{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T16:34:18Z","timestamp":1771000458012,"version":"3.50.1"},"reference-count":112,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["23\/10309-0"],"award-info":[{"award-number":["23\/10309-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["17\/09069-4"],"award-info":[{"award-number":["17\/09069-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["18\/24946-4"],"award-info":[{"award-number":["18\/24946-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fonds de Recherche du Qu\u00e9bec\u2013 Sant\u00e9","award":["Junior-2, No. 296512"],"award-info":[{"award-number":["Junior-2, No. 296512"]}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["314857\/2021-4"],"award-info":[{"award-number":["314857\/2021-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Muscle Res Cell Motil"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1007\/s10974-025-09706-x","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T07:19:42Z","timestamp":1755674382000},"page":"253-272","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Skeletal muscle alterations in Marfan syndrome: a systematic review"],"prefix":"10.1007","volume":"46","author":[{"given":"Audrei R.","family":"Santos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita M. S.","family":"Gutierrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana E.","family":"Koike","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Talita C.","family":"Conte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline C.","family":"Real","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas A.","family":"Dumont","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elen H.","family":"Miyabara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,20]]},"reference":[{"key":"9706_CR1","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.amjcard.2020.04.034","volume":"128","author":"A Al-Abcha","year":"2020","unstructured":"Al-Abcha A, Saleh Y, Mujer M et al (2020) Meta-analysis examining the usefulness of angiotensin receptor blockers for the prevention of aortic root dilation in patients with the Marfan syndrome. Am J Cardiol 128:101\u2013106. https:\/\/doi.org\/10.1016\/j.amjcard.2020.04.034","journal-title":"Am J Cardiol"},{"key":"9706_CR2","doi-asserted-by":"publisher","first-page":"455","DOI":"10.3233\/JND-160183","volume":"3","author":"HS Alameddine","year":"2016","unstructured":"Alameddine HS, Morgan JE (2016) Matrix metalloproteinases and tissue inhibitor of metalloproteinases in inflammation and fibrosis of skeletal muscles. J Neuromuscul Dis 3:455\u2013473. https:\/\/doi.org\/10.3233\/JND-160183","journal-title":"J Neuromuscul Dis"},{"key":"9706_CR3","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1084\/jem.20070075","volume":"204","author":"L Arnold","year":"2007","unstructured":"Arnold L, Henry A, Poron F et al (2007) Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis. J Exp Med 204:1057\u20131069. https:\/\/doi.org\/10.1084\/jem.20070075","journal-title":"J Exp Med"},{"key":"9706_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031892","volume":"23","author":"K Asano","year":"2022","unstructured":"Asano K, Cantalupo A, Sedes L, Ramirez F (2022) The multiple functions of Fibrillin-1 microfibrils in organismal physiology. Int J Mol Sci 23:1892. https:\/\/doi.org\/10.3390\/ijms23031892","journal-title":"Int J Mol Sci"},{"key":"9706_CR5","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1002\/jcsm.12731","volume":"12","author":"NL Beetz","year":"2021","unstructured":"Beetz NL, Maier C, Shnayien S et al (2021) Artificial intelligence-based analysis of body composition in Marfan: skeletal muscle density and psoas muscle index predict aortic enlargement. J Cachexia Sarcopenia Muscle 12:993\u2013999. https:\/\/doi.org\/10.1002\/jcsm.12731","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"9706_CR6","doi-asserted-by":"publisher","first-page":"227","DOI":"10.5603\/CJ.2013.0066","volume":"20","author":"K Benke","year":"2013","unstructured":"Benke K, \u00c1gg B, Szilveszter B et al (2013) The role of transforming growth factor-beta in Marfan syndrome. Cardiol J 20:227\u2013234. https:\/\/doi.org\/10.5603\/CJ.2013.0066","journal-title":"Cardiol J"},{"key":"9706_CR7","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1186\/s12888-017-1417-9","volume":"17","author":"K Benke","year":"2017","unstructured":"Benke K, \u00c1gg B, P\u00f3los M et al (2017) The effects of acute and elective cardiac surgery on the anxiety traits of patients with Marfan syndrome. BMC Psychiatry 17:253. https:\/\/doi.org\/10.1186\/s12888-017-1417-9","journal-title":"BMC Psychiatry"},{"key":"9706_CR8","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1186\/s13023-017-0679-0","volume":"12","author":"D Benninghoven","year":"2017","unstructured":"Benninghoven D, Hamann D, von Kodolitsch Y et al (2017) Inpatient rehabilitation for adult patients with Marfan syndrome: an observational pilot study. Orphanet J Rare Dis 12:127. https:\/\/doi.org\/10.1186\/s13023-017-0679-0","journal-title":"Orphanet J Rare Dis"},{"key":"9706_CR9","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.addr.2018.02.009","volume":"129","author":"S Bersini","year":"2018","unstructured":"Bersini S, Gilardi M, Mora M et al (2018) Tackling muscle fibrosis: from molecular mechanisms to next generation engineered models to predict drug delivery. Adv Drug Deliv Rev 129:64\u201377. https:\/\/doi.org\/10.1016\/j.addr.2018.02.009","journal-title":"Adv Drug Deliv Rev"},{"key":"9706_CR10","doi-asserted-by":"publisher","first-page":"196","DOI":"10.3109\/08977194.2011.595714","volume":"29","author":"A Biernacka","year":"2011","unstructured":"Biernacka A, Dobaczewski M, Frangogiannis NG (2011) TGF-\u03b2 signaling in fibrosis. Growth Factors 29:196\u2013202. https:\/\/doi.org\/10.3109\/08977194.2011.595714","journal-title":"Growth Factors"},{"key":"9706_CR11","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1097\/01.hco.0000162398.21972.cd","volume":"20","author":"C Boileau","year":"2005","unstructured":"Boileau C, Jondeau G, Mizuguchi T, Matsumoto N (2005) Molecular genetics of Marfan syndrome. Curr Opin Cardiol 20:194\u2013200. https:\/\/doi.org\/10.1097\/01.hco.0000162398.21972.cd","journal-title":"Curr Opin Cardiol"},{"key":"9706_CR12","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1002\/jcsm.12043","volume":"6","author":"TS Bowen","year":"2015","unstructured":"Bowen TS, Schuler G, Adams V (2015) Skeletal muscle wasting in cachexia and sarcopenia: molecular pathophysiology and impact of exercise training. J Cachexia Sarcopenia Muscle 6:197\u2013207. https:\/\/doi.org\/10.1002\/jcsm.12043","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"9706_CR13","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.mce.2011.11.019","volume":"350","author":"M Braga","year":"2012","unstructured":"Braga M, Bhasin S, Jasuja R et al (2012) Testosterone inhibits transforming growth factor-\u03b2 signaling during myogenic differentiation and proliferation of mouse satellite cells: potential role of follistatin in mediating testosterone action. Mol Cell Endocrinol 350:39\u201352. https:\/\/doi.org\/10.1016\/j.mce.2011.11.019","journal-title":"Mol Cell Endocrinol"},{"key":"9706_CR14","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.bbrc.2011.06.140","volume":"411","author":"ME Burchett","year":"2011","unstructured":"Burchett ME, Ling I-F, Estus S (2011) FBN1 isoform expression varies in a tissue and development-specific fashion. Biochem Biophys Res Commun 411:323\u2013328. https:\/\/doi.org\/10.1016\/j.bbrc.2011.06.140","journal-title":"Biochem Biophys Res Commun"},{"key":"9706_CR15","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/2044-5040-1-19","volume":"1","author":"TN Burks","year":"2011","unstructured":"Burks TN, Cohn RD (2011) Role of TGF-\u03b2 signaling in inherited and acquired myopathies. Skelet Muscle 1:19. https:\/\/doi.org\/10.1186\/2044-5040-1-19","journal-title":"Skelet Muscle"},{"key":"9706_CR16","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1093\/gerona\/gln031","volume":"64","author":"M Cesari","year":"2009","unstructured":"Cesari M, Pahor M, Lauretani F et al (2009) Skeletal muscle and mortality results from the InCHIANTI study. J Gerontol Biol Sci Med Sci 64:377\u2013384. https:\/\/doi.org\/10.1093\/gerona\/gln031","journal-title":"J Gerontol Biol Sci Med Sci"},{"key":"9706_CR17","doi-asserted-by":"publisher","first-page":"906","DOI":"10.2174\/138161210790883453","volume":"16","author":"S Ciciliot","year":"2010","unstructured":"Ciciliot S, Schiaffino S (2010) Regeneration of mammalian skeletal muscle. Basic mechanisms and clinical implications. Curr Pharm Des 16:906\u2013914. https:\/\/doi.org\/10.2174\/138161210790883453","journal-title":"Curr Pharm Des"},{"key":"9706_CR18","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/nm1536","volume":"13","author":"RD Cohn","year":"2007","unstructured":"Cohn RD, van Erp C, Habashi JP et al (2007) Angiotensin II type 1 receptor Blockade attenuates TGF-beta-induced failure of muscle regeneration in multiple myopathic States. Nat Med 13:204\u2013210. https:\/\/doi.org\/10.1038\/nm1536","journal-title":"Nat Med"},{"key":"9706_CR19","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1172\/JCI71059","volume":"124","author":"JR Cook","year":"2014","unstructured":"Cook JR, Carta L, B\u00e9nard L et al (2014) Abnormal muscle mechanosignaling triggers cardiomyopathy in mice with Marfan syndrome. J Clin Invest 124:1329\u20131339. https:\/\/doi.org\/10.1172\/JCI71059","journal-title":"J Clin Invest"},{"key":"9706_CR20","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1080\/10976640701317028","volume":"9","author":"JG Crilley","year":"2007","unstructured":"Crilley JG, Bendahan D, Boehm EA et al (2007) Investigation of muscle bioenergetics in the Marfan syndrome indicates reduced metabolic efficiency. J Cardiovasc Magn Reson 9:709\u2013717. https:\/\/doi.org\/10.1080\/10976640701317028","journal-title":"J Cardiovasc Magn Reson"},{"key":"9706_CR21","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1159\/000082265","volume":"7","author":"S De Bie","year":"2004","unstructured":"De Bie S, De Paepe A, Delvaux I et al (2004) Marfan syndrome in Europe. Public Health Genomics 7:216\u2013225. https:\/\/doi.org\/10.1159\/000082265","journal-title":"Public Health Genomics"},{"key":"9706_CR22","doi-asserted-by":"publisher","first-page":"1057070","DOI":"10.3389\/fped.2023.1057070","volume":"11","author":"L de Koning","year":"2023","unstructured":"de Koning L, Warnink-Kavelaars J, van Rossum M et al (2023) Physical activity and physical fitness in children with heritable connective tissue disorders. Front Pediatr 11:1057070. https:\/\/doi.org\/10.3389\/fped.2023.1057070","journal-title":"Front Pediatr"},{"key":"9706_CR23","doi-asserted-by":"publisher","unstructured":"de Koning L, Warnink-Kavelaars J, van Vulpen L et al (2025) Intensive physical training in children with heritable connective tissue disorders is feasible and safe: a pilot study. Disabil Rehabil 1\u201310. https:\/\/doi.org\/10.1080\/09638288.2025.2467772","DOI":"10.1080\/09638288.2025.2467772"},{"key":"9706_CR24","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1002\/(SICI)1096-8628(19960424)62:4<417::AID-AJMG15>3.0.CO;2-R","volume":"62","author":"A De Paepe","year":"1996","unstructured":"De Paepe A, Devereux RB, Dietz HC et al (1996) Revised diagnostic criteria for the Marfan syndrome. Am J Med Genet 62:417\u2013426. https:\/\/doi.org\/10.1002\/(SICI)1096-8628(19960424)62:4<417::AID-AJMG15>3.0.CO;2-R","journal-title":"Am J Med Genet"},{"key":"9706_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2021.116073","volume":"152","author":"RB de Souza","year":"2021","unstructured":"de Souza RB, Kawahara EI, Farinha-Arcieri LE et al (2021) Hyperkyphosis is not dependent on bone mass and quality in the mouse model of Marfan syndrome. Bone 152:116073. https:\/\/doi.org\/10.1016\/j.bone.2021.116073","journal-title":"Bone"},{"key":"9706_CR26","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1002\/cbin.10725","volume":"41","author":"K Delaney","year":"2017","unstructured":"Delaney K, Kasprzycka P, Ciemerych MA, Zimowska M (2017) The role of TGF-\u03b21 during skeletal muscle regeneration. Cell Biol Int 41:706\u2013715. https:\/\/doi.org\/10.1002\/cbin.10725","journal-title":"Cell Biol Int"},{"key":"9706_CR27","doi-asserted-by":"publisher","first-page":"755","DOI":"10.2147\/JEP.S265271","volume":"13","author":"V Deleeuw","year":"2021","unstructured":"Deleeuw V, De Clercq A, De Backer J, Sips P (2021) An overview of investigational and experimental drug treatment strategies for Marfan syndrome. J Exp Pharmacol 13:755\u2013779. https:\/\/doi.org\/10.2147\/JEP.S265271","journal-title":"J Exp Pharmacol"},{"key":"9706_CR28","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10100751","volume":"10","author":"A Demolder","year":"2020","unstructured":"Demolder A, von Kodolitsch Y, Mui\u00f1o-Mosquera L, De Backer J (2020) Myocardial function, heart failure and arrhythmia in Marfan syndrome: a systematic literature review. Diagnostics 10:751. https:\/\/doi.org\/10.3390\/diagnostics10100751","journal-title":"Diagnostics"},{"key":"9706_CR29","doi-asserted-by":"publisher","first-page":"21457","DOI":"10.1038\/s41598-024-72533-6","volume":"14","author":"A Deprez","year":"2024","unstructured":"Deprez A, El-Jalbout R, Cloutier A et al (2024) Adults born preterm have lower peripheral skeletal muscle area and strength. Sci Rep 14:21457. https:\/\/doi.org\/10.1038\/s41598-024-72533-6","journal-title":"Sci Rep"},{"key":"9706_CR30","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1086\/521409","volume":"81","author":"HC Dietz","year":"2007","unstructured":"Dietz HC (2007) 2006 Curt Stern award address. Marfan syndrome: from molecules to medicines. Am J Hum Genet 81:662\u2013667. https:\/\/doi.org\/10.1086\/521409","journal-title":"Am J Hum Genet"},{"key":"9706_CR31","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/352337a0","volume":"352","author":"HC Dietz","year":"1991","unstructured":"Dietz HC, Cutting GR, Pyeritz RE et al (1991) Marfan syndrome caused by a recurrent de Novo missense mutation in the fibrillin gene. Nature 352:337\u2013339. https:\/\/doi.org\/10.1038\/352337a0","journal-title":"Nature"},{"key":"9706_CR32","doi-asserted-by":"publisher","first-page":"22426","DOI":"10.1038\/srep22426","volume":"6","author":"GR Fernandes","year":"2016","unstructured":"Fernandes GR, Massironi SMG, Pereira LV (2016) Identification of loci modulating the cardiovascular and skeletal phenotypes of Marfan syndrome in mice. Sci Rep 6:22426. https:\/\/doi.org\/10.1038\/srep22426","journal-title":"Sci Rep"},{"key":"9706_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cytogfr.2018.05.001","volume":"41","author":"L Forcina","year":"2018","unstructured":"Forcina L, Miano C, Musar\u00f2 A (2018) The physiopathologic interplay between stem cells and tissue niche in muscle regeneration and the role of IL-6 on muscle homeostasis and diseases. Cytokine Growth Factor Rev 41:1\u20139. https:\/\/doi.org\/10.1016\/j.cytogfr.2018.05.001","journal-title":"Cytokine Growth Factor Rev"},{"key":"9706_CR34","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1161\/CIRCGENETICS.114.000950","volume":"8","author":"R Franken","year":"2015","unstructured":"Franken R, den Hartog AW, Radonic T et al (2015) Beneficial outcome of Losartan therapy depends on type of FBN1 mutation in Marfan syndrome. Circ Cardiovasc Genet 8:383\u2013388. https:\/\/doi.org\/10.1161\/CIRCGENETICS.114.000950","journal-title":"Circ Cardiovasc Genet"},{"key":"9706_CR35","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1111\/j.1651-2227.1997.tb15176.x","volume":"86","author":"J Fuchs","year":"1997","unstructured":"Fuchs J (1997) Marfan syndrome and other systemic disorders with congenital ectopia lentis. A Danish national survey. Acta Paediatr 86:947\u2013952. https:\/\/doi.org\/10.1111\/j.1651-2227.1997.tb15176.x","journal-title":"Acta Paediatr"},{"key":"9706_CR36","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.arr.2009.09.001","volume":"9","author":"L-G Gao","year":"2010","unstructured":"Gao L-G, Luo F, Hui R-T, Zhou X-L (2010) Recent molecular biological progress in Marfan syndrome and Marfan-associated disorders. Ageing Res Rev 9:363\u2013368. https:\/\/doi.org\/10.1016\/j.arr.2009.09.001","journal-title":"Ageing Res Rev"},{"key":"9706_CR37","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1097\/00008480-200202000-00006","volume":"14","author":"PF Giampietro","year":"2002","unstructured":"Giampietro PF, Raggio C, Davis JG (2002) Marfan syndrome: orthopedic and genetic review. Curr Opin Pediatr 14:35\u201341. https:\/\/doi.org\/10.1097\/00008480-200202000-00006","journal-title":"Curr Opin Pediatr"},{"key":"9706_CR38","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1002\/jor.1100170424","volume":"17","author":"A Gigante","year":"1999","unstructured":"Gigante A, Chillemi C, Potter KA et al (1999) Elastic fibers of musculoskeletal tissues in bovine Marfan syndrome: a morphometric study. J Orthop Res 17:624\u2013628. https:\/\/doi.org\/10.1002\/jor.1100170424","journal-title":"J Orthop Res"},{"key":"9706_CR39","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1002\/mus.22094","volume":"44","author":"AR Gillies","year":"2011","unstructured":"Gillies AR, Lieber RL (2011) Structure and function of the skeletal muscle extracellular matrix. Muscle Nerve 44:318\u2013331. https:\/\/doi.org\/10.1002\/mus.22094","journal-title":"Muscle Nerve"},{"key":"9706_CR40","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1113\/JP273376","volume":"595","author":"AR Gillies","year":"2017","unstructured":"Gillies AR, Chapman MA, Bushong EA et al (2017) High resolution three-dimensional reconstruction of fibrotic skeletal muscle extracellular matrix. J Physiol 595:1159\u20131171. https:\/\/doi.org\/10.1113\/JP273376","journal-title":"J Physiol"},{"key":"9706_CR41","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1038\/s41467-020-20289-8","volume":"12","author":"F Girardi","year":"2021","unstructured":"Girardi F, Taleb A, Ebrahimi M et al (2021) TGF\u03b2 signaling curbs cell fusion and muscle regeneration. Nat Commun 12:750. https:\/\/doi.org\/10.1038\/s41467-020-20289-8","journal-title":"Nat Commun"},{"key":"9706_CR42","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1080\/16501970306095","volume":"35","author":"L Giske","year":"2003","unstructured":"Giske L, Stanghelle JK, Rand-Hendrikssen S et al (2003) Pulmonary function, working capacity and strength in young adults with Marfan syndrome. J Rehabil Med 35:221\u2013228. https:\/\/doi.org\/10.1080\/16501970306095","journal-title":"J Rehabil Med"},{"key":"9706_CR43","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1093\/rheumatology\/34.2.126","volume":"34","author":"R Grahame","year":"1995","unstructured":"Grahame R, Pyeritz RE (1995) The Marfan syndrome: joint and skin manifestations are prevalent and correlated. Br J Rheumatol 34:126\u2013131. https:\/\/doi.org\/10.1093\/rheumatology\/34.2.126","journal-title":"Br J Rheumatol"},{"key":"9706_CR44","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1111\/j.1399-0004.1998.tb03714.x","volume":"54","author":"J Gray","year":"1998","unstructured":"Gray J, Bridges A, West R et al (1998) Life expectancy in British Marfan syndrome populations. Clin Genet 54:124\u2013128. https:\/\/doi.org\/10.1111\/j.1399-0004.1998.tb03714.x","journal-title":"Clin Genet"},{"key":"9706_CR45","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1007\/s00429-018-1631-3","volume":"223","author":"RMS Gutierrez","year":"2018","unstructured":"Gutierrez RMS, Ricci NA, Gomes QRS et al (2018) The effects of acrobatic exercise on brain plasticity: a systematic review of animal studies. Brain Struct Funct 223:2055\u20132071. https:\/\/doi.org\/10.1007\/s00429-018-1631-3","journal-title":"Brain Struct Funct"},{"key":"9706_CR46","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1126\/science.1124287","volume":"312","author":"JP Habashi","year":"2006","unstructured":"Habashi JP, Judge DP, Holm TM et al (2006) Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science 312:117\u2013121. https:\/\/doi.org\/10.1126\/science.1124287","journal-title":"Science"},{"key":"9706_CR47","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1002\/jbmr.2471","volume":"30","author":"E Haine","year":"2015","unstructured":"Haine E, Salles J-P, Van Kien K P, et al (2015) Muscle and bone impairment in children with Marfan syndrome: correlation with age and FBN1 genotype. J Bone Min Res 30:1369\u20131376. https:\/\/doi.org\/10.1002\/jbmr.2471","journal-title":"J Bone Min Res"},{"key":"9706_CR48","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1111\/j.1742-1241.2007.01407.x","volume":"61","author":"A Hasan","year":"2007","unstructured":"Hasan A, Poloniecki J, Child A (2007) Ageing in Marfan syndrome. Int J Clin Pract 61:1308\u20131320. https:\/\/doi.org\/10.1111\/j.1742-1241.2007.01407.x","journal-title":"Int J Clin Pract"},{"key":"9706_CR49","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/1471-2288-14-43","volume":"14","author":"CR Hooijmans","year":"2014","unstructured":"Hooijmans CR, Rovers MM, de Vries RBM et al (2014) SYRCLE\u2019s risk of bias tool for animal studies. BMC Med Res Methodol 14:43. https:\/\/doi.org\/10.1186\/1471-2288-14-43","journal-title":"BMC Med Res Methodol"},{"key":"9706_CR50","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20102446","volume":"20","author":"A Ismaeel","year":"2019","unstructured":"Ismaeel A, Kim J-S, Kirk JS et al (2019) Role of transforming growth factor-\u03b2 in skeletal muscle fibrosis: a review. Int J Mol Sci 20:2446. https:\/\/doi.org\/10.3390\/ijms20102446","journal-title":"Int J Mol Sci"},{"key":"9706_CR51","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/s0002-9394(14)70069-8","volume":"117","author":"NJ Izquierdo","year":"1994","unstructured":"Izquierdo NJ, Traboulsi EI, Enger C, Maumenee IH (1994) Strabismus in the Marfan syndrome. Am J Ophthalmol 117:632\u2013635. https:\/\/doi.org\/10.1016\/s0002-9394(14)70069-8","journal-title":"Am J Ophthalmol"},{"key":"9706_CR52","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1023\/a:1020904518336","volume":"23","author":"TAH J\u00e4rvinen","year":"2002","unstructured":"J\u00e4rvinen TAH, J\u00f3zsa L, Kannus P et al (2002) Organization and distribution of intramuscular connective tissue in normal and immobilized skeletal muscles. An immunohistochemical, polarization and scanning electron microscopic study. J Muscle Res Cell Motil 23:245\u2013254. https:\/\/doi.org\/10.1023\/a:1020904518336","journal-title":"J Muscle Res Cell Motil"},{"key":"9706_CR53","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s13005-024-00427-z","volume":"20","author":"T Jenabzadeh","year":"2024","unstructured":"Jenabzadeh T, Bohner L, K\u00f6ppe J et al (2024) Temporomandibular disorders in individuals with Marfan syndrome: an exploratory analysis. Head Face Med 20:26. https:\/\/doi.org\/10.1186\/s13005-024-00427-z","journal-title":"Head Face Med"},{"key":"9706_CR54","doi-asserted-by":"publisher","first-page":"263","DOI":"10.5582\/irdr.2021.01080","volume":"10","author":"S Jouini","year":"2021","unstructured":"Jouini S, Milleron O, Eliahou L et al (2021) Effects of a personalized home-based training program among patients suffering from Marfan syndrome: a pilot randomized and controlled study. Intractable Rare Dis Res 10:263\u2013268. https:\/\/doi.org\/10.5582\/irdr.2021.01080","journal-title":"Intractable Rare Dis Res"},{"key":"9706_CR55","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.033024","volume":"13","author":"S Jouini","year":"2024","unstructured":"Jouini S, Milleron O, Eliahou L et al (2024) Online personal training in patients with Marfan syndrome: A randomized controlled study of its impact on quality of life and physical capacity. J Am Heart Assoc 13:e033024. https:\/\/doi.org\/10.1161\/JAHA.123.033024","journal-title":"J Am Heart Assoc"},{"key":"9706_CR56","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1016\/S0140-6736(05)67789-6","volume":"366","author":"DP Judge","year":"2005","unstructured":"Judge DP, Dietz HC (2005) Marfan\u2019s syndrome. Lancet 366:1965\u20131976. https:\/\/doi.org\/10.1016\/S0140-6736(05)67789-6","journal-title":"Lancet"},{"key":"9706_CR57","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1172\/JCI20641","volume":"114","author":"DP Judge","year":"2004","unstructured":"Judge DP, Biery NJ, Keene DR et al (2004) Evidence for a critical contribution of haploinsufficiency in the complex pathogenesis of Marfan syndrome. J Clin Invest 114:172\u2013181. https:\/\/doi.org\/10.1172\/JCI20641","journal-title":"J Clin Invest"},{"key":"9706_CR58","doi-asserted-by":"publisher","first-page":"a022293","DOI":"10.1101\/cshperspect.a022293","volume":"10","author":"KK Kim","year":"2018","unstructured":"Kim KK, Sheppard D, Chapman HA (2018) TGF-\u03b21 signaling and tissue fibrosis. Cold Spring Harb Perspect Biol 10:a022293. https:\/\/doi.org\/10.1101\/cshperspect.a022293","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"9706_CR59","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1136\/bjophthalmol-2021-320871","volume":"107","author":"S Kjeldsen","year":"2023","unstructured":"Kjeldsen S, Andersen N, Groth K et al (2023) Ocular morbidity in Marfan syndrome: a nationwide epidemiological study. Br J Ophthalmol 107:1051\u20131055. https:\/\/doi.org\/10.1136\/bjophthalmol-2021-320871","journal-title":"Br J Ophthalmol"},{"key":"9706_CR60","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1097\/SPC.0b013e3282f31667","volume":"1","author":"M Lainscak","year":"2007","unstructured":"Lainscak M, Podbregar M, Anker SD (2007) How does cachexia influence survival in cancer, heart failure and other chronic diseases? Curr Opin Support Palliat Care 1:299\u2013305. https:\/\/doi.org\/10.1097\/SPC.0b013e3282f31667","journal-title":"Curr Opin Support Palliat Care"},{"key":"9706_CR61","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1038\/nm.3869","volume":"21","author":"DR Lemos","year":"2015","unstructured":"Lemos DR, Babaeijandaghi F, Low M et al (2015) Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro\/adipogenic progenitors. Nat Med 21:786\u2013794. https:\/\/doi.org\/10.1038\/nm.3869","journal-title":"Nat Med"},{"issue":"5","key":"9706_CR62","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v17.i5.107320","volume":"17","author":"P Li","year":"2025","unstructured":"Li P, Zhang H (2025) Osteosarcopenia in older adults undergoing transcatheter aortic valve replacement: a narrative review of mortality and frailty implications. World J Cardiol 17(5):107320. https:\/\/doi.org\/10.4330\/wjc.v17.i5.107320","journal-title":"World J Cardiol"},{"key":"9706_CR63","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/s0002-9440(10)63188-4","volume":"164","author":"Y Li","year":"2004","unstructured":"Li Y, Foster W, Deasy BM et al (2004) Transforming growth factor-beta1 induces the differentiation of myogenic cells into fibrotic cells in injured skeletal muscle: a key event in muscle fibrogenesis. Am J Pathol 164:1007\u20131019. https:\/\/doi.org\/10.1016\/s0002-9440(10)63188-4","journal-title":"Am J Pathol"},{"key":"9706_CR64","doi-asserted-by":"publisher","first-page":"e14136","DOI":"10.1371\/journal.pone.0014136","volume":"5","author":"BL Lima","year":"2010","unstructured":"Lima BL, Santos EJC, Fernandes GR et al (2010) A new mouse model for Marfan syndrome presents phenotypic variability associated with the genetic background and overall levels of Fbn1 expression. PLoS One 5:e14136. https:\/\/doi.org\/10.1371\/journal.pone.0014136","journal-title":"PLoS One"},{"key":"9706_CR65","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1136\/jmg.2009.072785","volume":"47","author":"BL Loeys","year":"2010","unstructured":"Loeys BL, Dietz HC, Braverman AC et al (2010) The revised Ghent nosology for the Marfan syndrome. J Med Genet 47:476\u2013485. https:\/\/doi.org\/10.1136\/jmg.2009.072785","journal-title":"J Med Genet"},{"key":"9706_CR66","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1093\/gerona\/glr010","volume":"67","author":"TM Manini","year":"2012","unstructured":"Manini TM, Clark BC (2012) Dynapenia and aging: an update. J Gerontol A Biol Sci Med Sci 67:28\u201340. https:\/\/doi.org\/10.1093\/gerona\/glr010","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"9706_CR67","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1038\/nrm3434","volume":"13","author":"J Massagu\u00e9","year":"2012","unstructured":"Massagu\u00e9 J (2012) TGF\u03b2 signalling in context. Nat Rev Mol Cell Biol 13:616\u2013630. https:\/\/doi.org\/10.1038\/nrm3434","journal-title":"Nat Rev Mol Cell Biol"},{"key":"9706_CR68","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1161\/01.cir.78.2.320","volume":"78","author":"BM Massie","year":"1988","unstructured":"Massie BM, Conway M, Rajagopalan B et al (1988) Skeletal muscle metabolism during exercise under ischemic conditions in congestive heart failure. Evidence for abnormalities unrelated to blood flow. Circulation 78:320\u2013326. https:\/\/doi.org\/10.1161\/01.cir.78.2.320","journal-title":"Circulation"},{"key":"9706_CR69","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1161\/CIRCULATIONAHA.108.841981","volume":"120","author":"P Matt","year":"2009","unstructured":"Matt P, Schoenhoff F, Habashi J et al (2009) Circulating transforming growth factor-beta in Marfan syndrome. Circulation 120:526\u2013532. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.108.841981","journal-title":"Circulation"},{"key":"9706_CR70","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1007\/s11739-016-1399-5","volume":"11","author":"D Melchiorre","year":"2016","unstructured":"Melchiorre D, Pratelli E, Torricelli E et al (2016) A group of patients with Marfan\u2019s syndrome, who have finger and toe contractures, displays tendons\u2019 alterations upon an ultrasound examination: are these features common among classical Marfan patients? Intern Emerg Med 11:703\u2013711. https:\/\/doi.org\/10.1007\/s11739-016-1399-5","journal-title":"Intern Emerg Med"},{"key":"9706_CR71","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1002\/mus.22232","volume":"45","author":"CL Mendias","year":"2012","unstructured":"Mendias CL, Gumucio JP, Davis ME et al (2012) Transforming growth factor-beta induces skeletal muscle atrophy and fibrosis through the induction of atrogin-1 and scleraxis. Muscle Nerve 45:55\u201359. https:\/\/doi.org\/10.1002\/mus.22232","journal-title":"Muscle Nerve"},{"key":"9706_CR72","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/nrneph.2016.48","volume":"12","author":"X-M Meng","year":"2016","unstructured":"Meng X-M, Nikolic-Paterson DJ, Lan HY (2016) TGF-\u03b2: the master regulator of fibrosis. Nat Rev Nephrol 12:325\u2013338. https:\/\/doi.org\/10.1038\/nrneph.2016.48","journal-title":"Nat Rev Nephrol"},{"key":"9706_CR73","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1007\/s12079-017-0409-3","volume":"12","author":"MG Morales","year":"2018","unstructured":"Morales MG, Acu\u00f1a MJ, Cabrera D et al (2018) The pro-fibrotic connective tissue growth factor (CTGF\/CCN2) correlates with the number of necrotic-regenerative foci in dystrophic muscle. J Cell Commun Signal 12:413\u2013421. https:\/\/doi.org\/10.1007\/s12079-017-0409-3","journal-title":"J Cell Commun Signal"},{"key":"9706_CR74","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/ng1116","volume":"33","author":"ER Neptune","year":"2003","unstructured":"Neptune ER, Frischmeyer PA, Arking DE et al (2003) Dysregulation of TGF-\u03b2 activation contributes to pathogenesis in Marfan syndrome. Nat Genet 33:407\u2013411. https:\/\/doi.org\/10.1038\/ng1116","journal-title":"Nat Genet"},{"key":"9706_CR75","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1172\/JCI22715","volume":"114","author":"CM Ng","year":"2004","unstructured":"Ng CM, Cheng A, Myers LA et al (2004) TGF-beta-dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome. J Clin Invest 114:1586\u20131592. https:\/\/doi.org\/10.1172\/JCI22715","journal-title":"J Clin Invest"},{"key":"9706_CR76","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1186\/s13023-025-03869-z","volume":"20","author":"M Nordeborn","year":"2025","unstructured":"Nordeborn M, Brandt N, Cider \u00c5, Ashman Kr\u00f6\u00f6nstr\u00f6m L (2025) Physical fitness and level of physical activity in adult patients with Marfan syndrome. Orphanet J Rare Dis 20:346. https:\/\/doi.org\/10.1186\/s13023-025-03869-z","journal-title":"Orphanet J Rare Dis"},{"key":"9706_CR77","doi-asserted-by":"publisher","first-page":"H1112","DOI":"10.1152\/ajpheart.00089.2018","volume":"315","author":"SJ Parker","year":"2018","unstructured":"Parker SJ, Stotland A, MacFarlane E et al (2018) Proteomics reveals rictor as a noncanonical TGF-\u03b2 signaling target during aneurysm progression in Marfan mice. Am J Physiol Heart Circ Physiol 315:H1112\u2013H1126. https:\/\/doi.org\/10.1152\/ajpheart.00089.2018","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"9706_CR78","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1111\/febs.14417","volume":"285","author":"LA Perandini","year":"2018","unstructured":"Perandini LA, Chimin P, Lutkemeyer D, da C\u00e2mara S NOS (2018) Chronic inflammation in skeletal muscle impairs satellite cells function during regeneration: can physical exercise restore the satellite cell niche? FEBS J 285:1973\u20131984. https:\/\/doi.org\/10.1111\/febs.14417","journal-title":"FEBS J"},{"key":"9706_CR79","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1093\/rheumatology\/kel450","volume":"46","author":"G Percheron","year":"2007","unstructured":"Percheron G, Fayet G, Ningler T et al (2007) Muscle strength and body composition in adult women with Marfan syndrome. Rheumatology (Oxford) 46:957\u2013962. https:\/\/doi.org\/10.1093\/rheumatology\/kel450","journal-title":"Rheumatology (Oxford)"},{"key":"9706_CR80","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1146\/annurev.med.51.1.481","volume":"51","author":"RE Pyeritz","year":"2000","unstructured":"Pyeritz RE (2000) The Marfan syndrome. Annu Rev Med 51:481\u2013510. https:\/\/doi.org\/10.1146\/annurev.med.51.1.481","journal-title":"Annu Rev Med"},{"key":"9706_CR81","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1111\/j.1399-0004.2011.01646.x","volume":"80","author":"T Radonic","year":"2011","unstructured":"Radonic T, de Witte P, Groenink M et al (2011) Critical appraisal of the revised Ghent criteria for diagnosis of Marfan syndrome. Clin Genet 80:346\u2013353. https:\/\/doi.org\/10.1111\/j.1399-0004.2011.01646.x","journal-title":"Clin Genet"},{"key":"9706_CR82","doi-asserted-by":"publisher","first-page":"e32963","DOI":"10.1371\/journal.pone.0032963","volume":"7","author":"T Radonic","year":"2012","unstructured":"Radonic T, de Witte P, Groenink M et al (2012) Inflammation aggravates disease severity in Marfan syndrome patients. PLoS One 7:e32963. https:\/\/doi.org\/10.1371\/journal.pone.0032963","journal-title":"PLoS One"},{"key":"9706_CR83","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1097\/GIM.0b013e3181ea4c1c","volume":"12","author":"S Rand-Hendriksen","year":"2010","unstructured":"Rand-Hendriksen S, Johansen H, Semb SO et al (2010) Health-related quality of life in Marfan syndrome: a cross-sectional study of short form 36 in 84 adults with a verified diagnosis. Genet Med 12:517\u2013524. https:\/\/doi.org\/10.1097\/GIM.0b013e3181ea4c1c","journal-title":"Genet Med"},{"key":"9706_CR84","doi-asserted-by":"publisher","first-page":"M168","DOI":"10.1093\/gerona\/55.3.m168","volume":"55","author":"T Rantanen","year":"2000","unstructured":"Rantanen T, Harris T, Leveille SG et al (2000) Muscle strength and body mass index as long-term predictors of mortality in initially healthy men. J Gerontol Biol Sci Med Sci 55:M168\u2013173. https:\/\/doi.org\/10.1093\/gerona\/55.3.m168","journal-title":"J Gerontol Biol Sci Med Sci"},{"key":"9706_CR85","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1136\/jmg.37.1.9","volume":"37","author":"PN Robinson","year":"2000","unstructured":"Robinson PN, Godfrey M (2000) The molecular genetics of Marfan syndrome and related microfibrillopathies. J Med Genet 37:9\u201325. https:\/\/doi.org\/10.1136\/jmg.37.1.9","journal-title":"J Med Genet"},{"key":"9706_CR86","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1016\/j.jpeds.2005.06.011","volume":"147","author":"L Rozendaal","year":"2005","unstructured":"Rozendaal L, le Cessie S, Wit JM et al (2005) Growth-reductive therapy in children with Marfan syndrome. J Pediatr 147:674\u2013679. https:\/\/doi.org\/10.1016\/j.jpeds.2005.06.011","journal-title":"J Pediatr"},{"key":"9706_CR87","doi-asserted-by":"publisher","first-page":"4118","DOI":"10.1111\/febs.12166","volume":"280","author":"M Saclier","year":"2013","unstructured":"Saclier M, Cuvellier S, Magnan M et al (2013) Monocyte\/macrophage interactions with myogenic precursor cells during skeletal muscle regeneration. FEBS J 280:4118\u20134130. https:\/\/doi.org\/10.1111\/febs.12166","journal-title":"FEBS J"},{"key":"9706_CR88","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1093\/ageing\/afl024","volume":"35","author":"AA Sayer","year":"2006","unstructured":"Sayer AA, Syddall HE, Martin HJ et al (2006) Is grip strength associated with health-related quality of life? Findings from the Hertfordshire cohort study. Age Ageing 35:409\u2013415. https:\/\/doi.org\/10.1093\/ageing\/afl024","journal-title":"Age Ageing"},{"key":"9706_CR89","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.semcdb.2016.09.013","volume":"64","author":"AL Serrano","year":"2017","unstructured":"Serrano AL, Mu\u00f1oz-C\u00e1noves P (2017) Fibrosis development in early-onset muscular dystrophies: mechanisms and translational implications. Semin Cell Dev Biol 64:181\u2013190. https:\/\/doi.org\/10.1016\/j.semcdb.2016.09.013","journal-title":"Semin Cell Dev Biol"},{"key":"9706_CR90","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/B978-0-12-385940-2.00007-3","volume":"96","author":"AL Serrano","year":"2011","unstructured":"Serrano AL, Mann CJ, Vidal B et al (2011) Cellular and molecular mechanisms regulating fibrosis in skeletal muscle repair and disease. Curr Top Dev Biol 96:167\u2013201. https:\/\/doi.org\/10.1016\/B978-0-12-385940-2.00007-3","journal-title":"Curr Top Dev Biol"},{"key":"9706_CR91","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s11357-009-9103-6","volume":"31","author":"MJ Sherratt","year":"2009","unstructured":"Sherratt MJ (2009) Tissue elasticity and the ageing elastic fibre. Age (Dordr) 31:305\u2013325. https:\/\/doi.org\/10.1007\/s11357-009-9103-6","journal-title":"Age (Dordr)"},{"key":"9706_CR92","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S0002-9149(00)80066-1","volume":"75","author":"DI Silverman","year":"1995","unstructured":"Silverman DI, Burton KJ, Gray J et al (1995) Life expectancy in the Marfan syndrome. Am J Cardiol 75:157\u2013160. https:\/\/doi.org\/10.1016\/S0002-9149(00)80066-1","journal-title":"Am J Cardiol"},{"key":"9706_CR93","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2018.01.014","author":"LR Smith","year":"2018","unstructured":"Smith LR, Barton ER (2018) Regulation of fibrosis in muscular dystrophy. Matrix Biol. https:\/\/doi.org\/10.1016\/j.matbio.2018.01.014","journal-title":"Matrix Biol"},{"key":"9706_CR94","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3389\/fphys.2018.00077","volume":"9","author":"ME Soto","year":"2018","unstructured":"Soto ME, Guarner-Lans V, Herrera-Morales KY, P\u00e9rez-Torres I (2018) Participation of arachidonic acid metabolism in the aortic aneurysm formation in patients with Marfan syndrome. Front Physiol 9:77. https:\/\/doi.org\/10.3389\/fphys.2018.00077","journal-title":"Front Physiol"},{"key":"9706_CR95","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21197024","volume":"21","author":"F Steijns","year":"2020","unstructured":"Steijns F, Renard M, Vanhomwegen M et al (2020) Spontaneous right ventricular pseudoaneurysms and increased arrhythmogenicity in a mouse model of Marfan syndrome. Int J Mol Sci 21:7024. https:\/\/doi.org\/10.3390\/ijms21197024","journal-title":"Int J Mol Sci"},{"key":"9706_CR96","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1186\/s13023-020-01569-4","volume":"15","author":"R Stengl","year":"2020","unstructured":"Stengl R, Bors A, \u00c1gg B et al (2020) Optimising the mutation screening strategy in Marfan syndrome and identifying genotypes with more severe aortic involvement. Orphanet J Rare Dis 15:290. https:\/\/doi.org\/10.1186\/s13023-020-01569-4","journal-title":"Orphanet J Rare Dis"},{"key":"9706_CR97","doi-asserted-by":"publisher","first-page":"787","DOI":"10.21037\/cdt-22-383","volume":"12","author":"MN Suleiman","year":"2022","unstructured":"Suleiman MN, Freilinger S, Meierhofer C et al (2022) The relation of aortic dimensions and obesity in adults with Marfan or Loeys-Dietz syndrome. Cardiovasc Diagn Ther 12:787\u2013802. https:\/\/doi.org\/10.21037\/cdt-22-383","journal-title":"Cardiovasc Diagn Ther"},{"key":"9706_CR98","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1093\/ageing\/afg111","volume":"32","author":"H Syddall","year":"2003","unstructured":"Syddall H, Cooper C, Martin F et al (2003) Is grip strength a useful single marker of frailty? Age Ageing 32:650\u2013656. https:\/\/doi.org\/10.1093\/ageing\/afg111","journal-title":"Age Ageing"},{"key":"9706_CR99","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1097\/MCO.0b013e328300ecc1","volume":"11","author":"BHL Tan","year":"2008","unstructured":"Tan BHL, Fearon KCH (2008) Cachexia: prevalence and impact in medicine. Curr Opin Clin Nutr Metab Care 11:400\u2013407. https:\/\/doi.org\/10.1097\/MCO.0b013e328300ecc1","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"9706_CR100","doi-asserted-by":"publisher","first-page":"e13889","DOI":"10.1111\/apha.13889","volume":"237","author":"M Tomaz da Silva","year":"2023","unstructured":"Tomaz da Silva M, Santos AR, Koike TE et al (2023) The fibrotic niche impairs satellite cell function and muscle regeneration in mouse models of Marfan syndrome. Acta Physiol (Oxf) 237:e13889. https:\/\/doi.org\/10.1111\/apha.13889","journal-title":"Acta Physiol (Oxf)"},{"key":"9706_CR101","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14267","volume":"7","author":"PHT Tran","year":"2019","unstructured":"Tran PHT, Skrba T, Wondimu E et al (2019) The influence of fibrillin-1 and physical activity upon tendon tissue morphology and mechanical properties in mice. Physiol Rep 7:e14267. https:\/\/doi.org\/10.14814\/phy2.14267","journal-title":"Physiol Rep"},{"key":"9706_CR102","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1111\/scd.12018","volume":"33","author":"AKL Tsang","year":"2013","unstructured":"Tsang AKL, Taverne A, Holcombe T (2013) Marfan syndrome: a review of the literature and case report. Spec Care Dentist 33:248\u2013254. https:\/\/doi.org\/10.1111\/scd.12018","journal-title":"Spec Care Dentist"},{"key":"9706_CR103","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1136\/adc.84.2.129","volume":"84","author":"CD van Karnebeek","year":"2001","unstructured":"van Karnebeek CD, Naeff MS, Mulder BJ et al (2001) Natural history of cardiovascular manifestations in Marfan syndrome. Arch Dis Child 84:129\u2013137. https:\/\/doi.org\/10.1136\/adc.84.2.129","journal-title":"Arch Dis Child"},{"key":"9706_CR104","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1002\/mgg3.489","volume":"6","author":"TT Vanem","year":"2018","unstructured":"Vanem TT, Geiran OR, Krohg-S\u00f8rensen K et al (2018) Survival, causes of death, and cardiovascular events in patients with Marfan syndrome. Mol Genet Genomic Med 6:1114\u20131123. https:\/\/doi.org\/10.1002\/mgg3.489","journal-title":"Mol Genet Genomic Med"},{"key":"9706_CR105","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1111\/j.1532-5415.2005.53257.x","volume":"53","author":"M Visser","year":"2005","unstructured":"Visser M, Simonsick EM, Colbert LH et al (2005) Type and intensity of activity and risk of mobility limitation: the mediating role of muscle parameters. J Am Geriatr Soc 53:762\u2013770. https:\/\/doi.org\/10.1111\/j.1532-5415.2005.53257.x","journal-title":"J Am Geriatr Soc"},{"key":"9706_CR106","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1111\/j.1399-0004.2009.01197.x","volume":"76","author":"Nc Voermans","year":"2009","unstructured":"Voermans Nc, Timmermans J, van Alfen N et al (2009) Neuromuscular features in Marfan syndrome. Clin Genet 76:25\u201337. https:\/\/doi.org\/10.1111\/j.1399-0004.2009.01197.x","journal-title":"Clin Genet"},{"key":"9706_CR107","doi-asserted-by":"publisher","first-page":"137","DOI":"10.2147\/TACG.S60472","volume":"8","author":"Y von Kodolitsch","year":"2015","unstructured":"von Kodolitsch Y, De Backer J, Sch\u00fcler H et al (2015) Perspectives on the revised Ghent criteria for the diagnosis of Marfan syndrome. Appl Clin Genet 8:137\u2013155. https:\/\/doi.org\/10.2147\/TACG.S60472","journal-title":"Appl Clin Genet"},{"key":"9706_CR108","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.bcp.2019.03.034","volume":"164","author":"AH Wagner","year":"2019","unstructured":"Wagner AH, Zaradzki M, Arif R et al (2019) Marfan syndrome: a therapeutic challenge for long-term care. Biochem Pharmacol 164:53\u201363. https:\/\/doi.org\/10.1016\/j.bcp.2019.03.034","journal-title":"Biochem Pharmacol"},{"key":"9706_CR109","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.matbio.2016.02.006","volume":"55","author":"TA Walji","year":"2016","unstructured":"Walji TA, Turecamo SE, DeMarsilis AJ et al (2016) Characterization of metabolic health in mouse models of fibrillin-1 perturbation. Matrix Biol 55:63\u201376. https:\/\/doi.org\/10.1016\/j.matbio.2016.02.006","journal-title":"Matrix Biol"},{"key":"9706_CR110","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.jneuroim.2018.01.004","volume":"317","author":"X Wang","year":"2018","unstructured":"Wang X, Zhao W, Ransohoff RM, Zhou L (2018) Infiltrating macrophages are broadly activated at the early stage to support acute skeletal muscle injury repair. J Neuroimmunol 317:55\u201366. https:\/\/doi.org\/10.1016\/j.jneuroim.2018.01.004","journal-title":"J Neuroimmunol"},{"key":"9706_CR111","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000035382","volume":"102","author":"Y Yoshida","year":"2023","unstructured":"Yoshida Y, Doi T, Oka H et al (2023) Reduced volume and altered composition of paraspinal muscles in Marfan syndrome: a retrospective cohort study. Medicine 102:e35382. https:\/\/doi.org\/10.1097\/MD.0000000000035382","journal-title":"Medicine"},{"key":"9706_CR112","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1089\/ten.TEC.2017.0216","volume":"23","author":"Y Zhou","year":"2017","unstructured":"Zhou Y, Lovell D, Bethea M et al (2017) The impact of age on skeletal muscle progenitor cell survival and fate after injury. Tissue Engineering Part C: Methods 23:1012\u20131021. https:\/\/doi.org\/10.1089\/ten.TEC.2017.0216","journal-title":"Tissue Engineering Part C: Methods"}],"container-title":["Journal of Muscle Research and Cell Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10974-025-09706-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10974-025-09706-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10974-025-09706-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T09:28:39Z","timestamp":1758533319000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10974-025-09706-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,20]]},"references-count":112,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["9706"],"URL":"https:\/\/doi.org\/10.1007\/s10974-025-09706-x","relation":{},"ISSN":["0142-4319","1573-2657"],"issn-type":[{"value":"0142-4319","type":"print"},{"value":"1573-2657","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,20]]},"assertion":[{"value":"15 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 August 2025","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original online version of this article was revised: The correct MOESM2 has been updated","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflicts of interest","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='BoldItalic' removed-->Consent to participate"}},{"value":"All authors have read and agreed to the publication of the manuscript.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='BoldItalic' removed-->Consent for publication"}}]}}