{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:51:23Z","timestamp":1792637483289,"version":"4.5.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Matern Child Health J"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Introduction<\/jats:title>\n            <jats:p>Both hypertension and polycystic ovary syndrome (PCOS) are risk factors for future cardiovascular diseases among women of reproductive age (18\u201344 years). We constructed an electronic health record (EHR)-based PCOS phenotype, reported PCOS prevalence, and investigated the association of PCOS and hypertension in the United States (US).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>This cross-sectional study used 2022 IQVIA\u2019s Ambulatory Electronic Medical Record (AEMR)-US data (May 2023 release). We constructed a phenotype for PCOS and reported PCOS prevalence for eligible women. We then described hypertension prevalence and hypertension control estimates stratified by PCOS status. Lastly, we calculated adjusted prevalence ratios (aPR) for hypertension and hypertension control by PCOS status, adjusting for age, race, and body mass index (BMI).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>We analyzed records for 1,301,425 eligible women, with mean (standard deviation) age of 31.5 (7.9) years. The prevalence of PCOS was 2.1%, but increased with weight category, reaching 6.7% among those with class 3 obesity (BMI\u2009\u2265\u200940\u00a0kg\/m<jats:sup>2<\/jats:sup>). Women with PCOS had 50% higher prevalence of hypertension than those without PCOS (aPR 1.50; 95% confidence interval [CI]: 1.48\u20131.52; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and slightly higher hypertension control prevalence (aPR 1.14; 95% CI: 1.12\u20131.17; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Discussion<\/jats:title>\n            <jats:p>Using a nationwide EHR dataset, we observed that women with PCOS had substantially higher hypertension prevalence than those without PCOS. PCOS prevalence was lower than previous estimates from global surveys. Following guideline-recommended blood pressure screening for women with PCOS could reduce the risk of long-term cardiovascular disease.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s10995-025-04155-x","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T10:34:05Z","timestamp":1756722845000},"page":"1352-1359","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hypertension and Polycystic Ovary Syndrome Among Women in a Nationwide Electronic Health Records Dataset in the United States"],"prefix":"10.1007","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0452-355X","authenticated-orcid":false,"given":"Siran","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omoye","family":"Imoisili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyudmyla","family":"Kompaniyets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Lundeen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena V.","family":"Kuklina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra L.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,1]]},"reference":[{"issue":"1","key":"4155_CR1","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1210\/clinem\/dgaa675","volume":"106","author":"KV Actkins","year":"2021","unstructured":"Actkins, K. V., Singh, K., Hucks, D., Velez Edwards, D. R., Aldrich, M., Cha, J., Wellons, M., & Davis, L. K. (2021). Characterizing the clinical and genetic spectrum of polycystic ovary syndrome in electronic health records. The Journal of Clinical Endocrinology and Metabolism, 106(1), 153\u2013167. https:\/\/doi.org\/10.1210\/clinem\/dgaa675","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"issue":"6","key":"4155_CR2","doi-asserted-by":"publisher","first-page":"e157","DOI":"10.1097\/AOG.0000000000002656","volume":"131","author":"American College of Obstetricians and Gynecologists\u2019 Committee on Practice Bulletins\u2014Gynecology","year":"2018","unstructured":"American College of Obstetricians and Gynecologists\u2019 Committee on Practice Bulletins\u2014Gynecology. (2018). ACOG practice bulletin 194: Polycystic ovary syndrome. Obstetrics and Gynecology, 131(6), e157\u2013e171. https:\/\/doi.org\/10.1097\/AOG.0000000000002656","journal-title":"Obstetrics and Gynecology"},{"issue":"1","key":"4155_CR3","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s12958-020-00576-1","volume":"18","author":"M Amiri","year":"2020","unstructured":"Amiri, M., Ramezani Tehrani, F., Behboudi-Gandevani, S., Bidhendi-Yarandi, R., & Carmina, E. (2020). Risk of hypertension in women with polycystic ovary syndrome: A systematic review, meta-analysis and meta-regression. Reproductive Biology and Endocrinology: RB&E, 18(1), 23. https:\/\/doi.org\/10.1186\/s12958-020-00576-1","journal-title":"Reproductive Biology and Endocrinology: RB&E"},{"issue":"7","key":"4155_CR4","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1007\/s11886-022-01706-4","volume":"24","author":"D Canoy","year":"2022","unstructured":"Canoy, D., Nazarzadeh, M., Copland, E., Bidel, Z., Rao, S., Li, Y., & Rahimi, K. (2022). How much lowering of blood pressure is required to prevent cardiovascular disease in patients with and without previous cardiovascular disease? Current Cardiology Reports,24(7), 851\u2013860. https:\/\/doi.org\/10.1007\/s11886-022-01706-4","journal-title":"Current Cardiology Reports"},{"key":"4155_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13061113","author":"JP Christ","year":"2023","unstructured":"Christ, J. P., & Cedars, M. I. (2023). Current guidelines for diagnosing PCOS. Diagnostics. https:\/\/doi.org\/10.3390\/diagnostics13061113","journal-title":"Diagnostics"},{"issue":"6","key":"4155_CR6","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1016\/j.fertnstert.2017.04.011","volume":"107","author":"A Dokras","year":"2017","unstructured":"Dokras, A., Saini, S., Gibson-Helm, M., Schulkin, J., Cooney, L., & Teede, H. (2017). Gaps in knowledge among physicians regarding diagnostic criteria and management of polycystic ovary syndrome. Fertility and Sterility, 107(6), 1380\u20131386e1. https:\/\/doi.org\/10.1016\/j.fertnstert.2017.04.011","journal-title":"Fertility and Sterility"},{"issue":"1","key":"4155_CR8","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.amepre.2023.09.010","volume":"66","author":"S He","year":"2024","unstructured":"He, S., Park, S., Fujii, Y., Pierce, S. L., Kraus, E. M., Wall, H. K., Therrien, N. L., & Jackson, S. L. (2024). State-level hypertension prevalence and control among adults in the U.S. American Journal of Preventive Medicine,66(1), 46\u201354. https:\/\/doi.org\/10.1016\/j.amepre.2023.09.010","journal-title":"American Journal of Preventive Medicine"},{"key":"4155_CR7","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpad081","author":"S He","year":"2023","unstructured":"He, S., Park, S., Kuklina, E., Therrien, N. L., Lundeen, E. A., Wall, H. K., Lampley, K., Kompaniyets, L., Pierce, S. L., Sperling, L., & Jackson, S. L. (2023). Leveraging electronic health records to construct a phenotype for hypertension surveillance in the United States. American Journal of Hypertension. https:\/\/doi.org\/10.1093\/ajh\/hpad081","journal-title":"American Journal of Hypertension"},{"issue":"12","key":"4155_CR9","doi-asserted-by":"publisher","first-page":"4565","DOI":"10.1210\/jc.2013-2350","volume":"98","author":"RS Legro","year":"2013","unstructured":"Legro, R. S., Arslanian, S. A., Ehrmann, D. A., Hoeger, K. M., Murad, M. H., Pasquali, R., Welt, C. K., Endocrine Society. (2013). Diagnosis and treatment of polycystic ovary syndrome: An Endocrine Society clinical practice guideline. The Journal of Clinical Endocrinology and Metabolism,98(12), 4565\u20134592. https:\/\/doi.org\/10.1210\/jc.2013-2350","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"issue":"7","key":"4155_CR10","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.1093\/humrep\/deaa099","volume":"35","author":"G Mills","year":"2020","unstructured":"Mills, G., Badeghiesh, A., Suarthana, E., Baghlaf, H., & Dahan, M. H. (2020). Polycystic ovary syndrome as an independent risk factor for gestational diabetes and hypertensive disorders of pregnancy: A population-based study on 9.1 million pregnancies. Human Reproduction, 35(7), 1666\u20131674. https:\/\/doi.org\/10.1093\/humrep\/deaa099","journal-title":"Human Reproduction"},{"key":"4155_CR11","unstructured":"National Institutes of Health. (2012). Final report. Evidence-based methodology workshop on polycystic ovary syndrome. 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Section\u00a0241(d); 5 U.S.C. Sect. 552a; 44 U.S.C. Sect. Section\u00a03501 et seq.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}