{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:39:46Z","timestamp":1790872786534,"version":"4.1.0"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2011,6,30]],"date-time":"2011-06-30T00:00:00Z","timestamp":1309392000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1007\/s11010-011-0930-2","type":"journal-article","created":{"date-parts":[[2011,6,29]],"date-time":"2011-06-29T14:13:36Z","timestamp":1309356816000},"page":"153-160","source":"Crossref","is-referenced-by-count":21,"title":["Chronic hyperhomocysteinemia induces oxidative damage in the rat lung"],"prefix":"10.1007","volume":"358","author":[{"given":"Aline A.","family":"da Cunha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a G. K.","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maira J.","family":"da Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina D.","family":"Pederzolli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora L.","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana G.","family":"Coelho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos S.","family":"Dutra-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela T. S.","family":"Wyse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,6,30]]},"reference":[{"key":"930_CR1","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1001\/archneur.57.10.1422","volume":"57","author":"R Diaz-Arrastia","year":"2000","unstructured":"Diaz-Arrastia R (2000) Homocysteine and neurologic disease. Arch Neurol 57:1422\u20131427","journal-title":"Arch Neurol"},{"key":"930_CR2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1515\/CCLM.2001.036","volume":"39","author":"A Andersson","year":"2001","unstructured":"Andersson A, Ankerst J, Lindgren A, Larsson K, Hultberg B (2001) Hyperhomocysteinemia and changed plasma thiol redox status in chronic obstructive pulmonary disease. Clin Chem Lab Med 39:229\u2013233","journal-title":"Clin Chem Lab Med"},{"key":"930_CR3","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0047-6374(01)00365-7","volume":"1","author":"MP Mattson","year":"2002","unstructured":"Mattson MP, Kruman II, Duan W (2002) Folic acid and homocysteine in age-related disease. Ageing Res Rev 1:95\u2013111","journal-title":"Ageing Res Rev"},{"key":"930_CR4","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.pnpbp.2005.06.021","volume":"29","author":"T Bottiglieri","year":"2005","unstructured":"Bottiglieri T (2005) Homocysteine and folate metabolism in depression. Prog Neuropsychopharmacol Biol Psychiatry 29:1103\u20131112","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"930_CR5","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1515\/CCLM.2007.356","volume":"45","author":"R Obeid","year":"2007","unstructured":"Obeid R, McCaddon A, Herrmann W (2007) The role of hyperhomocysteinemia and B-vitamin deficiency in neurological and psychiatric diseases. Clin Chem Lab Med 45:1590\u20131606","journal-title":"Clin Chem Lab Med"},{"key":"930_CR6","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1055\/s-2007-980112","volume":"75","author":"W Herrmann","year":"2007","unstructured":"Herrmann W, Lorenzl S, Obeid R (2007) Review of the role of hyperhomocysteinemia and B-vitamin deficiency in neurological and psychiatric disorders\u2014current evidence and preliminary recommendations. Fortschr Neurol Psychiatr 75:515\u2013527","journal-title":"Fortschr Neurol Psychiatr"},{"key":"930_CR7","first-page":"1279","volume-title":"The metabolic and molecular bases of inherited disease","author":"SH Mudd","year":"2001","unstructured":"Mudd SH, Levy HL, Skovby F (2001) Disorders of transsulfuration. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds) The metabolic and molecular bases of inherited disease, 8th edn. McGraw-Hill, New York, pp 1279\u20131327","edition":"8"},{"key":"930_CR8","volume-title":"Hepatic lesions in disorders of protein and amino acid metabolism","author":"G Klastin","year":"1993","unstructured":"Klastin G, Conn HO (1993) Hepatic lesions in disorders of protein and amino acid metabolism. Oxford University Press, New York"},{"key":"930_CR9","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s002340050119","volume":"37","author":"M Berg van der","year":"1995","unstructured":"van der Berg M, van der Knapp MS, Boers GH, Stehouwer CD, Rauwerda JA, Valk J (1995) Hyperhomocysteinemia; with reference to its neuroradiological aspects. Neuroradiology 37:403\u2013411","journal-title":"Neuroradiology"},{"key":"930_CR10","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1056\/NEJM199804093381507","volume":"338","author":"GN Welch","year":"1998","unstructured":"Welch GN, Loscalzo J (1998) Homocysteine and atherothrombosis. N Engl J Med 338:1042\u20131050","journal-title":"N Engl J Med"},{"key":"930_CR11","first-page":"117","volume":"216","author":"WK Kim","year":"1996","unstructured":"Kim WK, Pae YS (1996) Involvement of N-methyl-d-aspartate receptor and free radical in homocysteine-mediated toxicity on rat cerebellar granule cells in culture. Neurosci Lett 216:117\u2013120","journal-title":"Neurosci Lett"},{"key":"930_CR12","first-page":"R1704","volume":"274","author":"F Zhang","year":"1998","unstructured":"Zhang F, Slungaard A, Vercellotti GM, Ladecola C (1998) Superoxide-dependent cerebrovascular effects of homocysteine. Am J Physiol 274:R1704\u2013R1711","journal-title":"Am J Physiol"},{"key":"930_CR13","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0969-9961(03)00070-6","volume":"14","author":"PI Ho","year":"2003","unstructured":"Ho PI, Ashline D, Dhitavat S, Ortiz D, Collins SC, Shea TB, Rogers E (2003) Folate deprivation induces neurodegeneration: roles of oxidative stress and increased homocysteine. Neurobiol Dis 14:32\u201342","journal-title":"Neurobiol Dis"},{"key":"930_CR14","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/BF03033381","volume":"5","author":"A Jara-Prado","year":"2003","unstructured":"Jara-Prado A, Ortega-Vazquez A, Martinez-Ruano L, Rios C, Santamaria A (2003) Homocysteine-induced brain lipid peroxidation: effects of NMDA receptor blockade, antioxidant treatment, and nitric oxide synthase inhibition. Neurotox Res 5:237\u2013243","journal-title":"Neurotox Res"},{"key":"930_CR15","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1161\/01.STR.0000131749.81508.18","volume":"35","author":"S Dayal","year":"2004","unstructured":"Dayal S, Arning E, Bottiglieri T, Boger RH, Sigmund CD, Faraci FM, Lentz SR (2004) Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemic mice. Stroke 35:1957\u20131962","journal-title":"Stroke"},{"key":"930_CR16","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1161\/01.STR.0000115161.10646.67","volume":"35","author":"FM Faraci","year":"2004","unstructured":"Faraci FM, Lentz SR (2004) Hyperhomocysteinemia, oxidative stress, and cerebral vascular dysfunction. Stroke 35:345\u2013347","journal-title":"Stroke"},{"key":"930_CR17","doi-asserted-by":"crossref","first-page":"H2649","DOI":"10.1152\/ajpheart.00548.2005","volume":"289","author":"N Tyagi","year":"2005","unstructured":"Tyagi N, Sedoris KC, Steed M, Ovechkin AV, Moshal KS, Tyagi SC (2005) Mechanisms of homocysteine-induced oxidative stress. Am J Physiol Heart Circ Physiol 289:H2649\u2013H2656","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"930_CR18","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1111\/j.1471-4159.2006.03907.x","volume":"97","author":"B Halliwell","year":"2006","unstructured":"Halliwell B (2006) Oxidative stress and neurodegeneration: where are we now? J Neurochem 97:1634\u20131658","journal-title":"J Neurochem"},{"key":"930_CR19","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.jns.2007.01.039","volume":"257","author":"X Zhu","year":"2007","unstructured":"Zhu X, Smith MA, Honda K, Aliev G, Moreira PI, Nunomura A, Casadesus G, Harris PL, Siedlak SL, Perry G (2007) Vascular oxidative stress in Alzheimer disease. J Neurol Sci 257:240\u2013246","journal-title":"J Neurol Sci"},{"key":"930_CR20","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.2741\/2150","volume":"12","author":"H Shi","year":"2007","unstructured":"Shi H, Liu KJ (2007) Cerebral tissue oxygenation and oxidative brain injury during ischemia and reperfusion. Front Biosci 12:1318\u20131328","journal-title":"Front Biosci"},{"key":"930_CR21","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1556\/OH.2008.28356","volume":"149","author":"D Muhl","year":"2008","unstructured":"Muhl D (2008) Changes in oxidative stress and hemostatic parameters in the course of thrombolytic therapy of pulmonary embolism. Orv Hetil 149:935\u2013948","journal-title":"Orv Hetil"},{"key":"930_CR22","doi-asserted-by":"crossref","first-page":"685","DOI":"10.2165\/00002512-200118090-00004","volume":"18","author":"B Halliwell","year":"2001","unstructured":"Halliwell B (2001) Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment. Drugs Aging 18:685\u2013716","journal-title":"Drugs Aging"},{"key":"930_CR23","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/sj.bjp.0705776","volume":"142","author":"B Halliwell","year":"2004","unstructured":"Halliwell B, Whiteman M (2004) Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? Br J Pharmacol 142:231\u2013255","journal-title":"Br J Pharmacol"},{"key":"930_CR24","first-page":"79","volume-title":"Free radicals in biology and medicine","author":"B Halliwell","year":"2007","unstructured":"Halliwell B, Gutteridge JMC (2007) Free radicals in biology and medicine, 4th edn. Oxford University Press, New York, pp 79\u2013185","edition":"4"},{"key":"930_CR25","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1023\/A:1021647329937","volume":"27","author":"AT Wyse","year":"2002","unstructured":"Wyse AT, Zugno AI, Streck EL, Matt\u00e9 C, Calcagnotto T, Wannmacher CM, Wajner M (2002) Inhibition of Na+, K+-ATPase activity in hippocampus of rats subjected to acute administration of homocysteine is prevented by vitamins E and C treatment. Neurochem Res 27:1685\u20131689","journal-title":"Neurochem Res"},{"key":"930_CR26","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1023\/A:1023815119931","volume":"18","author":"EL Streck","year":"2003","unstructured":"Streck EL, Vieira PS, Wannmacher CM, Dutra-Filho C, Wajner M, Wyse AT (2003) In vitro effect of homocysteine on some parameters of oxidative stress in rat hippocampus. Metab Brain Dis 18:147\u2013154","journal-title":"Metab Brain Dis"},{"key":"930_CR27","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ijdevneu.2004.05.007","volume":"22","author":"C Matt\u00e9","year":"2004","unstructured":"Matt\u00e9 C, Monteiro SC, Calcagnotto T, Bavaresco CS, Netto CA, Wyse AT (2004) In vivo and in vitro effects of homocysteine on Na+, K+-ATPase activity in parietal, prefrontal and cingulate cortex of young rats. Int J Dev Neurosci 22:185\u2013190","journal-title":"Int J Dev Neurosci"},{"key":"930_CR28","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.ijdevneu.2007.10.003","volume":"25","author":"C Matt\u00e9","year":"2007","unstructured":"Matt\u00e9 C, Scherer EB, Stefanello FM, Barschak AG, Vargas CR, Netto CA, Wyse AT (2007) Concurrent folate treatment prevents Na+, K+-ATPase activity inhibition and memory impairments caused by chronic hyperhomocysteinemia during rat development. Int J Dev Neurosci 25:545\u2013552","journal-title":"Int J Dev Neurosci"},{"key":"930_CR29","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ijdevneu.2009.03.005","volume":"27","author":"C Matt\u00e9","year":"2009","unstructured":"Matt\u00e9 C, Stefanello FM, Mackedanz V, Pederzolli CD, Lamers ML, Dutra-Filho CS, dos Santos MF, Wyse AT (2009) Homocysteine induces oxidative stress, inflammatory infiltration, fibrosis and reduces glycogen\/glycoprotein content in liver of rats. Int J Dev Neurosci 27:337\u2013344","journal-title":"Int J Dev Neurosci"},{"key":"930_CR30","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1023\/A:1021670607647","volume":"27","author":"EL Streck","year":"2002","unstructured":"Streck EL, Matt\u00e9 C, Vieira PS, Rombaldi F, Wannmacher CM, Wajner M, Wyse AT (2002) Reduction of Na+, K+-ATPase activity in hippocampus of rats subjected to chemically induced hyperhomocysteinemia. Neurochem Res 27:1593\u20131598","journal-title":"Neurochem Res"},{"key":"930_CR31","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1177\/030089168507100305","volume":"71","author":"SF Llesuy","year":"1985","unstructured":"Llesuy SF, Milei J, Molina H, Boveris A, Milei S (1985) Comparison of lipid peroxidation and myocardial damage induced by adriamycin and 4\u2032-epiadriamycin in mice. Tumori 71:241\u2013249","journal-title":"Tumori"},{"key":"930_CR32","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351\u2013358","journal-title":"Anal Biochem"},{"key":"930_CR33","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0891-5849(90)90006-5","volume":"9","author":"ER Stadtman","year":"1990","unstructured":"Stadtman ER (1990) Metal ion-catalyzed oxidation of proteins: biochemical mechanism and biological consequences. Free Radic Biol Med 9:315\u2013325","journal-title":"Free Radic Biol Med"},{"key":"930_CR34","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s00726-003-0011-2","volume":"25","author":"ER Stadtman","year":"2003","unstructured":"Stadtman ER, Levine RL (2003) Free-radical mediated oxidation of free amino acids and amino acid residues in proteins. Amino Acids 25:207\u2013218","journal-title":"Amino Acids"},{"key":"930_CR35","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0076-6879(94)33041-7","volume":"233","author":"AZ Reznick","year":"1994","unstructured":"Reznick AZ, Packer L (1994) Oxidative damage to proteins: spectrophotometric method for carbonyl assay. Methods Enzymol 233:357\u2013363","journal-title":"Methods Enzymol"},{"key":"930_CR36","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0041-008X(90)90278-3","volume":"104","author":"CP LeBel","year":"1990","unstructured":"LeBel CP, Ali SF, McKee M, Bondy SC (1990) Organometal-induced increases in oxygen reactive species: the potential of 2\u2032,7\u2032-dichlorofluorescein diacetate as an index of neurotoxic damage. Toxicol Appl Pharmacol 104:17\u201324","journal-title":"Toxicol Appl Pharmacol"},{"key":"930_CR37","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3109\/10715769209079523","volume":"17","author":"E Lissi","year":"1992","unstructured":"Lissi E, Pascual C, Del Castillo MD (1992) Luminol luminescence induced by 2,2\u2032-azo-bis-(2-amidinopropane) thermolysis. Free Radic Res Commun 17:299\u2013311","journal-title":"Free Radic Res Commun"},{"key":"930_CR38","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1006\/abbi.2001.2292","volume":"388","author":"P Evelson","year":"2001","unstructured":"Evelson P, Travacio M, Repetto M, Escobar J, Llesuy S, Lissi EA (2001) Evaluation of total reactive antioxidant potential (TRAP) of tissue homogenates and their cytosols. Arch Biochem Biophys 388:261\u2013266","journal-title":"Arch Biochem Biophys"},{"key":"930_CR39","first-page":"243","volume-title":"Handbook of methods for oxygen radical research","author":"SL Marklund","year":"1985","unstructured":"Marklund SL (1985) Pyrogallol autoxidation. In: Greenwald RA (ed) Handbook of methods for oxygen radical research. CRC Press, Boca Raton, pp 243\u2013247"},{"key":"930_CR40","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","volume":"105","author":"H Aebi","year":"1984","unstructured":"Aebi H (1984) Catalase, in vitro. Methods Enzymol 105:121\u2013126","journal-title":"Methods Enzymol"},{"key":"930_CR41","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0076-6879(81)77046-0","volume":"77","author":"A Wendel","year":"1981","unstructured":"Wendel A (1981) Glutathione peroxidase. Methods Enzymol 77:325\u2013333","journal-title":"Methods Enzymol"},{"key":"930_CR42","first-page":"347","volume":"108","author":"RW Browne","year":"1998","unstructured":"Browne RW, Armstrong D (1998) Reduced glutathione and glutathione disulfide. Methods Mol Biol 108:347\u2013352","journal-title":"Methods Mol Biol"},{"key":"930_CR43","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1042\/bj2180131","volume":"218","author":"SF Leong","year":"1984","unstructured":"Leong SF, Clark JB (1984) Regional enzyme development in rat brain. Enzymes associated with glucose utilization. Biochem J 218:131\u2013138","journal-title":"Biochem J"},{"key":"930_CR44","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","volume":"126","author":"LC Green","year":"1982","unstructured":"Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR (1982) Analysis of nitrate, nitrite and [15N]nitrate in biological fluids. Anal Biochem 126:131\u2013138","journal-title":"Anal Biochem"},{"key":"930_CR45","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, Randal RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193:265\u2013275","journal-title":"J Biol Chem"},{"key":"930_CR46","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1056\/NEJM199104253241701","volume":"324","author":"R Clarke","year":"1999","unstructured":"Clarke R, Daly L, Robinson K (1999) Hyperhomocysteinemia: an independent risk factor for vascular disease. N Engl J Med 324:1149\u20131155","journal-title":"N Engl J Med"},{"key":"930_CR47","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.2174\/0929867033456864","volume":"10","author":"MP Mattson","year":"2003","unstructured":"Mattson MP, Haberman F (2003) Folate and homocysteine metabolism: therapeutic targets in cardiovascular and neurodegenerative disorders. Curr Med Chem 10:1923\u20131929","journal-title":"Curr Med Chem"},{"key":"930_CR48","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.bbrc.2005.09.160","volume":"337","author":"H Jiang","year":"2005","unstructured":"Jiang H, Wang XF, Fang L, Tang C, Zhu Y, Wang X (2005) Upregulation of aldose reductase by homocysteine in type II alveolar epithelial cells. Biochem Biophys Res Commun 337:1084\u20131091","journal-title":"Biochem Biophys Res Commun"},{"key":"930_CR49","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.yexmp.2007.04.005","volume":"83","author":"J Hamelet","year":"2007","unstructured":"Hamelet J, Maurin N, Fulchiron R, Delabar JM, Janel N (2007) Mice lacking cystathionine beta synthase have lung fibrosis and air space enlargement. Exp Mol Pathol 83:249\u2013253","journal-title":"Exp Mol Pathol"},{"key":"930_CR50","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/0049-3848(89)90387-3","volume":"55","author":"M Dikshit","year":"1989","unstructured":"Dikshit M, Srivastava R, Srimal RC (1989) Role of free radicals in pulmonary thromboembolism in mice. Thromb Res 55:549\u2013557","journal-title":"Thromb Res"},{"key":"930_CR51","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1093\/oxfordjournals.bmb.a072633","volume":"49","author":"A Ryrfeldt","year":"1993","unstructured":"Ryrfeldt A, Bannenberg G, Moldeus P (1993) Free radicals and lung disease. Br Med Bull 49:588\u2013603","journal-title":"Br Med Bull"},{"key":"930_CR52","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1093\/clinchem\/44.11.2238","volume":"44","author":"DW Jacobsen","year":"1998","unstructured":"Jacobsen DW (1998) Homocysteine and vitamins in cardiovascular disease. Clin Chem 44:1833\u20131843","journal-title":"Clin Chem"},{"key":"930_CR53","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1172\/JCI118776","volume":"98","author":"J Loscalzo","year":"1996","unstructured":"Loscalzo J (1996) The oxidant stress of hyperhomocyst(e)inemia. J Clin Invest 98:5\u20137","journal-title":"J Clin Invest"},{"key":"930_CR54","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1161\/01.ATV.15.2.232","volume":"15","author":"MA Mansoor","year":"1995","unstructured":"Mansoor MA, Bergmark C, Svardal AM, Lonning PE, Ueland PM (1995) Redox status and protein binding of plasma homocyst(e)ine and other aminothiols in patients with early-onset peripheral vascular disease. Arterioscler Thromb Vasc Biol 15:232\u2013240","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"930_CR55","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.neuint.2008.08.011","volume":"54","author":"C Matt\u00e9","year":"2009","unstructured":"Matt\u00e9 C, Mackedanz V, Stefanello FM, Scherer EB, Andreazza AC, Zanotto C, Moro AM, Garcia SC, Gon\u00e7alves CA, Erdtmann B, Salvador M, Wyse AT (2009) Chronic hyperhomocysteinemia alters antioxidant defenses and increases DNA damage in brain and blood os rats: protective effect of folic acid. Neurochem Int 54:7\u201313","journal-title":"Neurochem Int"},{"key":"930_CR56","first-page":"1","volume-title":"Physiology of oxygen radicals","author":"MB Grisham","year":"1986","unstructured":"Grisham MB, McCord J (1986) Chemistry and cytotoxicity of reactive oxygen metabolites. In: Taylor AE, Matalon S, Ward P (eds) Physiology of oxygen radicals. Williams and Wilkins Co, Baltimore, pp 1\u201318"},{"key":"930_CR57","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.atherosclerosis.2003.11.005","volume":"172","author":"M Alvarez-Maqueda","year":"2004","unstructured":"Alvarez-Maqueda M, El Bekay R, Monteseir\u00edn J, Alba G, Chac\u00f3n P, Vega A, Santa Mar\u00eda C, Tejedo JR, Mart\u00edn-Nieto J, Bedoya FJ, Pintado E, Sobrino F (2004) Homocysteine enhances superoxide anion release and NADPH oxidase assembly by human neutrophils. Effects on MAPK activation and neutrophil migration. Atherosclerosis 172:229\u2013238","journal-title":"Atherosclerosis"},{"key":"930_CR58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0003-9861(86)90526-6","volume":"247","author":"I Fridorich","year":"1986","unstructured":"Fridorich I (1986) Biological effects of the superoxide radical. Arch Biochem Biophys 247:1\u201311","journal-title":"Arch Biochem Biophys"},{"key":"930_CR59","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/0003-9861(85)90056-6","volume":"240","author":"J Blum","year":"1985","unstructured":"Blum J, Fridorich I (1985) Inactivation of glutathione peroxidase by superoxide radical. Arch Biochem Biophys 240:500\u2013508","journal-title":"Arch Biochem Biophys"},{"key":"930_CR60","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/1523-1747.ep12476735","volume":"100","author":"DA Vessey","year":"1993","unstructured":"Vessey DA, Lee KH (1993) Inactivation of enzymes of the glutathione antioxidant system by treatment of culture human keratinocytes with peroxides. J Invest Dermatol 100:829\u2013833","journal-title":"J Invest Dermatol"},{"key":"930_CR61","doi-asserted-by":"crossref","first-page":"10098","DOI":"10.1016\/S0021-9258(18)61082-8","volume":"21","author":"JW Heinecke","year":"1987","unstructured":"Heinecke JW, Rosen H, SuzukiI LA, Chait A (1987) The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein in arterial smooth muscle cells. J Biol Chem 21:10098\u201310103","journal-title":"J Biol Chem"},{"key":"930_CR62","doi-asserted-by":"crossref","first-page":"17012","DOI":"10.1074\/jbc.272.27.17012","volume":"272","author":"GR Upchurch Jr","year":"1997","unstructured":"Upchurch GR Jr, Welch GN, Fabian AJ, Freedman JE, Johnson JL, Keaney JF Jr, Loscalzo J (1997) Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase. J Biol Chem 272:17012\u201317017","journal-title":"J Biol Chem"},{"key":"930_CR63","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.clinbiochem.2004.07.011","volume":"37","author":"F Stern","year":"2004","unstructured":"Stern F, Berner YN, Polyak Z, Komarnitsky M, Sela BA, Hopp M, Dror Y (2004) Homocysteine effect on protein degradation rates. Clin Biochem 37:1002\u20131009","journal-title":"Clin Biochem"},{"key":"930_CR64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-511X-5-1","volume":"5","author":"P Sharma","year":"2006","unstructured":"Sharma P, Senthilkumar RD, Brahmachari V, Sundaramoorthy E, Mahajan A, Sharma A, Sengupta S (2006) Mining literature for a comprehensive pathway analysis: a case study for retrieval of homocysteine related genes for genetic and epigenetic studies. Lipids Health Dis 5:1\u201319","journal-title":"Lipids Health Dis"},{"key":"930_CR65","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1096\/fasebj.8.2.8119488","volume":"8","author":"RF Kletzien","year":"1994","unstructured":"Kletzien RF, Harris PK, Foellmi LA (1994) Glucose-6-phosphate dehydrogenase: a \u201chousekeeping\u201d enzyme subject to tissue-specific regulation by hormones, nutrients, and oxidant stress. FASEB J 8:174\u2013181","journal-title":"FASEB J"},{"key":"930_CR66","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0304-4165(02)00282-9","volume":"1572","author":"K Hashida","year":"2002","unstructured":"Hashida K, Sakakura Y, Makino N (2002) Kinetic studies on the hydrogen peroxide elimination by cultured PC12 cells: rate limitation by glucose-6-phosphate dehydrogenase. Biochim Biophys Acta 1572:85\u201390","journal-title":"Biochim Biophys Acta"},{"key":"930_CR67","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1161\/01.CIR.103.21.2617","volume":"103","author":"RD Rakhit","year":"2001","unstructured":"Rakhit RD, Mojet MH, Marber MS, Duchen MR (2001) Mitochondria as targets for nitric oxide-induced protection during simulated ischemia and reoxygenation in isolated neonatal cardiomyocytes. Circulation 103:2617\u20132623","journal-title":"Circulation"},{"key":"930_CR68","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1073\/pnas.87.4.1620","volume":"87","author":"JS Beckman","year":"1990","unstructured":"Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA (1990) Apparent hydroxyl radical production by peroxinitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 87:1620\u20131624","journal-title":"Proc Natl Acad Sci USA"},{"key":"930_CR69","doi-asserted-by":"crossref","first-page":"C1424","DOI":"10.1152\/ajpcell.1996.271.5.C1424","volume":"271","author":"JS Beckman","year":"1996","unstructured":"Beckman JS, Koppenol WH (1996) Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol 271:C1424\u2013C1437","journal-title":"Am J Physiol"},{"key":"930_CR70","doi-asserted-by":"crossref","first-page":"S1490","DOI":"10.1093\/ajcn\/62.6.1490S","volume":"62","author":"JP Eiserich","year":"1995","unstructured":"Eiserich JP, van der Vliet A, Handelman GJ, Halliwell B, Cross CE (1995) Dietary antioxidants and cigarette smoke-induced biomolecular damage: a complex interaction. Am J Clin Nutr 62:S1490\u2013S1500","journal-title":"Am J Clin Nutr"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-011-0930-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11010-011-0930-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-011-0930-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T03:58:56Z","timestamp":1637985536000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11010-011-0930-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,30]]},"references-count":70,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["930"],"URL":"https:\/\/doi.org\/10.1007\/s11010-011-0930-2","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,30]]}}}