{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:03:31Z","timestamp":1791187411917,"version":"4.1.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2008,5,23]],"date-time":"2008-05-23T00:00:00Z","timestamp":1211500800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1007\/s11010-008-9791-8","type":"journal-article","created":{"date-parts":[[2008,5,23]],"date-time":"2008-05-23T14:11:54Z","timestamp":1211551914000},"page":"75-84","source":"Crossref","is-referenced-by-count":28,"title":["Requirements of calcium fluxes and ERK kinase activation for glucose- and interleukin-1\u03b2-induced \u03b2-cell apoptosis"],"prefix":"10.1007","volume":"315","author":[{"given":"Hongqiang","family":"Fei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,5,23]]},"reference":[{"key":"9791_CR1","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1007\/BF00400649","volume":"39","author":"T Mandrup-Poulsen","year":"1996","unstructured":"Mandrup-Poulsen T (1996) The role of interleukin-1 in the pathogenesis of IDDM. Diabetologia 39:1005\u20131029. doi: 10.1007\/BF00400649","journal-title":"Diabetologia"},{"key":"9791_CR2","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1172\/JCI200215318","volume":"110","author":"K Maedler","year":"2002","unstructured":"Maedler K, Sergeev P, Ris F et al (2002) Glucose-induced \u03b2 cell production of IL-1\u03b2 contributes to glucotoxicity in human pancreatic islets. J Clin Invest 110:851\u2013860","journal-title":"J Clin Invest"},{"key":"9791_CR3","doi-asserted-by":"crossref","first-page":"15294","DOI":"10.1074\/jbc.273.24.15294","volume":"273","author":"CM Larsen","year":"1998","unstructured":"Larsen CM, Wadt KA, Juhl LF et al (1998) Interleukin-1beta-induced rat pancreatic islet nitric oxide synthesis requires both the p38 and extracellular signal-regulated kinase 1\/2 mitogen-activated protein kinases. J Biol Chem 273:15294\u201315300. doi: 10.1074\/jbc.273.24.15294","journal-title":"J Biol Chem"},{"key":"9791_CR4","first-page":"267","volume":"11","author":"D Pavlovic","year":"2000","unstructured":"Pavlovic D, Andersen NA, Mandrup-Poulsen T et al (2000) Activation of extracellular signal-regulated kinase (ERK)1\/2 contributes to cytokine induced apoptosis in purified rat pancreatic beta-cells. Eur Cytokine Netw 11:267\u2013274","journal-title":"Eur Cytokine Netw"},{"key":"9791_CR5","doi-asserted-by":"crossref","first-page":"21110","DOI":"10.1074\/jbc.M101257200","volume":"276","author":"LM Dickson","year":"2001","unstructured":"Dickson LM, Lingohr MK, McCuaig J et al (2001) Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1). J Biol Chem 276:21110\u201321120. doi: 10.1074\/jbc.M101257200","journal-title":"J Biol Chem"},{"key":"9791_CR6","doi-asserted-by":"crossref","first-page":"7882","DOI":"10.1074\/jbc.270.14.7882","volume":"270","author":"M Frodin","year":"1995","unstructured":"Frodin M, Sekine N, Roche E et al (1995) Glucose, other secretagogues, and nerve growth factor stimulate mitogen-activated protein kinase in the insulin-secreting beta cell line, INS-1. J Biol Chem 270:7882\u20137889. doi: 10.1074\/jbc.270.14.7882","journal-title":"J Biol Chem"},{"key":"9791_CR7","doi-asserted-by":"crossref","first-page":"17771","DOI":"10.1074\/jbc.273.28.17771","volume":"273","author":"SR Hugl","year":"1998","unstructured":"Hugl SR, White MF, Rhodes CJ (1998) Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta cell growth is glucose-dependent: synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells. J Biol Chem 273:17771\u201317779. doi: 10.1074\/jbc.273.28.17771","journal-title":"J Biol Chem"},{"key":"9791_CR8","doi-asserted-by":"crossref","first-page":"5599","DOI":"10.1073\/pnas.94.11.5599","volume":"94","author":"S Khoo","year":"1997","unstructured":"Khoo S, Cobb MH (1997) Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion. Proc Natl Acad Sci USA 94:5599\u20135604. doi: 10.1073\/pnas.94.11.5599","journal-title":"Proc Natl Acad Sci USA"},{"key":"9791_CR9","doi-asserted-by":"crossref","first-page":"966","DOI":"10.2337\/diabetes.51.4.966","volume":"51","author":"MK Lingohr","year":"2002","unstructured":"Lingohr MK, Dickson LM, McCuaig JF et al (2002) Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-\u03b1 or EGF, augments pancreatic \u03b2-cell proliferation. Diabetes 51:966\u2013976. doi: 10.2337\/diabetes.51.4.966","journal-title":"Diabetes"},{"key":"9791_CR10","doi-asserted-by":"crossref","first-page":"974","DOI":"10.2337\/diabetes.52.4.974","volume":"52","author":"I Briaud","year":"2003","unstructured":"Briaud I, Lingohr MK, Dickson LM et al (2003) Differential activation mechanisms of Erk-1\/2 and p70(S6K) by glucose in pancreatic \u03b2-cells. Diabetes 52:974\u2013983. doi: 10.2337\/diabetes.52.4.974","journal-title":"Diabetes"},{"key":"9791_CR11","doi-asserted-by":"crossref","first-page":"16683","DOI":"10.1074\/jbc.M211744200","volume":"278","author":"LB Maggi Jr","year":"2003","unstructured":"Maggi LB Jr, Moran JM, Buller RM et al (2003) ERK activation is required for double-stranded RNA- and virus-induced interleukin-1 expression by macrophages. J Biol Chem 278:16683\u201316689. doi: 10.1074\/jbc.M211744200","journal-title":"J Biol Chem"},{"key":"9791_CR12","doi-asserted-by":"crossref","first-page":"5599","DOI":"10.1073\/pnas.94.11.5599","volume":"94","author":"S Khoo","year":"1997","unstructured":"Khoo S, Cobb MH (1997) Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion. Proc Natl Acad Sci USA 94:5599\u20135604. doi: 10.1073\/pnas.94.11.5599","journal-title":"Proc Natl Acad Sci USA"},{"key":"9791_CR13","doi-asserted-by":"crossref","first-page":"15507","DOI":"10.1074\/jbc.273.25.15507","volume":"273","author":"C Benes","year":"1998","unstructured":"Benes C, Roisin MP, Van Tan H et al (1998) Rapid activation and nuclear translocation of mitogen-activated protein kinases in response to physiological concentration of glucose in the MIN6 pancreatic \u03b2 cell line. J Biol Chem 273:15507\u201315513. doi: 10.1074\/jbc.273.25.15507","journal-title":"J Biol Chem"},{"key":"9791_CR14","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.2337\/diabetes.50.12.2721","volume":"50","author":"CD Major","year":"2001","unstructured":"Major CD, Wolf BA (2001) Interleukin-1\u03b2 stimulation of c-Jun NH2-terminal kinase activity in insulin-secreting cells: evidence for cytoplasmic restriction. Diabetes 50:2721\u20132728. doi: 10.2337\/diabetes.50.12.2721","journal-title":"Diabetes"},{"issue":"Suppl 1","key":"9791_CR15","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.2337\/diabetes.50.2007.S70","volume":"50","author":"SV Zaitsev","year":"2001","unstructured":"Zaitsev SV, Appelskog LB, Kapelioukh IL et al (2001) Imidazoline compounds protect against interleukin 1\u03b2-induced \u03b2-cell apoptosis. Diabetes 50(Suppl 1):S70\u2013S76. doi: 10.2337\/diabetes.50.2007.S70","journal-title":"Diabetes"},{"key":"9791_CR16","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.2337\/diabetes.53.7.1706","volume":"53","author":"K Maedler","year":"2004","unstructured":"Maedler K, Storling J, Sturis J et al (2004) Glucose- and interleukin-1\u03b2-induced \u03b2-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1\/2 activation and is prevented by a sulfonylurea receptor 1\/inwardly rectifying K+ channel 6.2 (SUR\/Kir6.2) selective potassium channel opener in human islets. Diabetes 53:1706\u20131713. doi: 10.2337\/diabetes.53.7.1706","journal-title":"Diabetes"},{"key":"9791_CR17","doi-asserted-by":"crossref","first-page":"7008","DOI":"10.4049\/jimmunol.172.11.7008","volume":"172","author":"I Chang","year":"2004","unstructured":"Chang I, Cho N, Kim S et al (2004) Role of calcium in pancreatic islet cell death by IFN-\u03b3\/TNF-\u03b1. J Immunol 172:7008\u20137012","journal-title":"J Immunol"},{"key":"9791_CR18","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1210\/endo.140.3.6556","volume":"140","author":"L Wang","year":"1999","unstructured":"Wang L, Bhattacharjee A, Zuo Z et al (1999) A low voltage-activated Ca2+ current mediates cytokine-induced pancreatic \u03b2-cell death. Endocrinology 140:1200\u20131204. doi: 10.1210\/en.140.3.1200","journal-title":"Endocrinology"},{"key":"9791_CR19","unstructured":"Brunstedt J, Nielsen JH, Lernmark A, the Hagedorn Study Group (1984) Isolation of islets from mice and rats. In: Larner J, Pohl SL (eds) Methods in diabetes research. Wiley, New York, pp 254\u2013288"},{"key":"9791_CR20","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1038\/sj.bjp.0702422","volume":"126","author":"S Hortelano","year":"1999","unstructured":"Hortelano S, L\u00f3pez-Collazo E, Bosc\u00e1 L (1999) Protective effect of cyclosporin A and FK506 from nitric oxide-dependent apoptosis in activated macrophages. Br J Pharmacol 126:1139\u20131146. doi: 10.1038\/sj.bjp.0702422","journal-title":"Br J Pharmacol"},{"key":"9791_CR21","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","volume":"260","author":"G Grynkiewicz","year":"1985","unstructured":"Grynkiewicz G, Poenie M, Tsien RY (1985) A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem 260:3440\u20133450","journal-title":"J Biol Chem"},{"key":"9791_CR22","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1161\/01.STR.29.12.2631","volume":"29","author":"AM Malek","year":"1998","unstructured":"Malek AM, Goss GG, Jiang L et al (1998) Mannitol at clinical concentrations activates multiple signaling pathways and induces apoptosis in endothelial cells. Stroke 29:2631\u20132640","journal-title":"Stroke"},{"key":"9791_CR23","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1172\/JCI200215318","volume":"110","author":"K Maedler","year":"2002","unstructured":"Maedler K, Sergeev P, Ris F et al (2002) Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. J Clin Invest 110:851\u2013860","journal-title":"J Clin Invest"},{"key":"9791_CR24","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.2337\/diabetes.53.7.1706","volume":"53","author":"K Maedler","year":"2004","unstructured":"Maedler K, Storling J, Sturis J et al (2004) Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1\/2 activation and is prevented by a sulfonylurea receptor 1\/inwardly rectifying K+ channel 6.2 (SUR\/Kir6.2) selective potassium channel opener in human islets. Diabetes 53:1706\u20131713. doi: 10.2337\/diabetes.53.7.1706","journal-title":"Diabetes"},{"key":"9791_CR25","doi-asserted-by":"crossref","first-page":"15294","DOI":"10.1074\/jbc.273.24.15294","volume":"273","author":"CM Larsen","year":"1998","unstructured":"Larsen CM, Wadt KA, Juhl LF et al (1998) Interleukin-1beta-induced rat pancreatic islet nitric oxide synthesis requires both the p38 and extracellular signal-regulated kinase \u00bd mitogen-activated protein kinases. J Biol Chem 273:15294\u201315300. doi: 10.1074\/jbc.273.24.15294","journal-title":"J Biol Chem"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-008-9791-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11010-008-9791-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-008-9791-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,11]],"date-time":"2021-09-11T03:06:45Z","timestamp":1631329605000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11010-008-9791-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,23]]},"references-count":25,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["9791"],"URL":"https:\/\/doi.org\/10.1007\/s11010-008-9791-8","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,23]]}}}