{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T19:48:11Z","timestamp":1770752891837,"version":"3.50.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2011,1,13]],"date-time":"2011-01-13T00:00:00Z","timestamp":1294876800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1007\/s11010-011-0718-4","type":"journal-article","created":{"date-parts":[[2011,1,12]],"date-time":"2011-01-12T02:44:10Z","timestamp":1294800250000},"page":"117-123","source":"Crossref","is-referenced-by-count":33,"title":["Association of L55M and Q192R polymorphisms in paraoxonase 1 (PON1) gene with breast cancer risk and their clinical significance"],"prefix":"10.1007","volume":"351","author":[{"given":"Yousri M.","family":"Hussein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal F.","family":"Gharib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasha L.","family":"Etewa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wael H.","family":"ElSawy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,1,13]]},"reference":[{"key":"718_CR1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3322\/canjclin.56.3.168","volume":"56","author":"C Smigal","year":"2006","unstructured":"Smigal C, Jemal A, Ward E, Cokkinides V, Smith R, Howe HL, Thun M (2006) Trends in breast cancer by race and ethnicity: update. CA Cancer J Clin 56:168\u2013183","journal-title":"CA Cancer J Clin"},{"key":"718_CR2","doi-asserted-by":"crossref","unstructured":"Gu D, Wang M (2010) VEGF 936C\u00a0>\u00a0T polymorphism and breast cancer risk: evidence from 5,729 cases and 5,868 controls. Breast Cancer Res Treat. doi: 10.1007\/s10549\u2013010\u20130991-z","DOI":"10.1007\/s10549-010-0991-z"},{"key":"718_CR3","first-page":"584","volume":"12","author":"MJ Fattahi","year":"2009","unstructured":"Fattahi MJ, Mojtahedi Z, Karimaghaee N, Talei AR, Ranani SJ, Ghaderi A (2009) Analysis of BRCA1 and BRCA2 mutations in southern Iranian breast cancer patient. Arch Iran Med 12:584\u2013587","journal-title":"Arch Iran Med"},{"key":"718_CR4","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.clinbiochem.2007.06.007","volume":"40","author":"I Delimaris","year":"2007","unstructured":"Delimaris I, Faviou E, Antonakos G, Stathopoulou E, Zachari A, Dionyssiou-Asteriou A (2007) Oxidized LDL, serum oxidizability and serum lipid levels in patients with breast or ovarian cancer. Clin Biochem 40:1129\u20131134","journal-title":"Clin Biochem"},{"key":"718_CR5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2005.12.009","volume":"160","author":"M Valko","year":"2006","unstructured":"Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M (2006) Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 160:1\u201340","journal-title":"Chem Biol Interact"},{"key":"718_CR6","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1023\/A:1006357330486","volume":"59","author":"G Ray","year":"2005","unstructured":"Ray G, Batra S, Shukla NK, Deo S, Raina V, Ashor S, Husain SA (2005) Lipid peroxidation, free radical, and antioxidant status in breast cancer. Breast Cancer Res Treat 59:163\u2013170","journal-title":"Breast Cancer Res Treat"},{"key":"718_CR7","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1016\/0006-2952(90)90469-2","volume":"40","author":"R Chander","year":"1990","unstructured":"Chander R, Kapoor NK (1990) High-density lipoprotein is a scavenger of superoxide anions. Biochem Pharmacol 40:1663\u20131665","journal-title":"Biochem Pharmacol"},{"issue":"3","key":"718_CR8","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0306-3623(98)00028-7","volume":"31","author":"B Mackness","year":"1998","unstructured":"Mackness B, Durrington PN, Mackness MI (1998) Human serum paraoxonase. Gen Pharmacol 31(3):329\u2013336","journal-title":"Gen Pharmacol"},{"key":"718_CR9","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/28406","volume":"394","author":"DM Shih","year":"1998","unstructured":"Shih DM, Gu L, Xia YR, Navab M, Li WF, Hama S, Castellani LW, Furlong CE, Costa LG, Fogelman AM, Lusis AJ (1998) Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis. Nature 394:284\u2013287","journal-title":"Nature"},{"key":"718_CR10","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/ng0193-73","volume":"3","author":"R Humbert","year":"1993","unstructured":"Humbert R, Adler DA, Disteche CM, Hassett C, Omiecinski CJ, Furlong CE (1993) The molecular basis of the human serum paraoxonase activity polymorphism. Nat Genet 3:73\u201376","journal-title":"Nat Genet"},{"key":"718_CR11","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1086\/320600","volume":"68","author":"VH Brophy","year":"2001","unstructured":"Brophy VH, Jampsa RL, Clendenning JB, McKinstry LA, Jarvik GP, Furlong CE (2001) Effects of 5\u2032 regulatory-region polymorphisms on paraoxonase-gene (PON1) expression. Am J Hum Genet 68:1428\u20131436","journal-title":"Am J Hum Genet"},{"key":"718_CR12","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1161\/01.CIR.101.21.2510","volume":"101","author":"M Aviram","year":"2000","unstructured":"Aviram M, Hardak E, Vaya J, Mahmood S, Milo S, Hoffman A, Billicke S, Draganoy D, Rosenblat M (2000) Human serum paraoxonases (PON1) Q and R selectively decrease lipid peroxides in human coronary and carotid atherosclerotic lesions: PON1 esterase and peroxidase-like activities. Circulation 101:2510\u20132517","journal-title":"Circulation"},{"key":"718_CR13","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1158\/1055-9965.EPI-05-0930","volume":"15","author":"VL Stevens","year":"2006","unstructured":"Stevens VL, Rodriguez C, Pavluck AL, Thun MJ, Calle EE (2006) Association of polymorphisms in the paraoxonase 1 gene with breast cancer incidence in the CPS-II Nutrition Cohort. Cancer Epidemiol Biomarkers Prev 15:1226\u20131228","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"718_CR14","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.cdp.2007.02.004","volume":"31","author":"L Gallicchio","year":"2007","unstructured":"Gallicchio L, McSorley MA, Newschaffer CJ, Huang HY, Thuita LW, Hoffman SC, Helzlsouer KJ (2007) Body mass, polymorphisms in obesity-related genes, and the risk of developing breast cancer among women with benign breast disease. Cancer Detect Prev 31:95\u2013101","journal-title":"Cancer Detect Prev"},{"key":"718_CR15","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/bjc.1957.43","volume":"11","author":"HI Bloom","year":"1957","unstructured":"Bloom HI, Richardson WW (1957) Histological grading and prognosis. Br J Cancer 11:359\u2013377","journal-title":"Br J Cancer"},{"key":"718_CR16","unstructured":"Breast. AJCC cancer staging manual (2002) In: American joint committee on cancer. 6th edn. Springer, New York, pp 171\u2013180"},{"key":"718_CR17","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.1161\/01.ATV.17.12.3565","volume":"17","author":"T Zama","year":"1997","unstructured":"Zama T, Murata M, Matsubara Y, Kawano K, Aoki N, Yoshino H, Watanabe G, Ishikawa K, Ikeda Y (1997) A 192Arg variant of the human paraoxonase (HUMPONA) gene polymorphism is associated with an increased risk for coronary artery disease in the Japanese. Arterioscler Thromb Vasc Biol 17:3565\u20133569","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"718_CR18","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1093\/carcin\/17.11.2279","volume":"17","author":"HS Feigelson","year":"1996","unstructured":"Feigelson HS, Henderson BE (1996) Estrogens and breast cancer. Carcinogenesis 17:2279\u20132284","journal-title":"Carcinogenesis"},{"key":"718_CR19","first-page":"3","volume":"10","author":"C Willett Walter","year":"2000","unstructured":"Willett Walter C (2000) American association for cancer research diet and cancer: one view at the start of the millennium. Cancer Epidemiol Biomarkers Prev 10:3\u20138","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"718_CR20","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1089\/ars.2000.2.4-903","volume":"2","author":"CB Ambrosone","year":"2000","unstructured":"Ambrosone CB (2000) Oxidants and antioxidants in breast cancer. Antioxid Redox Signal 2:903\u2013917","journal-title":"Antioxid Redox Signal"},{"key":"718_CR21","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.cellbi.2006.02.005","volume":"30","author":"A G\u00f6nen\u00e7","year":"2006","unstructured":"G\u00f6nen\u00e7 A, Erten D, Aslan S, Akinci M, Simsek B, Torun M (2006) Lipid peroxidation and antioxidant status in blood and tissue of malignant breast tumor and benign breast disease. Cell Biol Int 30:376\u2013380","journal-title":"Cell Biol Int"},{"key":"718_CR22","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/cbf.1308","volume":"25","author":"DE Sener","year":"2007","unstructured":"Sener DE, Gonenc A, Akinci M, Torun M (2007) Lipid peroxidation and total antioxidant status in patients with breast cancer. Cell Biochem Funct 25:377\u2013382","journal-title":"Cell Biochem Funct"},{"key":"718_CR23","first-page":"219","volume":"54","author":"P Tesarov\u00e1","year":"2007","unstructured":"Tesarov\u00e1 P, Kalousov\u00e1 M, Trnkov\u00e1 B, Soukupov\u00e1 J, Argal\u00e1sov\u00e1 S, Mestek O, Petruzelka L, Zima T (2007) Carbonyl and oxidative stress in patients with breast cancer\u2014is there a relation to the stage of the disease? Neoplasma 54:219\u2013224","journal-title":"Neoplasma"},{"key":"718_CR24","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1080\/07357900701560521","volume":"25","author":"P Tesarov\u00e1","year":"2007","unstructured":"Tesarov\u00e1 P, Kalousov\u00e1 M, J\u00e1chymov\u00e1 M, Mestek O, Petruzelka L, Zima T (2007) Receptor for advanced glycation end products (RAGE)-soluble form (sRAGE) and gene polymorphisms in patients with breast cancer. Cancer Invest 25:720\u2013725","journal-title":"Cancer Invest"},{"key":"718_CR25","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1152\/physrev.1994.74.1.139","volume":"74","author":"BP Yu","year":"1994","unstructured":"Yu BP (1994) Cellular defenses against damage from reactive oxygen species. Physiol Rev 74:139\u2013162","journal-title":"Physiol Rev"},{"key":"718_CR26","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1002\/ijc.23653","volume":"123","author":"SA Salama","year":"2008","unstructured":"Salama SA, Kamel M, Awad M, Nasser AH, Al-Hendy A, Botting S, Arrastia C (2008) Catecholestrogens induce oxidative stress and malignant transformation in human endometrial glandular cells: protective effect of catechol-O-methyltransferase. Int J Cancer 123:1246\u20131254","journal-title":"Int J Cancer"},{"key":"718_CR27","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1089\/dna.1996.15.273","volume":"15","author":"DW Nebert","year":"1996","unstructured":"Nebert DW, McKinnon RA, Puga A (1996) Human drug-metabolizing enzyme polymorphisms: effects on risk of toxicity and cancer. DNA Cell Biol 15:273\u2013280","journal-title":"DNA Cell Biol"},{"key":"718_CR28","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/1471-2407-9-115","volume":"9","author":"C Antognelli","year":"2009","unstructured":"Antognelli C, Buono CD, Ludovini V, Gori S, Talesa VN, Crino L, Barberini F, Rulli A (2009) CYP17, GSTP1, PON1, and GLO1 gene polymorphisms as risk factors for breast cancer: an Italian case-control study. BMC Cancer 9:115\u2013128","journal-title":"BMC Cancer"},{"key":"718_CR29","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s12253-010-9267-5","volume":"16","author":"R Naidu","year":"2010","unstructured":"Naidu R, Har YC, Taib NAM (2010) Genetic polymorphisms of paraoxonase 1 (PON1) gene: association between L55M or Q192R with breast cancer risk and clinico-pathological parameters. Pathol Oncol Res 16:533\u2013540","journal-title":"Pathol Oncol Res"},{"key":"718_CR30","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1097\/00008571-200007000-00008","volume":"10","author":"VH Brophy","year":"2000","unstructured":"Brophy VH, Jarvik GP, Richter RJ, Rozek LS, Schellenberg GD, Furlong CE (2000) Analysis of paraoxonase (PON1) L55M status requires both genotype and phenotype. Pharmacogenetics 10:453\u2013460","journal-title":"Pharmacogenetics"},{"key":"718_CR31","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1373\/49.9.1491","volume":"49","author":"N Ferr\u00e8","year":"2003","unstructured":"Ferr\u00e8 N, Camps J, Fernandez-Ballart J, Arija V, Murphy MM, Ceruelo S, Biarnes E, Vilella E, Tous M, Joven J (2003) Regulation of serum paraoxonase activity by genetic, nutritional, and lifestyle factors in the general population. Clin Chem 49:1491\u20131497","journal-title":"Clin Chem"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-011-0718-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11010-011-0718-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-011-0718-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T15:35:23Z","timestamp":1559921723000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11010-011-0718-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,13]]},"references-count":31,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["718"],"URL":"https:\/\/doi.org\/10.1007\/s11010-011-0718-4","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,13]]}}}