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To better understand the role of MEGF10 in satellite cells, we overexpressed human MEGF10 in mouse\n                    <jats:italic>H-2k<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>b<\/jats:italic>\n                    <\/jats:sup>\n                    -tsA58 myoblasts and found that it inhibited fusion. Addition of purified extracellular domains of human MEGF10, with (ECD) or without (EGF) the N-terminal EMI domain to\n                    <jats:italic>H-2k<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>b<\/jats:italic>\n                    <\/jats:sup>\n                    -tsA58 myoblasts, showed that the ECD was more effective at reducing myoblast adhesion and fusion by day 7 of differentiation, yet promoted adhesion of myoblasts to non-adhesive surfaces, highlighting the importance of the EMI domain in these behaviours. We additionally tested the role of Megf10 in vivo using transgenic mice with reduced (\n                    <jats:italic>Megf10<\/jats:italic>\n                    <jats:sup>+\/\u2212<\/jats:sup>\n                    ) or no (\n                    <jats:italic>Megf10<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) Megf10. We found that the extensor digitorum longus muscle had fewer anti-Pax7 stained cell nuclei and was less able to undergo hypertrophy in response to muscle overload concomitant with a lower level of satellite cell activation. Taken together, our data suggest that MEGF10 may promote satellite cell adhesion and survival and prevent premature fusion helping to explain its role in EMARDD.\n                  <\/jats:p>","DOI":"10.1007\/s10974-024-09686-4","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T20:30:44Z","timestamp":1737145844000},"page":"275-292","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The role of MEGF10 in myoblast fusion and hypertrophic response to overload of skeletal muscle"],"prefix":"10.1007","volume":"46","author":[{"given":"Louise","family":"Richardson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin A.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Egginton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3754-2028","authenticated-orcid":false,"given":"Michelle","family":"Peckham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,18]]},"reference":[{"key":"9686_CR1","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1113\/JP283658","volume":"601","author":"JR Bagley","year":"2023","unstructured":"Bagley JR, Denes LT, McCarthy JJ, Wang ET, Murach KA (2023) The myonuclear domain in adult skeletal muscle fibres: past, present and future. 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