{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:37:05Z","timestamp":1788928625817,"version":"build-2803163510"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1007\/s11010-012-1450-4","type":"journal-article","created":{"date-parts":[[2012,11,30]],"date-time":"2012-11-30T22:20:19Z","timestamp":1354314019000},"page":"1-9","source":"Crossref","is-referenced-by-count":34,"title":["Treatment with hydrogen molecule alleviates TNF\u03b1-induced cell injury in osteoblast"],"prefix":"10.1007","volume":"373","author":[{"given":"Wen-Wen","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Hua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Sheng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Hua","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,12,1]]},"reference":[{"key":"1450_CR1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1146\/annurev.immunol.14.1.397","volume":"14","author":"M Feldmann","year":"1996","unstructured":"Feldmann M, Brennan FM, Maini RN (1996) Role of cytokines in rheumatoid arthritis. Annu Rev Immunol 14:397\u2013440","journal-title":"Annu Rev Immunol"},{"key":"1450_CR2","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1007\/BF03194342","volume":"7","author":"E Romas","year":"1997","unstructured":"Romas E, Martin TJ (1997) Cytokines in the pathogenesis of osteoporosis. Osteoporos Int 7:S47\u2013S53","journal-title":"Osteoporos Int"},{"key":"1450_CR3","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0378-5122(96)01080-8","volume":"26","author":"SX Zheng","year":"1997","unstructured":"Zheng SX, Vrindts Y, Lopez M, De Groote D, Zangerle PF, Collette J, Franchimont N, Geenen V, Albert A, Reginster JY (1997) Increase in cytokine production (IL-1 beta, IL-6, TNF-alpha but not IFN-gamma, GM-CSF or LIF) by stimulated whole blood cells in postmenopausal osteoporosis. Maturitas 26:63\u201371","journal-title":"Maturitas"},{"key":"1450_CR4","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.mehy.2006.04.069","volume":"67","author":"D Kastelan","year":"2006","unstructured":"Kastelan D, Kastelan M, Massari LP, Korsic M (2006) Possible association of psoriasis and reduced bone mineral density due to increased TNF-alpha and IL-6 concentrations. Med Hypotheses 67:1403\u20131405","journal-title":"Med Hypotheses"},{"key":"1450_CR5","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1056\/NEJMct055183","volume":"355","author":"DL Scott","year":"2006","unstructured":"Scott DL, Kingsley GH (2006) Tumor necrosis factor inhibitors for rheumatoid arthritis. New Engl J Med 355:704\u2013712","journal-title":"New Engl J Med"},{"key":"1450_CR6","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1146\/annurev.immunol.19.1.163","volume":"19","author":"M Feldmann","year":"2001","unstructured":"Feldmann M, Maini RN (2001) Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned? Annu Rev Immunol 19:163\u2013196","journal-title":"Annu Rev Immunol"},{"key":"1450_CR7","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1210\/en.134.6.2524","volume":"134","author":"H Kuno","year":"1994","unstructured":"Kuno H, Kurian SM, Hendy GN, White J, deLuca HF, Evans CO, Nanes MS (1994) Inhibition of 1, 25-dihydroxyvitamin D3 stimulated osteocalcin gene transcription by tumor necrosis factor-alpha: structural determinants within the vitamin D response element. Endocrinology 134:2524\u20132531","journal-title":"Endocrinology"},{"key":"1450_CR8","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/8756-3282(96)00181-0","volume":"19","author":"I Kitajima","year":"1996","unstructured":"Kitajima I, Soejima Y, Takasaki I, Beppu H, Tokioka T, Maruyama I (1996) Ceramide-induced nuclear translocation of NF-kappa B is a potential mediator of the apoptotic response to TNF-alpha in murine clonal osteoblasts. Bone 19:263\u2013270","journal-title":"Bone"},{"key":"1450_CR9","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1210\/en.141.11.3956","volume":"141","author":"L Gilbert","year":"2000","unstructured":"Gilbert L, He X, Farmer P, Boden S, Kozlowski M, Rubin J, Nanes MS (2000) Inhibition of osteoblast differentiation by tumor necrosis factor-alpha. Endocrinology 141:3956\u20133964","journal-title":"Endocrinology"},{"key":"1450_CR10","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/SHK.0b013e3181cdc4ae","volume":"34","author":"KL Xie","year":"2010","unstructured":"Xie KL, Yu YH, Pei YP, Hou L, Chen S, Xiong L, Wang G (2010) Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release. Shock 34:90\u201397","journal-title":"Shock"},{"key":"1450_CR11","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1097\/SHK.0b013e31824ddc81","volume":"37","author":"K Xie","year":"2012","unstructured":"Xie K, Yu Y, Huang Y, Zheng L, Li J, Chen H, Han H, Hou L, Gong G, Wang G (2012) Molecular hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice through reducing inflammation and apoptosis. Shock 37:548\u2013555","journal-title":"Shock"},{"key":"1450_CR12","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1476-9255-9-2","volume":"9","author":"Z Xu","year":"2012","unstructured":"Xu Z, Zhou J, Cai J, Zhu Z, Sun X, Jiang C (2012) Anti-inflammation effects of hydrogen saline in LPS activated macrophages and carrageenan induced paw oedema. J Inflamm 9:2\u20138","journal-title":"J Inflamm"},{"key":"1450_CR13","doi-asserted-by":"crossref","unstructured":"Ji X, Tian Y, Xie K, Liu W, Qu Y, Fei Z (2012) Protective effects of hydrogen-rich saline in a rat model of traumatic brain injury Via reducing oxidative stress. J Surg Res. 2012 Mar 22. [Epub ahead of print]","DOI":"10.1016\/j.jss.2011.12.038"},{"key":"1450_CR14","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s11010-012-1264-4","volume":"365","author":"YS Yu","year":"2012","unstructured":"Yu YS, Zheng H (2012) Chronic hydrogen-rich saline treatment reduces oxidative stress and attenuates left ventricular hypertrophy in spontaneous hypertensive rats. Mol Cell Biochem 365:233\u2013242","journal-title":"Mol Cell Biochem"},{"key":"1450_CR15","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.bcp.2012.01.031","volume":"83","author":"H Zheng","year":"2012","unstructured":"Zheng H, Yu YS (2012) Chronic hydrogen-rich saline treatment attenuates vascular dysfunction in spontaneous hypertensive rats. Biochem Pharmacol 83:1269\u20131277","journal-title":"Biochem Pharmacol"},{"key":"1450_CR16","unstructured":"Chang WJ, Toledo-Pereyra LH (2012) The potential benefits of hydrogen-rich saline in ischemia and reperfusion injury. J Surg Res. 2012 Mar 10. [Epub ahead of print]"},{"key":"1450_CR17","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1242\/jcs.109.6.1369","volume":"109","author":"A Moursi","year":"1996","unstructured":"Moursi A, Damsky C, Lull J, Zimmerman D, Doty S, Aota S, Globus R (1996) Fibronectin regulates calvarial osteoblast differentiation. J Cell Sci 109:1369\u20131380","journal-title":"J Cell Sci"},{"key":"1450_CR18","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nm1577","volume":"13","author":"I Ohsawa","year":"2007","unstructured":"Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y, Asoh S, Ohta S (2007) Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med 13:688\u2013694","journal-title":"Nat Med"},{"key":"1450_CR19","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1002\/(SICI)1521-3773(19991102)38:21<3209::AID-ANIE3209>3.0.CO;2-6","volume":"38","author":"H Kojima","year":"1999","unstructured":"Kojima H, Urano Y, Kikuchi K, Higuchi T, Hirata Y, Nagano T (1999) Fluorescent indicators for imaging nitric oxide production. Angew Chem Int Ed 38:3209\u20133212","journal-title":"Angew Chem Int Ed"},{"key":"1450_CR20","first-page":"112","volume":"10","author":"PV Rao","year":"2004","unstructured":"Rao PV, Maddala R, John F, Zigler JS Jr (2004) Expression of nonphagocytic NADPH oxidase system in the ocular lens. Mol Vis 10:112\u2013121","journal-title":"Mol Vis"},{"key":"1450_CR21","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0027-5107(98)00220-6","volume":"423","author":"CY Lu","year":"1999","unstructured":"Lu CY, Lee HC, Fahn HJ, Wei YH (1999) Oxidative damage elicited by imbalance of free radical scavenging enzymes is associated with large-scale mtDNA deletions in aging human skin. Mutat Res 423:11\u201321","journal-title":"Mutat Res"},{"key":"1450_CR22","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/0003-2697(89)90192-9","volume":"179","author":"DR Spitz","year":"1989","unstructured":"Spitz DR, Oberley LW (1989) An assay for superoxide dismutase activity in mammalian tissue homogenates. Anal Biochem 179:8\u201318","journal-title":"Anal Biochem"},{"key":"1450_CR23","doi-asserted-by":"crossref","first-page":"F298","DOI":"10.1152\/ajprenal.90628.2008","volume":"296","author":"CM Elks","year":"2009","unstructured":"Elks CM, Mariappan N, Haque M, Guggilam A, Majid DS, Francis J (2009) Chronic NF-kB blockade reduces cytosolic and mitochondrial oxidative stress and attenuates renal injury and hypertension in SHR. Am J Physiol Renal Physiol 296:F298\u2013F305","journal-title":"Am J Physiol Renal Physiol"},{"key":"1450_CR24","doi-asserted-by":"crossref","unstructured":"Sun Y, Shuang F, Chen DM, Zhou RB (2012). Treatment of hydrogen molecule abates oxidative stress and alleviates bone loss induced by modeled microgravity in rats. Osteoporos Int (in press)","DOI":"10.1007\/s00198-012-2028-4"},{"key":"1450_CR25","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1042\/BJ20100357","volume":"433","author":"CC Mandal","year":"2010","unstructured":"Mandal CC, Ganapathy S, Gorin Y, Mahadev K, Block K, Abboud HE, Harris SE, Ghosh-Choudhury G, Ghosh-Choudhury N (2010) Reactive oxygen species derived from Nox4 mediate BMP2 gene transcription and osteoblast differentiation. Biochem J 433:393\u2013402","journal-title":"Biochem J"},{"key":"1450_CR26","doi-asserted-by":"crossref","first-page":"4977","DOI":"10.1210\/en.2009-0248","volume":"150","author":"Y Wittrant","year":"2009","unstructured":"Wittrant Y, Gorin Y, Mohan S, Wagner B, Abboud-Werner SL (2009) Colony-stimulating factor-1 (CSF-1) directly inhibits receptor activator of nuclear factor-{kappa}B ligand (RANKL) expression by osteoblasts. Endocrinology 150:4977\u20134988","journal-title":"Endocrinology"},{"key":"1450_CR27","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1016\/j.freeradbiomed.2006.01.036","volume":"40","author":"FL Muller","year":"2006","unstructured":"Muller FL, Song W, Liu Y, Chaudhuri A, Pieke-Dahl S, Strong R, Huang TT, Epstein CJ, Roberts LJ 2nd, Csete M, Faulkner JA, Van Remmen H (2006) Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy. Free Radic Biol Med 40:1993\u20132004","journal-title":"Free Radic Biol Med"},{"key":"1450_CR28","first-page":"210","volume":"8","author":"R Noor","year":"2002","unstructured":"Noor R, Mittal S, Iqbal J (2002) Superoxide dismutase-applications and relevance to human diseases. Med Sci Monit 8:210\u2013215","journal-title":"Med Sci Monit"},{"key":"1450_CR29","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.bbrc.2010.11.006","volume":"403","author":"MJ Smietana","year":"2010","unstructured":"Smietana MJ, Arruda EM, Faulkner JA, Brooks SV, Larkin LM (2010) Reactive oxygen species on bone mineral density and mechanics in Cu, Zn superoxide dismutase (Sod1) knockout mice. Biochem Biophys Res Commun 403:149\u2013153","journal-title":"Biochem Biophys Res Commun"},{"key":"1450_CR30","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1210\/en.2004-1021","volume":"146","author":"JM Lean","year":"2005","unstructured":"Lean JM, Jagger CJ, Kirstein B, Fuller K, Chambers TJ (2005) Hydrogen peroxide is essential for estrogen-deficiency bone loss and osteoclast formation. Endocrinology 146:728\u2013735","journal-title":"Endocrinology"},{"key":"1450_CR31","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nm.1954","volume":"15","author":"J Chang","year":"2009","unstructured":"Chang J, Wang Z, Tang E, Fan Z, McCauley L, Franceschi R, Guan K, Krebsbach PH, Wang CY (2009) Inhibition of osteoblastic bone formation by nuclear factor-kappaB. Nat Med 15:682\u2013689","journal-title":"Nat Med"},{"key":"1450_CR32","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1359\/jbmr.070121","volume":"22","author":"Y Li","year":"2007","unstructured":"Li Y, Li A, Strait K, Zhang H, Nanes MS, Weitzmann MN (2007) Endogenous TNFalpha lowers maximum peak bone mass and inhibits osteoblastic smad activation, through NF-kappaB. J Bone Miner Res 22:646\u2013655","journal-title":"J Bone Miner Res"},{"key":"1450_CR33","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1359\/jbmr.1998.13.8.1290","volume":"13","author":"K Kurokouchi","year":"1998","unstructured":"Kurokouchi K, Kambe F, Yasukawa K, Izumi R, Ishiguro N, Iwata H, Seo H (1998) TNF-alpha increases expression of IL-6 and ICAM-1 genes through activation of NF-kappaB in osteoblast-like ROS17\/2.8\u00a0cells. J Bone Miner Res 13:1290\u20131299","journal-title":"J Bone Miner Res"},{"key":"1450_CR34","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1359\/jbmr.1999.14.12.2137","volume":"14","author":"KE Armour","year":"1999","unstructured":"Armour KE, Van\u2019T Hof RJ, Grabowski PS, Reid DM, Ralston SH (1999) Evidence for a pathogenic role of nitric oxide in inflammation-induced osteoporosis. J Bone Miner Res 14:2137\u20132142","journal-title":"J Bone Miner Res"},{"key":"1450_CR35","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.orthres.2004.08.011","volume":"23","author":"RM Chen","year":"2005","unstructured":"Chen RM, Chen TL, Chiu WT, Chang CC (2005) Molecular mechanism of nitric oxide-induced osteoblast apoptosis. J Orthop Res 23:462\u2013468","journal-title":"J Orthop Res"},{"key":"1450_CR36","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S8756-3282(98)00173-2","volume":"24","author":"H MacPherson","year":"1999","unstructured":"MacPherson H, Noble BS, Ralston SH (1999) Expression and functional role of nitric oxide synthase isoforms in human osteoblast-like cells. Bone 24:179\u2013185","journal-title":"Bone"},{"key":"1450_CR37","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1042\/CBI20100832","volume":"35","author":"L Yan","year":"2011","unstructured":"Yan L, Yinghui T, Bo Y, Gang Z, Xian X, Lu Z (2011) Effect of calcitonin gene-related peptide on nitric oxide production in osteoblasts: an experimental study. Cell Biol Int 35:757\u2013765","journal-title":"Cell Biol Int"},{"key":"1450_CR38","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ejphar.2011.11.024","volume":"674","author":"H Yin","year":"2012","unstructured":"Yin H, Shi ZG, Yu YS, Hu J, Wang R, Luan ZP, Guo DH (2012) Protection against osteoporosis by statins is linked to a reduction of oxidative stress and restoration of nitric oxide formation in aged and ovariectomized rats. Eur J Pharmacol 674:200\u2013206","journal-title":"Eur J Pharmacol"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-012-1450-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11010-012-1450-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-012-1450-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T19:40:54Z","timestamp":1643744454000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11010-012-1450-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,1]]},"references-count":38,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["1450"],"URL":"https:\/\/doi.org\/10.1007\/s11010-012-1450-4","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,1]]}}}