{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T08:45:47Z","timestamp":1779180347304,"version":"3.51.4"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2009,7,23]],"date-time":"2009-07-23T00:00:00Z","timestamp":1248307200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1007\/s11010-009-0218-y","type":"journal-article","created":{"date-parts":[[2009,7,22]],"date-time":"2009-07-22T10:05:36Z","timestamp":1248257136000},"page":"181-187","source":"Crossref","is-referenced-by-count":6,"title":["Differential regulation of Apak by various DNA damage signals"],"prefix":"10.1007","volume":"333","author":[{"given":"Shan","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyan","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingtiang","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guichun","family":"Xing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuchu","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingqiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,7,23]]},"reference":[{"key":"218_CR1","first-page":"1","volume-title":"25 years of p53 research","author":"H Robins","year":"2005","unstructured":"Robins H, Alexe G, Harris SL et al (2005) The first twenty-five years of p53 research. In: Hainaut P, Wiman KG (eds) 25 years of p53 research. Springer, Dordrecht, pp 1\u201326"},{"key":"218_CR2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/35042675","volume":"408","author":"B Vogelstein","year":"2000","unstructured":"Vogelstein B, Lane D, Levine AJ (2000) Surfing the p53 network. Nature 408:307\u2013310","journal-title":"Nature"},{"key":"218_CR3","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/sj.cdd.4401910","volume":"13","author":"AJ Levine","year":"2006","unstructured":"Levine AJ, Hui W, Feng Z (2006) The p53 pathway: what questions remain to be explored? Cell Death Differ 13:1027\u20131036","journal-title":"Cell Death Differ"},{"key":"218_CR4","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1093\/jnci\/89.11.783","volume":"89","author":"O Micheau","year":"1997","unstructured":"Micheau O, Solary E, Hammann A et al (1997) Dimanche-Boitrel, sensitization of cancer cells treated with cytotoxic drugs to Fas-mediated cytotoxicity. J Natl Cancer Inst 89:783\u2013789","journal-title":"J Natl Cancer Inst"},{"key":"218_CR5","first-page":"2912","volume":"60","author":"XX Wu","year":"2000","unstructured":"Wu XX, Mizutani Y, Kakehi Y et al (2000) Enhancement of Fas mediated apoptosis in renal cell carcinoma cells by adriamycin. Cancer Res 60:2912\u20132918","journal-title":"Cancer Res"},{"issue":"Suppl 1","key":"218_CR6","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1023\/A:1024393926965","volume":"79","author":"M Piccart","year":"2003","unstructured":"Piccart M (2003) The role of taxanes in the adjuvant treatment of early stage breast cancer. Breast Cancer Res Treat 79(Suppl 1):25\u201334","journal-title":"Breast Cancer Res Treat"},{"key":"218_CR7","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1081\/CNV-200055970","volume":"23","author":"F Pellegrini","year":"2005","unstructured":"Pellegrini F, Budman DR (2005) Review: tubulin function, action of antitubulin drugs, and new drug development. Cancer Investig 23:264\u2013273","journal-title":"Cancer Investig"},{"key":"218_CR8","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0079-6107(96)00017-X","volume":"66","author":"DZ Yang","year":"1997","unstructured":"Yang DZ, Wang HJ (1997) Structural studies of interactions between anticancer platinum drugs and DNA. Prog Biophys Mol Biol 66:81\u2013111","journal-title":"Prog Biophys Mol Biol"},{"key":"218_CR9","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1124\/mol.59.4.657","volume":"59","author":"M Victor","year":"2001","unstructured":"Victor M, Gonzalez MA, Fuertes CA (2001) Is cisplatin induced cell death always produced by apoptosis? Mol Pharm 59:657\u2013663","journal-title":"Mol Pharm"},{"key":"218_CR10","doi-asserted-by":"crossref","first-page":"4994","DOI":"10.1002\/j.1460-2075.1995.tb00182.x","volume":"14","author":"MJ Allday","year":"1995","unstructured":"Allday MJ, Inman GJ, Crawford DH, Farrel PJ (1995) DNA damage in human B cells can induce apoptosis, proceeding from G1\/S when p53 is transactivation competent and G2\/M when it is transactivation defective. EMBO J 14:4994\u20135005","journal-title":"EMBO J"},{"key":"218_CR11","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0021-9258(17)42175-2","volume":"269","author":"G Chu","year":"1994","unstructured":"Chu G (1994) Cellular responses to cisplatin. J Biol Chem 269:787\u2013790","journal-title":"J Biol Chem"},{"key":"218_CR12","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1080\/10715760303849","volume":"37","author":"G Mantovani","year":"2003","unstructured":"Mantovani G, Maccio A, Madeddu C (2003) The impact of different antioxidant agents alone or in combination on reactive oxygen species, antioxidant enzymes and cytokines in a series of advanced cancer patients at different sites: correlation with disease progression. Free Radic Res 37:213\u2013223","journal-title":"Free Radic Res"},{"key":"218_CR13","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1615\/JEnvPathToxOncol.v22.i1.20","volume":"22","author":"G Mantovani","year":"2003","unstructured":"Mantovani G, Maccio A, Madeddu C et al (2003) Reactive oxygen species, antioxidant mechanisms, and serum cytokines levels in cancer patients: impact of an antioxidant treatment. J Environ Pathol Toxicol Oncol 22:17\u201328","journal-title":"J Environ Pathol Toxicol Oncol"},{"key":"218_CR14","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s10495-005-0810-x","volume":"10","author":"U Wenzel","year":"2005","unstructured":"Wenzel U, Nickel A, Daniel H (2005) \u03b1-lipoic acid induces apoptosis in human colon cancer cells by increasing mitochondrial respiration with a concomitant O2 \u2212 generation. Apoptosis 10:359\u2013368","journal-title":"Apoptosis"},{"key":"218_CR15","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/sj.cdd.4400514","volume":"6","author":"CK Sen","year":"1999","unstructured":"Sen CK, Roy S, Packer L et al (1999) Fas mediated apoptosis of human Jurkat T-cells: intracellular events and potentiation by redox-active alpha-lipoic acid. Cell Death Differ 6:481\u2013491","journal-title":"Cell Death Differ"},{"key":"218_CR16","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/jcp.10205","volume":"194","author":"K Mark Van De","year":"2003","unstructured":"Van De Mark K, Chen J, Steliou K et al (2003) Faller, \u03b1-lipoic acid induces p27kip1-dependent cell cycle arrest in non transformed cell lines and apoptosis in tumor cell lines. J Cell Physiol 194:325\u2013340","journal-title":"J Cell Physiol"},{"key":"218_CR17","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0306-3623(96)00474-0","volume":"29","author":"GP Biewenga","year":"1997","unstructured":"Biewenga GP, Haenen GR, Bast A (1997) The pharmacology of the antioxidant lipoic acid. Gen Pharmacol 29:315\u2013331","journal-title":"Gen Pharmacol"},{"key":"218_CR18","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S1054-3589(08)60980-1","volume":"38","author":"L Packer","year":"1997","unstructured":"Packer L, Roy S, Sen CK (1997) \u03b1 lipoic acid: a metabolic antioxidant and potential redox modulator of transcription. Adv Pharmacol 38:79\u2013101","journal-title":"Adv Pharmacol"},{"key":"218_CR19","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.tca.2006.10.011","volume":"452","author":"W Du","year":"2007","unstructured":"Du W, Wang L, Li J et al (2007) Actinomycin D binds to single stranded DNA oligomers which contain double GTC triplets. Thermochim Acta 452:31\u201335","journal-title":"Thermochim Acta"},{"key":"218_CR20","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.1128\/MCB.20.9.3224-3233.2000","volume":"20","author":"M Ashcroft","year":"2000","unstructured":"Ashcroft M, Taya Y, Vousden KH (2000) Stress signals utilize multiple pathways to stabilize p53. Mol Cell Biol 20:3224\u20133233","journal-title":"Mol Cell Biol"},{"key":"218_CR21","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1126\/science.281.5383.1674","volume":"281","author":"S Banin","year":"1998","unstructured":"Banin S, Moyal L, Shieh S et al (1998) Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 281:1674\u20131677","journal-title":"Science"},{"key":"218_CR22","doi-asserted-by":"crossref","first-page":"7654","DOI":"10.1128\/MCB.24.17.7654-7668.2004","volume":"24","author":"MS Dai","year":"2004","unstructured":"Dai MS, Zeng SX, Jin Y et al (2004) Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. Mol Cell Biol 24:7654\u20137668","journal-title":"Mol Cell Biol"},{"key":"218_CR23","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/ncb1446","volume":"8","author":"Y Ziv","year":"2006","unstructured":"Ziv Y, Bielopolski D, Galanty Y et al (2006) Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway. Nat Cell Biol 8:870\u2013876","journal-title":"Nat Cell Biol"},{"key":"218_CR24","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/ncb1864","volume":"11","author":"C Tian","year":"2009","unstructured":"Tian C, Xing G, Xie P et al (2009) KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis. Nat Cell Biol 11:580\u2013591","journal-title":"Nat Cell Biol"},{"key":"218_CR25","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/j.cellsig.2005.10.017","volume":"18","author":"L Zhang","year":"2006","unstructured":"Zhang L, Tie Y, Tian C et al (2006) CKIP-1 recruits nuclear ATM partially to the plasma membrane through interaction with ATM. Cell Signal 18:1386\u20131395","journal-title":"Cell Signal"},{"key":"218_CR26","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1038\/ncb1760","volume":"10","author":"K Lu","year":"2008","unstructured":"Lu K, Yin X, Weng T et al (2008) Targeting WW domains linker of HECT type ubiquitin ligase Smurf1 for activation by CKIP-1. Nat Cell Biol 10:994\u20131002","journal-title":"Nat Cell Biol"},{"key":"218_CR27","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/sj.cdd.4401916","volume":"13","author":"O Laptenko","year":"2006","unstructured":"Laptenko O, Prives C (2006) Transcriptional regulation by p53: one protein, many possibilities. Cell Death Differ 13:951\u2013961","journal-title":"Cell Death Differ"},{"key":"218_CR28","doi-asserted-by":"crossref","first-page":"4967","DOI":"10.1093\/emboj\/19.18.4967","volume":"19","author":"C Chao","year":"2000","unstructured":"Chao C, Saito S, Kang J et al (2000) p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage. EMBO J 19:4967\u20134975","journal-title":"EMBO J"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-009-0218-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11010-009-0218-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-009-0218-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T23:35:52Z","timestamp":1633736152000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11010-009-0218-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,23]]},"references-count":28,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["218"],"URL":"https:\/\/doi.org\/10.1007\/s11010-009-0218-y","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,23]]}}}