{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:39:31Z","timestamp":1793741971513,"version":"4.6.1"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:00:00Z","timestamp":1740182400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:00:00Z","timestamp":1740182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Matern Child Health J"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>To examine the changes over recent years in neonatal survival to discharge, prevalence of adverse events, surgical procedures, tracheostomy and\/or gastrostomy tube (G-tube) placement, and length of stay (LOS) in infants with Trisomy 13.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We identified newborn infants with Trisomy 13 in the National Inpatient Sample in the years 2003\u20132018. We calculated prevalence of associated conditions. We examined procedures done, and common adverse events associated with each condition, survival rates, and LOS. We also calculated changes in trends over the years.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The study identified 5792 newborn infants with Trisomy 13. Mortality during neonatal period was 58%. There was no significant change in mortality trends over the years, (p\u2009&lt;\u20090.001). Average LOS was 10 (+\u200934) days which had significantly increased over recent years (p\u2009&lt;\u20090.001) and it was highest in conditions of NEC followed by gastrointestinal anomalies and sepsis. Among survivors, 2% were discharged with tracheostomy and 9% with G-tubes. LOS was significantly increased in association with these procedures.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>There was a slight decrease in infants admitted to neonatal intensive care units with Trisomy 13 over recent years. In-hospital neonatal mortality was unchanged. However, there was a significant increase in LOS, which was increased with procedures such as tracheostomy and G-tube placement, which may reflect a trend toward increasing interventions without a corresponding improvement in mortality.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s10995-025-04072-z","type":"journal-article","created":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T21:04:15Z","timestamp":1740258255000},"page":"622-627","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Changes in Hospital Care of Newborn Infants with Trisomy 13"],"prefix":"10.1007","volume":"29","author":[{"given":"Allison O.","family":"Ignatz-Hoover","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1475-2145","authenticated-orcid":false,"given":"Mohsen A. A.","family":"Farghaly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Crist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alshimaa","family":"Abdalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hany","family":"Aly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,22]]},"reference":[{"key":"4072_CR1","unstructured":"Healthcare Cost and Utilization Project (HCUP) Agency for Healthcare Research and Quality; Rockville, MD (2024). HCUP NIS description of data elements. Retrieved September 1, 2025, from www.hcup-us.ahrq.gov\/nisoverview.jsp"},{"issue":"2","key":"4072_CR2","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1542\/peds.2012-0151","volume":"130","author":"A Janvier","year":"2012","unstructured":"Janvier, A., Farlow, B., & Wilfond, B. S. (2012). The experience of families with children with trisomy 13 and 18 in social networks. Pediatrics, 130(2), 293\u2013298.","journal-title":"Pediatrics"},{"issue":"Suppl 1","key":"4072_CR3","doi-asserted-by":"publisher","first-page":"S9","DOI":"10.1542\/peds.2020-0818D","volume":"146","author":"JC Kett","year":"2020","unstructured":"Kett, J. C. (2020). Who is the next \u201cBaby Doe?\u201d from trisomy 21 to trisomy 13 and 18 and beyond. Pediatrics, 146(Suppl 1), S9\u2013S12.","journal-title":"Pediatrics"},{"issue":"4","key":"4072_CR4","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1001\/jama.2016.9470","volume":"316","author":"JD Lantos","year":"2016","unstructured":"Lantos, J. D. (2016). Trisomy 13 and 18\u2013treatment decisions in a stable gray zone. JAMA, 316(4), 396\u2013398.","journal-title":"JAMA"},{"issue":"4","key":"4072_CR5","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1002\/ajmg.a.37495","volume":"170A","author":"RE Meyer","year":"2016","unstructured":"Meyer, R. E., Liu, G., Gilboa, S. M., Ethen, M. K., Aylsworth, A. S., Powell, C. M., Flood, T. J., Mai, C. T., Wang, Y., Canfield, M. A., & Network, N. B. D. P. (2016). Survival of children with trisomy 13 and trisomy 18: A multi-state population-based study. American Journal of Medical Genetics. Part A, 170A(4), 825\u2013837.","journal-title":"American Journal of Medical Genetics. Part A"},{"issue":"5","key":"4072_CR6","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1542\/peds.2011-2139","volume":"129","author":"KE Nelson","year":"2012","unstructured":"Nelson, K. E., Hexem, K. R., & Feudtner, C. (2012). Inpatient hospital care of children with trisomy 13 and trisomy 18 in the United States. Pediatrics, 129(5), 869\u2013876.","journal-title":"Pediatrics"},{"issue":"4","key":"4072_CR7","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1001\/jama.2016.9819","volume":"316","author":"KE Nelson","year":"2016","unstructured":"Nelson, K. E., Rosella, L. C., Mahant, S., & Guttmann, A. (2016). Survival and surgical interventions for children with trisomy 13 and 18. JAMA, 316(4), 420\u2013428.","journal-title":"JAMA"},{"issue":"12","key":"4072_CR8","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1038\/s41372-018-0227-3","volume":"38","author":"JE Nguyen","year":"2018","unstructured":"Nguyen, J. E., Salemi, J. L., Tanner, J. P., Kirby, R. S., Sutsko, R. P., Ashmeade, T. L., Salihu, H. M., & Drach, L. L. (2018). Survival and healthcare utilization of infants diagnosed with lethal congenital malformations. Journal of Perinatology\u202f: Official Journal of the California Perinatal Association, 38(12), 1674\u20131684.","journal-title":"Journal of Perinatology : Official Journal of the California Perinatal Association"},{"issue":"6","key":"4072_CR9","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1016\/j.athoracsur.2017.02.068","volume":"103","author":"JK Peterson","year":"2017","unstructured":"Peterson, J. K., Kochilas, L. K., Catton, K. G., Moller, J. H., & Setty, S. P. (2017). Long-term outcomes of children with trisomy 13 and 18 after congenital heart disease interventions. The Annals of Thoracic Surgery, 103(6), 1941\u20131949.","journal-title":"The Annals of Thoracic Surgery"},{"issue":"9","key":"4072_CR10","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1038\/s41372-018-0151-6","volume":"38","author":"AK Pyle","year":"2018","unstructured":"Pyle, A. K., Fleischman, A. R., Hardart, G., & Mercurio, M. R. (2018). Management options and parental voice in the treatment of trisomy 13 and 18. Journal of Perinatology: Official Journal of the California Perinatal Association, 38(9), 1135\u20131143.","journal-title":"Journal of Perinatology: Official Journal of the California Perinatal Association"},{"issue":"12","key":"4072_CR11","doi-asserted-by":"publisher","first-page":"3062","DOI":"10.1002\/ajmg.a.37355","volume":"167A","author":"A Springett","year":"2015","unstructured":"Springett, A., Wellesley, D., Greenlees, R., Loane, M., Addor, M. C., Arriola, L., et al. (2015). Congenital anomalies associated with trisomy 18 or trisomy 13: A registry-based study in 16 European countries, 2000\u20132011. American Journal of Medical Genetics. Part A, 167A(12), 3062\u20133069.","journal-title":"American Journal of Medical Genetics. Part A"}],"container-title":["Maternal and Child Health Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10995-025-04072-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10995-025-04072-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10995-025-04072-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T16:30:02Z","timestamp":1747931402000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10995-025-04072-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,22]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["4072"],"URL":"https:\/\/doi.org\/10.1007\/s10995-025-04072-z","relation":{},"ISSN":["1092-7875","1573-6628"],"issn-type":[{"value":"1092-7875","type":"print"},{"value":"1573-6628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,22]]},"assertion":[{"value":"10 February 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare that they have no competing interests to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Not applicable, since data are based on previously collected data.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}