{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:55:28Z","timestamp":1791312928167,"version":"4.3.1"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"crossref","award":["21-75-00063"],"award-info":[{"award-number":["21-75-00063"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"crossref","award":["21-75-00063"],"award-info":[{"award-number":["21-75-00063"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"crossref","award":["21-75-00063"],"award-info":[{"award-number":["21-75-00063"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"crossref","award":["21-75-00063"],"award-info":[{"award-number":["21-75-00063"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"crossref","award":["21-75-00063"],"award-info":[{"award-number":["21-75-00063"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Muscle Res Cell Motil"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1007\/s10974-025-09700-3","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:06:01Z","timestamp":1751501161000},"page":"215-229","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The impact of mitokine MOTS-c administration on the soleus muscle of rats subjected to a 7-day hindlimb suspension"],"prefix":"10.1007","volume":"46","author":[{"given":"Daria A.","family":"Sidorenko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina D.","family":"Lvova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey A.","family":"Tyganov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris S.","family":"Shenkman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina A.","family":"Sharlo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"key":"9700_CR1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb01045.x","author":"DR Alessi","year":"1996","unstructured":"Alessi DR, Andjelkovic M, Caudwell B et al (1996) Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J. https:\/\/doi.org\/10.1002\/j.1460-2075.1996.tb01045.x. 15:","journal-title":"EMBO J"},{"key":"9700_CR2","doi-asserted-by":"crossref","unstructured":"Allen DG, Lamb GD, Westerblad H (2008) Skeletal muscle fatigue: cellular mechanisms. Physiol Rev 88","DOI":"10.1152\/physrev.00015.2007"},{"key":"9700_CR3","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1152\/JAPPLPHYSIOL.00703.2016","volume":"122","author":"LM Baehr","year":"2017","unstructured":"Baehr LM, West DWD, Marshall AG et al (2017) Muscle-specific and age-related changes in protein synthesis and protein degradation in response to hindlimb unloading in rats. J Appl Physiol 122:1336\u20131350. https:\/\/doi.org\/10.1152\/JAPPLPHYSIOL.00703.2016","journal-title":"J Appl Physiol"},{"key":"9700_CR4","doi-asserted-by":"publisher","unstructured":"Bajotto G, Sato Y, Kitaura Y, Shimomura Y (2011) Effect of branched-chain amino acid supplementation during unloading on regulatory components of protein synthesis in atrophied soleus muscles. Eur J Appl Physiol 111. https:\/\/doi.org\/10.1007\/s00421-010-1825-8","DOI":"10.1007\/s00421-010-1825-8"},{"key":"9700_CR5","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1152\/JAPPLPHYSIOL.00415.2022","volume":"133","author":"SP Belova","year":"2022","unstructured":"Belova SP, Zaripova K, Sharlo K et al (2022) Metformin attenuates an increase of calcium-dependent and ubiquitin-proteasome markers in unloaded muscle. J Appl Physiol 133:1149\u20131163. https:\/\/doi.org\/10.1152\/JAPPLPHYSIOL.00415.2022","journal-title":"J Appl Physiol"},{"key":"9700_CR6","doi-asserted-by":"publisher","first-page":"23977","DOI":"10.1074\/jbc.C200171200","volume":"277","author":"DR Bolster","year":"2002","unstructured":"Bolster DR, Crozier SJ, Kimball SR, Jefferson LS (2002) AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of Rapamycin (mTOR) signaling. J Biol Chem 277:23977\u201323980. https:\/\/doi.org\/10.1074\/jbc.C200171200","journal-title":"J Biol Chem"},{"key":"9700_CR7","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1042\/BST20060223","volume":"34","author":"RW Brownsey","year":"2006","unstructured":"Brownsey RW, Boone AN, Elliott JE et al (2006) Regulation of acetyl-CoA carboxylase. Biochem Soc Trans 34:223\u2013227. https:\/\/doi.org\/10.1042\/BST20060223","journal-title":"Biochem Soc Trans"},{"key":"9700_CR8","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1113\/JPHYSIOL.1974.SP010540","volume":"238","author":"RE Burke","year":"1974","unstructured":"Burke RE, Levine DN, Salcman M, Tsairis P (1974) Motor units in Cat soleus muscle: physiological, histochemical and morphological characteristics. J Physiol 238:503. https:\/\/doi.org\/10.1113\/JPHYSIOL.1974.SP010540","journal-title":"J Physiol"},{"key":"9700_CR9","doi-asserted-by":"publisher","unstructured":"Desplanches D, Mayet MH, Sempore B, Flandrois R (1987) Structural and functional responses to prolonged hindlimb suspension in rat muscle. J Appl Physiol 63. https:\/\/doi.org\/10.1152\/jappl.1987.63.2.558","DOI":"10.1152\/jappl.1987.63.2.558"},{"key":"9700_CR10","doi-asserted-by":"publisher","DOI":"10.1152\/AJPENDO.1996.270.4.E627","author":"AA Ferrando","year":"1996","unstructured":"Ferrando AA, Lane HW, Stuart CA et al (1996) Prolonged bed rest decreases skeletal muscle and whole body protein synthesis. Am J Physiol. https:\/\/doi.org\/10.1152\/AJPENDO.1996.270.4.E627. 270:","journal-title":"Am J Physiol"},{"key":"9700_CR11","doi-asserted-by":"publisher","unstructured":"Gordon AM, Huxley AF, Julian FJ (1966) The variation in isometric tension with sarcomere length in vertebrate muscle fibres. J Physiol 184. https:\/\/doi.org\/10.1113\/jphysiol.1966.sp007909","DOI":"10.1113\/jphysiol.1966.sp007909"},{"key":"9700_CR12","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/J.TCB.2015.10.013","volume":"26","author":"DG Hardie","year":"2016","unstructured":"Hardie DG, Schaffer BE, Brunet A (2016) AMPK: an Energy-Sensing pathway with multiple inputs and outputs. Trends Cell Biol 26:190\u2013201. https:\/\/doi.org\/10.1016\/J.TCB.2015.10.013","journal-title":"Trends Cell Biol"},{"key":"9700_CR13","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/0014-4886(88)90093-3","volume":"102","author":"ME Herbert","year":"1988","unstructured":"Herbert ME, Roy RR, Edgerton VR (1988) Influence of one-week hindlimb suspension and intermittent high load exercise on rat muscles. Exp Neurol 102:190\u2013198. https:\/\/doi.org\/10.1016\/0014-4886(88)90093-3","journal-title":"Exp Neurol"},{"key":"9700_CR14","first-page":"79","volume":"14","author":"EA Il\u2019in","year":"1980","unstructured":"Il\u2019in EA, Novikov VE (1980) Stand for modelling the physiological effects of weightlessness in laboratory experiments with rats. Kosm Biol Aviakosm Med 14:79\u201380","journal-title":"Kosm Biol Aviakosm Med"},{"key":"9700_CR15","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1021\/ACSCHEMNEURO.0C00782\/SUPPL_FILE\/CN0C00782_SI_001.PDF","volume":"12","author":"J Jiang","year":"2021","unstructured":"Jiang J, Chang X, Nie Y et al (2021) Peripheral administration of a Cell-Penetrating MOTS-c analogue enhances memory and attenuates A\u03b21-42- or LPS-Induced memory impairment through inhibiting neuroinflammation. ACS Chem Neurosci 12:1506\u20131518. https:\/\/doi.org\/10.1021\/ACSCHEMNEURO.0C00782\/SUPPL_FILE\/CN0C00782_SI_001.PDF","journal-title":"ACS Chem Neurosci"},{"key":"9700_CR16","doi-asserted-by":"publisher","first-page":"E680","DOI":"10.1152\/AJPENDO.00275.2020\/ASSET","volume":"320","author":"H Kumagai","year":"2021","unstructured":"Kumagai H, Coelho AR, Wan J et al (2021) MOTS-c reduces myostatin and muscle atrophy signaling. Am J Physiol - Endocrinol Metab 320:E680\u2013E690. https:\/\/doi.org\/10.1152\/AJPENDO.00275.2020\/ASSET\/IMAGES\/LARGE\/AJPENDO.00275.2020-F0008.JPEG.","journal-title":"Am J Physiol - Endocrinol Metab"},{"key":"9700_CR18","doi-asserted-by":"publisher","unstructured":"Kumagai H, Natsume T, Kim SJ et al (2022) The MOTS-c K14Q polymorphism in the MtDNA is associated with muscle fiber composition and muscular performance. Biochim Biophys Acta Gen Subj 1866. https:\/\/doi.org\/10.1016\/J.BBAGEN.2021.130048","DOI":"10.1016\/J.BBAGEN.2021.130048"},{"key":"9700_CR17","doi-asserted-by":"publisher","unstructured":"Kumagai H, Kim S-J, Miller B et al (2024) Mitochondrial-derived microprotein MOTS-c attenuates immobilization-induced skeletal muscle atrophy by suppressing lipid infiltration. https:\/\/doi.org\/10.1152\/ajpendo.00285.2023. https:\/\/doi.org\/10.1152\/AJPENDO.00285.2023","DOI":"10.1152\/ajpendo.00285.2023"},{"key":"9700_CR19","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.cmet.2015.02.009","volume":"21","author":"C Lee","year":"2015","unstructured":"Lee C, Zeng J, Drew BG et al (2015) The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab 21:443\u2013454. https:\/\/doi.org\/10.1016\/j.cmet.2015.02.009","journal-title":"Cell Metab"},{"key":"9700_CR21","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1172\/JCI10268","volume":"106","author":"JJ Lehman","year":"2000","unstructured":"Lehman JJ, Barger PM, Kovacs A et al (2000) Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J Clin Invest 106:847\u2013856. https:\/\/doi.org\/10.1172\/JCI10268","journal-title":"J Clin Invest"},{"key":"9700_CR22","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/241204a0","volume":"2415386 241","author":"DJ Millward","year":"1973","unstructured":"Millward DJ, Garlick PJ, James WPT et al (1973) Relationship between protein synthesis and RNA content in skeletal muscle. Nat 1973 2415386 241:204\u2013205. https:\/\/doi.org\/10.1038\/241204a0","journal-title":"Nat 1973"},{"key":"9700_CR23","doi-asserted-by":"publisher","unstructured":"Mirzoev T, Tyganov S, Vilchinskaya N et al (2016) Key markers of mTORC1-Dependent and mTORC1-Independent signaling pathways regulating protein synthesis in rat soleus muscle during early stages of hindlimb unloading. Cell Physiol Biochem 39. https:\/\/doi.org\/10.1159\/000447808","DOI":"10.1159\/000447808"},{"key":"9700_CR24","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1152\/JAPPLPHYSIOL.00969.2001","volume":"92","author":"ER Morey-Holton","year":"2002","unstructured":"Morey-Holton ER, Globus RK (2002) Hindlimb unloading rodent model: technical aspects. J Appl Physiol 92:1367\u20131377. https:\/\/doi.org\/10.1152\/JAPPLPHYSIOL.00969.2001","journal-title":"J Appl Physiol"},{"key":"9700_CR25","unstructured":"Netreba AI, Khusnutdinova DR, Vinogradova OL, Kozlovskaya IB (2004) Effect of dry immersion in combination with stimulation of foot support zones upon muscle force-velocity characteristics. J Gravit Physiol 11"},{"key":"9700_CR26","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/0094-5765(94)90115-5","volume":"33","author":"Y Ohira","year":"1994","unstructured":"Ohira Y, Yasui W, Kariya F et al (1994) Metabolic adaptation of skeletal muscles to gravitational unloading. Acta Astronaut 33:113\u2013117. https:\/\/doi.org\/10.1016\/0094-5765(94)90115-5","journal-title":"Acta Astronaut"},{"key":"9700_CR27","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/S0273-1177(02)00395-2","volume":"30","author":"Y Ohira","year":"2002","unstructured":"Ohira Y, Yoshinaga T, Nomura T et al (2002) Gravitational unloading effects on muscle fiber size, phenotype and myonuclear number. Adv Sp Res 30:777\u2013781. https:\/\/doi.org\/10.1016\/S0273-1177(02)00395-2","journal-title":"Adv Sp Res"},{"key":"9700_CR28","doi-asserted-by":"publisher","first-page":"E45","DOI":"10.1093\/NAR\/29.9.E45","volume":"29","author":"MW Pfaffl","year":"2001","unstructured":"Pfaffl MW (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29:E45. https:\/\/doi.org\/10.1093\/NAR\/29.9.E45","journal-title":"Nucleic Acids Res"},{"key":"9700_CR29","first-page":"205","volume":"61","author":"DJ Pierotti","year":"1990","unstructured":"Pierotti DJ, Roy RR, Flores V, Edgerton VR (1990) Influence of 7 days of hindlimb suspension and intermittent weight support on rat muscle mechanical properties. Aviat Space Environ Med 61:205\u2013210","journal-title":"Aviat Space Environ Med"},{"key":"9700_CR30","doi-asserted-by":"publisher","first-page":"2307","DOI":"10.1249\/MSS.0000000000000975","volume":"48","author":"SK Powers","year":"2016","unstructured":"Powers SK, Lynch GS, Murphy KT et al (2016) Disease-Induced skeletal muscle atrophy and fatigue. Med Sci Sports Exerc 48:2307\u20132319. https:\/\/doi.org\/10.1249\/MSS.0000000000000975","journal-title":"Med Sci Sports Exerc"},{"key":"9700_CR31","doi-asserted-by":"publisher","unstructured":"Reynolds JC, Lai RW, Woodhead JST et al (2021) MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun 12. https:\/\/doi.org\/10.1038\/S41467-020-20790-0","DOI":"10.1038\/S41467-020-20790-0"},{"key":"9700_CR32","doi-asserted-by":"publisher","first-page":"2062","DOI":"10.2337\/DB07-0255","volume":"56","author":"KSC R\u00f6ckl","year":"2007","unstructured":"R\u00f6ckl KSC, Hirshman MF, Brandauer J et al (2007) Skeletal muscle adaptation to exercise training: AMP-activated protein kinase mediates muscle fiber type shift. Diabetes 56:2062\u20132069. https:\/\/doi.org\/10.2337\/DB07-0255","journal-title":"Diabetes"},{"key":"9700_CR33","doi-asserted-by":"publisher","unstructured":"Rommel C, Bodine SC, Clarke BA et al (2001) Mediation of IGF-1-induced skeletal myotube hypertrophy by Pl(3)K\/Alt\/mTOR and Pl(3)K\/Akt\/GSK3 pathways. Nat Cell Biol 3. https:\/\/doi.org\/10.1038\/ncb1101-1009","DOI":"10.1038\/ncb1101-1009"},{"key":"9700_CR34","doi-asserted-by":"crossref","unstructured":"Roy RR, Baldwin KM, Edgerton VR (1991) The plasticity of skeletal muscle: effects of neuromuscular activity. Exerc Sport Sci Rev 19","DOI":"10.1249\/00003677-199101000-00008"},{"key":"9700_CR35","doi-asserted-by":"publisher","unstructured":"Roy RR, Zhong H, Monti RJ et al (2002) Mechanical properties of the electrically silent adult rat soleus muscle. Muscle Nerve 26. https:\/\/doi.org\/10.1002\/mus.10219","DOI":"10.1002\/mus.10219"},{"key":"9700_CR36","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/J.ACTAASTRO.2021.05.036","volume":"186","author":"SV Rozhkov","year":"2021","unstructured":"Rozhkov SV, Sharlo KA, Mirzoev TM, Shenkman BS (2021) Temporal changes in the markers of ribosome biogenesis in rat soleus muscle under simulated microgravity. Acta Astronaut 186:252\u2013258. https:\/\/doi.org\/10.1016\/J.ACTAASTRO.2021.05.036","journal-title":"Acta Astronaut"},{"key":"9700_CR37","doi-asserted-by":"publisher","first-page":"232751","DOI":"10.3390\/IJMS23052751","volume":"23","author":"SV Rozhkov","year":"2022","unstructured":"Rozhkov SV, Sharlo KA, Shenkman BS, Mirzoev TM (2022) The role of glycogen synthase Kinase-3 in the regulation of ribosome biogenesis in rat soleus muscle under disuse conditions. Int J Mol Sci 2022 23:232751. https:\/\/doi.org\/10.3390\/IJMS23052751","journal-title":"Int J Mol Sci 2022"},{"key":"9700_CR38","doi-asserted-by":"publisher","unstructured":"Schiaffino S, Mammucari C (2011) Regulation of skeletal muscle growth by the IGF1-Akt\/PKB pathway: insights from genetic models. https:\/\/doi.org\/10.1186\/2044-5040-1-4. Skelet Muscle 1:","DOI":"10.1186\/2044-5040-1-4"},{"key":"9700_CR39","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1152\/PHYSREV.00031.2010","volume":"91","author":"S Schiaffino","year":"2011","unstructured":"Schiaffino S, Reggiani C (2011) Fiber types in mammalian skeletal muscles. Physiol Rev 91:1447\u20131531. https:\/\/doi.org\/10.1152\/PHYSREV.00031.2010","journal-title":"Physiol Rev"},{"key":"9700_CR40","doi-asserted-by":"publisher","unstructured":"Sergeeva XV, Lvova ID, Sharlo KA (2024) Disuse-Induced Muscle Fatigue: Facts and Assumptions. Int J Mol Sci 2024, Vol 25, Page 4984 25:4984. https:\/\/doi.org\/10.3390\/IJMS25094984","DOI":"10.3390\/IJMS25094984"},{"key":"9700_CR45","doi-asserted-by":"publisher","unstructured":"Sharlo KA, Paramonova II, Lvova ID et al (2020) NO-Dependent mechanisms of myosin heavy chain transcription regulation in rat soleus muscle after 7-Days hindlimb unloading. https:\/\/doi.org\/10.3389\/fphys.2020.00814. Front Physiol 11:","DOI":"10.3389\/fphys.2020.00814"},{"key":"9700_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/IJMS22031372","volume":"22","author":"KA Sharlo","year":"2021","unstructured":"Sharlo KA, Paramonova II, Lvova ID et al (2021) Plantar mechanical stimulation maintains slow myosin expression in disused rat soleus muscle via NO-Dependent signaling. Int J Mol Sci 22:1\u201323. https:\/\/doi.org\/10.3390\/IJMS22031372","journal-title":"Int J Mol Sci"},{"key":"9700_CR41","doi-asserted-by":"publisher","unstructured":"Sharlo KA, Lvova ID, Belova SP et al (2023a) Metformin attenuates Slow-to-Fast Fiber shift and proteolysis markers increase in rat soleus after 7 days of rat hindlimb unloading. Int J Mol Sci 24. https:\/\/doi.org\/10.3390\/IJMS24010503","DOI":"10.3390\/IJMS24010503"},{"key":"9700_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/J.ABB.2023.109647","author":"KA Sharlo","year":"2023","unstructured":"Sharlo KA, Lvova ID, Sidorenko DA et al (2023b) \u0392-GPA administration activates slow oxidative muscle signaling pathways and protects soleus muscle against the increased fatigue under 7-days of rat hindlimb suspension. Arch Biochem Biophys. https:\/\/doi.org\/10.1016\/J.ABB.2023.109647. 743:","journal-title":"Arch Biochem Biophys"},{"key":"9700_CR58","doi-asserted-by":"publisher","unstructured":"Sharlo K, Lvova I, Turtikova O, Tyganov S, Kalashnikov V, Shenkman B (2022) Plantar stimulation prevents the decrease in fatigue resistance in rat soleus muscle under one week of hindlimb suspension. Arch Biochem Biophys 718:109150. https:\/\/doi.org\/10.1016\/j.abb.2022.109150","DOI":"10.1016\/j.abb.2022.109150"},{"key":"9700_CR43","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1134\/S0022093023020278","volume":"592 59","author":"KA Sharlo","year":"2023","unstructured":"Sharlo KA, Lvova ID, Tyganov SA et al (2023c) Role of L-Type calcium channels in increased fatigue of the rat soleus muscle under functional unloading. J Evol Biochem Physiol 2023 592 59:620\u2013629. https:\/\/doi.org\/10.1134\/S0022093023020278","journal-title":"J Evol Biochem Physiol 2023"},{"key":"9700_CR46","doi-asserted-by":"publisher","first-page":"e1232","DOI":"10.1016\/S2214-109X(24)00150-5","volume":"12","author":"T Strain","year":"2024","unstructured":"Strain T, Flaxman S, Guthold R et al (2024) National, regional, and global trends in insufficient physical activity among adults from 2000 to 2022: a pooled analysis of 507 population-based surveys with 5\u00b77 million participants. Lancet Glob Heal 12:e1232\u2013e1243. https:\/\/doi.org\/10.1016\/S2214-109X(24)00150-5","journal-title":"Lancet Glob Heal"},{"issue":"Pt 1","key":"9700_CR47","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1042\/BJ2960015","volume":"296","author":"C Sutherland","year":"1993","unstructured":"Sutherland C, Leighton IA, Cohen P (1993) Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling. Biochem J 296(Pt 1):15\u201319. https:\/\/doi.org\/10.1042\/BJ2960015","journal-title":"Biochem J"},{"key":"9700_CR48","doi-asserted-by":"publisher","unstructured":"Theeuwes WF, Gosker HR, Langen RCJ et al (2017) Inactivation of glycogen synthase kinase-3\u03b2 (GSK-3\u03b2) enhances skeletal muscle oxidative metabolism. Biochim Biophys Acta - Mol Basis Dis 1863. https:\/\/doi.org\/10.1016\/j.bbadis.2017.09.018","DOI":"10.1016\/j.bbadis.2017.09.018"},{"key":"9700_CR49","doi-asserted-by":"crossref","unstructured":"Thomason DB, Booth FW (1990) Atrophy of the soleus muscle by hindlimb unweighting. J Appl Physiol 68","DOI":"10.1152\/jappl.1990.68.1.1"},{"key":"9700_CR57","doi-asserted-by":"publisher","unstructured":"Trevino M, Zhang X, Standley R, Wang M, Han X, Reis F, Periasamy M, Yu G, Kelly D, Goodpaster B, Vega R, Coen P (2019) Loss of mitochondrial energetics is associated with poor recovery of muscle function but not mass following disuse atrophy. Am J Physiol Endocrinol Metab 317(5):E899\u2013E910. https:\/\/doi.org\/10.1152\/ajpendo.00161.2019","DOI":"10.1152\/ajpendo.00161.2019"},{"key":"9700_CR50","doi-asserted-by":"publisher","unstructured":"Tyganov SA, Mochalova EP, Belova SP et al (2019) Effects of plantar mechanical stimulation on anabolic and catabolic signaling in rat postural muscle under Short-Term simulated gravitational unloading. https:\/\/doi.org\/10.3389\/FPHYS.2019.01252. Front Physiol 10:","DOI":"10.3389\/FPHYS.2019.01252"},{"key":"9700_CR51","doi-asserted-by":"publisher","unstructured":"Tyganov SA, Mochalova EP, Melnikov IY et al (2021) NOS-dependent effects of plantar mechanical stimulation on mechanical characteristics and cytoskeletal proteins in rat soleus muscle during hindlimb suspension. FASEB J 35. https:\/\/doi.org\/10.1096\/FJ.202100783R","DOI":"10.1096\/FJ.202100783R"},{"key":"9700_CR52","doi-asserted-by":"publisher","unstructured":"Vainshtein A, Sandri M (2020) Signaling Pathways That Control Muscle Mass. Int J Mol Sci 2020, Vol 21, Page 4759 21:4759. https:\/\/doi.org\/10.3390\/IJMS21134759","DOI":"10.3390\/IJMS21134759"},{"key":"9700_CR53","doi-asserted-by":"publisher","unstructured":"Vilchinskaya NA, Krivoi II, Shenkman BS (2018) AMP-Activated protein kinase as a key trigger for the Disuse-Induced skeletal muscle remodeling. Int J Mol Sci 19. https:\/\/doi.org\/10.3390\/IJMS19113558","DOI":"10.3390\/IJMS19113558"},{"key":"9700_CR54","doi-asserted-by":"publisher","unstructured":"Yang B, Yu Q, Chang B et al (2021) MOTS-c interacts synergistically with exercise intervention to regulate PGC-1\u03b1 expression, attenuate insulin resistance and enhance glucose metabolism in mice via AMPK signaling pathway. Biochim Biophys Acta Mol Basis Dis 1867. https:\/\/doi.org\/10.1016\/J.BBADIS.2021.166126","DOI":"10.1016\/J.BBADIS.2021.166126"},{"key":"9700_CR55","doi-asserted-by":"publisher","first-page":"402","DOI":"10.4093\/dmj.2022.0092","volume":"46","author":"TK Yoon","year":"2022","unstructured":"Yoon TK, Lee CH, Kwon O, Kim M-S (2022) Exercise, mitohormesis, and mitochondrial ORF of the 12S rRNA Type-C (MOTS-c). Diabetes Metab J 46:402\u2013413. https:\/\/doi.org\/10.4093\/dmj.2022.0092","journal-title":"Diabetes Metab J"}],"container-title":["Journal of Muscle Research and Cell Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10974-025-09700-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10974-025-09700-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10974-025-09700-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T09:28:41Z","timestamp":1758533321000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10974-025-09700-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,3]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["9700"],"URL":"https:\/\/doi.org\/10.1007\/s10974-025-09700-3","relation":{},"ISSN":["0142-4319","1573-2657"],"issn-type":[{"value":"0142-4319","type":"print"},{"value":"1573-2657","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,3]]},"assertion":[{"value":"4 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}