{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:45:49Z","timestamp":1791319549476,"version":"4.3.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2012,2,18]],"date-time":"2012-02-18T00:00:00Z","timestamp":1329523200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1007\/s11010-012-1261-7","type":"journal-article","created":{"date-parts":[[2012,2,17]],"date-time":"2012-02-17T16:34:44Z","timestamp":1329496484000},"page":"203-210","source":"Crossref","is-referenced-by-count":26,"title":["Biogenesis of Epstein\u2013Barr virus microRNAs"],"prefix":"10.1007","volume":"365","author":[{"given":"Do Nyun","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suk Kyeong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,2,18]]},"reference":[{"issue":"7335","key":"1261_CR1","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/S0140-6736(64)91524-7","volume":"1","author":"MA Epstein","year":"1964","unstructured":"Epstein MA, Achong BG, Barr YM (1964) Virus Particles in Cultured Lymphoblasts from Burkitt\u2019s Lymphoma. Lancet 1(7335):702\u2013703","journal-title":"Lancet"},{"issue":"33","key":"1261_CR2","doi-asserted-by":"crossref","first-page":"5108","DOI":"10.1038\/sj.onc.1206556","volume":"22","author":"LS Young","year":"2003","unstructured":"Young LS, Murray PG (2003) Epstein\u2013Barr virus and oncogenesis: from latent genes to tumours. Oncogene 22(33):5108\u20135121","journal-title":"Oncogene"},{"issue":"10","key":"1261_CR3","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nrc1452","volume":"4","author":"LS Young","year":"2004","unstructured":"Young LS, Rickinson AB (2004) Epstein\u2013Barr virus: 40\u00a0years on. Nat Rev Cancer 4(10):757\u2013768","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"1261_CR4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1040-8428(02)00078-1","volume":"45","author":"JM Middeldorp","year":"2003","unstructured":"Middeldorp JM, Brink AA, van den Brule AJ, Meijer CJ (2003) Pathogenic roles for Epstein\u2013Barr virus (EBV) gene products in EBV-associated proliferative disorders. Crit Rev Oncol Hematol 45(1):1\u201336","journal-title":"Crit Rev Oncol Hematol"},{"issue":"Pt 10","key":"1261_CR5","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1099\/vir.0.19196-0","volume":"84","author":"J Beek van","year":"2003","unstructured":"van Beek J, Brink AA, Vervoort MB, van Zijp MJ, Meijer CJ, van den Brule AJ, Middeldorp JM (2003) In vivo transcription of the Epstein\u2013Barr virus (EBV) BamHI-A region without associated in vivo BARF0 protein expression in multiple EBV-associated disorders. J Gen Virol 84(Pt 10):2647\u20132659","journal-title":"J Gen Virol"},{"issue":"7","key":"1261_CR6","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0753-3322(01)00084-1","volume":"55","author":"A Hiraki","year":"2001","unstructured":"Hiraki A, Fujii N, Masuda K, Ikeda K, Tanimoto M (2001) Genetics of Epstein\u2013Barr virus infection. Biomed Pharmacother 55(7):369\u2013372","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"1261_CR7","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","volume":"116","author":"DP Bartel","year":"2004","unstructured":"Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116(2):281\u2013297","journal-title":"Cell"},{"issue":"2","key":"1261_CR8","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/nrm2632","volume":"10","author":"VN Kim","year":"2009","unstructured":"Kim VN, Han J, Siomi MC (2009) Biogenesis of small RNAs in animals. Natl Rev Mol Cell Biol 10(2):126\u2013139","journal-title":"Natl Rev Mol Cell Biol"},{"issue":"12","key":"1261_CR9","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/nsmb1167","volume":"13","author":"GM Borchert","year":"2006","unstructured":"Borchert GM, Lanier W, Davidson BL (2006) RNA polymerase III transcribes human microRNAs. Nat Struct Mol Biol 13(12):1097\u20131101","journal-title":"Nat Struct Mol Biol"},{"issue":"4","key":"1261_CR10","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nmeth746","volume":"2","author":"S Pfeffer","year":"2005","unstructured":"Pfeffer S, Sewer A, Lagos-Quintana M, Sheridan R, Sander C, Grasser FA, van Dyk LF, Ho CK, Shuman S, Chien M, Russo JJ, Ju J, Randall G, Lindenbach BD, Rice CM, Simon V, Ho DD, Zavolan M, Tuschl T (2005) Identification of microRNAs of the herpesvirus family. Nat Methods 2(4):269\u2013276","journal-title":"Nat Methods"},{"issue":"7006","key":"1261_CR11","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature02871","volume":"431","author":"V Ambros","year":"2004","unstructured":"Ambros V (2004) The functions of animal microRNAs. Nature 431(7006):350\u2013355","journal-title":"Nature"},{"key":"1261_CR12","doi-asserted-by":"crossref","first-page":"R121","DOI":"10.1093\/hmg\/ddi101","volume":"14 Spec No 1","author":"JS Mattick","year":"2005","unstructured":"Mattick JS, Makunin IV (2005) Small regulatory RNAs in mammals. Hum Mol Genet 14 Spec No 1:R121\u2013R132","journal-title":"Hum Mol Genet"},{"issue":"12","key":"1261_CR13","doi-asserted-by":"crossref","first-page":"R473","DOI":"10.1016\/S0960-9822(03)00405-6","volume":"13","author":"EH Baehrecke","year":"2003","unstructured":"Baehrecke EH (2003) miRNAs: micro managers of programmed cell death. Curr Biol 13(12):R473\u2013R475","journal-title":"Curr Biol"},{"issue":"5671","key":"1261_CR14","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1126\/science.1096781","volume":"304","author":"S Pfeffer","year":"2004","unstructured":"Pfeffer S, Zavolan M, Grasser FA, Chien M, Russo JJ, Ju J, John B, Enright AJ, Marks D, Sander C, Tuschl T (2004) Identification of virus-encoded microRNAs. Science 304(5671):734\u2013736","journal-title":"Science"},{"issue":"5","key":"1261_CR15","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1261\/rna.2326106","volume":"12","author":"A Grundhoff","year":"2006","unstructured":"Grundhoff A, Sullivan CS, Ganem D (2006) A combined computational and microarray-based approach identifies novel microRNAs encoded by human gamma-herpesviruses. RNA 12(5):733\u2013750","journal-title":"RNA"},{"issue":"3","key":"1261_CR16","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1371\/journal.ppat.0020023","volume":"2","author":"X Cai","year":"2006","unstructured":"Cai X, Schafer A, Lu S, Bilello JP, Desrosiers RC, Edwards R, Raab-Traub N, Cullen BR (2006) Epstein\u2013Barr virus microRNAs are evolutionarily conserved and differentially expressed. PLoS Pathog 2(3):e23","journal-title":"PLoS Pathog"},{"issue":"2","key":"1261_CR17","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1128\/JVI.02271-06","volume":"81","author":"N Kim do","year":"2007","unstructured":"Kim do N, Chae HS, Oh ST, Kang JH, Park CH, Park WS, Takada K, Lee JM, Lee WK, Lee SK (2007) Expression of viral microRNAs in Epstein\u2013Barr virus-associated gastric carcinoma. J Virol 81(2):1033\u20131036","journal-title":"J Virol"},{"issue":"2","key":"1261_CR18","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1365-2141.2008.07186.x","volume":"142","author":"SM Jun","year":"2008","unstructured":"Jun SM, Hong YS, Seo JS, Ko YH, Yang CW, Lee SK (2008) Viral microRNA profile in Epstein\u2013Barr virus-associated peripheral T cell lymphoma. Br J Haematol 142(2):320\u2013323","journal-title":"Br J Haematol"},{"issue":"4","key":"1261_CR19","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/ijc.11289","volume":"107","author":"J Nishikawa","year":"2003","unstructured":"Nishikawa J, Kiss C, Imai S, Takada K, Okita K, Klein G, Szekely L (2003) Upregulation of the truncated basic hair keratin 1(hHb1-DeltaN) in carcinoma cells by Epstein\u2013Barr virus (EBV). Int J Cancer 107(4):597\u2013602","journal-title":"Int J Cancer"},{"issue":"20","key":"1261_CR20","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1038\/sj.emboj.7600385","volume":"23","author":"Y Lee","year":"2004","unstructured":"Lee Y, Kim M, Han J, Yeom KH, Lee S, Baek SH, Kim VN (2004) MicroRNA genes are transcribed by RNA polymerase II. EMBO J 23(20):4051\u20134060","journal-title":"EMBO J"},{"issue":"5531","key":"1261_CR21","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1126\/science.1062961","volume":"293","author":"G Hutvagner","year":"2001","unstructured":"Hutvagner G, McLachlan J, Pasquinelli AE, Balint E, Tuschl T, Zamore PD (2001) A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science 293(5531):834\u2013838","journal-title":"Science"},{"issue":"4","key":"1261_CR22","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/bjc.1996.412","volume":"74","author":"M Sugiura","year":"1996","unstructured":"Sugiura M, Imai S, Tokunaga M, Koizumi S, Uchizawa M, Okamoto K, Osato T (1996) Transcriptional analysis of Epstein\u2013Barr virus gene expression in EBV-positive gastric carcinoma: unique viral latency in the tumour cells. Br J Cancer 74(4):625\u2013631","journal-title":"Br J Cancer"},{"issue":"2","key":"1261_CR23","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1128\/JVI.01528-10","volume":"85","author":"R Amoroso","year":"2011","unstructured":"Amoroso R, Fitzsimmons L, Thomas WA, Kelly GL, Rowe M, Bell AI (2011) Quantitative studies of Epstein\u2013Barr virus-encoded microRNAs provide novel insights into their regulation. J Virol 85(2):996\u20131010","journal-title":"J Virol"},{"issue":"18","key":"1261_CR24","doi-asserted-by":"crossref","first-page":"9094","DOI":"10.1128\/JVI.00785-08","volume":"82","author":"RH Edwards","year":"2008","unstructured":"Edwards RH, Marquitz AR, Raab-Traub N (2008) Epstein\u2013Barr virus BART microRNAs are produced from a large intron prior to splicing. J Virol 82(18):9094\u20139106","journal-title":"J Virol"},{"issue":"6","key":"1261_CR25","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1128\/JVI.67.6.3182-3190.1993","volume":"67","author":"LA Brooks","year":"1993","unstructured":"Brooks LA, Lear AL, Young LS, Rickinson AB (1993) Transcripts from the Epstein\u2013Barr virus BamHI A fragment are detectable in all three forms of virus latency. J Virol 67(6):3182\u20133190","journal-title":"J Virol"},{"issue":"9","key":"1261_CR26","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1182\/blood.V93.9.3026","volume":"93","author":"H Chen","year":"1999","unstructured":"Chen H, Smith P, Ambinder RF, Hayward SD (1999) Expression of Epstein\u2013Barr virus BamHI-A rightward transcripts in latently infected B cells from peripheral blood. Blood 93(9):3026\u20133032","journal-title":"Blood"},{"issue":"4","key":"1261_CR27","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1128\/JVI.67.4.2006-2013.1993","volume":"67","author":"R Longnecker","year":"1993","unstructured":"Longnecker R, Miller CL, Miao XQ, Tomkinson B, Kieff E (1993) The last seven transmembrane and carboxy-terminal cytoplasmic domains of Epstein\u2013Barr virus latent membrane protein 2 (LMP2) are dispensable for lymphocyte infection and growth transformation in vitro. J Virol 67(4):2006\u20132013","journal-title":"J Virol"},{"issue":"2","key":"1261_CR28","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1128\/JVI.36.2.506-518.1980","volume":"36","author":"W King","year":"1980","unstructured":"King W, Thomas-Powell AL, Raab-Traub N, Hawke M, Kieff E (1980) Epstein\u2013Barr virus RNA. V. Viral RNA in a restringently infected, growth-transformed cell line. J Virol 36(2):506\u2013518","journal-title":"J Virol"},{"issue":"18","key":"1261_CR29","doi-asserted-by":"crossref","first-page":"9967","DOI":"10.1128\/JVI.02244-06","volume":"81","author":"L Xing","year":"2007","unstructured":"Xing L, Kieff E (2007) Epstein\u2013Barr virus BHRF1 micro- and stable RNAs during latency III and after induction of replication. J Virol 81(18):9967\u20139975","journal-title":"J Virol"},{"issue":"5","key":"1261_CR30","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1128\/JVI.64.5.2126-2134.1990","volume":"64","author":"SD Abbot","year":"1990","unstructured":"Abbot SD, Rowe M, Cadwallader K, Ricksten A, Gordon J, Wang F, Rymo L, Rickinson AB (1990) Epstein\u2013Barr virus nuclear antigen 2 induces expression of the virus-encoded latent membrane protein. J Virol 64(5):2126\u20132134","journal-title":"J Virol"},{"issue":"7","key":"1261_CR31","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1128\/JVI.64.7.3407-3416.1990","volume":"64","author":"F Wang","year":"1990","unstructured":"Wang F, Tsang SF, Kurilla MG, Cohen JI, Kieff E (1990) Epstein\u2013Barr virus nuclear antigen 2 transactivates latent membrane protein LMP1. J Virol 64(7):3407\u20133416","journal-title":"J Virol"},{"key":"1261_CR32","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0065-230X(03)01004-2","volume":"89","author":"H Li","year":"2003","unstructured":"Li H, Minarovits J (2003) Host cell-dependent expression of latent Epstein\u2013Barr virus genomes: regulation by DNA methylation. Adv Cancer Res 89:133\u2013156","journal-title":"Adv Cancer Res"},{"issue":"1","key":"1261_CR33","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S1521-6616(03)00198-0","volume":"109","author":"Q Tao","year":"2003","unstructured":"Tao Q, Robertson KD (2003) Stealth technology: how Epstein\u2013Barr virus utilizes DNA methylation to cloak itself from immune detection. Clin Immunol 109(1):53\u201363","journal-title":"Clin Immunol"},{"issue":"4","key":"1261_CR34","doi-asserted-by":"crossref","first-page":"3216","DOI":"10.1128\/MCB.19.4.3216","volume":"19","author":"L Zhang","year":"1999","unstructured":"Zhang L, Pagano JS (1999) Interferon regulatory factor 2 represses the Epstein\u2013Barr virus BamHI Q latency promoter in type III latency. Mol Cell Biol 19(4):3216\u20133223","journal-title":"Mol Cell Biol"},{"issue":"1","key":"1261_CR35","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.bbrc.2008.04.137","volume":"372","author":"F Tang","year":"2008","unstructured":"Tang F, Hajkova P, O\u2019Carroll D, Lee C, Tarakhovsky A, Lao K, Surani MA (2008) MicroRNAs are tightly associated with RNA-induced gene silencing complexes in vivo. Biochem Biophys Res Commun 372(1):24\u201329","journal-title":"Biochem Biophys Res Commun"},{"issue":"17","key":"1261_CR36","doi-asserted-by":"crossref","first-page":"8929","DOI":"10.1128\/JVI.00336-11","volume":"85","author":"L Xing","year":"2011","unstructured":"Xing L, Kieff E (2011) cis-Acting effects on RNA processing and Drosha cleavage prevent Epstein\u2013Barr virus latency III BHRF1 expression. J Virol 85(17):8929\u20138939","journal-title":"J Virol"},{"issue":"3","key":"1261_CR37","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1128\/JVI.79.3.1724-1733.2005","volume":"79","author":"H Chen","year":"2005","unstructured":"Chen H, Huang J, Wu FY, Liao G, Hutt-Fletcher L, Hayward SD (2005) Regulation of expression of the Epstein\u2013Barr virus BamHI-A rightward transcripts. J Virol 79(3):1724\u20131733","journal-title":"J Virol"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-012-1261-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11010-012-1261-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-012-1261-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T16:35:15Z","timestamp":1593707715000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11010-012-1261-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,18]]},"references-count":37,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["1261"],"URL":"https:\/\/doi.org\/10.1007\/s11010-012-1261-7","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,18]]}}}