{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:30:50Z","timestamp":1793039450515,"version":"4.5.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2008,6,19]],"date-time":"2008-06-19T00:00:00Z","timestamp":1213833600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1007\/s11010-008-9836-z","type":"journal-article","created":{"date-parts":[[2008,6,18]],"date-time":"2008-06-18T15:46:34Z","timestamp":1213803994000},"page":"105-111","source":"Crossref","is-referenced-by-count":36,"title":["Circadian variations of serotonin in plasma and different brain regions of rats"],"prefix":"10.1007","volume":"317","author":[{"given":"Soledad","family":"S\u00e1nchez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio D.","family":"Paredes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Cubero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana B.","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Barriga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,6,19]]},"reference":[{"key":"9836_CR1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0006-8993(00)01963-6","volume":"859","author":"JD Glass","year":"2000","unstructured":"Glass JD, DiNardo LA, Ehlen JC (2000) Dorsal raphe nuclear stimulation of SCN serotonin and circadian phase-resetting. Brain Res 859:224\u2013232. doi: 10.1016\/S0006-8993(00)01963-6","journal-title":"Brain Res"},{"key":"9836_CR2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/cne.902840110","volume":"284","author":"JP Card","year":"1989","unstructured":"Card JP, Moore RY (1989) Organization of lateral geniculate-hypothalamic connections in the rat. J Comp Neurol 284:135\u2013147. doi: 10.1002\/cne.902840110","journal-title":"J Comp Neurol"},{"key":"9836_CR3","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/cne.901790311","volume":"79","author":"EC Azmitia","year":"1978","unstructured":"Azmitia EC, Segal M (1978) An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat. J Comp Neurol 79:641\u2013667. doi: 10.1002\/cne.901790311","journal-title":"J Comp Neurol"},{"key":"9836_CR4","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0891-0618(03)00042-5","volume":"25","author":"A Hay-Schmidt","year":"2003","unstructured":"Hay-Schmidt A, Vrang N, Larsen PJ, Mikkelsen JD (2003) Projections from the raphe nuclei to the suprachiasmatic nucleus of the rat. J Chem Neuroanat 25:293\u2013310. doi: 10.1016\/S0891-0618(03)00042-5","journal-title":"J Chem Neuroanat"},{"key":"9836_CR5","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0304-3940(96)12795-6","volume":"212","author":"H Kawano","year":"1996","unstructured":"Kawano H, Decker K, Reuss S (1996) Is there a direct retina-raphesuprachiasmatic nucleus pathway in the rat? Neurosci Lett 212:143\u2013146. doi: 10.1016\/0304-3940(96)12795-6","journal-title":"Neurosci Lett"},{"issue":"1","key":"9836_CR6","first-page":"60","volume":"62","author":"JM Monti","year":"1998","unstructured":"Monti JM (1998) La hip\u00f3tesis serotonin\u00e9rgica de la depresi\u00f3n. Rev Psiquiatr Uruguay 62(1):60\u201368","journal-title":"Rev Psiquiatr Uruguay"},{"key":"9836_CR7","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1038\/nrn1256","volume":"4","author":"P Gaspar","year":"2003","unstructured":"Gaspar P, Cases O, Maroteaux L (2003) The developmental role of serotonin: news from mouse molecular genetics. Nat Rev Neurosci 4:1002\u20131012. doi: 10.1038\/nrn1256","journal-title":"Nat Rev Neurosci"},{"issue":"4","key":"9836_CR8","first-page":"548","volume":"3","author":"G G\u00f3mez","year":"2000","unstructured":"G\u00f3mez G, Llorca R (2000) Amino\u00e1cidos. Biopsicologia 3(4):548\u2013576","journal-title":"Biopsicologia"},{"key":"9836_CR9","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1023\/B:MCBI.0000049363.97713.74","volume":"267","author":"S Esteban","year":"2004","unstructured":"Esteban S, Nicolaus C, Garmundi A, Rial RV, Rodr\u00edguez AB, Ortega E et al (2004) Effect of orally administered L-tryptophan on serotonin, melatonin, and the innate immune response in the rat. Mol Cell Biochem 267:39\u201346. doi: 10.1023\/B:MCBI.0000049363.97713.74","journal-title":"Mol Cell Biochem"},{"key":"9836_CR10","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.exger.2005.09.010","volume":"41","author":"C Garau","year":"2006","unstructured":"Garau C, Aparicio S, Rial RV, Nicolau MC, Esteban S (2006) Age-related changes in circadian rhythm of serotonin in ring doves: effects of increased tryptophan ingestion. Exp Gerontol 41:40\u201348. doi: 10.1016\/j.exger.2005.09.010","journal-title":"Exp Gerontol"},{"key":"9836_CR11","doi-asserted-by":"crossref","first-page":"4686","DOI":"10.1073\/pnas.062585499","volume":"99","author":"X Sun","year":"2002","unstructured":"Sun X, Deng J, Liu T, Borjigin J (2002) Circadian 5-HT production regulated by adrenergic signaling. Proc Natl Acad Sci USA 99:4686\u20134691. doi: 10.1073\/pnas.062585499","journal-title":"Proc Natl Acad Sci USA"},{"key":"9836_CR12","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1073\/pnas.53.2.301","volume":"53","author":"SH Snyder","year":"1965","unstructured":"Snyder SH, Zweig M, Axelrod J, Fischer JE (1965) Control of the circadian rhythm in serotonin content of the rat pineal gland. Proc Natl Acad Sci USA 53:301\u2013305. doi: 10.1073\/pnas.53.2.301","journal-title":"Proc Natl Acad Sci USA"},{"key":"9836_CR13","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0014-2999(93)90854-B","volume":"238","author":"G Huether","year":"1993","unstructured":"Huether G, Poeggeler B, Adler L, Ruther E (1993) Effects of indirectly acting 5-HT receptor agonists on circulating melatonin levels in rat. Eur J Pharmacol 238:249\u2013255. doi: 10.1016\/0014-2999(93)90854-B","journal-title":"Eur J Pharmacol"},{"key":"9836_CR14","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1111\/j.1471-4159.1990.tb04952.x","volume":"55","author":"D Sugden","year":"1990","unstructured":"Sugden D (1990) 5-hydroxytryptamine amplified \u03b2 adrenergic stimulation of N-acetyltransferase activity in rat pinealocytes. J Neurochem 55:1655\u20131658. doi: 10.1111\/j.1471-4159.1990.tb04952.x","journal-title":"J Neurochem"},{"key":"9836_CR15","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1111\/j.1365-2826.1995.tb00740.x","volume":"7","author":"JM Miguez","year":"1995","unstructured":"Miguez JM, Simonneaux V, Pevet P (1995) Evidence for regulatory role of melatonin on serotonin release and uptake in the pineal gland. J Neuroendocrinol 7:949\u2013956","journal-title":"J Neuroendocrinol"},{"key":"9836_CR16","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1600-079X.1997.tb00337.x","volume":"23","author":"JM Miguez","year":"1997","unstructured":"Miguez JM, Simonneaux V, Pevet P (1997) The role of the intracellular and extracellular serotonin in the regulation of melatonin production in rat pinealocytes. J Pineal Res 23:63\u201371. doi: 10.1111\/j.1600-079X.1997.tb00337.x","journal-title":"J Pineal Res"},{"key":"9836_CR17","first-page":"266","volume":"295","author":"L Steardo","year":"2000","unstructured":"Steardo L, Monte Lone P, Trabace L, Cannizzaro C, Maj M, Cuomo V (2000) Serotonergic modulation of rat pineal gland activity: in vivo evidence for hydroxytryptamine (2C) receptor involvement. J Pharmacol Exp Ther 295:266\u2013273","journal-title":"J Pharmacol Exp Ther"},{"key":"9836_CR18","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1111\/j.1471-4159.1993.tb13390.x","volume":"60","author":"A Adell","year":"1993","unstructured":"Adell A, Carceller A, Artigas F (1993) In vivo brain dialysis study of the somatodendritic release of serotonin in the raphe nuclei of the rat: effects of 8-hydroxy-2-(di-n-propylamino)tetralin. J Neurochem 60:1673\u20131681. doi: 10.1111\/j.1471-4159.1993.tb13390.x","journal-title":"J Neurochem"},{"key":"9836_CR19","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s002109900045","volume":"360","author":"S Esteban","year":"1999","unstructured":"Esteban S, Llado J, Sastre-Coll A, Garc\u00eda-Sevilla JA (1999) Activation and desensitization by cyclic antidepressant drugs of alpha2-autoreceptors, alpha2-heteroreceptors and 5-HT1A-autoreceptors regulating monamine synthesis in the rat brain in vivo. Naunyn Schmiedebergs Arch Pharmacol 360:135\u2013143","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"9836_CR20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/074873049300800101","volume":"8","author":"RA Prosser","year":"1993","unstructured":"Prosser RA, Dean RR, Edgar DM, Heller HC, Miller JD (1993) Serotonin and the mammalian circadian system: I. In vitro phase shifts by serotonergic agonists and antagonists. J Biol Rhythms 8:1\u201316. doi: 10.1177\/074873049300800101","journal-title":"J Biol Rhythms"},{"key":"9836_CR21","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/0006-2952(65)90102-4","volume":"14","author":"SH Snyder","year":"1965","unstructured":"Snyder SH, Axelrod J, Zweig M (1965) A sensitive and specific fluorescence assay for tissue serotonin. Biochem Pharmacol 14:831\u2013835. doi: 10.1016\/0006-2952(65)90102-4","journal-title":"Biochem Pharmacol"},{"key":"9836_CR22","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s004080000009","volume":"178","author":"M Miyata","year":"2000","unstructured":"Miyata M, Ito M, Sasajima T, Ohira H, Sato Y, Kasukawa R (2000) Development of monocrotaline-induced pulmonary hypertension is attenuated by a serotonin receptor antagonist. Lung 178:63\u201373. doi: 10.1007\/s004080000009","journal-title":"Lung"},{"key":"9836_CR23","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1096\/fj.02-1122fje","volume":"17","author":"CG Nebigil","year":"2003","unstructured":"Nebigil CG, Etienne N, Messaddeq N, Maroteaux L (2003) Serotonin is a novel survival factor of cardiomyocytes: mitochondria as a target of 5-HT2B receptor signaling. FASEB J 17:1373\u20131375","journal-title":"FASEB J"},{"key":"9836_CR24","doi-asserted-by":"crossref","unstructured":"Kato S, Fujiwara I, Yoshida N (1999) Nitrogen-containing heteroalicycles with serotonin receptor binding affinity: development of gastroprokinetic and antiemetic agents. Med Res Rev 19:25\u201373. doi:10.1002\/(SICI)1098-1128(199901)19:1<25::AID-MED3>3.0.CO;2-E","DOI":"10.1002\/(SICI)1098-1128(199901)19:1<25::AID-MED3>3.0.CO;2-E"},{"key":"9836_CR25","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"M Bradford","year":"1976","unstructured":"Bradford M (1976) A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254. doi: 10.1016\/0003-2697(76)90527-3","journal-title":"Anal Biochem"},{"key":"9836_CR26","first-page":"55","volume":"110","author":"J Berger","year":"1983","unstructured":"Berger J (1983) Seasonal influences on circadian rhythms in the blood picture of SPF rats housed under artificial illumination. Folia Hematol 110:55\u201370","journal-title":"Folia Hematol"},{"key":"9836_CR27","first-page":"833","volume":"115","author":"J Berger","year":"1988","unstructured":"Berger J (1988) HEMA-particles phagocytosis of rat neutrophils. Folia Hematol 115:833\u2013836","journal-title":"Folia Hematol"},{"key":"9836_CR28","doi-asserted-by":"crossref","first-page":"341","DOI":"10.55782\/ane-1996-1138","volume":"56","author":"K Skwarlo-Sonta","year":"1996","unstructured":"Skwarlo-Sonta K (1996) Functional connections between the pineal gland and immune system. Acta Neurobiol Exp (Warsz) 56:341\u2013357","journal-title":"Acta Neurobiol Exp (Warsz)"},{"key":"9836_CR29","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1600-079X.1999.tb00564.x","volume":"26","author":"AB Rodr\u00edguez","year":"1999","unstructured":"Rodr\u00edguez AB, Marchena JM, Nogales G, Dur\u00e1n J, Barriga C (1999) Correlation between circadian rhythm of melatonin and the phagocytosis and superoxide anion levels in ring dove heterophils. J Pineal Res 26:35\u201342. doi: 10.1111\/j.1600-079X.1999.tb00564.x","journal-title":"J Pineal Res"},{"issue":"3","key":"9836_CR30","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1034\/j.1600-079X.2001.300307.x","volume":"30","author":"C Barriga","year":"2001","unstructured":"Barriga C, Mart\u00edn MI, Tabla R, Ortega E, Rodr\u00edguez AB (2001) Circadian rhythm of melatonin, corticosterone and phagocytosis: effect of stress. J Pineal Res 30(3):180\u2013187. doi: 10.1034\/j.1600-079X.2001.300307.x","journal-title":"J Pineal Res"},{"key":"9836_CR31","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1055\/s-0028-1095603","volume":"8","author":"I Sauerbier","year":"1976","unstructured":"Sauerbier I, Von Mayersbach H (1976) Circadian variation of serotonin levels in human blood. Horm Metab Res 8:157\u2013158","journal-title":"Horm Metab Res"},{"key":"9836_CR32","first-page":"1579","volume":"19","author":"RC Arora","year":"1984","unstructured":"Arora RC, Kregel L, Meltzer HY (1984) Circadian rhythm of serotonin uptake in the blood platelets of normal controls. Biol Psychiatry 19:1579\u20131584","journal-title":"Biol Psychiatry"},{"key":"9836_CR33","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/BF00178513","volume":"88","author":"I Modai","year":"1986","unstructured":"Modai I, Malmgren R, Asberg M, Beving H (1986) Circadian rhythm of serotonin transport in human platelets. Psychopharmacology (Berl) 88:493\u2013495. doi: 10.1007\/BF00178513","journal-title":"Psychopharmacology (Berl)"},{"key":"9836_CR34","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0049-3848(90)90188-I","volume":"60","author":"MH Pietraszek","year":"1990","unstructured":"Pietraszek MH, Urano Umiyoshi K (1990) Circadian rhythm of serotonin: influence of age. Thromb Res 60:253\u2013357. doi: 10.1016\/0049-3848(90)90188-I","journal-title":"Thromb Res"},{"key":"9836_CR35","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0304-3940(91)90441-U","volume":"132","author":"T Azekawa","year":"1991","unstructured":"Azekawa T, Sano A, Sei H, Morita Y (1991) Diurnal changes in pineal extracellular indoles of freely moving rats. Neurosci Lett 132:93\u201396. doi: 10.1016\/0304-3940(91)90441-U","journal-title":"Neurosci Lett"},{"issue":"13","key":"9836_CR36","doi-asserted-by":"crossref","first-page":"5045","DOI":"10.1523\/JNEUROSCI.18-13-05045.1998","volume":"18","author":"TE Dudley","year":"1998","unstructured":"Dudley TE, DiNardo LA, Glass JD (1998) Endogenous regulation of serotonin release in the hamster suprachiasmatic nucleus. J Neurosci 18(13):5045\u20135052","journal-title":"J Neurosci"},{"key":"9836_CR37","first-page":"R504","volume":"265","author":"JD Glass","year":"1993","unstructured":"Glass JD, Hauser UE, Blank JL, Selim M, Rea MA (1993) Differential timing of amino acid and 5-HIAA rhythms in suprachiasmatic hypothalamus. Am J Physiol 265:R504\u2013R511","journal-title":"Am J Physiol"},{"key":"9836_CR38","first-page":"111","volume":"279","author":"H Faradji","year":"1983","unstructured":"Faradji H, Cespuglio R, Jouvert (1983) Voltametric measurements of 5-hydroxyindole compounds in the suprachiasmatic nuclei. Circadian fluctuations. Brain Res 279:111\u2013119. doi: 10.1016\/0006-8993(83)90168-3","journal-title":"Circadian fluctuations. Brain Res"},{"key":"9836_CR39","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1159\/000124857","volume":"46","author":"AD Ramirez","year":"1987","unstructured":"Ramirez AD, Ramirez VD, Meyer DC (1987) The nature and magnitude of in vivo 5-hydroxyindoleacetic acid output from 5-hydroxytryptamine terminals is related to specific regions of the the suprachiasmatic nucleus. Neuroendocrinology 46:430\u2013438. doi: 10.1159\/000124857","journal-title":"Neuroendocrinology"},{"key":"9836_CR40","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1159\/000126277","volume":"56","author":"JD Glass","year":"1992","unstructured":"Glass JD, Randolph WW, Ferreira SA, Rea MA, Hauser UE, Blank JL, De Vries MJ (1992) Diurnal variation in 5-hydroxyindoleacetic acid output in the suprachiasmatic region of the Siberian hamster assessed by in vivo microdialysis: evidence for nocturnal activation of serotonin release. Neuroendocrinology 56:582\u2013590","journal-title":"Neuroendocrinology"},{"issue":"4","key":"9836_CR41","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1080\/07420520600827145","volume":"23","author":"SD Paredes","year":"2006","unstructured":"Paredes SD, Terr\u00f3n MP, Cubero J, Valero V, Barriga C, Reiter RJ et al (2006) Comparative study of the activity\/rest rhythms in young and old ringdove (Streptopelia risoria): correlation with serum levels of melatonin and serotonin. Chronobiol Int 23(4):779\u2013793. doi: 10.1080\/07420520600827145","journal-title":"Chronobiol Int"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-008-9836-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11010-008-9836-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-008-9836-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T12:21:45Z","timestamp":1709036505000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11010-008-9836-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,19]]},"references-count":41,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["9836"],"URL":"https:\/\/doi.org\/10.1007\/s11010-008-9836-z","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,19]]}}}