{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T22:52:59Z","timestamp":1792882379728,"version":"4.5.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2013,5,10]],"date-time":"2013-05-10T00:00:00Z","timestamp":1368144000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1007\/s11010-013-1686-7","type":"journal-article","created":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T12:14:03Z","timestamp":1368101643000},"page":"41-50","source":"Crossref","is-referenced-by-count":50,"title":["Exogenous hydrogen sulfide prevents cardiomyocyte apoptosis from cardiac hypertrophy induced by isoproterenol"],"prefix":"10.1007","volume":"381","author":[{"given":"Fanghao","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyun","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hulun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changqing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,5,10]]},"reference":[{"key":"1686_CR1","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1016\/j.jacc.2003.11.064","volume":"43","author":"MH Drazner","year":"2004","unstructured":"Drazner MH, Rame JE, Marino EK, Gottdiener JS, Kitzman DW, Gardin JM, Manolio TA, Dries DL, Siscovick DS (2004) Increased left ventricular mass is a risk factor for the development of a depressed left ventricular ejection fraction within 5\u00a0years: the cardiovascular health study. J Am Coll Cardiol 43:2207\u20132215","journal-title":"J Am Coll Cardiol"},{"key":"1686_CR2","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3109\/15376516.2012.666650","volume":"22","author":"SK Maulik","year":"2012","unstructured":"Maulik SK, Kumar S (2012) Oxidative stress and cardiac hypertrophy: a review. Toxicol Mech Methods 22:359\u2013366","journal-title":"Toxicol Mech Methods"},{"issue":"8","key":"1686_CR3","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1136\/hrt.2005.068270","volume":"93","author":"M Seddon","year":"2007","unstructured":"Seddon M, Looi YH, Shah AM (2007) Oxidative stress and redox signalling in cardiac hypertrophy and heart failure. Heart 93(8):903\u2013907","journal-title":"Heart"},{"key":"1686_CR4","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1172\/JCI200524408","volume":"115","author":"FJ Giordano","year":"2005","unstructured":"Giordano FJ (2005) Oxygen, oxidative stress, hypoxia, and heart failure. J Clin Invest. 115:500\u2013508","journal-title":"J Clin Invest."},{"key":"1686_CR5","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1161\/CIRCRESAHA.109.213116","volume":"106","author":"T Ago","year":"2010","unstructured":"Ago T, Kuroda J, Pain J, Fu C, Li H, Sadoshima J (2010) Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes. Circ Res 106:1253\u20131264","journal-title":"Circ Res"},{"key":"1686_CR6","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00044.2005","volume":"87","author":"K Bedard","year":"2007","unstructured":"Bedard K, Krause KH (2007) The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev 87:245\u2013313","journal-title":"Physiol Rev"},{"key":"1686_CR7","doi-asserted-by":"crossref","first-page":"15565","DOI":"10.1073\/pnas.1002178107","volume":"107","author":"J Kuroda","year":"2010","unstructured":"Kuroda J, Ago T, Matsushima S, Zhai P, Schneider M, Sadoshima J (2010) NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart Proc. Natl Acad Sci USA 107:15565\u201315570","journal-title":"Natl Acad Sci USA"},{"issue":"13","key":"1686_CR8","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1096\/fj.02-0211hyp","volume":"16","author":"R Wang","year":"2002","unstructured":"Wang R (2002) Two\u2019s company, three\u2019s a crowd: can H2S be the third endogenous gaseous transmitter? FASEB J 16(13):1792\u20131798","journal-title":"FASEB J"},{"issue":"2","key":"1686_CR9","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1152\/physrev.00017.2011","volume":"92","author":"R Wang","year":"2012","unstructured":"Wang R (2012) Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. Physiol Rev 92(2):791\u2013896","journal-title":"Physiol Rev"},{"issue":"1","key":"1686_CR10","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1089\/ars.2011.4349","volume":"17","author":"LL Pan","year":"2012","unstructured":"Pan LL, Liu XH, Gong QH, Yang HB, Zhu YZ (2012) Role of cystathionine gamma-lyase\/hydrogen sulfide pathway in cardiovascular disease: a novel therapeutic strategy? Antioxid Redox Signal 17(1):106\u2013118","journal-title":"Antioxid Redox Signal"},{"issue":"2","key":"1686_CR11","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1152\/ajpheart.00682.2009","volume":"298","author":"PK Mishra","year":"2010","unstructured":"Mishra PK, Tyagi N, Sen U, Givvimani S, Tyagi SC (2010) H2S ameliorates oxidative and proteolytic stresses and protects the heart against adverse remodeling in chronic heart failure. Am J Physiol Heart Circ Physiol 298(2):451\u2013456","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"11","key":"1686_CR12","doi-asserted-by":"crossref","first-page":"27294","DOI":"10.1371\/journal.pone.0027294","volume":"6","author":"L Ni","year":"2011","unstructured":"Ni L, Zhou CQ, Duan QL, Lv JG, Fu XN, Xia Y, Wang DW (2011) \u03b2-AR blockers suppresses ER stress in cardiac hypertrophy and heart failure. PLoS ONE 6(11):27294\u201327305","journal-title":"PLoS ONE"},{"key":"1686_CR13","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.2337\/db06-0739","volume":"56","author":"J Fauconnier","year":"2007","unstructured":"Fauconnier J, Andersson DC, Zhang SJ, Lanner JT, Wibom R, Katz A et al (2007) Effects of palmitate on Ca2+ handling in adult control and ob\/ob cardiomyocytes: impact of mitochondrial reactive oxygen species. Diabetes 56:1136\u20131142","journal-title":"Diabetes"},{"key":"1686_CR14","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.cardiores.2006.05.014","volume":"71","author":"FR Heinzel","year":"2006","unstructured":"Heinzel FR, Luo Y, Dodoni G, Boengler K, Petrat F, Di Lisa F (2006) Formation of reactive oxygen species at increased contraction frequency in rat cardiomyocytes. Cardiovasc Res 71:374\u2013382","journal-title":"Cardiovasc Res"},{"key":"1686_CR15","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1002\/(SICI)1521-3773(19991102)38:21<3209::AID-ANIE3209>3.0.CO;2-6","volume":"38","author":"H Kojima","year":"1999","unstructured":"Kojima H, Urano Y, Kikuchi K, Higuchi T, Hirata Y, Nagano T (1999) Fluorescent indicators for imaging nitric oxide production. Angew Chem Int Ed Engl 38:3209\u20133212","journal-title":"Angew Chem Int Ed Engl"},{"key":"1686_CR16","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1136\/hrt.2003.032482","volume":"90","author":"AM Shah","year":"2004","unstructured":"Shah AM, Channon KC (2004) Free radicals and redox signalling in cardiovascular disease (mini-symposium). Heart 90:485\u2013487","journal-title":"Heart"},{"key":"1686_CR17","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1084\/jem.192.7.1001","volume":"192","author":"DB Zorov","year":"2000","unstructured":"Zorov DB, Filburn CR, Klotz LO, Zweier JL, Sollott SJ (2000) Reactive oxygen species (ROS)-induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes. J Exp Med 192:1001\u20131014","journal-title":"J Exp Med"},{"key":"1686_CR18","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1098\/rstb.2005.1772","volume":"360","author":"AC Cave","year":"2005","unstructured":"Cave AC, Grieve DJ, Johar S et al (2005) NADPH oxidase-derived reactive oxygen species in cardiac pathophysiology. Philos Trans R Soc 360:2327\u20132334","journal-title":"Philos Trans R Soc"},{"key":"1686_CR19","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1016\/S0735-1097(03)00471-6","volume":"41","author":"C Heymes","year":"2003","unstructured":"Heymes C, Bendall JK, Ratajczak P et al (2003) Increased myocardial NADPH oxidase activity in human heart failure. J Am Coll Cardiol 41:2164\u20132171","journal-title":"J Am Coll Cardiol"},{"key":"1686_CR20","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1161\/01.CIR.0000091084.46500.BB","volume":"108","author":"C Maack","year":"2003","unstructured":"Maack C, Kartes T, Kilter H et al (2003) Oxygen free radical release in human failing myocardium is associated with increased activity of Rac1-GTPase and represents a target for statin treatment. Circulation 108:1567\u20131574","journal-title":"Circulation"},{"key":"1686_CR21","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1161\/hc0302.103712","volume":"105","author":"JK Bendall","year":"2002","unstructured":"Bendall JK, Cave AC, Heymes C et al (2002) Pivotal role of a gp91phox-containing NADPH oxidase in angiotensin II-induced cardiac hypertrophy in mice. Circulation 105:293\u2013296","journal-title":"Circulation"},{"key":"1686_CR22","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1161\/CIRCRESAHA.107.148015","volume":"101","author":"M Mittal","year":"2007","unstructured":"Mittal M, Roth M, Konig P, Hofmann S, Dony E, Goyal P, Selbitz AC, Schermuly RT, Ghofrani HA, Kwapiszewska G, Kummer W, Klepetko W, Hoda MA, Fink L, Hanze J, Seeger W, Grimminger F, Schmidt HH, Weissmann N (2007) Hypoxia-dependent regulation of nonphagocytic NADPH oxidase subunit NOX4 in the pulmonary vasculature. Circ Res 101:258\u2013267","journal-title":"Circ Res"},{"key":"1686_CR23","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1161\/01.RES.0000187457.24338.3D","volume":"97","author":"I Cucoranu","year":"2005","unstructured":"Cucoranu I, Clempus R, Dikalova A, Phelan PJ, Ariyan S, Dikalov S, Sorescu D (2005) NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts. Circ Res 97:900\u2013907","journal-title":"Circ Res"},{"issue":"2","key":"1686_CR24","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1152\/ajpheart.00377.2008","volume":"295","author":"S Jha","year":"2008","unstructured":"Jha S, Calvert JW, Duranski MR, Ramachandran A, Lefer DJ (2008) Hydrogensulfide attenuates hepatic ischemia-reperfusion injury: role of antioxidant and antiapoptotic signaling. Am J Physiol Heart Circ Physiol 295(2):801\u2013806","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"1686_CR25","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1089\/ars.2012.4612","volume":"17","author":"BL Predmore","year":"2012","unstructured":"Predmore BL, Lefer DJ, Gojon G (2012) Hydrogen sulfide in biochemistry and medicine. Antioxid Redox Signal 17(1):119\u2013140","journal-title":"Antioxid Redox Signal"},{"issue":"3","key":"1686_CR26","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1161\/01.STR.0000204184.34946.41","volume":"37","author":"K Qu","year":"2006","unstructured":"Qu K, Chen CP, Halliwell B, Moore PK, Wong PT (2006) Hydrogen sulfide is a mediator of cerebral ischemic damage. Stroke 37(3):889\u2013893","journal-title":"Stroke"},{"key":"1686_CR27","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.yjmcc.2005.09.012","volume":"39","author":"L Argaud","year":"2005","unstructured":"Argaud L, Gomez L, Gateau-Roesch O, Couture-Lepetit E, Loufouat J, Robert D et al (2005) Trimetazidine inhibits mitochondrial permeability transition pore opening and prevents lethal ischemia\u2013reperfusion injury. J Mol Cell Cardiol 39:893\u2013899","journal-title":"J Mol Cell Cardiol"},{"key":"1686_CR28","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.cell.2005.05.011","volume":"122","author":"M Giorgio","year":"2005","unstructured":"Giorgio M, Migliaccio E, Orsini F, Paolucci D, Moroni M, Contursi C et al (2005) Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis. Cell 122:221\u2013233","journal-title":"Cell"},{"key":"1686_CR29","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00395-007-0666-z","volume":"102","author":"C Maack","year":"2007","unstructured":"Maack C, O\u2019Rourke B (2007) Excitation\u2013contraction coupling and mitochondrial energetics. Basic Res Cardiol 102:369\u2013392","journal-title":"Basic Res Cardiol"},{"key":"1686_CR30","first-page":"167","volume-title":"Calcium and the heart","author":"M Crompton","year":"1990","unstructured":"Crompton M (1990) The role of Ca2+ in the function and dysfunction of heart mitochondria. In: Langer GA (ed) Calcium and the heart. Raven Press, New York, pp 167\u2013198"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-013-1686-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11010-013-1686-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-013-1686-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T22:15:17Z","timestamp":1559340917000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11010-013-1686-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,10]]},"references-count":30,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["1686"],"URL":"https:\/\/doi.org\/10.1007\/s11010-013-1686-7","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,10]]}}}