{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T17:09:45Z","timestamp":1782320985134,"version":"3.54.5"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2006,2,14]],"date-time":"2006-02-14T00:00:00Z","timestamp":1139875200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2006,5,12]]},"DOI":"10.1007\/s11010-005-9012-7","type":"journal-article","created":{"date-parts":[[2006,2,13]],"date-time":"2006-02-13T10:20:47Z","timestamp":1139826047000},"page":"49-55","source":"Crossref","is-referenced-by-count":75,"title":["Effects of administration of Embelin and Curcumin on lipid peroxidation, hepatic glutathione antioxidant defense and hematopoietic system during N-nitrosodiethylamine\/Phenobarbital-induced hepatocarcinogenesis in Wistar rats"],"prefix":"10.1007","volume":"284","author":[{"given":"Meenakshisundaram","family":"Sreepriya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geetha","family":"Bali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,2,14]]},"reference":[{"issue":"2","key":"9012_CR1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0304-3835(96)04226-7","volume":"103","author":"G Guner","year":"1996","unstructured":"Guner G, Islekel H, Oto O, Hazan E, Acikel V: Evaluation of some antioxidant enzymes in lung carcinoma tissues. Cancer Letters 103(2): 233\u2013239, 1996","journal-title":"Cancer Letters"},{"issue":"8924","key":"9012_CR2","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0140-6736(94)92211-X","volume":"344","author":"B Halliwell","year":"1994","unstructured":"Halliwell B: Free radicals, antioxidants and human disease. Lancet 344(8924): 721\u2013724, 1994","journal-title":"Lancet"},{"key":"9012_CR3","first-page":"283","volume":"41","author":"S Mukhopadhyay","year":"2003","unstructured":"Mukhopadhyay S, Mandal A, Poddar KM: Chronic administration of caffeine: Effect on the activities of hepatic antioxidant enzymes of Ehrlich ascites tumor bearing mice.Indian J Exp Biol 41: 283\u2013289, 2003","journal-title":"Indian J Exp Biol"},{"issue":"3","key":"9012_CR4","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/mc.1022","volume":"30","author":"TJ Park","year":"2001","unstructured":"Park TJ, Kim HS, Byun KH, Jang JJ, Lee YS, Kim IK: Sequential changes in hepatocarcinogenesis induced by diethylnitrosamine plus thioacetamide in Fischer 344 rats: induction of gankyrin expression in liver fibrosis, pRB degradation in cirrhosis and methylation of p16(1NK4A) exon in hepatocellular carcinoma. Mol Carcinog 30(3): 138\u2013150, 2001","journal-title":"Mol Carcinog"},{"key":"9012_CR5","first-page":"5685","volume":"62","author":"S Loppen","year":"2002","unstructured":"Loppen S, Schneider D, Gaunitz F, Liebhardt R, Kurek R, Buchmann A, Schwarz M: Cancer Res 62: 5685\u20135688, 2002","journal-title":"Cancer Res"},{"key":"9012_CR6","first-page":"861","volume":"41","author":"MA Indap","year":"2003","unstructured":"Indap MA, Barkume MS: Efficacies of plant phenolics on sodium butyrate induced anti-tumor activity. Indian J Exp Biol 41: 861\u2013864, 2003","journal-title":"Indian J Exp Biol"},{"key":"9012_CR7","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/bjc.1991.410","volume":"64","author":"H Yoshiji","year":"1991","unstructured":"Yoshiji H, Nakae D, Kinugasa T, Matsuzaki M, Denda A, Tsujii T, Konishi Y: Inhibitory effect of dietary iron deficiency on the induction of putative preneoplastic foci in rat liver initiated with diethylnitrosamine and promoted by Phenobarbital. Br J Cancer 64: 839\u2013842, 1991.","journal-title":"Br J Cancer"},{"key":"9012_CR8","unstructured":"Raghuramulu N, Nair KM, Kalyanasundaram S: A Manual of Laboratory Techniques. In: Raghuramulu N, Nair KM (eds) NIN, ICMR, Hyderabad pp. 254\u2013255"},{"key":"9012_CR9","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0163-7258(90)90063-8","volume":"47","author":"KJ Huxtable","year":"1990","unstructured":"Huxtable KJ: Activation and pulmonary toxicity of pyrrolizadine alkaloids. Pharmacol Ther 47: 371\u2013390, 1990","journal-title":"Pharmacol Ther"},{"key":"9012_CR10","volume-title":"Practical Hematology","author":"JV Dacie","year":"1995","unstructured":"Dacie JV, Lewis SM: Practical Hematology. In: S.M. Lewis, B.J. Bain and I. Bates (eds). 8th edition, Edinburgh, Scotland, Churchill livingstone, 1995","edition":"8"},{"key":"9012_CR11","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0021-9258(18)76122-X","volume":"98","author":"DL Drabkin","year":"1932","unstructured":"Drabkin DL, Austin JH: Spectrophotometric studies, spectophotometric constants for common haemoglobin derivatives in human, dog, and rabbit blood. J Biol Chem 98: 719\u2013733, 1932","journal-title":"J Biol Chem"},{"key":"9012_CR12","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/0006-2944(76)90049-1","volume":"15","author":"K Yagi","year":"1976","unstructured":"Yagi K: Simple fluorimetric assay for lipid peroxides in blood plasma. Biochem Med 15: 212\u2013215, 1976","journal-title":"Biochem Med"},{"key":"9012_CR13","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa H, Ohishi N, Yagi K: Assay of lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biocem 95: 351\u2013358, 1979","journal-title":"Anal Biocem"},{"issue":"1","key":"9012_CR14","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0304-4165(79)90289-7","volume":"582","author":"MS Moron","year":"1979","unstructured":"Moron MS, Depierre JN, Mannervik B: Levels of glutathione, glutathione reductase, and glutathione-S-transferase activities in rat lung and liver. Biochim Biophys Acta 582(1): 67\u201378, 1979","journal-title":"Biochim Biophys Acta"},{"key":"9012_CR15","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1126\/science.179.4073.588","volume":"179","author":"JT Rotruck","year":"1973","unstructured":"Rotruck JT, Pop AL, Ganther HP, Swanson AB, Hafeman BG, Hoeksira WG: Selenium: Biochemical role as a component of glutathione peroxidase. Science 179: 588\u2013590, 1973","journal-title":"Science"},{"key":"9012_CR16","first-page":"7130","volume":"249","author":"WH Habig","year":"1974","unstructured":"Habig WH, Pabst MJ, Jakoby WB: Glutathione-S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 249: 7130\u20137139, 1974","journal-title":"The first enzymatic step in mercapturic acid formation. J Biol Chem"},{"key":"9012_CR17","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1042\/bj3130017","volume":"313","author":"H Wiseman","year":"1996","unstructured":"Wiseman H, Halliwell B: Damage to DNA by reactive oxygen and nitrogen species: Role in inflammatory disease and progression to cancer. Biochem J 313: 17\u201329, 1996","journal-title":"Biochem J"},{"issue":"9","key":"9012_CR18","first-page":"916","volume":"38","author":"AK Bansal","year":"2000","unstructured":"Bansal AK, Trivedi R, Soni GL, Bhatnagar D: Hepatic and renal oxidative stress in acute toxicity of N-nitrosodiethylamine in rats. Indian J Exp Biol 38(9): 916\u2013920, 2000","journal-title":"Indian J Exp Biol"},{"key":"9012_CR19","first-page":"587","volume":"26","author":"M Sreepriya","year":"1998","unstructured":"Sreepriya M, Porckodi M, Devaki T, Nayeem M: Antioxidant effects of L- arginine against isoproterenol-induced myocardial stress in rats. Medical Science Research 26: 587\u2013593, 1998","journal-title":"Medical Science Research"},{"key":"9012_CR20","first-page":"135","volume":"41","author":"J Karthikeyan","year":"2003","unstructured":"Karthikeyan J, Rani P: Enzymatic and non enzymatic antioxidants in selected piper species. Indian J Exp Biol 41: 135\u2013140, 2003","journal-title":"Indian J Exp Biol"},{"issue":"9","key":"9012_CR21","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.3748\/wjg.v10.i9.1268","volume":"10","author":"MC Banakar","year":"2004","unstructured":"Banakar MC, Paramasivam SK, Chattopadhyay MB, Datta S, Chakraborty P, Chatterjee M, Kannan K, Thyagarajan E: 1 alpha 25-dihydroxy vitamin D3 prevents DNA damage and restores antioxidant enzymes in rat hepatocarcinogenesis induced by diethylnitrosamine and promoted by Phenobarbital. World J Gastroenterol 10(9): 1268\u20131275, 2004","journal-title":"World J Gastroenterol"},{"issue":"4","key":"9012_CR22","first-page":"459","volume":"19","author":"NV Rajeshkumar","year":"2000","unstructured":"Rajeshkumar NV, Kuttan R: Inhibition of N-nitrosodiethylamine-induced hepatocarcinogenesis by Picroliv. I Exp Clin Cancer Res 19(4): 459\u2013465, 2000","journal-title":"I Exp Clin Cancer Res"},{"key":"9012_CR23","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/(SICI)1099-0461(2000)14:3<131::AID-JBT2>3.0.CO;2-Q","volume":"3","author":"H Razo","year":"2000","unstructured":"Razo H, Ahmed I, John A, Sharma AK: Modulation of xenebiotic metabolism and oxidative stress in chronic streptozotocin induced diabetic rats fed with Momondica Charantia fruit extract. J Biochem Mol Toxicol 3: 131\u2013139, 2000","journal-title":"J Biochem Mol Toxicol"},{"issue":"1","key":"9012_CR24","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0167-4943(01)00194-7","volume":"34","author":"J Miquel","year":"2002","unstructured":"Miquel J, Bernd A, Sempere JM, Diaz-Alperi J, Ramirez A: The curcuma antioxidants: Pharmacological effects and prospects for future clinical use. A review.Arch Gerontol Geriatr 34(1): 37\u201346, 2002","journal-title":"A review.Arch Gerontol Geriatr"},{"key":"9012_CR25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1055\/s-2006-960004","volume":"57","author":"AP Ammon","year":"1991","unstructured":"Ammon AP, Wahl MA: Pharmacology of Curcuma longa. Planta Med 57: 1\u20137, 1991","journal-title":"Planta Med"},{"issue":"3","key":"9012_CR26","first-page":"213","volume":"28","author":"RK Johri","year":"1990","unstructured":"Johri RK, Dhar SK, Pahwa GS, Sharma SC, Kaul JL, Zutshi V: Toxicity studies with potassium embelate, a new analgesic compound. Indian J Exp Biol 28(3): 213\u2013217, 1990","journal-title":"Indian J Exp Biol"},{"key":"9012_CR27","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/S0014-5793(02)02292-5","volume":"512","author":"T Choudhuri","year":"2002","unstructured":"Choudhuri T, Pal S, Agarwal ML, Das T, Sa G: Curcumin induces apoptosis in human breast cancer cells through p 53-dependent Bax induction. FEBS Lett 512: 334\u2013340, 2002","journal-title":"FEBS Lett"},{"key":"9012_CR28","doi-asserted-by":"crossref","first-page":"22064","DOI":"10.1074\/jbc.M910346199","volume":"275","author":"R Hofer-Warbinek","year":"2000","unstructured":"Hofer-Warbinek R, Schmid JA, Stehlik C, Binder BR, Lipp J, deMartin R: Activation of NF kappa B by XIAP, the X-chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1. J Biol Chem 275: 22064\u201322068, 2000","journal-title":"J Biol Chem"},{"issue":"10","key":"9012_CR29","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1021\/jm030420+","volume":"47","author":"N Coleska","year":"2004","unstructured":"Coleska N, Xu L, Hu Z, Tomita Y, Li P, Roller PP, Wang R, Fang X, Guo R, Zhang M, Lippman ME, Yang D, Wang S: Discovery of embelin as a cell permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database. J Med Chem 47(10): 2430\u20132440, 2004","journal-title":"J Med Chem"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-005-9012-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11010-005-9012-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-005-9012-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T21:04:43Z","timestamp":1627074283000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11010-005-9012-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2,14]]},"references-count":29,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2006,5,12]]}},"alternative-id":["9012"],"URL":"https:\/\/doi.org\/10.1007\/s11010-005-9012-7","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2,14]]}}}