{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T11:41:06Z","timestamp":1789904466725,"version":"4.0.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1007\/s11010-006-0233-1","type":"journal-article","created":{"date-parts":[[2005,12,2]],"date-time":"2005-12-02T13:47:09Z","timestamp":1133531229000},"page":"45-54","source":"Crossref","is-referenced-by-count":35,"title":["Apoptosis at a distance: Remote activation of caspase-3 occurs early after myocardial infarction"],"prefix":"10.1007","volume":"281","author":[{"given":"Kerstin","family":"Schwarz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Simonis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjian","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Wiedemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth H.","family":"Strasser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"233_CR1","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1161\/01.CIR.81.4.1161","volume":"81","author":"MA Pfeffer","year":"1990","unstructured":"Pfeffer MA, Braunwald E: Ventricular remodeling after myocardial infarction. Experimental observations and clinical implication. Circulation 81: 1161\u20131172, 1990","journal-title":"Circulation"},{"key":"233_CR2","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1006\/jmcc.1996.0143","volume":"28","author":"A Laser","year":"1996","unstructured":"Laser A, Ingwall JS, Tian R, Reis I, Hu K, Gaudron P, Ertl G, Neubauer S: Regional biochemical remodeling in non-infarcted tissue of rat heart post-myocardial infarction. J Mol Cell Cardiol 28: 1531\u20131538, 1996","journal-title":"J Mol Cell Cardiol"},{"key":"233_CR3","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1152\/physrev.1999.79.1.215","volume":"79","author":"B Swynghedauw","year":"1999","unstructured":"Swynghedauw B: Molecular mechanisms of myocardial remodeling. Physiol Rev 79: 215\u2013262, 1999","journal-title":"Physiol Rev"},{"key":"233_CR4","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1161\/01.RES.68.3.856","volume":"68","author":"G Olivetti","year":"1991","unstructured":"Olivetti G, Capasso JM, Meggs LG, Sonnenblick EH, Anversa P: Cellular basis of ventricular remodeling after myocardial infarction in rats. Circ Res 68: 856\u2013869, 1991","journal-title":"Circ Res"},{"key":"233_CR5","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1161\/01.RES.0000053618.86362.DF","volume":"92","author":"B Nadal-Ginard","year":"2003","unstructured":"Nadal-Ginard B, Kajstura J, Leri A, Anversa P: Myocyte death, growth, and regeneration in cardiac hypertrophy and heart failure. Circ Res 92: 139\u2013150, 2003","journal-title":"Circ Res"},{"key":"233_CR6","first-page":"H2726","volume":"280","author":"E Palojoki","year":"2001","unstructured":"Palojoki E, Saraste A, Eriksson A, Pulkki K, Kallajoki M, Voipio-Pulkii LM, Tikkanen I: Cardiomyocyte apoptosis adn ventricular remodeling after myocardial infarction in rats. Am J Physiol 280: H2726\u2013H2731, 2001","journal-title":"Am J Physiol"},{"key":"233_CR7","first-page":"H422","volume":"279","author":"F Sam","year":"2000","unstructured":"Sam F, Sawyer DB, Chang DF, Eberli F, Ngoy S, Jain M, Amin Y, Apstein CS, Colucci WS: Progressive left ventricular remodeling and apoptosis late after myocardial infarction in mouse heart. Am J Physiol 279: H422\u2013H428, 2000","journal-title":"Am J Physiol"},{"key":"233_CR8","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1006\/excr.1996.0232","volume":"226","author":"W Cheng","year":"1996","unstructured":"Cheng W, Kajstura J, Nitahara JA, Li B, Reiss K, Liu Y, Clark WA, Krajewski S, Reed JC, Olivetti G, Anversa P: Programmed myocyte cell death affects the viable myocardium after infarction in rats. Exp Cell Res 226: 316\u2013327, 1996","journal-title":"Exp Cell Res"},{"key":"233_CR9","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1006\/jmcc.1996.0193","volume":"28","author":"G Olivetti","year":"1996","unstructured":"Olivetti G, Quaini F, Sala R, Lagrasta C, Corradi D, Bonacina E, Gambert SR, Cigola E, Anversa P: Acute myocardial infarction in humans is associated with activation of programmed myocyte cell death in the surviving portion of the heart. J Mol Cell Cardiol 28: 2005\u20132016, 1996","journal-title":"J Mol Cell Cardiol"},{"key":"233_CR10","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1161\/01.CIR.90.1.556","volume":"90","author":"TN James","year":"1994","unstructured":"James TN: Normal and abnormal consequences of apoptosis in the human heart. From postnatal morphogenesis to paroxysmal arrhythmias. Circulation 90: 556\u2013573, 1994","journal-title":"Circulation"},{"key":"233_CR11","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1056\/NEJM199610173351603","volume":"335","author":"J Narula","year":"1996","unstructured":"Narula J, Haider N, Virmani R, DiSalvo TG, Kolodgie FD, Hajjar RJ, Schmidt U, Semigran MJ, Dec GW, Khaw BA: Apoptosis in myocytes in end-stage heart failure. N Engl J Med 335: 1182\u20131189, 1996","journal-title":"N Engl J Med"},{"issue":"Suppl 3","key":"233_CR12","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s003950050195","volume":"93","author":"P Anversa","year":"1998","unstructured":"Anversa P, Cheng W, Liu Y, Leri A, Redaelli G, Kajstura J: Apoptosis and myocardial infarction. Basic Res Cardiol 93(Suppl 3): 8\u201312, 1998","journal-title":"Basic Res Cardiol"},{"key":"233_CR13","first-page":"1325","volume":"146","author":"G Itoh","year":"1995","unstructured":"Itoh G, Tamura J, Suzuki M, Suzuki Y, Koike M, Nomura M, Jie T, Ito K: DNA fragmentation of human infarcted myocardial cells demonstrated by the nick end labeling method and DNA agarose gel electrophoresis. Am J Pathol 146: 1325\u20131331, 1995","journal-title":"Am J Pathol"},{"key":"233_CR14","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1006\/jmcc.2001.1498","volume":"34","author":"A Baldi","year":"2002","unstructured":"Baldi A, Abbate A, Bussani R, Patti G, Melfi R, Angelini A, Dobrina A, Rossiello R, Silvestri F, Baldi F, Di Sciascio G: Apoptosis and post-infarction left ventricular remodeling. J Mol Cell Cardiol 34: 165\u2013174, 2002","journal-title":"J Mol Cell Cardiol"},{"key":"233_CR15","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0040-8166(97)80049-3","volume":"29","author":"K Akiyama","year":"1997","unstructured":"Akiyama K, Gluckman TL, Terhakopian A, Jinadasa PM, Narayan S, Singaswamy S, Massey B, Bing RJ: Apoptosis in experimental myocardial infarction in situ and in the isolated perfused heart in vitro. Tissue Cell 29: 733\u2013743, 1997","journal-title":"Tissue Cell"},{"key":"233_CR16","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0046-8177(97)90039-3","volume":"28","author":"JP Veinot","year":"1997","unstructured":"Veinot JP, Gattinger DA, Fliss H: Early apoptosis in human myocardial infarcts. Hum Pathol 28: 485\u2013492, 1997","journal-title":"Hum Pathol"},{"key":"233_CR17","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1161\/01.CIR.95.2.320","volume":"95","author":"A Saraste","year":"1997","unstructured":"Saraste A, Pulkki K, Kallajoki M, Henriksen K, Parvinen M, Voipio-Pulkki L-M: Apoptosis in human acute myocardial infarction. Circulation 95: 320\u2013323, 1997","journal-title":"Circulation"},{"key":"233_CR18","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s003950050066","volume":"93","author":"B Freude","year":"1998","unstructured":"Freude B, Masters TN, Kostin N, Robicsek F, Schaper J: Cardiomyocyte apoptosis in acute and chronic conditions. Basic Res Cardiol 93: 85\u201389, 1998","journal-title":"Basic Res Cardiol"},{"key":"233_CR19","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1080\/078538902321012414","volume":"34","author":"M Rodriguez","year":"2002","unstructured":"Rodriguez M, Lucchesi BR, Schaper J: Apoptosis in myocardial infarction. Ann Med 34: 470\u2013479, 2002","journal-title":"Ann Med"},{"key":"233_CR20","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1161\/01.CIR.99.21.2757","volume":"99","author":"M Kanoh","year":"1999","unstructured":"Kanoh M, Takemura G, Misao J, Hayakawa K, Aoyama T, Nishigaki K, Noda T, Fujiwara T, Fukuda K, Minatoguchi S, Fujiwara H: Significance of myocytes with positive DNA in situ nick end-labeling (TUNEL) in hearts with dilated cardiomyopathy: Not apoptosis but DNA repair. Circulation 99: 2757\u20132764, 1999","journal-title":"Circulation"},{"key":"233_CR21","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1161\/01.CIR.98.14.1422","volume":"98","author":"M Ohno","year":"1998","unstructured":"Ohno M, Takemura G, Ohno A, Misao J, Hayakawa Y, Minatoguchi S, Fujiwara H: Apoptotic myocytes in infarct area in rabbit hearts may be oncotic with DNA fragmentation. Analysis by electron microscopy combined with in situ nick end labeling. Circulation 98: 1422\u20131430, 1998","journal-title":"Circulation"},{"key":"233_CR22","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1161\/01.RES.86.2.121","volume":"86","author":"P Anversa","year":"2000","unstructured":"Anversa P: Myocyte death in the pathological heart. Circ Res 86: 121\u2013124, 2000","journal-title":"Circ Res"},{"key":"233_CR23","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1161\/01.RES.82.11.1111","volume":"82","author":"A Haunstetter","year":"1998","unstructured":"Haunstetter A, Izumo S: Apoptosis: basic mechanism and implications for cardiovascular disease. Circ Res 82: 1111\u20131129, 1998","journal-title":"Circ Res"},{"key":"233_CR24","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2170\/jjphysiol.53.247","volume":"53","author":"T Saitoh","year":"2003","unstructured":"Saitoh T, Nakajima M, Kawahara Y: Possible involvement of apoptotic death of myocytes in left ventricular remodeling after myocardial infarction. Jpn J Physiol 53: 247\u2013252, 2003","journal-title":"Jpn J Physiol"},{"key":"233_CR25","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1161\/01.RES.44.4.503","volume":"44","author":"MA Pfeffer","year":"1979","unstructured":"Pfeffer MA, Pfeffer JM, Fishbein MC, Fletcher PJ, Spadaro J, Kloner RA, Braunwald E: Myocardial infarct size and ventricular function in rats. Circ Res 44: 503\u2013512, 1979","journal-title":"Circ Res"},{"key":"233_CR26","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s003950200015","volume":"97","author":"G Simonis","year":"2002","unstructured":"Simonis G, Honold J, Schwarz K, Braun MU, Strasser RH: Regulation of the isozymes of protein kinase C in the surviving rat myocardium after myocardial infarction: distinct modulation for PKC-alpha and PKC-delta. Basic Res Cardiol 97: 223\u2013231, 2002","journal-title":"Basic Res Cardiol"},{"key":"233_CR27","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1161\/01.RES.85.1.77","volume":"85","author":"RH Strasser","year":"1999","unstructured":"Strasser RH, Simonis G, Sch\u00f6n S, Braun MU, Ihl-Vahl R, Weinbrenner C, Marquetant R, K\u00fcbler W: Two distinct mechanisms mediate a differential regulation of protein kinase C isozymes in acute and prolonged myocardial ischemia. Circ Res 85: 77\u201387, 1999","journal-title":"Circ Res"},{"key":"233_CR28","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1161\/01.RES.85.9.867","volume":"85","author":"J Schaper","year":"1999","unstructured":"Schaper J, Els\u00e4sser A, Kostin N: The role of cell death in heart failure. Circ Res 85: 867\u2013869, 1999","journal-title":"Circ Res"},{"key":"233_CR29","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1006\/jmcc.1999.1066","volume":"32","author":"B Freude","year":"2000","unstructured":"Freude B, Masters TN, Robicsek F, Fokin A, Kostin S, Zimmermann R, Ullmann C, Lorenz-Meyer S, Schaper J: Apoptosis is initiated by myocardial ischemia and executed during reperfusion. J Mol Cell Cardiol 32: 197\u2013208, 2000","journal-title":"J Mol Cell Cardiol"},{"key":"233_CR30","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1006\/jmcc.1998.0660","volume":"30","author":"SC Black","year":"1998","unstructured":"Black SC, Huang JQ, Rezaiefar P, Radinovic S, Eberhart A, Nicholson DW, Rodger IW: Co-localization of the cysteine protease caspase-3 with apoptotic myocytes after in vivo myocardial ischemia and reperfusion in the rat. J Mol Cell Cardiol 30: 733\u2013742, 1998","journal-title":"J Mol Cell Cardiol"},{"key":"233_CR31","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1161\/01.CIR.97.3.276","volume":"97","author":"H Yaoita","year":"1998","unstructured":"Yaoita H, Ogawa K, Maehara K, Maruyama Y: Inhibition of ischemia\/reperfusion injury in rats by a caspase inhibitor. Circulation 97:276\u2013281, 1998","journal-title":"Circulation"},{"key":"233_CR32","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/S0008-6363(99)00271-0","volume":"45","author":"T Okamura","year":"2003","unstructured":"Okamura T, Miura T, Takemura G, Fujiwara H, Iwamoto H, Kawamura K, Kimura M, Ikeda Y, Iwatate M, Matsuzaki M: Effect of caspase inhibitors on myocardial infarct size and myocyte DNA fragmentation in the ischemia-reperfused rat heart. Cardiovasc Res 45: 642\u2013650, 2003","journal-title":"Cardiovasc Res"},{"key":"233_CR33","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0014-2999(00)00477-5","volume":"402","author":"JQ Huang","year":"2000","unstructured":"Huang JQ, Radinovic S, Rezaiefar P, Black SC: In vivo myocardial infarct size reduction by a caspase inhibitor administered after the onset of ischemia. Eur J Pharmacol 402: 139\u2013142, 2000","journal-title":"Eur J Pharmacol"},{"key":"233_CR34","doi-asserted-by":"crossref","first-page":"9977","DOI":"10.1073\/pnas.161120198","volume":"98","author":"G Condorelli","year":"2001","unstructured":"Condorelli G, Roncarati R, Ross J, Jr, Pisani A, Stassi G, Todaro M, Trocha S, Drusco A, Gu Y, Russo MA, Frati G, Jones SP, Lefer DJ, Napoli C, Croce CM: Heart-targeted overexpression of caspase 3 in mice increases infarct size and depresses cardiac function. Proc Natl Acad Sci 98: 9977\u20139982, 2001","journal-title":"Proc Natl Acad Sci"},{"key":"233_CR35","first-page":"86","volume":"74","author":"J Kajstura","year":"1996","unstructured":"Kajstura J, Cheng W, Reiss K, Clark WA, Sonnenblick EH, Krajewski S, Reed JC, Anversa P: Apoptotic and necrotic myocyte death are independent contributing variables of infarct size in rats. Lab Invest 74: 86\u2013107, 1996","journal-title":"Lab Invest"},{"key":"233_CR36","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0002-9440(10)61739-7","volume":"159","author":"R Maruyama","year":"2001","unstructured":"Maruyama R, Takemura G, Aoyama T, Hayakawa K, Koda M, Kawase Y: Dynamic process of apoptosis in adult rat cardiomyocytes analyzed using 48-h videomicroscopy and elecron microscopy. Am J Pathol 159: 683\u2013691, 2001","journal-title":"Am J Pathol"},{"key":"233_CR37","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1006\/jmcc.1998.0660","volume":"30","author":"SC Black","year":"1998","unstructured":"Black SC, Huang JQ, Rezaiefar P, Radinovic S, Eberhart A, Nicholson DW, Rodger IW: Co-localization of the cysteine protease caspase 3 with apoptotic myocytes after in vivo myocardial ischemia and reperfusion in the rat. J Mol Cell Cardiol 30: 733\u2013742, 1998","journal-title":"J Mol Cell Cardiol"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-006-0233-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11010-006-0233-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-006-0233-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T02:06:02Z","timestamp":1559354762000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11010-006-0233-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":37,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["233"],"URL":"https:\/\/doi.org\/10.1007\/s11010-006-0233-1","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}