{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:44:54Z","timestamp":1786981494523,"version":"build-2736575974"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2008,7,4]],"date-time":"2008-07-04T00:00:00Z","timestamp":1215129600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1007\/s11010-008-9848-8","type":"journal-article","created":{"date-parts":[[2008,7,3]],"date-time":"2008-07-03T03:20:01Z","timestamp":1215055201000},"page":"189-196","source":"Crossref","is-referenced-by-count":38,"title":["Activation of peroxisome proliferator-activated receptor gamma inhibits endothelin-1-induced cardiac hypertrophy via the calcineurin\/NFAT signaling pathway"],"prefix":"10.1007","volume":"317","author":[{"given":"Yingxia","family":"Bao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birong","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaorui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiqing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,7,4]]},"reference":[{"key":"9848_CR1","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nm0698-661","volume":"4","author":"S Izumo","year":"1998","unstructured":"Izumo S, Aoki H (1998) Calcineurin\u2014the missing link in cardiac hypertrophy. Nat Med 4:661\u2013662. doi: 10.1038\/nm0698-661","journal-title":"Nat Med"},{"key":"9848_CR2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.phrs.2004.07.012","volume":"51","author":"BP Kota","year":"2005","unstructured":"Kota BP, Huang TH-W, Roufogalis BD (2005) An overview on biological mechanisms of PPARs. Pharmacol Res 51:85\u201394. doi: 10.1016\/j.phrs.2004.07.012","journal-title":"Pharmacol Res"},{"key":"9848_CR3","doi-asserted-by":"crossref","first-page":"17042","DOI":"10.1074\/jbc.274.24.17042","volume":"274","author":"D Bishop-Bailey","year":"1999","unstructured":"Bishop-Bailey D, Hla T (1999) Endothelial cell apoptosis induced by the peroxisome proliferator-activated receptor (PPAR) ligand 15-deoxy-Delta12,14-prostaglandin J2. J Biol Chem 274:17042\u201317048. doi: 10.1074\/jbc.274.24.17042","journal-title":"J Biol Chem"},{"key":"9848_CR4","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1161\/01.CIR.0000016049.86468.23","volume":"105","author":"QN Diep","year":"2002","unstructured":"Diep QN, Mabrouk ME, Cohn JS et al (2002) Structure, endothelial function, cell growth, and inflammation in blood vessels of angiotensin II-infused rats role of peroxisome proliferator-activated receptor-\u03b3. Circulation 105:2296\u20132302. doi: 10.1161\/01.CIR.0000016049.86468.23","journal-title":"Circulation"},{"key":"9848_CR5","doi-asserted-by":"crossref","first-page":"16S","DOI":"10.1042\/CS103S016S","volume":"103","author":"S Sakai","year":"2002","unstructured":"Sakai S, Miyauchi T, Irukayama-Tomobe Y et al (2002) Peroxisome proliferator-activated receptor-\u03b3 activators inhibit endothelin-1-related cardiac hypertrophy in rats. Clin Sci 103:16S\u201320S","journal-title":"Clin Sci"},{"key":"9848_CR6","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1161\/hc1002.105225","volume":"105","author":"M Asakawa","year":"2002","unstructured":"Asakawa M, Takano H, Nagai T et al (2002) Peroxisome proliferator-activated receptor \u03b3 plays a critical role in inhibition of cardiac hypertrophy in vitro and in vivo. Circulation 105:1240\u20131246. doi: 10.1161\/hc1002.105225","journal-title":"Circulation"},{"key":"9848_CR7","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1139\/y04-094","volume":"82","author":"QN Diep","year":"2004","unstructured":"Diep QN, Amiri F, Benkirane K et al (2004) Long-term effects of the PPAR\u03b3 activator pioglitazone on cardiac inflammation in stroke prone spontaneously hypertensive rats. Can J Physiol Pharmacol 82:976\u2013985. doi: 10.1139\/y04-094","journal-title":"Can J Physiol Pharmacol"},{"key":"9848_CR8","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1161\/hc4001.097186","volume":"104","author":"K Yamamoto","year":"2001","unstructured":"Yamamoto K, Ohki R, Lee RT et al (2001) Peroxisome proliferator-activated receptor \u03b3 activators inhibit cardiac hypertrophy in cardiac myocytes. Circulation 104:1670\u20131675. doi: 10.1161\/hc4001.097186","journal-title":"Circulation"},{"key":"9848_CR9","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0092-8674(00)81573-1","volume":"93","author":"JD Molkentin","year":"1998","unstructured":"Molkentin JD, Lu J-R, Antos CL et al (1998) A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 93:215\u2013228. doi: 10.1016\/S0092-8674(00)81573-1","journal-title":"Cell"},{"key":"9848_CR10","doi-asserted-by":"crossref","first-page":"13571","DOI":"10.1074\/jbc.275.18.13571","volume":"275","author":"LJD Windt","year":"2000","unstructured":"Windt LJD, Lim HW, Haq S et al (2000) Calcineurin promotes protein kinase C and c-Jun NH2-terminal kinase activation in the heart. J Biol Chem 275:13571\u201313579. doi: 10.1074\/jbc.275.18.13571","journal-title":"J Biol Chem"},{"key":"9848_CR11","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.cardiores.2004.04.002","volume":"63","author":"B Fiedler","year":"2004","unstructured":"Fiedler B, Wollert KC (2004) Interference of antihypertrophic molecules and signaling pathways with the Ca2+-calcineurin-NFAT cascade in cardiac myocytes. Cardiovasc Res 63:450\u2013457. doi: 10.1016\/j.cardiores.2004.04.002","journal-title":"Cardiovasc Res"},{"key":"9848_CR12","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1161\/01.CIR.104.1.97","volume":"104","author":"Y Zou","year":"2001","unstructured":"Zou Y, Hiroi Y, Uozumi H et al (2001) Calcineurin plays a critical role in the development of pressure overload-induced cardiac hypertrophy. Circulation 104:97\u2013101. doi: 10.1161\/hc2601.090987","journal-title":"Circulation"},{"key":"9848_CR13","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.bbrc.2004.07.121","volume":"322","author":"BJ Wilkins","year":"2004","unstructured":"Wilkins BJ, Molkentin JD (2004) Calcium-calcineurin signaling in the regulation of cardiac hypertrophy. Biochem Biophys Res Commun 322:1178\u20131191. doi: 10.1016\/j.bbrc.2004.07.121","journal-title":"Biochem Biophys Res Commun"},{"key":"9848_CR14","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1124\/mol.64.5.1169","volume":"64","author":"SW Chung","year":"2003","unstructured":"Chung SW, Kang BY, Kim TS (2003) Inhibition of interleukin-4 production in CD4+ T cells by PPAR-\u03b3 ligands: involvement of physical association between PPAR-\u03b3 and the nuclear factor of activated T cells transcription factor. Mol Pharmacol 64:1169\u20131179. doi: 10.1124\/mol.64.5.1169","journal-title":"Mol Pharmacol"},{"key":"9848_CR15","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/jcb.21044","volume":"100","author":"L Liu","year":"2007","unstructured":"Liu L, Clipstone NA (2007) Prostaglandin F2\u03b1 inhibits adipocyte differentiation via a G\u03b1q-calcium-calcineurin-dependent signaling pathway. J Cell Biochem 100:161\u2013173. doi: 10.1002\/jcb.21044","journal-title":"J Cell Biochem"},{"key":"9848_CR16","doi-asserted-by":"crossref","first-page":"3892","DOI":"10.1128\/MCB.22.11.3892-3904.2002","volume":"22","author":"TTC Yang","year":"2002","unstructured":"Yang TTC, Xiong Q, Enslen H et al (2002) Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases. Mol Cell Biol 22:3892\u20133904. doi: 10.1128\/MCB.22.11.3892-3904.2002","journal-title":"Mol Cell Biol"},{"key":"9848_CR17","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/sj.bjp.0703149","volume":"129","author":"D Bishop-Bailey","year":"2000","unstructured":"Bishop-Bailey D (2000) Peroxisome proliferator-activated receptors in the cardiovascular system. Br J Pharmacol 129:823\u2013834. doi: 10.1038\/sj.bjp.0703149","journal-title":"Br J Pharmacol"},{"key":"9848_CR18","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s10616-006-6334-6","volume":"49","author":"JJ Fu","year":"2005","unstructured":"Fu JJ, Gao J, Pi RB et al (2005) An optimized protocol for culture of cardiomyocyte from neonatal rat. Cytotechnology 49:109\u2013116. doi: 10.1007\/s10616-006-6334-6","journal-title":"Cytotechnology"},{"key":"9848_CR19","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1745-7254.2006.00263.x","volume":"27","author":"C Xu","year":"2006","unstructured":"Xu C, Wang L, Liu H et al (2006) C333H, a novel PPAR\u03b1\/\u03b3 dual agonist, has beneficial effects on insulin resistance and lipid metabolism. Acta Pharmacol Sin 27:223\u2013228. doi: 10.1111\/j.1745-7254.2006.00263.x","journal-title":"Acta Pharmacol Sin"},{"key":"9848_CR20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.regpep.2004.07.034","volume":"125","author":"M Chena","year":"2005","unstructured":"Chena M, Lia X, Dongb Q et al (2005) Neuropeptide Y induces cardiomyocyte hypertrophy via calcineurin signaling in rats. Regul Pept 125:9\u201315. doi: 10.1016\/j.regpep. 2004.07.034","journal-title":"Regul Pept"},{"key":"9848_CR21","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1111\/j.1742-4658.2005.04614.x","volume":"272","author":"W Liao","year":"2005","unstructured":"Liao W, Wang S, Han C et al (2005) 14-3-3 Proteins regulate glycogen synthase 3beta phosphorylation and inhibit cardiomyocyte hypertrophy. FEBS J 272:1845\u20131854. doi: 10.1111\/j.1742-4658.2005.04614.x","journal-title":"FEBS J"},{"key":"9848_CR22","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.yjmcc.2006.10.020","volume":"42","author":"O Takayoshi","year":"2007","unstructured":"Takayoshi O, Hiroyuki W, Manabu M et al (2007) Upregulation of TRPC1 in the development of cardiac hypertrophy. J Mol Cell Cardiol 42:498\u2013507. doi: 10.1016\/j.yjmcc.2006.10.020","journal-title":"J Mol Cell Cardiol"},{"key":"9848_CR23","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1016\/j.bcp.2007.08.022","volume":"74","author":"Y Lu","year":"2007","unstructured":"Lu Y, Shioda N, Han F et al (2007) Imbalance between CaM kinase II and calcineurin activities impairs caffeine-induced calcium release in hypertrophic cardiomyocytes. Biochem Pharmacol 74:1727\u20131737. doi: 10.1016\/j.bcp. 2007.08.022","journal-title":"Biochem Pharmacol"},{"key":"9848_CR24","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1016\/j.febslet.2007.06.017","volume":"581","author":"R Li","year":"2007","unstructured":"Li R, Zheng W, Pi R et al (2007) Activation of peroxisome proliferator-activated receptor-\u03b1 prevents glycogen synthase 3\u03b2 phosphorylation and inhibits cardiac hypertrophy. FEBS Lett 581:3311\u20133316. doi: 10.1016\/j.febslet.2007.06.017","journal-title":"FEBS Lett"},{"key":"9848_CR25","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.cardiores.2004.03.015","volume":"63","author":"SE Hardta","year":"2004","unstructured":"Hardta SE, Sadoshima J (2004) Negative regulators of cardiac hypertrophy. Cardiovasc Res 63:500\u2013509. doi: 10.1016\/j.cardiores.2004.03.015","journal-title":"Cardiovasc Res"},{"key":"9848_CR26","doi-asserted-by":"crossref","first-page":"6640","DOI":"10.1021\/bi0159581","volume":"41","author":"LM Leesnitzer","year":"2002","unstructured":"Leesnitzer LM, Parks DJ, Bledsoe RK et al (2002) Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662. Biochemistry 41:6640\u20136650. doi: 10.1021\/bi0159581","journal-title":"Biochemistry"},{"key":"9848_CR27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.abb.2007.03.013","volume":"462","author":"P Laidler","year":"2007","unstructured":"Laidler P, Duli\u0144ska J, Mrozicki S (2007) Does the inhibition of c-myc expression mediate the anti-tumor activity of PPAR\u2019s ligands in prostate cancer cell lines? Arch Biochem Biophys 462:1\u201312. doi: 10.1016\/j.abb.2007.03.013","journal-title":"Arch Biochem Biophys"},{"key":"9848_CR28","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1161\/01.RES.0000127122.22685.0A","volume":"94","author":"N Marx","year":"2004","unstructured":"Marx N, Duez H, Fruchart J-C et al (2004) Peroxisome proliferator-activated receptors and atherogenesis regulators of gene expression in vascular cells. Circ Res 94:1168\u20131178. doi: 10.1161\/01.RES.0000127122.22685.0A","journal-title":"Circ Res"},{"key":"9848_CR29","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1161\/01.CIR.101.18.2134","volume":"101","author":"Y Eto","year":"2000","unstructured":"Eto Y, Yonekura K, Sonoda M et al (2000) Calcineurin is activated in rat hearts with physiological left ventricular hypertrophy induced by voluntary exercise training. Circulation 101:2134\u20132137","journal-title":"Circulation"},{"key":"9848_CR30","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1161\/01.CIR.102.16.1996","volume":"102","author":"M Shimoyama","year":"2000","unstructured":"Shimoyama M, Hayashi D, Zou Y et al (2000) Calcineurin inhibitor attenuates the development and induces the regression of cardiac hypertrophy in rats with salt-sensitive hypertension. Circulation 102:1996\u20132004","journal-title":"Circulation"},{"key":"9848_CR31","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1161\/hc0602.104675","volume":"105","author":"Y Takeda","year":"2002","unstructured":"Takeda Y, Yoneda T, Demura M et al (2002) Calcineurin inhibition attenuates mineralocorticoid-induced cardiac hypertrophy. Circulation 105:677\u2013679. doi: 10.1161\/hc0602.104675","journal-title":"Circulation"},{"key":"9848_CR32","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/S0022-2828(03)00234-7","volume":"35","author":"T Saito","year":"2003","unstructured":"Saito T, Fukuzawa J, Osaki J et al (2003) Roles of calcineurin and calcium\/calmodulin-dependent protein kinase II in pressure overload-induced cardiac hypertrophy. J Mol Cell Cardiol 35:1153\u20131160. doi: 10.1016\/S0022-2828(03)00234-7","journal-title":"J Mol Cell Cardiol"},{"key":"9848_CR33","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/6430","volume":"5","author":"HW Lim","year":"1999","unstructured":"Lim HW, Molkentin JD (1999) Calcineurin and human heart failure. Nat Med 5:246\u2013247. doi: 10.1038\/6430","journal-title":"Nat Med"},{"key":"9848_CR34","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1161\/01.CIR.0000016044.19527.96","volume":"105","author":"O Ritter","year":"2002","unstructured":"Ritter O, Hack S, Schuh K et al (2002) Calcineurin in human heart hypertrophy. Circulation 105:2265\u20132269. doi: 10.1161\/01.CIR.0000016044.19527.96","journal-title":"Circulation"},{"key":"9848_CR35","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.cardiores.2004.01.021","volume":"63","author":"JD Molkentin","year":"2004","unstructured":"Molkentin JD (2004) Calcineurin\u2013NFAT signaling regulates the cardiac hypertrophic response in coordination with the MAPKs. Cardiovasc Res 63:467\u2013475. doi: 10.1016\/j.cardiores.2004.01.021","journal-title":"Cardiovasc Res"},{"key":"9848_CR36","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1101\/gad.1102703","volume":"17","author":"PG Hogan","year":"2003","unstructured":"Hogan PG, Chen L, Nardone J et al (2003) Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev 17:2205\u20132232. doi: 10.1101\/gad.1102703","journal-title":"Genes Dev"},{"key":"9848_CR37","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1161\/01.RES.0000243208.59795.d8","volume":"99","author":"M Hallhuber","year":"2006","unstructured":"Hallhuber M, Burkard N, Wu R et al (2006) Inhibition of nuclear import of calcineurin prevents myocardial hypertrophy. Circ Res 99:626\u2013635. doi: 10.1161\/01.RES.0000243208.59795.d8","journal-title":"Circ Res"},{"key":"9848_CR38","doi-asserted-by":"crossref","first-page":"13872","DOI":"10.1074\/jbc.275.18.13872","volume":"275","author":"Arco PGd","year":"2000","unstructured":"PGd Arco, Mart\u00ednez-Mart\u00ednez S, Maldonado JL et al (2000) A role for the p38 MAP kinase pathway in the nuclear shuttling of NFATp. J Biol Chem 275:13872\u201313878. doi: 10.1074\/jbc.275.18.13872","journal-title":"J Biol Chem"},{"key":"9848_CR39","doi-asserted-by":"crossref","first-page":"4541","DOI":"10.1074\/jbc.275.7.4541","volume":"275","author":"XY Yang","year":"2000","unstructured":"Yang XY, Wang LH, Chen T et al (2000) Activation of human T lymphocytes is inhibited by peroxisome proliferator activated receptor\u03b3 (PPAR\u03b3) agonists. PPAR\u03b3 co-association with transcription factor NFAT. J Biol Chem 275:4541\u20134544. doi: 10.1074\/jbc.275.7.4541","journal-title":"J Biol Chem"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-008-9848-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11010-008-9848-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-008-9848-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T22:11:24Z","timestamp":1559340684000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11010-008-9848-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,4]]},"references-count":39,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["9848"],"URL":"https:\/\/doi.org\/10.1007\/s11010-008-9848-8","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,4]]}}}