge interactions with thin filaments by familial hypertrophic cardiomyopathy mutations in alpha-tropomyosin. J Biomed Biotechnol 2011:435271. doi:\n                    10.1155\/2011\/435271","journal-title":"J Biomed Biotechnol"},{"key":"9447_CR96","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1136\/hrt.76.1.63","volume":"76","author":"K Yamauchi-Takihara","year":"1996","unstructured":"Yamauchi-Takihara K, Nakajima-Taniguchi C, Matsui H, Fujio Y, Kunisada K, Nagata S, Kishimoto T (1996) Clinical implications of hypertrophic cardiomyopathy associated with mutations in the alpha-tropomyosin gene. Heart 76:63\u201365","journal-title":"Heart"},{"key":"9447_CR97","doi-asserted-by":"publisher","first-page":"16235","DOI":"10.1074\/jbc.M113.458695","volume":"288","author":"S Yar","year":"2013","unstructured":"Yar S et al (2013) Conserved Asp-137 is important for both structure and regulatory functions of cardiac alpha-tropomyosin (alpha-TM) in a novel transgenic mouse model expressing alpha-TM-D137L. J Biol Chem 288:16235\u201316246. doi:\n                    10.1074\/jbc.M113.458695","journal-title":"J Biol Chem"},{"key":"9447_CR98","doi-asserted-by":"publisher","first-page":"6278","DOI":"10.1093\/hmg\/ddv334","volume":"24","author":"M Yuen","year":"2015","unstructured":"Yuen M et al (2015) Muscle weakness in TPM3-myopathy is due to reduced Ca2+-sensitivity and impaired acto-myosin cross-bridge cycling in slow fibres. Hum Mol Genet 24:6278\u20136292. doi:\n                    10.1093\/hmg\/ddv334","journal-title":"Hum Mol Genet"},{"key":"9447_CR99","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1529\/biophysj.107.109215","volume":"93","author":"X Zheng","year":"2007","unstructured":"Zheng X, Diraviyam K, Sept D (2007) Nucleotide effects on the structure and dynamics of actin. Biophys J 93:1277\u20131283. doi:\n                    10.1529\/biophysj.107.109215","journal-title":"Biophys J"},{"key":"9447_CR100","doi-asserted-by":"publisher","first-page":"1882","DOI":"10.1016\/j.bpj.2013.09.003","volume":"105","author":"W Zheng","year":"2013","unstructured":"Zheng W, Barua B, Hitchcock-DeGregori SE (2013) Probing the flexibility of tropomyosin and its binding to filamentous actin using molecular dynamics simulations. Biophys J 105:1882\u20131892. doi:\n                    10.1016\/j.bpj.2013.09.003","journal-title":"Biophys J"}],"container-title":["Journal of Muscle Research and Cell Motility"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10974-016-9447-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10974-016-9447-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10974-016-9447-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T20:06:03Z","timestamp":1589659563000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10974-016-9447-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,4]]},"references-count":100,"journal-issue":{"issue":"4-5","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["9447"],"URL":"https:\/\/doi.org\/10.1007\/s10974-016-9447-3","relation":{},"ISSN":["0142-4319","1573-2657"],"issn-type":[{"value":"0142-4319","type":"print"},{"value":"1573-2657","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,4]]},"assertion":[{"value":"23 January 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 June 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}