{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:19:33Z","timestamp":1791123573346,"version":"4.1.0"},"reference-count":155,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2009,4,22]],"date-time":"2009-04-22T00:00:00Z","timestamp":1240358400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1007\/s11010-009-0111-8","type":"journal-article","created":{"date-parts":[[2009,4,21]],"date-time":"2009-04-21T06:44:06Z","timestamp":1240296246000},"page":"73-91","source":"Crossref","is-referenced-by-count":145,"title":["Dictyostelium discoideum\u2014a model for many reasons"],"prefix":"10.1007","volume":"329","author":[{"given":"Sarah J.","family":"Annesley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,4,22]]},"reference":[{"key":"111_CR1","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1126\/science.290.5493.972","volume":"290","author":"SL Baldauf","year":"2000","unstructured":"Baldauf SL, Roger AJ, Wenk-Siefert I et al (2000) A kingdom-level phylogeny of eukaryotes based on combined protein. Science 290:972\u2013977. doi: 10.1126\/science.290.5493.972","journal-title":"Science"},{"key":"111_CR2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nature03481","volume":"435","author":"L Eichinger","year":"2005","unstructured":"Eichinger L, Pachebat JA, Glockner G et al (2005) The genome of the social amoeba Dictyostelium discoideum. Nature 435:43\u201357. doi: 10.1038\/nature03481","journal-title":"Nature"},{"key":"111_CR3","doi-asserted-by":"crossref","first-page":"D423","DOI":"10.1093\/nar\/gkj090","volume":"34","author":"RL Chisholm","year":"2006","unstructured":"Chisholm RL, Gaudet P, Just EM et al (2006) dictyBase, the model organism database for Dictyostelium discoideum. Nucleic Acids Res 34:D423\u2013D427. doi: 10.1093\/nar\/gkj090","journal-title":"Nucleic Acids Res"},{"key":"111_CR4","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1371\/journal.pgen.0020038","volume":"2","author":"JM Goldberg","year":"2006","unstructured":"Goldberg JM, Manning G, Liu A et al (2006) The Dictyostelium kinome\u2014analysis of the protein kinases from a simple model organism. PLoS Genet 2:e38. doi: 10.1371\/journal.pgen.0020038","journal-title":"PLoS Genet"},{"key":"111_CR5","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/1471-2180-6-75","volume":"6","author":"P Torija","year":"2006","unstructured":"Torija P, Robles A, Escalante R (2006) Optimization of a large-scale gene disruption protocol in Dictyostelium and analysis of conserved genes of unknown function. BMC Microbiol 6:75. doi: 10.1186\/1471-2180-6-75","journal-title":"BMC Microbiol"},{"key":"111_CR6","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1242\/jcs.02819","volume":"119","author":"P Torija","year":"2006","unstructured":"Torija P, Vicente JJ, Rodrigues TB et al (2006) Functional genomics in Dictyostelium: MidA, a novel conserved protein is required for mitochondrial function and development. J Cell Sci 119:1154\u20131164. doi: 10.1242\/jcs.02819","journal-title":"J Cell Sci"},{"key":"111_CR7","doi-asserted-by":"crossref","first-page":"3442","DOI":"10.1091\/mbc.e08-01-0075","volume":"19","author":"J Calvo-Garrido","year":"2008","unstructured":"Calvo-Garrido J, Carilla-Latorre S, L\u00e1zaro-Di\u00e9guez F et al (2008) Vacuole membrane protein 1 is an endoplasmic reticulum protein required for organelle biogenesis, protein secretion, and development. Mol Biol Cell 19:3442\u20133453. doi: 10.1091\/mbc.E08-01-0075","journal-title":"Mol Biol Cell"},{"key":"111_CR8","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.1128\/MCB.4.12.2890","volume":"4","author":"W Nellen","year":"1984","unstructured":"Nellen W, Silan C, Firtel RA (1984) DNA-mediated transformation in Dictyostelium discoideum: regulated expression of an actin gene fusion. Mol Cell Biol 4:2890\u20132898","journal-title":"Mol Cell Biol"},{"key":"111_CR9","volume-title":"Dictyostelium discoideum protocols. Methods in molecular biology","year":"2006","unstructured":"Eichinger L, Rivero F (eds) (2006) Dictyostelium discoideum protocols. Methods in molecular biology, vol 346. Humana Press, Totowo"},{"key":"111_CR10","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0074-7696(02)21014-1","volume":"221","author":"M Maniak","year":"2002","unstructured":"Maniak M (2002) Conserved features of endocytosis in Dictyostelium. Int Rev Cytol 221:257\u2013287. doi: 10.1016\/S0074-7696(02)21014-1","journal-title":"Int Rev Cytol"},{"key":"111_CR11","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1034\/j.1600-0854.2001.002005311.x","volume":"2","author":"J Cardelli","year":"2001","unstructured":"Cardelli J (2001) Phagocytosis and macropinocytosis in Dictyostelium: phosphoinositide-based processes, biochemically distinct. Traffic 2:311\u2013320. doi: 10.1034\/j.1600-0854.2001.002005311.x","journal-title":"Traffic"},{"key":"111_CR12","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0304-4165(01)00105-2","volume":"1525","author":"M Maniak","year":"2001","unstructured":"Maniak M (2001) Fluid-phase uptake and transit in axenic Dictyostelium cells. Biochim Biophys Acta 1525:197\u2013204","journal-title":"Biochim Biophys Acta"},{"key":"111_CR13","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1462-5822.2005.00493.x","volume":"7","author":"M Steinert","year":"2005","unstructured":"Steinert M, Heuner K (2005) Dictyostelium as host model for pathogenesis. Cell Microbiol 7:307\u2013314. doi: 10.1111\/j.1462-5822.2005.00493.x","journal-title":"Cell Microbiol"},{"key":"111_CR14","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.ejcb.2006.06.003","volume":"85","author":"SS Willard","year":"2006","unstructured":"Willard SS, Devreotes PN (2006) Signaling pathways mediating chemotaxis in the social amoeba, Dictyostelium discoideum. Eur J Cell Biol 85:897\u2013904. doi: 10.1016\/j.ejcb.2006.06.003","journal-title":"Eur J Cell Biol"},{"key":"111_CR15","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.ejcb.2006.04.007","volume":"85","author":"AT Sasaki","year":"2006","unstructured":"Sasaki AT, Firtel RA (2006) Regulation of chemotaxis by the orchestrated activation of Ras, PI3K, and TOR. Eur J Cell Biol 85:873\u2013895. doi: 10.1016\/j.ejcb.2006.04.007","journal-title":"Eur J Cell Biol"},{"key":"111_CR16","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1083\/jcb.200709180","volume":"180","author":"DM Veltman","year":"2008","unstructured":"Veltman DM, Keizer-Gunnik I, van Haastert PJM (2008) Four key signaling pathways mediating chemotaxis in Dictyostelium discoideum. J Cell Biol 180:747\u2013753. doi: 10.1083\/jcb.200709180","journal-title":"J Cell Biol"},{"key":"111_CR17","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1016\/j.febslet.2008.04.035","volume":"582","author":"C Janetopoulos","year":"2008","unstructured":"Janetopoulos C, Firtel RA (2008) Directional sensing during chemotaxis. FEBS Lett 582:2075\u20132085. doi: 10.1016\/j.febslet.2008.04.035","journal-title":"FEBS Lett"},{"key":"111_CR18","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/bies.950190507","volume":"19","author":"PR Fisher","year":"1997","unstructured":"Fisher PR (1997) Genetics of phototaxis in a model eukaryote, Dictyostelium discoideum. Bioessays 19:397\u2013408. doi: 10.1002\/bies.950190507","journal-title":"Bioessays"},{"key":"111_CR19","first-page":"519","volume-title":"Photomovement. ESP comprehensive series in photosciences","author":"PR Fisher","year":"2001","unstructured":"Fisher PR (2001) Genetic analysis of phototaxis in Dictyostelium. In: Hader DP, Lebert M (eds) Photomovement. ESP comprehensive series in photosciences, vol 1. Elsevier Science Ltd, Amsterdam, pp 519\u2013559"},{"key":"111_CR20","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/sj.embor.7400714","volume":"7","author":"JG Williams","year":"2006","unstructured":"Williams JG (2006) Transcriptional regulation of Dictyostelium pattern formation. EMBO Rep 7:694\u2013698. doi: 10.1038\/sj.embor.7400714","journal-title":"EMBO Rep"},{"key":"111_CR21","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/nrm1224","volume":"4","author":"P Golstein","year":"2003","unstructured":"Golstein P, Aubry L, Levraud JP (2003) Cell-death alternative model organisms: why and which? Nat Rev Mol Cell Biol 4:798\u2013807. doi: 10.1038\/nrm1224","journal-title":"Nat Rev Mol Cell Biol"},{"key":"111_CR22","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/sj.cdd.4401994","volume":"14","author":"C Laporte","year":"2007","unstructured":"Laporte C, Kosta A, Klein G et al (2007) A necrotic cell death model in a protist. Cell Death Differ 14:266\u2013274. doi: 10.1038\/sj.cdd.4401994","journal-title":"Cell Death Differ"},{"key":"111_CR23","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1242\/jcs.113.5.759","volume":"113","author":"AA Noegel","year":"2000","unstructured":"Noegel AA, Schleicher M (2000) The actin cytoskeleton of Dictyostelium: a story told by mutants. J Cell Sci 113:759\u2013766","journal-title":"J Cell Sci"},{"key":"111_CR24","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ceb.2003.11.008","volume":"16","author":"CA Parent","year":"2004","unstructured":"Parent CA (2004) Making all the right moves: chemotaxis in neutrophils and Dictyostelium. Curr Opin Cell Biol 16:4\u201313. doi: 10.1016\/j.ceb.2003.11.008","journal-title":"Curr Opin Cell Biol"},{"key":"111_CR25","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1083\/jcb.108.3.973","volume":"108","author":"PR Fisher","year":"1989","unstructured":"Fisher PR, Merkl G, Gerisch G (1989) Quantitative analysis of cell motility and chemotaxis in Dictyostelium discoideum using an image processing system and a novel chemotaxis chamber providing stationary chemical gradients. J Cell Biol 108:973\u2013984. doi: 10.1083\/jcb.108.3.973","journal-title":"J Cell Biol"},{"key":"111_CR26","first-page":"87","volume":"1","author":"PR Fisher","year":"1990","unstructured":"Fisher PR (1990) Pseudopodium activation and inhibition signals in chemotaxis by Dictyostelium discoideum amoebae. Semin Cell Biol 1:87\u201397","journal-title":"Semin Cell Biol"},{"key":"111_CR27","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1023\/A:1024479728970","volume":"23","author":"C Chung","year":"2002","unstructured":"Chung C, Firtel RA (2002) Signaling pathways at the leading edge of chemotaxing cells. J Muscle Res Cell Motil 23:773\u2013779. doi: 10.1023\/A:1024479728970","journal-title":"J Muscle Res Cell Motil"},{"key":"111_CR28","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1126\/science.3047871","volume":"241","author":"PS Klein","year":"1988","unstructured":"Klein PS, Sun TJ, Saxe CLIII et al (1988) A chemoattractant receptor controls development in Dictyostelium discoideum. Science 241:1467\u20131472. doi: 10.1126\/science.3047871","journal-title":"Science"},{"key":"111_CR29","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s12026-008-8056-7","volume":"43","author":"T Jin","year":"2009","unstructured":"Jin T, Xu X, Fang J, et al (2009) How human leukocytes track down and destroy pathogens: lessons learned from the model organism Dictyostelium discoideum. Immunol Res 43:118\u2013127. doi: 10.1007\/s12026-008-8056-7","journal-title":"Immunol Res"},{"key":"111_CR30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cyto.2008.06.017","volume":"44","author":"T Jin","year":"2008","unstructured":"Jin T, Xu X, Hereld D (2008) Chemotaxis, chemokine receptors and human disease. Cytokine 44:1\u20138. doi: 10.1016\/j.cyto.2008.06.017","journal-title":"Cytokine"},{"key":"111_CR31","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0968-0004(01)01804-7","volume":"26","author":"JA Brzostowski","year":"2001","unstructured":"Brzostowski JA, Kimmel AR (2001) Signaling at zero G: G-protein independent functions for 7-TM receptors. Trends Biochem Sci 26:291\u2013297. doi: 10.1016\/S0968-0004(01)01804-7","journal-title":"Trends Biochem Sci"},{"key":"111_CR32","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.devcel.2005.06.003","volume":"9","author":"M Affolter","year":"2005","unstructured":"Affolter M, Weijer CJ (2005) Signaling to cytoskeletal dynamics during chemotaxis. Dev Cell 9:19\u201334. doi: 10.1016\/j.devcel.2005.06.003","journal-title":"Dev Cell"},{"key":"111_CR33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0074-7696(07)63001-0","volume":"263","author":"AC Philipsborn von","year":"2007","unstructured":"von Philipsborn AC, Bastmeyer M (2007) Mechanisms of gradient detection: a comparison of axon pathfinding with eukaryotic cell migration. Int Rev Cytol 263:1\u201362. doi: 10.1016\/S0074-7696(07)63001-0","journal-title":"Int Rev Cytol"},{"key":"111_CR34","doi-asserted-by":"crossref","first-page":"4543","DOI":"10.1091\/mbc.e05-11-1019","volume":"17","author":"P Bolourani","year":"2006","unstructured":"Bolourani P, Spiegelman GB, Weeks G (2006) Delineation of the roles played by RasG and RasC in cAMP-dependent signal transduction during the early development of Dictyostelium discoideum. Mol Biol Cell 17:4543\u20134550. doi: 10.1091\/mbc.E05-11-1019","journal-title":"Mol Biol Cell"},{"key":"111_CR35","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1242\/jcs.023333","volume":"121","author":"V K\u00f6lsch","year":"2008","unstructured":"K\u00f6lsch V, Charest PG, Firtel RA (2008) The regulation of cell motility and chemotaxis by phospholipid signaling. J Cell Sci 121:551\u2013559. doi: 10.1242\/jcs.023333","journal-title":"J Cell Sci"},{"key":"111_CR36","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1083\/jcb.153.4.795","volume":"153","author":"S Funamoto","year":"2001","unstructured":"Funamoto S, Milan K, Meili R et al (2001) Role of phosphatidylinositol 3\u2019 kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in Dictyostelium. J Cell Biol 153:795\u2013810. doi: 10.1083\/jcb.153.4.795","journal-title":"J Cell Biol"},{"key":"111_CR37","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.ejcb.2006.04.011","volume":"85","author":"G Vlahou","year":"2006","unstructured":"Vlahou G, Rivero F (2006) Rho GTPase signaling in Dictyostelium discoideum: insights from the genome. Eur J Cell Biol 85:947\u2013959. doi: 10.1016\/j.ejcb.2006.04.011","journal-title":"Eur J Cell Biol"},{"key":"111_CR38","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S1097-2765(01)00247-7","volume":"7","author":"CY Chung","year":"2001","unstructured":"Chung CY, Potikyan G, Firtel RA (2001) Control of cell polarity and chemotaxis by Akt\/PKB and PI3 kinase through the regulation of PAKa. Mol Cell 7:937\u2013947. doi: 10.1016\/S1097-2765(01)00247-7","journal-title":"Mol Cell"},{"key":"111_CR39","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/cm.10005","volume":"50","author":"R Insall","year":"2001","unstructured":"Insall R, Muller-Taubenberger A, Machesky L et al (2001) Dynamics of the Dictyostelium Arp2\/3 complex in endocytosis, cytokinesis, and chemotaxis. Cell Motil Cytoskeleton 50:115\u2013128. doi: 10.1002\/cm.10005","journal-title":"Cell Motil Cytoskeleton"},{"key":"111_CR40","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1091\/mbc.e06-06-0518","volume":"18","author":"D Caracino","year":"2007","unstructured":"Caracino D, Jones C, Compton M (2007) The N-terminus of Dictyostelium scar interacts with Abi and HSPC300 and is essential for proper regulation and function. Mol Biol Cell 18:1609\u20131620. doi: 10.1091\/mbc.E06-06-0518","journal-title":"Mol Biol Cell"},{"key":"111_CR41","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.cub.2008.06.068","volume":"18","author":"Y Kamimura","year":"2008","unstructured":"Kamimura Y, Xiong Y, Iglesias PA, Hoeller O, Bolourani P, Devreotes PN (2008) PIP3-independent activation of TorC2 and PKB at the cell\u2019s leading edge mediates chemotaxis. Curr Biol 18:1034\u20131043. doi: 10.1016\/j.cub.2008.06.068","journal-title":"Curr Biol"},{"key":"111_CR42","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0092-8674(02)00745-6","volume":"109","author":"M Iijima","year":"2002","unstructured":"Iijima M, Devreotes P (2002) Tumor suppressor PTEN mediates sensing of chemoattractant gradients. Cell 109:599\u2013610. doi: 10.1016\/S0092-8674(02)00745-6","journal-title":"Cell"},{"key":"111_CR43","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0092-8674(02)00755-9","volume":"109","author":"S Funamoto","year":"2002","unstructured":"Funamoto S, Meili R, Lee S, Parry L, Firtel RA (2002) Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. Cell 109:611\u2013623. doi: 10.1016\/S0092-8674(02)00755-9","journal-title":"Cell"},{"key":"111_CR44","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0092-8674(02)00765-1","volume":"109","author":"FI Comer","year":"2002","unstructured":"Comer FI, Parent CA (2002) PI 3-kinases and PTEN: how opposites chemoattract. Cell 109:541\u2013544. doi: 10.1016\/S0092-8674(02)00765-1","journal-title":"Cell"},{"key":"111_CR45","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1242\/jcs.010876","volume":"120","author":"D Wessels","year":"2007","unstructured":"Wessels D, Lusche DF, Kuhl S et al (2007) PTEN plays a role in the suppression of lateral pseudopod formation during Dictyostelium motility and chemotaxis. J Cell Sci 120:2517\u20132531. doi: 10.1242\/jcs.010876","journal-title":"J Cell Sci"},{"key":"111_CR46","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1242\/jcs.109.11.2673","volume":"109","author":"S Yumura","year":"1996","unstructured":"Yumura S, Furuya K, Takeuchi I (1996) Intracellular free calcium responses during chemotaxis of Dictyostelium cells. J Cell Sci 109:2673\u20132678","journal-title":"J Cell Sci"},{"key":"111_CR47","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1242\/jcs.110.22.2845","volume":"110","author":"T Nebl","year":"1997","unstructured":"Nebl T, Fisher PR (1997) Intracellular Ca2+ signals in Dictyostelium chemotaxis are mediated exclusively by Ca2+ influx. J Cell Sci 110:2845\u20132853","journal-title":"J Cell Sci"},{"key":"111_CR48","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/cm.20098","volume":"62","author":"C Pikzack","year":"2005","unstructured":"Pikzack C, Prassler J, Furukawa R et al (2005) Role of calcium-dependent actin-bundling proteins: characterization of Dictyostelium mutants lacking fimbrin and the 34-kilodalton protein. Cell Motil Cytoskeleton 62:210\u2013231. doi: 10.1002\/cm.20098","journal-title":"Cell Motil Cytoskeleton"},{"key":"111_CR49","doi-asserted-by":"crossref","first-page":"4846","DOI":"10.1093\/emboj\/19.17.4846","volume":"19","author":"D Traynor","year":"2000","unstructured":"Traynor D, Milne JLS, Insall RH et al (2000) Ca2+ signalling is not required for chemotaxis in Dictyostelium. EMBO J 19:4846\u20134854. doi: 10.1093\/emboj\/19.17.4846","journal-title":"EMBO J"},{"key":"111_CR50","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1023\/A:1024431813040","volume":"23","author":"L Bosgraaf","year":"2002","unstructured":"Bosgraaf L, van Haastert PJM (2002) A model for cGMP signal transduction in Dictyostelium in perspective of 25\u00a0years of cGMP research. J Muscle Res Cell Motil 23:781\u2013791. doi: 10.1023\/A:1024431813040","journal-title":"J Muscle Res Cell Motil"},{"key":"111_CR51","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1126\/science.3576222","volume":"236","author":"A Lozanne De","year":"1987","unstructured":"De Lozanne A, Spudich JA (1987) Disruption of the Dictyostelium myosin heavy chain gene by homologous recombination. Science 236:1086\u20131091. doi: 10.1126\/science.3576222","journal-title":"Science"},{"key":"111_CR52","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1126\/science.3576221","volume":"236","author":"DA Knecht","year":"1987","unstructured":"Knecht DA, Loomis WF (1987) Antisense RNA inactivation of myosin heavy chain gene expression in Dictyostelium discoideum. Science 236:1081\u20131086. doi: 10.1126\/science.3576221","journal-title":"Science"},{"key":"111_CR53","doi-asserted-by":"crossref","first-page":"6186","DOI":"10.1073\/pnas.86.16.6186","volume":"86","author":"G Jung","year":"1989","unstructured":"Jung G, Saxe CLIII, Kimmel AR et al (1989) Dictyostelium discoideum contains a gene encoding a myosin I heavy chain. Proc Natl Acad Sci USA 86:6186\u20136190. doi: 10.1073\/pnas.86.16.6186","journal-title":"Proc Natl Acad Sci USA"},{"key":"111_CR54","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/1471-2164-7-183","volume":"7","author":"M Kollmar","year":"2006","unstructured":"Kollmar M (2006) Thirteen is enough: the myosins of Dictyostelium discoideum and their light chains. BMC Genomics 7:183. doi: 10.1186\/1471-2164-7-183","journal-title":"BMC Genomics"},{"key":"111_CR55","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.1242\/jcs.00696","volume":"116","author":"DL Falk","year":"2003","unstructured":"Falk DL, Wessels D, Jenkins L et al (2003) Shared, unique and redundant functions of three members of the class I myosins (MyoA, MyoB and MyoF) in motility and chemotaxis in Dictyostelium. J Cell Sci 116:3985\u20133999. doi: 10.1242\/jcs.00696","journal-title":"J Cell Sci"},{"key":"111_CR56","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.devcel.2007.03.005","volume":"12","author":"L Chen","year":"2007","unstructured":"Chen L, Iijima M, Tang M et al (2007) PLA2 and PI3K\/PTEN pathways act in parallel to mediate chemotaxis. Dev Cell 12:603\u2013614. doi: 10.1016\/j.devcel.2007.03.005","journal-title":"Dev Cell"},{"key":"111_CR57","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.cub.2007.04.004","volume":"17","author":"O Hoeller","year":"2007","unstructured":"Hoeller O, Kay RR (2007) Chemotaxis in the absence of PIP3 gradients. Curr Biol 17:813\u2013817. doi: 10.1016\/j.cub.2007.04.004","journal-title":"Curr Biol"},{"key":"111_CR58","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1023\/A:1024435913949","volume":"23","author":"D Duhon","year":"2002","unstructured":"Duhon D, Cardelli J (2002) The regulation of phagosome maturation in Dictyostelium. J Muscle Res Cell Motil 23:803\u2013808. doi: 10.1023\/A:1024435913949","journal-title":"J Muscle Res Cell Motil"},{"key":"111_CR59","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1937-6448(08)01206-9","volume":"271","author":"S Bozzaro","year":"2008","unstructured":"Bozzaro S, Bucci C, Steinert M (2008) Phagocytosis and host-pathogen interactions in Dictyostelium with a look at macrophages. Int Rev Cell Mol Biol 271:253\u2013300. doi: 10.1016\/S1937-6448(08)01206-9","journal-title":"Int Rev Cell Mol Biol"},{"key":"111_CR60","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S0966-842X(00)01852-7","volume":"8","author":"JM Solomon","year":"2000","unstructured":"Solomon JM, Isberg RR (2000) Growth of Legionella pneumophila in Dictyostelium discoideum: a novel system for genetic analysis of host-pathogen interactions. Trends Microbiol 8:478\u2013480. doi: 10.1016\/S0966-842X(00)01852-7","journal-title":"Trends Microbiol"},{"key":"111_CR61","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1046\/j.1462-5822.2000.00044.x","volume":"2","author":"S Haegele","year":"2000","unstructured":"Haegele S, Kohler R, Merkert H et al (2000) Dictyostelium discoideum: a new host model system for intracellular pathogens of the genus Legionella. Cell Microbiol 2:165\u2013171. doi: 10.1046\/j.1462-5822.2000.00044.x","journal-title":"Cell Microbiol"},{"key":"111_CR62","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1073\/pnas.052704399","volume":"99","author":"S Pukatzki","year":"2002","unstructured":"Pukatzki S, Kessin RH, Mekalanos JJ (2002) The human pathogen Pseudomonas aeruginosa utilizes conserved virulence pathways to infect the social amoeba Dictyostelium discoideum. Proc Natl Acad Sci USA 99:3159\u20133164. doi: 10.1073\/pnas.052704399","journal-title":"Proc Natl Acad Sci USA"},{"key":"111_CR63","doi-asserted-by":"crossref","first-page":"4862","DOI":"10.1128\/IAI.71.9.4862-4872.2003","volume":"71","author":"JN Steenbergen","year":"2003","unstructured":"Steenbergen JN, Nosanchuk JD, Malliaris SD et al (2003) Cryptococcus neoformans virulence is enhanced after growth in the genetically malleable host Dictyostelium discoideum. Infect Immun 71:4862\u20134872. doi: 10.1128\/IAI.71.9.4862-4872.2003","journal-title":"Infect Immun"},{"key":"111_CR64","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1078\/1438-4221-00177","volume":"291","author":"C Skriwan","year":"2002","unstructured":"Skriwan C, Fajardo M, Hagele S et al (2002) Various bacterial pathogens and symbionts infect the amoeba Dictyostelium discoideum. Int J Med Microbiol 291:615\u2013624. doi: 10.1078\/1438-4221-00177","journal-title":"Int J Med Microbiol"},{"key":"111_CR65","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1073\/pnas.0510322103","volume":"103","author":"S Pukatzki","year":"2006","unstructured":"Pukatzki S, Ma AT, Sturtevant D et al (2006) Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system. Proc Natl Acad Sci USA 103:1528\u20131533. doi: 10.1073\/pnas.0510322103","journal-title":"Proc Natl Acad Sci USA"},{"key":"111_CR66","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1462-5822.2005.00607.x","volume":"8","author":"M Benghezal","year":"2006","unstructured":"Benghezal M, Fauvarque MO, Tournebize R et al (2006) Specific host genes required for the killing of Klebsiella bacteria by phagocytes. Cell Microbiol 8:139\u2013148. doi: 10.1111\/j.1462-5822.2005.00607.x","journal-title":"Cell Microbiol"},{"key":"111_CR67","first-page":"BR134","volume":"14","author":"AMR Colucci","year":"2008","unstructured":"Colucci AMR, Peracino B, Bozzaro S et al (2008) Dictyostelium discoideum as a model host for meningococcal pathogenesis. Med Sci Monit 14:BR134\u2013BR140","journal-title":"Med Sci Monit"},{"key":"111_CR68","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1128\/JB.184.11.3027-3033.2002","volume":"184","author":"P Cosson","year":"2002","unstructured":"Cosson P, Zulianello L, Join-Lambert O et al (2002) Pseudomonas aeruginosa virulence analyzed in a Dictyostelium discoideum host system. J Bacteriol 184:3027\u20133033. doi: 10.1128\/JB.184.11.3027-3033.2002","journal-title":"J Bacteriol"},{"key":"111_CR69","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/j.1462-5822.2005.00633.x","volume":"8","author":"P Farbrother","year":"2005","unstructured":"Farbrother P, Wagner C, Na J et al (2005) Dictyostelium transcriptional host cell response upon infection with Legionella. Cell Microbiol 8:438\u2013456. doi: 10.1111\/j.1462-5822.2005.00633.x","journal-title":"Cell Microbiol"},{"key":"111_CR70","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.molmed.2006.07.003","volume":"12","author":"RSB Williams","year":"2006","unstructured":"Williams RSB, Boeckeler K, Gr\u00e4f R (2006) Towards a molecular understanding of human diseases using Dictyostelium discoideum. Trends Mol Med 12:415\u2013424. doi: 10.1016\/j.molmed.2006.07.003","journal-title":"Trends Mol Med"},{"key":"111_CR71","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.pnpbp.2005.03.020","volume":"29","author":"RSB Williams","year":"2005","unstructured":"Williams RSB (2005) Pharmacogenetics in model systems: defining a common mechanism of action for mood stabilisers. Prog Neuropsychopharmacol Biol Psychiatry 29:1029\u20131037. doi: 10.1016\/j.pnpbp.2005.03.020","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"111_CR72","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0074-7696(07)63005-8","volume":"263","author":"C Barth","year":"2007","unstructured":"Barth C, Le P, Fisher PR (2007) Mitochondrial biology and disease in Dictyostelium. Int Rev Cytol 263:207\u2013252. doi: 10.1016\/S0074-7696(07)63005-8","journal-title":"Int Rev Cytol"},{"key":"111_CR73","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0140-6736(06)68970-8","volume":"368","author":"AHV Schapira","year":"2006","unstructured":"Schapira AHV (2006) Mitochondrial disease. Lancet 368:70\u201382. doi: 10.1016\/S0140-6736(06)68970-8","journal-title":"Lancet"},{"key":"111_CR74","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1097\/WCO.0b013e3282ef58cd","volume":"20","author":"M Zeviani","year":"2007","unstructured":"Zeviani M, Carelli V (2007) Mitochondrial disorders. Curr Opin Neurol 20:564\u2013571","journal-title":"Curr Opin Neurol"},{"key":"111_CR75","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1006\/bbrc.1997.6574","volume":"234","author":"Z Wilczynska","year":"1997","unstructured":"Wilczynska Z, Barth C, Fisher PR (1997) Mitochondrial mutations impair signal transduction in Dictyostelium discoideum slugs. Biochem Biophys Res Commun 234:39\u201343. doi: 10.1006\/bbrc.1997.6574","journal-title":"Biochem Biophys Res Commun"},{"key":"111_CR76","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1023\/A:1024444215766","volume":"23","author":"M Kotsifas","year":"2002","unstructured":"Kotsifas M, Barth C, Lay ST et al (2002) Chaperonin 60 and mitochondrial disease in Dictyostelium. J Muscle Res Cell Motil 23:839\u2013852. doi: 10.1023\/A:1024444215766","journal-title":"J Muscle Res Cell Motil"},{"key":"111_CR77","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1091\/mbc.e06-09-0881","volume":"18","author":"PB Bokko","year":"2007","unstructured":"Bokko PB, Francioni L, Ahmed AU et al (2007) Diverse mitochondrial cytopathologies are caused by AMPK signalling. Mol Biol Cell 18:1874\u20131886. doi: 10.1091\/mbc.E06-09-0881","journal-title":"Mol Biol Cell"},{"key":"111_CR78","doi-asserted-by":"crossref","first-page":"8839","DOI":"10.1073\/pnas.1533136100","volume":"100","author":"SP Hong","year":"2003","unstructured":"Hong SP, Leiper FC, Woods A et al (2003) Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases. Proc Natl Acad Sci USA 100:8839\u20138843. doi: 10.1073\/pnas.1533136100","journal-title":"Proc Natl Acad Sci USA"},{"key":"111_CR79","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1016\/j.cub.2003.10.031","volume":"13","author":"A Woods","year":"2003","unstructured":"Woods A, Johnstone SR, Dickerson K et al (2003) LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol 13:2004\u20132008. doi: 10.1016\/j.cub.2003.10.031","journal-title":"Curr Biol"},{"key":"111_CR80","doi-asserted-by":"crossref","first-page":"21804","DOI":"10.1074\/jbc.M501887200","volume":"280","author":"S-P Hong","year":"2005","unstructured":"Hong S-P, Momcilovic M, Carlson M (2005) Function of mammalian LKB1 and Ca2+\/calmodulin-dependent protein kinase kinase \u03b1 as Snf1-activating kinases in yeast. J Biol Chem 280:21804\u201321809. doi: 10.1074\/jbc.M501887200","journal-title":"J Biol Chem"},{"key":"111_CR81","doi-asserted-by":"crossref","first-page":"29060","DOI":"10.1074\/jbc.M503824200","volume":"280","author":"RL Hurley","year":"2005","unstructured":"Hurley RL, Anderson KA, Franzone JM et al (2005) The Ca2+\/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases. J Biol Chem 280:29060\u201329066. doi: 10.1074\/jbc.M503824200","journal-title":"J Biol Chem"},{"key":"111_CR82","doi-asserted-by":"crossref","first-page":"25336","DOI":"10.1074\/jbc.M604399200","volume":"281","author":"M Momcilovic","year":"2006","unstructured":"Momcilovic M, Hong S-P, Carlson M (2006) Mammalian TAK1 activates Snf1 protein kinase in yeast and phosphorylates AMP-activated protein kinase in\u00a0vitro. J Biol Chem 281:25336\u201325343. doi: 10.1074\/jbc.M604399200","journal-title":"J Biol Chem"},{"key":"111_CR83","doi-asserted-by":"crossref","first-page":"15983","DOI":"10.1073\/pnas.252625599","volume":"99","author":"H Zong","year":"2002","unstructured":"Zong H, Ren JM, Young LH et al (2002) AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proc Natl Acad Sci USA 99:15983\u201315987. doi: 10.1073\/pnas.252625599","journal-title":"Proc Natl Acad Sci USA"},{"key":"111_CR84","doi-asserted-by":"crossref","first-page":"5479","DOI":"10.1242\/jcs.01540","volume":"117","author":"DG Hardie","year":"2004","unstructured":"Hardie DG (2004) The AMP-activated protein kinase pathway\u2014new players upstream and downstream. J Cell Sci 117:5479\u20135487. doi: 10.1242\/jcs.01540","journal-title":"J Cell Sci"},{"key":"111_CR85","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cmet.2004.12.003","volume":"1","author":"BB Kahn","year":"2005","unstructured":"Kahn BB, Alquier T, Carling D et al (2005) AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 1:15\u201325. doi: 10.1016\/j.cmet.2004.12.003","journal-title":"Cell Metab"},{"key":"111_CR86","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1152\/physiol.00044.2005","volume":"21","author":"DG Hardie","year":"2006","unstructured":"Hardie DG, Sakamoto K (2006) AMPK: a key sensor of fuel and energy status in skeletal muscle. Physiology (Bethesda) 21:48\u201360. doi: 10.1152\/physiol.00044.2005","journal-title":"Physiology (Bethesda)"},{"key":"111_CR87","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/BF02254975","volume":"9","author":"AM James","year":"2002","unstructured":"James AM, Murphy MP (2002) How mitochondrial damage affects cell function. J Biomed Sci 9:475\u2013487. doi: 10.1007\/BF02254975","journal-title":"J Biomed Sci"},{"key":"111_CR88","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1042\/bj20021594","volume":"370","author":"R Rossignol","year":"2003","unstructured":"Rossignol R, Faustin B, Rocher C et al (2003) Mitochondrial threshold effects. Biochem J 370:751\u2013762. doi: 10.1042\/BJ20021594","journal-title":"Biochem J"},{"key":"111_CR89","doi-asserted-by":"crossref","first-page":"S103","DOI":"10.2337\/diabetes.53.2007.S103","volume":"53","author":"JA Maassen","year":"2004","unstructured":"Maassen JA, \u2018t Hart LM, Van Essen E et al (2004) Mitochondrial diabetes. Molecular mechanisms and clinical presentation. Diabetes 53:S103\u2013S109. doi: 10.2337\/diabetes.53.2007.S103","journal-title":"Diabetes"},{"key":"111_CR90","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1023\/B:NERE.0000014829.42364.dd","volume":"29","author":"M McKenzie","year":"2004","unstructured":"McKenzie M, Liolitsa D, Hanna MG (2004) Mitochondrial disease: mutations and mechanisms. Neurochem Res 29:589\u2013600. doi: 10.1023\/B:NERE.0000014829.42364.dd","journal-title":"Neurochem Res"},{"key":"111_CR91","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.devcel.2005.11.006","volume":"9","author":"S Mandal","year":"2005","unstructured":"Mandal S, Guptan P, Owusu-Ansah E et al (2005) Mitochondrial regulation of cell cycle progression during development as revealed by the tenured mutation in Drosophila. Dev Cell 9:843\u2013854. doi: 10.1016\/j.devcel.2005.11.006","journal-title":"Dev Cell"},{"key":"111_CR92","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2337\/diabetes.49.4.527","volume":"49","author":"T Hayashi","year":"2000","unstructured":"Hayashi T, Hirshman MF, Fujii N et al (2000) Metabolic stress and altered glucose transport. Activation of AMP-activated protein kinase as a unifying coupling mechanism. Diabetes 49:1\u20135. doi: 10.2337\/diabetes.49.4.527","journal-title":"Diabetes"},{"key":"111_CR93","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0306-4522(02)00836-9","volume":"117","author":"M Garcia-Gil","year":"2003","unstructured":"Garcia-Gil M, Pesi R, Perna S et al (2003) 5\u2032-Aminoimidazole-4-carboxamide riboside induces apoptosis in human neuroblastoma cells. Neuroscience 117:811\u2013820. doi: 10.1016\/S0306-4522(02)00836-9","journal-title":"Neuroscience"},{"key":"111_CR94","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1113\/jphysiol.2006.110122","volume":"574","author":"S Ramamurthy","year":"2006","unstructured":"Ramamurthy S, Ronnett GV (2006) Developing a head for energy sensing: AMP-activated protein kinase as a multifunctional metabolic sensor in the brain. J Physiol 574:85\u201393. doi: 10.1113\/jphysiol.2006.110122","journal-title":"J Physiol"},{"key":"111_CR95","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1086\/421475","volume":"74","author":"S Marie","year":"2004","unstructured":"Marie S, Heron B, Bitoun P et al (2004) AICA-ribosiduria: a novel, neurologically devastating inborn error of purine biosynthesis caused by mutation of ATIC. Am J Hum Genet 74:1276\u20131281. doi: 10.1086\/421475","journal-title":"Am J Hum Genet"},{"key":"111_CR96","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/j.1471-4159.2005.03029.x","volume":"93","author":"SY Chou","year":"2005","unstructured":"Chou SY, Lee YC, Chen HM et al (2005) CGS21680 attenuates symptoms of Huntington\u2019s disease in a transgenic mouse model. J Neurochem 93:310\u2013320. doi: 10.1111\/j.1471-4159.2005.03029.x","journal-title":"J Neurochem"},{"key":"111_CR97","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1523\/JNEUROSCI.4345-06.2007","volume":"27","author":"C Lopez-Lopez","year":"2007","unstructured":"Lopez-Lopez C, Dietrich MO, Metzger F et al (2007) Disturbed cross talk between insulin-like growth factor I and AMP-activated protein kinase as a possible cause of vascular dysfunction in the amyloid precursor protein\/Presenilin 2 mouse model of Alzheimer\u2019s disease. J Neurosci 27:824\u2013831. doi: 10.1523\/JNEUROSCI.4345-06.2007","journal-title":"J Neurosci"},{"key":"111_CR98","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1128\/EC.2.6.1315-1326.2003","volume":"2","author":"PR Gilson","year":"2003","unstructured":"Gilson PR, Yu X-C, Hereld D et al (2003) Two Dictyostelium orthologs of the prokaryotic cell division protein FtsZ localize to mitochondria and are required for the maintenance of normal mitochondrial morphology. Eukaryot Cell 2:1315\u20131326. doi: 10.1128\/EC.2.6.1315-1326.2003","journal-title":"Eukaryot Cell"},{"key":"111_CR99","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1091\/mbc.e05-01-0069","volume":"16","author":"M Rehberg","year":"2005","unstructured":"Rehberg M, Kleylein-Sohn J, Faix J et al (2005) Dictyostelium LIS1 is a centrosomal protein required for microtubule\/cell cortex interactions, nucleus\/centrosome linkage, and actin dynamics. Mol Biol Cell 16:2759\u20132771. doi: 10.1091\/mbc.E05-01-0069","journal-title":"Mol Biol Cell"},{"key":"111_CR100","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0006-2952(03)00187-4","volume":"66","author":"AJ Harwood","year":"2003","unstructured":"Harwood AJ, Agam G (2003) Search for a common mechanism of mood stabilizers. Biochem Pharmacol 66:179\u2013189. doi: 10.1016\/S0006-2952(03)00187-4","journal-title":"Biochem Pharmacol"},{"key":"111_CR101","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/0006-291X(65)90073-2","volume":"20","author":"AW Norman","year":"1965","unstructured":"Norman AW, Wedding RT, Black MK (1965) Detection of phosphohistidine in nucleoside diphosphokinase isolated from Jerusalem artichoke mitochondria. Biochem Biophys Res Commun 20:703\u2013709. doi: 10.1016\/0006-291X(65)90073-2","journal-title":"Biochem Biophys Res Commun"},{"key":"111_CR102","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1432-1033.1995.200_c.x","volume":"234","author":"M Engel","year":"1995","unstructured":"Engel M, Veron M, Theisinger B et al (1995) A novel serine\/threonine-specific protein phosphotransferase activity of Nm23\/nucleoside-diphosphate kinase. Eur J Biochem 234:200\u2013207. doi: 10.1111\/j.1432-1033.1995.200_c.x","journal-title":"Eur J Biochem"},{"key":"111_CR103","doi-asserted-by":"crossref","first-page":"25469","DOI":"10.1016\/S0021-9258(19)74415-9","volume":"268","author":"H Troll","year":"1993","unstructured":"Troll H, Winckler T, Lascu I et al (1993) Separate nuclear genes encode cytosolic and mitochondrial nucleoside diphosphate kinase in Dictyostelium discoideum. J Biol Chem 268:25469\u201325475","journal-title":"J Biol Chem"},{"key":"111_CR104","doi-asserted-by":"crossref","first-page":"10012","DOI":"10.1016\/S0021-9258(19)38771-X","volume":"265","author":"ML Lacombe","year":"1990","unstructured":"Lacombe ML, Wallet V, Troll H et al (1990) Functional cloning of a nucleoside diphosphate kinase from Dictyostelium discoideum. J Biol Chem 265:10012\u201310018","journal-title":"J Biol Chem"},{"key":"111_CR105","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1002\/j.1460-2075.1992.tb05397.x","volume":"11","author":"C Dumas","year":"1992","unstructured":"Dumas C, Lascu I, Morera S et al (1992) X-ray structure of nucleoside diphosphate kinase. EMBO J 11:3203\u20133208","journal-title":"EMBO J"},{"key":"111_CR106","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1093\/jnci\/82.14.1199","volume":"82","author":"V Wallet","year":"1990","unstructured":"Wallet V, Mutzle R, Troll H et al (1990) Dictyostelium nucleoside diphosphate kinase highly homologous to Nm23 and Awd proteins involved in mammalian tumor metastasis and Drosophila development. J Natl Cancer Inst 82:1199\u20131202. doi: 10.1093\/jnci\/82.14.1199","journal-title":"J Natl Cancer Inst"},{"key":"111_CR107","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S1874-6047(08)60069-4","volume":"8","author":"REJ Parks","year":"1973","unstructured":"Parks REJ, Agarwal RP (1973) Nucleoside diphosphokinases. Enzymes 8:307\u2013334","journal-title":"Enzymes"},{"key":"111_CR108","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1006\/jmbi.1994.1689","volume":"243","author":"S Morera","year":"1994","unstructured":"Morera S, LeBras G, Lascu I et al (1994) Refined X-ray structure of Dictyostelium discoideum nucleoside diphosphate kinase at 1.8\u00a0\u00c5 resolution. J Mol Biol 243:873\u2013890. doi: 10.1006\/jmbi.1994.1689","journal-title":"J Mol Biol"},{"key":"111_CR109","doi-asserted-by":"crossref","first-page":"E1340","DOI":"10.1152\/ajpendo.2001.281.6.E1340","volume":"281","author":"R Bergeron","year":"2001","unstructured":"Bergeron R, Ren JM, Cadman KS et al (2001) Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis. Am J Physiol Endocrinol Metab 281:E1340\u2013E1346","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"111_CR110","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1002\/bies.10009","volume":"23","author":"DG Hardie","year":"2001","unstructured":"Hardie DG, Hawley SA (2001) AMP-activated protein kinase: the energy charge hypothesis revisited. Bioessays 23:1112\u20131119. doi: 10.1002\/bies.10009","journal-title":"Bioessays"},{"key":"111_CR111","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1126\/science.3041592","volume":"241","author":"ER Kantrowitz","year":"1988","unstructured":"Kantrowitz ER, Lipscomb WN (1988) Escherichia coli aspartate trancarbamylase. The relation between structure and function. Science 241:669\u2013674. doi: 10.1126\/science.3041592","journal-title":"Science"},{"key":"111_CR112","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/348515a0","volume":"348","author":"K Nagai","year":"1990","unstructured":"Nagai K, Oubridge C, Jessen TH et al (1990) Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A. Nature 348:515\u2013520. doi: 10.1038\/348515a0","journal-title":"Nature"},{"key":"111_CR113","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1016\/S0021-9258(19)43829-5","volume":"248","author":"ET Adman","year":"1973","unstructured":"Adman ET, Sieker LC, Jensen LH (1973) The structure of a bacterial ferredoxin. J Biol Chem 248:3987\u20133996","journal-title":"J Biol Chem"},{"key":"111_CR114","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/j.1460-2075.1991.tb07914.x","volume":"10","author":"M Coll","year":"1991","unstructured":"Coll M, Guasch A, Aviles FX et al (1991) Three-dimensional structure of porcine procarboxypeptidase B: a structural basis of its inactivity. EMBO J 10:1\u20139","journal-title":"EMBO J"},{"key":"111_CR115","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/0022-2836(92)91005-A","volume":"224","author":"A Pastore","year":"1992","unstructured":"Pastore A, Saudek V, Ramponi G et al (1992) Three dimensional structure of acylphosphatase: refinement and structure analysis. J Mol Biol 224:427\u2013440. doi: 10.1016\/0022-2836(92)91005-A","journal-title":"J Mol Biol"},{"key":"111_CR116","doi-asserted-by":"crossref","first-page":"19928","DOI":"10.1074\/jbc.271.33.19928","volume":"271","author":"A Karlsson","year":"1996","unstructured":"Karlsson A, Mesnildrey S, Xu Y et al (1996) Nucleoside diphosphate kinase. J Biol Chem 271:19928\u201319934. doi: 10.1074\/jbc.271.49.31426","journal-title":"J Biol Chem"},{"key":"111_CR117","doi-asserted-by":"crossref","first-page":"20268","DOI":"10.1016\/S0021-9258(20)80724-8","volume":"268","author":"I Lascu","year":"1993","unstructured":"Lascu I, Deville-Bonne D, Glaser P et al (1993) Equilibrium dissociation and unfolding of nucleoside diphosphate kinase from Dictyostelium discoideum. J Biol Chem 268:20268\u201320275","journal-title":"J Biol Chem"},{"key":"111_CR118","doi-asserted-by":"crossref","first-page":"17845","DOI":"10.1074\/jbc.271.30.17845","volume":"271","author":"A Giartosio","year":"1996","unstructured":"Giartosio A, Erent M, Cervoni L et al (1996) Thermal stability of hexameric and tetrameric nucleoside diphosphate kinases. J Biol Chem 271:17845\u201317851. doi: 10.1074\/jbc.271.30.17845","journal-title":"J Biol Chem"},{"key":"111_CR119","doi-asserted-by":"crossref","first-page":"32175","DOI":"10.1016\/S0021-9258(18)31617-X","volume":"269","author":"AD Tepper","year":"1994","unstructured":"Tepper AD, Dammann H, Bominaar AA et al (1994) Investigation of the active site and the conformational stability of nucleoside diphosphate kinase by site-directed mutagenesis. J Biol Chem 269:32175\u201332180","journal-title":"J Biol Chem"},{"key":"111_CR120","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1021\/bi00168a010","volume":"33","author":"S Morera","year":"1994","unstructured":"Morera S, Lascu I, Dumas C et al (1994) Adenosine 5\u2032-diphosphoate binding and the active site of nucleoside diphosphate kinase. Biochem 33:459\u2013467. doi: 10.1021\/bi00168a010","journal-title":"Biochem"},{"key":"111_CR121","doi-asserted-by":"crossref","first-page":"12445","DOI":"10.1021\/bi00038a043","volume":"34","author":"A Lecroisey","year":"1995","unstructured":"Lecroisey A, Lascu I, Bominaar A et al (1995) Phosphorylation mechanism of nucleoside diphosphate kinase: 31P-nuclear magnetic resonance studies. Biochemistry 34:12445\u201312450. doi: 10.1021\/bi00038a043","journal-title":"Biochemistry"},{"key":"111_CR122","doi-asserted-by":"crossref","first-page":"9062","DOI":"10.1021\/bi00197a006","volume":"3","author":"J Cherflis","year":"1994","unstructured":"Cherflis J, Morera S, Lascu I et al (1994) X-ray structure of nucleoside diphosphate kinase complexed with thymidine diphosphate and Mg2+ at 2-\u00c5 resolution. Biochemistry 3:9062\u20139069. doi: 10.1021\/bi00197a006","journal-title":"Biochemistry"},{"key":"111_CR123","doi-asserted-by":"crossref","first-page":"11062","DOI":"10.1021\/bi00035a011","volume":"34","author":"S Morera","year":"1995","unstructured":"Morera S, Chiadmi M, LeBras G et al (1995) Mechanism of phosphate transfer by nucleoside diphosphate kinase: X-ray structures of the phosphohistidine intermediate of the enzymes from Drosophila and Dictyostelium. Biochemistry 34:11062\u201311070. doi: 10.1021\/bi00035a011","journal-title":"Biochemistry"},{"key":"111_CR124","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1365-2958.1995.tb02393.x","volume":"16","author":"O Sellam","year":"1995","unstructured":"Sellam O, Veron M, Hildebrandt M (1995) Overexpression of wild-type and mutant NDP kinase in Dictyostelium discoideum. Mol Microbiol 16:79\u201385. doi: 10.1111\/j.1365-2958.1995.tb02393.x","journal-title":"Mol Microbiol"},{"key":"111_CR125","doi-asserted-by":"crossref","first-page":"25780","DOI":"10.1016\/S0021-9258(19)74458-5","volume":"268","author":"NJ MacDonald","year":"1993","unstructured":"MacDonald NJ, De La Rosa A, Benedict MA et al (1993) A serine phosphorylation of Nm23, and not its nucleoside diphosphate kinase activity, correlates with suppression of tumour metastatic potential. J Biol Chem 268:25780\u201325789","journal-title":"J Biol Chem"},{"key":"111_CR126","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1002\/j.1460-2075.1993.tb05881.x","volume":"12","author":"AA Bominaar","year":"1993","unstructured":"Bominaar AA, Molijn AC, Pestel M et al (1993) Activation of G-proteins by receptor-stimulated nucleoside diphosphate kinase in Dictyostelium. EMBO J 12:2275\u20132279","journal-title":"EMBO J"},{"key":"111_CR127","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1002\/1615-9861(200109)1:9<1119::AID-PROT1119>3.0.CO;2-X","volume":"1","author":"S Srinivasan","year":"2001","unstructured":"Srinivasan S, Traini M, Herbert B et al (2001) Proteomic analysis of a developmentally regulated secretory vesicle. Proteomics 1:1119\u20131127. doi: 10.1002\/1615-9861(200109)1:9<1119::AID-PROT1119>3.0.CO;2-X","journal-title":"Proteomics"},{"key":"111_CR128","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S0022-5320(69)90050-1","volume":"26","author":"H Hohl","year":"1969","unstructured":"Hohl H, Hamamoto S (1969) Ultrastructure of spore differentiation in Dictyostelium: the prespore vacuole. J Ultrastruct Res 26:442\u2013453. doi: 10.1016\/S0022-5320(69)90050-1","journal-title":"J Ultrastruct Res"},{"key":"111_CR129","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/S0955-0674(97)80025-7","volume":"9","author":"P Novick","year":"1997","unstructured":"Novick P, Zerial M (1997) The diversity of Rab proteins in vesicle transport. Curr Opin Cell Biol 9:496\u2013504. doi: 10.1016\/S0955-0674(97)80025-7","journal-title":"Curr Opin Cell Biol"},{"key":"111_CR130","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1074\/jbc.273.2.793","volume":"273","author":"O Laurent","year":"1998","unstructured":"Laurent O, Bruckert F, Adessi C et al (1998) In\u00a0vitro reconstituted Dictyostelium discoideum early endosome fusion is regulated by Rab7 but proceeds in the absence of ATP-Mg2+ from the bulk solution. J Biol Chem 273:793\u2013799. doi: 10.1074\/jbc.273.2.793","journal-title":"J Biol Chem"},{"key":"111_CR131","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1432-1033.1991.tb15706.x","volume":"195","author":"PJM Haastert Van","year":"1991","unstructured":"Van Haastert PJM, Janssens PMW, Erneux C (1991) Sensory transduction in eukaryotes. Eur J Biochem 195:289\u2013303. doi: 10.1111\/j.1432-1033.1991.tb15706.x","journal-title":"Eur J Biochem"},{"key":"111_CR132","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/342177a0","volume":"342","author":"AM Rosengard","year":"1989","unstructured":"Rosengard AM, Krutzsch HC, Shearn A et al (1989) Reduced Nm23\/Awd protein in tumour metastasis and aberrant Drosphila development. Nature 342:177\u2013180. doi: 10.1038\/342177a0","journal-title":"Nature"},{"key":"111_CR133","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/(SICI)1097-0169(1996)34:3<194::AID-CM3>3.0.CO;2-A","volume":"34","author":"C Aguado-Velasco","year":"1996","unstructured":"Aguado-Velasco C, Veron M, Rambow JA et al (1996) NDP kinase can modulate contraction of Dictyostelium cytoskeletons. Cell Motil Cytoskeleton 34:194\u2013205. doi: 10.1002\/(SICI)1097-0169(1996)34:3<194::AID-CM3>3.0.CO;2-A","journal-title":"Cell Motil Cytoskeleton"},{"key":"111_CR134","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0955-0674(92)90055-H","volume":"4","author":"RE Cheney","year":"1992","unstructured":"Cheney RE, Mosseker MS (1992) Unconventional myosins. Curr Opin Cell Biol 4:27\u201335. doi: 10.1016\/0955-0674(92)90055-H","journal-title":"Curr Opin Cell Biol"},{"key":"111_CR135","doi-asserted-by":"crossref","first-page":"4826","DOI":"10.1093\/emboj\/16.16.4826","volume":"16","author":"AU Amerik","year":"1997","unstructured":"Amerik AU, Swaminathan S, Krantz BA et al (1997) In\u00a0vivo disassembly of free polyubiquitin chains by yeast Ubp14 modulates rates of protein degradation by the proteasome. EMBO J 16:4826\u20134838. doi: 10.1093\/emboj\/16.16.4826","journal-title":"EMBO J"},{"key":"111_CR136","doi-asserted-by":"crossref","first-page":"29178","DOI":"10.1074\/jbc.273.44.29178","volume":"273","author":"DF Lindsey","year":"1998","unstructured":"Lindsey DF, Amerik A, Deery WJ et al (1998) A deubiquitinating enzyme that disassembles free polyubiquitin chains is required for development but not growth in Dictyostelium. J Biol Chem 273:29178\u201329187. doi: 10.1074\/jbc.273.44.29178","journal-title":"J Biol Chem"},{"key":"111_CR137","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/S0960-9822(00)00797-1","volume":"10","author":"A Wilkins","year":"2000","unstructured":"Wilkins A, Chubb JR, Insall RH (2000) A novel Dictyostelium RasGEF is required for normal endocytosis, cell motility and multicellular development. Curr Biol 10:1427\u20131437. doi: 10.1016\/S0960-9822(00)00797-1","journal-title":"Curr Biol"},{"key":"111_CR138","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1128\/EC.2.4.778-787.2003","volume":"2","author":"A Maselli","year":"2003","unstructured":"Maselli A, Furukawa R, Thomson SAM et al (2003) Formation of Hirano bodies induced by expression of an actin cross-linking protein with a gain-of-function mutation. Eukaryot Cell 2:778\u2013787. doi: 10.1128\/EC.2.4.778-787.2003","journal-title":"Eukaryot Cell"},{"key":"111_CR139","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00401-007-0275-9","volume":"115","author":"RC Davis","year":"2008","unstructured":"Davis RC, Furukawa R, Fechheimer M (2008) A cell culture model for investigation of Hirano bodies. Acta Neuropathol 115:205\u2013217. doi: 10.1007\/s00401-007-0275-9","journal-title":"Acta Neuropathol"},{"key":"111_CR140","doi-asserted-by":"crossref","first-page":"6202","DOI":"10.1073\/pnas.94.12.6202","volume":"94","author":"F Chaumont","year":"1997","unstructured":"Chaumont F, Loomis WF, Chrispeels M (1997) Expression of a plant plasma membrane aquaporin in Dictyostelium results in hypo-osmotic sensitivity and developmental abnormalities. Proc Natl Acad Sci USA 94:6202\u20136209. doi: 10.1073\/pnas.94.12.6202","journal-title":"Proc Natl Acad Sci USA"},{"key":"111_CR141","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1242\/dev.02287","volume":"133","author":"H MacWilliams","year":"2006","unstructured":"MacWilliams H, Doquang K, Pedrola R et al (2006) A retinoblastoma ortholog controls stalk\/spore preference in Dictyostelium. Development 133:1287\u20131297. doi: 10.1242\/dev.02287","journal-title":"Development"},{"key":"111_CR142","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1242\/dev.125.12.2291","volume":"125","author":"GM Souza","year":"1998","unstructured":"Souza GM, Lu S, Kuspa A (1998) YakA, a protein kinase required for the transition from growth to development in Dictyostelium. Development 125:2291\u20132302","journal-title":"Development"},{"key":"111_CR143","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0167-4781(92)90049-6","volume":"1132","author":"C Michaelis","year":"1992","unstructured":"Michaelis C, Weeks G (1992) Isolation and characterization of a cdc2 cDNA from Dictyostelium discoideum. Biochim et Biophys Acta\u2014Gene Struct Expr 1132:35\u201342","journal-title":"Biochim et Biophys Acta\u2014Gene Struct Expr"},{"key":"111_CR144","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.bbrc.2008.10.124","volume":"377","author":"A Naorem","year":"2008","unstructured":"Naorem A, Sadhale PP (2008) Identification and characterisation of DdRPB4, a subunit of Dictyostelium discoideum RNA polymerase II. Biochem Biophys Res Commun 377:1141\u20131146. doi: 10.1016\/j.bbrc.2008.10.124","journal-title":"Biochem Biophys Res Commun"},{"key":"111_CR145","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1242\/jcs.01140","volume":"117","author":"J Chida","year":"2004","unstructured":"Chida J, Yamaguchi H, Amagai A et al (2004) The necessity of mitochondrial genome DNA for normal development of Dictyostelium cells. J Cell Sci 117:3141\u20133152. doi: 10.1242\/jcs.01140","journal-title":"J Cell Sci"},{"key":"111_CR146","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/(SICI)1520-6408(1999)25:4<339::AID-DVG8>3.0.CO;2-3","volume":"25","author":"Y Inazu","year":"1999","unstructured":"Inazu Y, Chae SC, Maeda Y (1999) Transient expression of a mitochondrial gene cluster including rps4 is essential for the phase-shift of Dictyostelium cells from growth to differentiation. Dev Genet 25:339\u2013352. doi: 10.1002\/(SICI)1520-6408(1999)25:4<339::AID-DVG8>3.0.CO;2-3","journal-title":"Dev Genet"},{"key":"111_CR147","doi-asserted-by":"crossref","first-page":"7308","DOI":"10.1073\/pnas.94.14.7308","volume":"9","author":"Q Zhu","year":"1997","unstructured":"Zhu Q, Hulen D, Liu T et al (1997) The cluA\u2212 mutant of Dictyostelium identifies a novel class of proteins required for dispersion of mitochondria. Proc Natl Acad Sci USA 9:7308\u20137313. doi: 10.1073\/pnas.94.14.7308","journal-title":"Proc Natl Acad Sci USA"},{"key":"111_CR148","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1083\/jcb.152.3.621","volume":"152","author":"S Es van","year":"2001","unstructured":"van Es S, Wessels D, Soll DR et al (2001) Tortoise, a novel mitochondrial protein, is required for directional responses of Dictyostelium in chemotactic gradients. J Cell Biol 152:621\u2013632. doi: 10.1083\/jcb.152.3.621","journal-title":"J Cell Biol"},{"key":"111_CR149","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.yexcr.2004.10.010","volume":"303","author":"T Morita","year":"2005","unstructured":"Morita T, Yamaguchi H, Amagai A et al (2005) Involvement of the TRAP-1 homologue, Dd-TRAP1, in spore differentiation during Dictyostelium development. Exp Cell Res 303:425\u2013431. doi: 10.1016\/j.yexcr.2004.10.010","journal-title":"Exp Cell Res"},{"key":"111_CR150","unstructured":"Peitsch, MC (1995) Protein modeling by E-mail Bio\/Technology. 13:658\u2013660"},{"key":"111_CR151","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1002\/elps.1150181505","volume":"18","author":"N Guex","year":"1997","unstructured":"Guex N, Peitsch MC (1997) SWISS-MODEL and the Swiss-Pdb Viewer: an environment for comparative protein modeling. Electrophoresis 18:2714\u20132723. doi: 10.1002\/elps.1150181505","journal-title":"Electrophoresis"},{"key":"111_CR152","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1093\/nar\/gkg520","volume":"31","author":"T Schwede","year":"2003","unstructured":"Schwede T, Kopp J, Guex NP et al (2003) SWISS-MODEL: an automated protein homology-modeling server. Nucleic Acids Res 31:3381\u20133385. doi: 10.1093\/nar\/gkg520","journal-title":"Nucleic Acids Res"},{"key":"111_CR153","doi-asserted-by":"crossref","first-page":"D230","DOI":"10.1093\/nar\/gkh008","volume":"32","author":"J Kopp","year":"2004","unstructured":"Kopp J, Schwede T (2004) The SWISS-MODEL Repository of annotated and three-dimensional protein structure homology models. Nucleic Acids Res 32:D230\u2013D234. doi: 10.1093\/nar\/gkh008","journal-title":"Nucleic Acids Res"},{"key":"111_CR154","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1093\/emboj\/19.14.3520","volume":"19","author":"P Meyer","year":"2000","unstructured":"Meyer P, Schneider B, Sarfati S, Deville-Bonne D, Guerreiro C, Boretto J, Janin J, Veron M, Canard B (2000) Structural basis for activation of alpha-boranophosphate nucleotide analogues targeting drug-resistant reverse transcriptase. EMBO J 19:3520\u20133529. doi: 10.1093\/emboj\/19.14.3520","journal-title":"EMBO J"},{"key":"111_CR155","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","volume":"28","author":"HM Berman","year":"2000","unstructured":"Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE (2000) The Protein Data Bank. Nucleic Acids Res 28:235\u2013242. doi: 10.1093\/nar\/28.1.235","journal-title":"Nucleic Acids Res"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-009-0111-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11010-009-0111-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-009-0111-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T06:06:00Z","timestamp":1633327560000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11010-009-0111-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,22]]},"references-count":155,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["111"],"URL":"https:\/\/doi.org\/10.1007\/s11010-009-0111-8","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,22]]}}}