{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T10:00:31Z","timestamp":1783764031551,"version":"3.55.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T00:00:00Z","timestamp":1684540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T00:00:00Z","timestamp":1684540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Muscle Res Cell Motil"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Paravertebral muscles (PVM) act as one of the major dynamic factors to maintain human upright activities and play a remarkable role in maintaining the balance of the trunk. Adult degenerative scoliosis (ADS) has become one of the important causes of disability in the elderly population owing to the changes in spinal biomechanics, atrophy and degeneration of PVM, and imbalance of the spine. Previously, many studies focused on the physical evaluation of PVM degeneration. However, the molecular biological changes are still not completely known. In this study, we established a rat model of scoliosis and performed the proteomic analysis of the PVM of ADS. The results showed that the degree of atrophy, muscle fat deposition, and fibrosis of the PVM of rats positively correlated with the angle of scoliosis. The proteomic results showed that 177 differentially expressed proteins were present in the ADS group, which included 105 upregulated proteins and 72 downregulated proteins compared with the PVM in individuals without spinal deformities. Through the construction of a protein\u2013protein interaction network, 18 core differentially expressed proteins were obtained, which included fibrinogen beta chain, apolipoprotein E, fibrinogen gamma chain, thrombospondin-1, integrin alpha-6, fibronectin-1, platelet factor 4, coagulation factor XIII A chain, ras-related protein Rap-1b, platelet endothelial cell adhesion molecule 1, complement C1q subcomponent subunit A, cathepsin G, myeloperoxidase, von Willebrand factor, integrin beta-1, integrin alpha-1, leukocyte surface antigen CD47, and complement C1q subcomponent subunit B. Further analysis of the Kyoto Encyclopedia of Genes and Genomes pathway (KEGG) and immunofluorescence showed that the neutrophil extracellular traps (NETs) formation signaling pathway plays a major role in the pathogenesis of PVM degeneration in ADS. The results of the present study preliminarily laid the molecular biological foundation of PVM atrophy in ADS, which will provide a new therapeutic target for alleviating PVM atrophy and decreasing the occurrence of scoliosis.<\/jats:p>","DOI":"10.1007\/s10974-023-09650-8","type":"journal-article","created":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T08:02:07Z","timestamp":1684569727000},"page":"287-297","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Bioinformatics analysis of paravertebral muscles atrophy in adult degenerative scoliosis"],"prefix":"10.1007","volume":"44","author":[{"given":"Zhigang","family":"Rong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengmin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongxi","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,20]]},"reference":[{"issue":"1","key":"9650_CR1","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.jspd.2018.06.008","volume":"7","author":"T Banno","year":"2019","unstructured":"Banno T et al (2019) The effect of paravertebral muscle on the maintenance of upright posture in patients with adult spinal deformity. Spine Deform 7 (1):125\u2013131","journal-title":"Spine Deform"},{"issue":"2","key":"9650_CR2","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.phrs.2008.06.008","volume":"58","author":"S Brunelli","year":"2008","unstructured":"Brunelli S, Rovere-Querini P (2008) The immune system and the repair of skeletal muscle. Pharmacol Res 58 (2):117\u2013121","journal-title":"Pharmacol Res"},{"key":"9650_CR3","doi-asserted-by":"crossref","unstructured":"Buell TJ et al (2019) Surgical correction of severe adult lumbar scoliosis (major curves >\/= 75 degrees ): retrospective analysis with minimum 2-year follow-up. J Neurosurg Spine 1\u201314.","DOI":"10.3171\/2019.3.SPINE1966"},{"key":"9650_CR4","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1007\/978-981-13-1435-3_29","volume":"1088","author":"RY Cao","year":"2018","unstructured":"Cao RY et al (2018) Muscle atrophy: present and future. Adv Exp Med Biol 1088:605\u2013624","journal-title":"Adv Exp Med Biol"},{"issue":"5","key":"9650_CR5","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1161\/01.RES.66.5.1436","volume":"66","author":"DL Carden","year":"1990","unstructured":"Carden DL, Smith JK, Korthuis RJ (1990) Neutrophil-mediated microvascular dysfunction in postischemic canine skeletal muscle. Role of granulocyte adherence. Circ Res 66 (5):1436\u20131444","journal-title":"Circ Res"},{"issue":"6","key":"9650_CR6","doi-asserted-by":"publisher","first-page":"R1831","DOI":"10.1152\/ajpregu.90318.2008","volume":"295","author":"N Dumont","year":"2008","unstructured":"Dumont N, Bouchard P, Frenette J (2008) Neutrophil-induced skeletal muscle damage: a calculated and controlled response following hindlimb unloading and reloading. Am J Physiol Regul Integr Comp Physiol 295 (6):R1831\u2013R1838","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"6","key":"9650_CR7","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.1128\/iai.62.6.2195-2201.1994","volume":"62","author":"C Elbim","year":"1994","unstructured":"Elbim C et al (1994) Differential priming effects of proinflammatory cytokines on human neutrophil oxidative burst in response to bacterial N-formyl peptides. Infect Immun 62 (6):2195\u20132201","journal-title":"Infect Immun"},{"issue":"6","key":"9650_CR8","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1007\/s00586-019-06243-3","volume":"29","author":"E Ferrero","year":"2020","unstructured":"Ferrero E et al (2020) Relationships between radiographic parameters and spinopelvic muscles in adult spinal deformity patients. Eur Spine J 29 (6):1328\u20131339","journal-title":"Eur Spine J"},{"key":"9650_CR9","doi-asserted-by":"crossref","unstructured":"Glassman SD et al (2005) Correlation of radiographic parameters and clinical symptoms in adult scoliosis. Spine (Phila Pa 1976) 30 (6):682\u2013688.","DOI":"10.1097\/01.brs.0000155425.04536.f7"},{"issue":"10","key":"9650_CR10","doi-asserted-by":"publisher","first-page":"3420","DOI":"10.1093\/nar\/gkn176","volume":"36","author":"S Gotz","year":"2008","unstructured":"Gotz S et al (2008) High-throughput functional annotation and data mining with the Blast2GO suite. Nucleic Acids Res 36 (10):3420\u20133435","journal-title":"Nucleic Acids Res"},{"key":"9650_CR11","doi-asserted-by":"crossref","unstructured":"Hides JA et al (1994) Evidence of lumbar multifidus muscle wasting ipsilateral to symptoms in patients with acute\/subacute low back pain. Spine (Phila Pa 1976) 19 (2):165\u2013172.","DOI":"10.1097\/00007632-199401001-00009"},{"issue":"2","key":"9650_CR12","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1053\/crad.1999.0340","volume":"55","author":"DF Kader","year":"2000","unstructured":"Kader DF, Wardlaw D, Smith FW (2000) Correlation between the MRI changes in the lumbar multifidus muscles and leg pain. Clin Radiol 55 (2):145\u2013149","journal-title":"Clin Radiol"},{"key":"9650_CR13","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1741-7015-5-2","volume":"5","author":"P Kjaer","year":"2007","unstructured":"Kjaer P et al (2007) Are MRI-defined fat infiltrations in the multifidus muscles associated with low back pain? BMC Med 5:2","journal-title":"BMC Med"},{"issue":"1","key":"9650_CR14","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1096\/fj.03-0610com","volume":"18","author":"SH Lecker","year":"2004","unstructured":"Lecker SH et al (2004) Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression. FASEB J 18 (1):39\u201351","journal-title":"FASEB J"},{"key":"9650_CR16","doi-asserted-by":"crossref","unstructured":"Liu L et al (2011) The creation of scoliosis by scapula-to-contralateral ilium tethering procedure in bipedal rats: a kyphoscoliosis model. Spine (Phila Pa 1976) 36 (17):1340\u20131349.","DOI":"10.1097\/BRS.0b013e3181f3d164"},{"key":"9650_CR15","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.clinbiomech.2019.03.013","volume":"65","author":"Y Liu","year":"2019","unstructured":"Liu Y et al (2019) Asymmetric biomechanical characteristics of the paravertebral muscle in adolescent idiopathic scoliosis. Clin Biomech (bristol, Avon) 65:81\u201386","journal-title":"Clin Biomech (bristol, Avon)"},{"issue":"1","key":"9650_CR18","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1097\/01.moh.0000190113.31027.d5","volume":"13","author":"TJ Moraes","year":"2006","unstructured":"Moraes TJ, Zurawska JH, Downey GP (2006) Neutrophil granule contents in the pathogenesis of lung injury. Curr Opin Hematol 13 (1):21\u201327","journal-title":"Curr Opin Hematol"},{"issue":"6","key":"9650_CR19","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/S1471-4906(03)00117-0","volume":"24","author":"WA Muller","year":"2003","unstructured":"Muller WA (2003) Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response. Trends Immunol 24 (6):327\u2013334","journal-title":"Trends Immunol"},{"issue":"5","key":"9650_CR20","doi-asserted-by":"publisher","first-page":"E453","DOI":"10.1152\/ajpendo.00553.2012","volume":"304","author":"NJ Pillon","year":"2013","unstructured":"Pillon NJ et al (2013) Cross-talk between skeletal muscle and immune cells: muscle-derived mediators and metabolic implications. Am J Physiol Endocrinol Metab 304 (5):E453\u2013E465","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"9650_CR21","first-page":"160","volume":"23","author":"M Sandri","year":"2008","unstructured":"Sandri M (2008) Signaling in muscle atrophy and hypertrophy. Physiology (bethesda) 23:160\u2013170","journal-title":"Physiology (bethesda)"},{"key":"9650_CR22","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/978-981-13-1435-3_20","volume":"1088","author":"E Skorupska","year":"2018","unstructured":"Skorupska E (2018) Muscle atrophy measurement as assessment method for low back pain patients. Adv Exp Med Biol 1088:437\u2013461","journal-title":"Adv Exp Med Biol"},{"issue":"2","key":"9650_CR23","doi-asserted-by":"publisher","first-page":"R345","DOI":"10.1152\/ajpregu.00454.2004","volume":"288","author":"JG Tidball","year":"2005","unstructured":"Tidball JG (2005) Inflammatory processes in muscle injury and repair. Am J Physiol Regul Integr Comp Physiol 288 (2):R345\u2013R353","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"2","key":"9650_CR17","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1002\/mus.21822","volume":"43","author":"SF van der Meer","year":"2011","unstructured":"van der Meer SF et al (2011) Time-course of changes in the myonuclear domain during denervation in young-adult and old rat gastrocnemius muscle. Muscle Nerve 43 (2):212\u2013222","journal-title":"Muscle Nerve"},{"issue":"1","key":"9650_CR24","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1186\/s12891-020-03844-8","volume":"21","author":"S Yang","year":"2020","unstructured":"Yang S et al (2020) Assessment of isokinetic trunk muscle strength and its association with health-related quality of life in patients with degenerative spinal deformity. BMC Musculoskelet Disord 21 (1):827","journal-title":"BMC Musculoskelet Disord"},{"issue":"17","key":"9650_CR25","doi-asserted-by":"publisher","first-page":"4658","DOI":"10.1111\/jcmm.17495","volume":"26","author":"Z You","year":"2022","unstructured":"You Z et al (2022) Molecular feature of neutrophils in immune microenvironment of muscle atrophy. J Cell Mol Med 26 (17):4658\u20134665","journal-title":"J Cell Mol Med"}],"container-title":["Journal of Muscle Research and Cell Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10974-023-09650-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10974-023-09650-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10974-023-09650-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T15:02:01Z","timestamp":1700665321000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10974-023-09650-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,20]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["9650"],"URL":"https:\/\/doi.org\/10.1007\/s10974-023-09650-8","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-2473451\/v1","asserted-by":"object"}]},"ISSN":["0142-4319","1573-2657"],"issn-type":[{"value":"0142-4319","type":"print"},{"value":"1573-2657","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,20]]},"assertion":[{"value":"13 January 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 April 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}