{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:43:14Z","timestamp":1790275394339,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2006,4,20]],"date-time":"2006-04-20T00:00:00Z","timestamp":1145491200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2006,6]]},"DOI":"10.1007\/s11010-005-9003-8","type":"journal-article","created":{"date-parts":[[2006,4,19]],"date-time":"2006-04-19T08:08:57Z","timestamp":1145434137000},"page":"11-15","source":"Crossref","is-referenced-by-count":74,"title":["Effects of melatonin in reducing the toxic effects of doxorubicin"],"prefix":"10.1007","volume":"286","author":[{"given":"Eser","family":"\u00d6z","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa N.","family":"\u0130lhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,4,20]]},"reference":[{"key":"9003_CR1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1034\/j.1600-079X.2001.310104.x","volume":"31","author":"MT Agapito","year":"2001","unstructured":"Agapito MT, Antolin Y, del Brio MT, Lopes-Burillo S, Pablos MI, Recio JM: Protective effect of melatonin against adriamycin toxicity in the rat. J Pineal Res 31: 23\u201330, 2001","journal-title":"J Pineal Res"},{"key":"9003_CR2","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1096\/fasebj.4.13.2210154","volume":"4","author":"RD Olson","year":"1990","unstructured":"Olson RD, Mushlin PS: Doxorubicin cardiotoxicity: analysis of prevailing hypotheses.The FASEB Journal 4: 3076\u20133086, 1990","journal-title":"The FASEB Journal"},{"issue":"17","key":"9003_CR3","first-page":"4766","volume":"48","author":"S Rajagopalan","year":"1988","unstructured":"Rajagopalan S, Politi PM, Sinha BK, Myers E: Adriamycin-induced free radical formation in the perfused rat heart: implications for cardiotoxicity. Cancer Res 48(17): 4766\u20134769, 1988","journal-title":"Cancer Res"},{"key":"9003_CR4","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/0022-2828(95)90074-8","volume":"27","author":"PK Singal","year":"1995","unstructured":"Singal PK, Siveski-Iliskovic N, Hill M, Thomas TP, Li T: Combination therapy with probucol prevents adriamycin-induced cardiomyopathy. J Mol Cell Cardiol 27: 1055\u20131063, 1995","journal-title":"J Mol Cell Cardiol"},{"key":"9003_CR5","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1016\/S0024-3205(97)00030-1","volume":"60","author":"R Reiter","year":"1997","unstructured":"Reiter R, Tang L, Garcia JJ, Munoz-Hoyos A: Pharmacological actions of melatonin in oxygen radical pathophysiology. Life Sci 60: 2255\u20132271, 1997","journal-title":"Life Sci"},{"key":"9003_CR6","first-page":"1329","volume":"18","author":"B Neri","year":"1998","unstructured":"Neri B, de Leonardis V, Gemelli MT, di Loro F, Mottola A, Ponchietti R, Raugei A, Cini G: Melatonin as biological response modifier in cancer patients. Anticancer Res 18: 1329\u20131332, 1998","journal-title":"Anticancer Res"},{"key":"9003_CR7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1600-079X.1993.tb00498.x","volume":"14","author":"B Poeggeler","year":"1993","unstructured":"Poeggeler B, Reiter RJ, Tan DX, Chen LD, Manchester LC: Melatonin, hydroxy radical-mediated oxidative damage, and aging: a hypothesis. J Pineal Res 14: 151\u2013168, 1993","journal-title":"J Pineal Res"},{"key":"9003_CR8","doi-asserted-by":"crossref","first-page":"PL 271","DOI":"10.1016\/0024-3205(94)00666-0","volume":"55","author":"C Pieri","year":"1994","unstructured":"Pieri C, Marra M, Moroni F, Recchioni R, Marcheselli F: Melatonin: a peroxyl radical scavenger more effective than vitamin E. Life Sci 55: PL 271\u2013276, 1994","journal-title":"Life Sci"},{"key":"9003_CR9","doi-asserted-by":"crossref","first-page":"PL 169","DOI":"10.1016\/S0024-3205(97)00008-8","volume":"60","author":"E Gilad","year":"1997","unstructured":"Gilad E, Cuzzocrea S, Zingarelli B, Salzman AL, Szabo C: Melatonin is a scavenger of peroxynitrite. Life Sci 60: PL 169\u2013174, 1997","journal-title":"Life Sci"},{"key":"9003_CR10","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1600-079X.1997.tb00312.x","volume":"22","author":"ZR Li","year":"1997","unstructured":"Li ZR, Reiter RJ, Fujimori O, Oh CS, Duan YP: Cataractogenesis and lipid peroxidation in newborn rats treated with buthionine sulfoximine: preventive actions of melatonin. J Pineal Res 22: 117\u2013123, 1997","journal-title":"J Pineal Res"},{"key":"9003_CR11","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/S0008-6363(96)00030-2","volume":"31","author":"S Bertuglia","year":"1996","unstructured":"Bertuglia S, Marchiafava PL, Colantuoni A: Melatonin prevents ischemia reperfusion injury in hamster cheek pouch microcirculation. Cardiovasc Res 31: 947\u2013952, 1996","journal-title":"Cardiovasc Res"},{"key":"9003_CR12","first-page":"205","volume":"15","author":"DJ Duncker","year":"2001","unstructured":"Duncker DJ, Verdouw PD: Has melatonin a future as a cardioprotective agent? Cardiovasc. Drugs and Therapy 15: 205\u2013207, 2001","journal-title":"Drugs and Therapy"},{"issue":"2","key":"9003_CR13","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1600-079X.1998.tb00544.x","volume":"25","author":"PL Montilla","year":"1998","unstructured":"Montilla PL, Tunez IF, Munoz de Agueda C, Gascon FL, Soria JV: Protective role of melatonin and retinol palmitate in oxidative stress and hyperlipidemic nephropathy induced by adriamycin in rats. J Pineal Res 25(2): 86\u201393, 1998","journal-title":"J Pineal Res"},{"issue":"3","key":"9003_CR14","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1159\/000190202","volume":"76","author":"P Montilla","year":"1997","unstructured":"Montilla P, Tunez I, Munoz MC, Lopez A, Soria JV: Hyperlipidemic nephropathy induced by adriamycin: effect of melatonin administration. Nephron 76(3): 345\u2013350, 1997","journal-title":"Nephron"},{"issue":"1","key":"9003_CR15","first-page":"45","volume":"13","author":"V Rapozzi","year":"1999","unstructured":"Rapozzi V, Comelli M, Mavelli I, Sentjurc M, Schara M, Perissin L, Giraldi T: Melatonin and oxidative damage in mice liver induced by the prooxidant antitumor drug, adriamycin. In vivo 13(1): 45\u201350, 1999","journal-title":"In vivo"},{"key":"9003_CR16","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/cbf.897","volume":"19","author":"G Baydas","year":"2001","unstructured":"Baydas G, Ercel E, Canatan H, D\u00f6nder E, Akyol A: Effect of melatonin on oxidative status of rat brain, liver and kidney tissues under constant light exposure. Cell Biochem Funct 19: 37\u201341, 2001","journal-title":"Cell Biochem Funct"},{"key":"9003_CR17","first-page":"181","volume":"106","author":"\u00d6 Timlio\u011flu","year":"1999","unstructured":"Timlio\u011flu \u00d6, Kutsal \u015e, \u00d6zkur M, Uluo\u011flu \u00d6, Ar\u0131c\u0131o\u011flu A, \u00c7evik C, D\u00fczg\u00fcn E, Sancak B, Poyraz A: The effect of EGb 761 on the doxorubicin cardiomyopathy. Research Communications in Molecular Pathology and Pharmacology 106: 181\u2013192, 1999","journal-title":"Research Communications in Molecular Pathology and Pharmacology"},{"key":"9003_CR18","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1159\/000022065","volume":"45","author":"KG Akbulut","year":"1999","unstructured":"Akbulut KG, G\u00f6n\u00fcl B, Akbulut H: Differential effects of pharmacological doses of melatonin on malondialdehyde and glutathione levels in young and old rats.Gerontology 45: 67\u201371, 1999","journal-title":"Gerontology"},{"key":"9003_CR19","doi-asserted-by":"crossref","first-page":"G573","DOI":"10.1152\/ajpcell.1992.263.3.C573","volume":"263","author":"H Kurtel","year":"1992","unstructured":"Kurtel H, Granger DN, Tso P, Grisham MB: Vulnerability of intestinal interstitial fluid to oxidant stres. Am J Physiol 263: G573\u2013578, 1992","journal-title":"Am J Physiol"},{"key":"9003_CR20","first-page":"520","volume":"123","author":"A Casini","year":"1986","unstructured":"Casini A, Ferrali M, Pompella A, Maellaro E, Comborti M: Lipid reroxidation and cellular damage in extrahepatic tissues of bromobenzene intoxicated mice. Am J Pathol 123: 520\u2013531, 1986","journal-title":"Am J Pathol"},{"key":"9003_CR21","unstructured":"Oz E, Erbas D, S\u00fcr\u00fcc\u00fc HS, D\u00fczg\u00fcn E: Prevention of doxorubicin induced cardiotoxicity by melatonin. Molecular and Cellular Biochemistry, in press"},{"key":"9003_CR22","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2165\/00003495-199447020-00002","volume":"47","author":"DJ Booser","year":"1994","unstructured":"Booser DJ, Hortobagyi GN: Anthracycline antibiotics in cancer therapy. Drugs 47: 223\u2013258, 1994","journal-title":"Drugs"},{"key":"9003_CR23","first-page":"72","volume":"25","author":"MA Grenier","year":"1998","unstructured":"Grenier MA, Lipshultz SE: Epidemiology of anthracycline cardiotoxicity in children and adults. Semin Oncol 25: 72\u201385, 1998","journal-title":"Semin Oncol"},{"key":"9003_CR24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/00003495-199700544-00003","volume":"54","author":"GN Hortobagyi","year":"1997","unstructured":"Hortobagyi GN: Anthracyclines in the treatment of cancer. Drugs 54: 1\u20137, 1997","journal-title":"Drugs"},{"key":"9003_CR25","doi-asserted-by":"crossref","first-page":"PL 271","DOI":"10.1016\/0024-3205(94)00666-0","volume":"55","author":"C Pieri","year":"1994","unstructured":"Pieri C, Marra M, Moroni F, Recchioni R, Marcheselli F: Melatonin: a peroxyl radical scavenger more effective than vitamin E. Life Sci 55: PL 271\u2013276, 1994","journal-title":"Life Sci"},{"key":"9003_CR26","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0149-7634(05)80016-8","volume":"17","author":"R Hardeland","year":"1993","unstructured":"Hardeland R, Reiter RJ, Poeggeler B, Tan DX: The significance of the metabolism of the neurohormone melatonin: antioxidative protection and formation of bioactive substances. Neurosci Biobehav Rev 17: 347\u2013357, 1993","journal-title":"Neurosci Biobehav Rev"},{"key":"9003_CR27","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0163-7258(91)90076-X","volume":"51","author":"A Meister","year":"1991","unstructured":"Meister A: Glutathione deficiency produced by inhibition of it's synthesis and it's reversal: Applications in research and therapy. Pharmacol Ther 51: 155\u2013194, 1991","journal-title":"Pharmacol Ther"},{"issue":"1","key":"9003_CR28","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/cbf.994","volume":"21","author":"I Tunez","year":"2003","unstructured":"Tunez I, del Carmen Munoz M, Feijoo M, Valdervira ME, Rafael Munoz-Castaneda J, Montilla P: Melatonin effect on renal oxidative stress under constant light exposure. Cell Biochem Funct 21(1): 35\u201340, 2003","journal-title":"Cell Biochem Funct"},{"issue":"2","key":"9003_CR29","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/BF03179846","volume":"58","author":"L Tunez","year":"2002","unstructured":"Tunez L, Munoz MC, Feijoo-Lopez AL, Valdvira E, Bujalance-Arenas L, Montilla P: Effect of melatonin on hyperlipidemic nephropathy under constant light exposure. J Physiol Biochem 58(2): 109\u2013114, 2002","journal-title":"J Physiol Biochem"},{"issue":"3","key":"9003_CR30","first-page":"301","volume":"53","author":"P Montilla","year":"1997","unstructured":"Montilla P, Tunez I, Munoz MC, Soria JV, Lopez A: Antioxidative effect of melatonin in rat brain oxidative stress induced by adriamycin. Rev Esp Fisiol 53(3): 301\u2013305, 1997","journal-title":"Rev Esp Fisiol"},{"issue":"19","key":"9003_CR31","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/S0024-3205(98)00442-1","volume":"63","author":"V Rapozzi","year":"1998","unstructured":"Rapozzi V, Zorzet S, Comelli M, Mavelli I, Perissin L, Giraldi T: Melatonin} decreases bone marrow and lymphatic toxicity of adriamycin in mice bearing TLX5 lymphoma. Life Sciences 63(19): 1701\u20131713, 1998","journal-title":"Life Sciences"},{"key":"9003_CR32","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1034\/j.1600-079X.2001.310303.x","volume":"31","author":"M Granzotti","year":"2001","unstructured":"Granzotti M, Rapozzi V, Decorti G, Giraldi T: Effects of melatonin on doxorubicin cytotoxicity in sensitive and pleiotropically resistant tumor cells. J Pineal Res 31: 206\u2013213, 2001","journal-title":"J Pineal Res"},{"key":"9003_CR33","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1034\/j.1600-079X.2002.02902.x","volume":"33","author":"P Dziegiel","year":"2002","unstructured":"Dziegiel P, Suder E, Surowiak P, Jethon Z, Rabczynski J, Januszewska L, Sopel M, Zabel M: Role of exogenous melatonin in reducing the nephrotoxic effect of daunorubicin and doxorubicin in the rat. J Pineal Res 33: 95\u2013100, 2002","journal-title":"J Pineal Res"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-005-9003-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11010-005-9003-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-005-9003-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T22:05:59Z","timestamp":1559340359000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11010-005-9003-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,20]]},"references-count":33,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["9003"],"URL":"https:\/\/doi.org\/10.1007\/s11010-005-9003-8","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4,20]]}}}