{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T11:30:47Z","timestamp":1778067047419,"version":"3.51.4"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2014,3,13]],"date-time":"2014-03-13T00:00:00Z","timestamp":1394668800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1007\/s11010-013-1870-9","type":"journal-article","created":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T04:46:48Z","timestamp":1394599608000},"page":"1-8","source":"Crossref","is-referenced-by-count":34,"title":["Diphenyl diselenide administration enhances cortical mitochondrial number and activity by increasing hemeoxygenase type 1 content in a methylmercury-induced neurotoxicity mouse model"],"prefix":"10.1007","volume":"390","author":[{"given":"Viviane","family":"Glaser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta de Paula","family":"Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Julia Hoffmann","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliana de Medeiros","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos Raniel","family":"Straliotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge Humberto","family":"Mukdsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia In\u00e9s","family":"Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreza Fabro","family":"de Bem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Farina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Batista Teixeira","family":"da Rocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Lucia","family":"De Paul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Latini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,3,13]]},"reference":[{"key":"1870_CR1","doi-asserted-by":"crossref","first-page":"6255","DOI":"10.1021\/cr0406559","volume":"104","author":"CW Nogueira","year":"2004","unstructured":"Nogueira CW, Zeni G, Rocha JB (2004) Organoselenium and organotellurium compounds: toxicology and pharmacology. Chem Rev 104:6255\u20136285. doi: 10.1021\/cr0406559","journal-title":"Chem Rev"},{"key":"1870_CR2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1023\/A:1014907228580","volume":"27","author":"JI Rossato","year":"2002","unstructured":"Rossato JI, Ketzer LA, Centuriao FB, Silva SJ, Ludtke DS, Zeni G, Braga AL, Rubin MA, Rocha JB (2002) Antioxidant properties of new chalcogenides against lipid peroxidation in rat brain. Neurochem Res 27:297\u2013303","journal-title":"Neurochem Res"},{"key":"1870_CR3","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ejphar.2006.10.003","volume":"555","author":"L Savegnago","year":"2007","unstructured":"Savegnago L, Pinto LG, Jesse CR, Alves D, Rocha JB, Nogueira CW, Zeni G (2007) Antinociceptive properties of diphenyl diselenide: evidences for the mechanism of action. Eur J Pharmacol 555:129\u2013138. doi: 10.1016\/j.ejphar.2006.10.003","journal-title":"Eur J Pharmacol"},{"key":"1870_CR4","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1177\/1753425911431285","volume":"18","author":"LL Rupil","year":"2012","unstructured":"Rupil LL, de Bem AF, Roth GA (2012) Diphenyl diselenide-modulation of macrophage activation: down-regulation of classical and alternative activation markers. Innate Immun 18:627\u2013637. doi: 10.1177\/1753425911431285","journal-title":"Innate Immun"},{"key":"1870_CR5","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.toxlet.2007.07.011","volume":"173","author":"C Luchese","year":"2007","unstructured":"Luchese C, Brandao R, de Oliveira R, Nogueira CW, Santos FW (2007) Efficacy of diphenyl diselenide against cerebral and pulmonary damage induced by cadmium in mice. Toxicol Lett 173:181\u2013190. doi: 10.1016\/j.toxlet.2007.07.011","journal-title":"Toxicol Lett"},{"key":"1870_CR6","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.cbi.2006.08.004","volume":"163","author":"NB Barbosa","year":"2006","unstructured":"Barbosa NB, Rocha JB, Wondracek DC, Perottoni J, Zeni G, Nogueira CW (2006) Diphenyl diselenide reduces temporarily hyperglycemia: possible relationship with oxidative stress. Chem Biol Interact 163:230\u2013238. doi: 10.1016\/j.cbi.2006.08.004","journal-title":"Chem Biol Interact"},{"key":"1870_CR7","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/FJC.0b013e31821d1149","volume":"58","author":"MA Hort","year":"2011","unstructured":"Hort MA, Straliotto MR, Netto PM, da Rocha JB, de Bem AF, Ribeiro-do-Valle RM (2011) Diphenyl diselenide effectively reduces atherosclerotic lesions in LDLr \u2212\/\u2212 mice by attenuation of oxidative stress and inflammation. J Cardiovasc Pharmacol 58:91\u2013101. doi: 10.1097\/FJC.0b013e31821d1149","journal-title":"J Cardiovasc Pharmacol"},{"key":"1870_CR8","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.cbi.2005.12.010","volume":"160","author":"LP Borges","year":"2006","unstructured":"Borges LP, Nogueira CW, Panatieri RB, Rocha JB, Zeni G (2006) Acute liver damage induced by 2-nitropropane in rats: effect of diphenyl diselenide on antioxidant defenses. Chem Biol Interact 160:99\u2013107. doi: 10.1016\/j.cbi.2005.12.010","journal-title":"Chem Biol Interact"},{"key":"1870_CR9","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.pbb.2007.09.015","volume":"88","author":"L Savegnago","year":"2008","unstructured":"Savegnago L, Jesse CR, Pinto LG, Rocha JB, Barancelli DA, Nogueira CW, Zeni G (2008) Diphenyl diselenide exerts antidepressant-like and anxiolytic-like effects in mice: involvement of l-arginine-nitric oxide-soluble guanylate cyclase pathway in its antidepressant-like action. Pharmacol Biochem Behav 88:418\u2013426. doi: 10.1016\/j.pbb.2007.09.015","journal-title":"Pharmacol Biochem Behav"},{"key":"1870_CR10","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1007\/s11064-012-0853-7","volume":"37","author":"CA Bruning","year":"2012","unstructured":"Bruning CA, Prigol M, Luchese C, Jesse CR, Duarte MM, Roman SS, Nogueira CW (2012) Protective effect of diphenyl diselenide on ischemia and reperfusion-induced cerebral injury: involvement of oxidative stress and pro-inflammatory cytokines. Neurochem Res 37:2249\u20132258. doi: 10.1007\/s11064-012-0853-7","journal-title":"Neurochem Res"},{"key":"1870_CR11","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.brainres.2008.01.004","volume":"1199","author":"T Posser","year":"2008","unstructured":"Posser T, Franco JL, dos Santos DA, Rigon AP, Farina M, Dafre AL, Teixeira Rocha JB, Leal RB (2008) Diphenyl diselenide confers neuroprotection against hydrogen peroxide toxicity in hippocampal slices. Brain Res 1199:138\u2013147. doi: 10.1016\/j.brainres.2008.01.004","journal-title":"Brain Res"},{"key":"1870_CR12","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.jnutbio.2012.06.012","volume":"24","author":"S Pinton","year":"2013","unstructured":"Pinton S, Bruning CA, Sartori Oliveira CE, Prigol M, Nogueira CW (2013) Therapeutic effect of organoselenium dietary supplementation in a sporadic dementia of Alzheimer\u2019s type model in rats. J Nutr Biochem 24:311\u2013317. doi: 10.1016\/j.jnutbio.2012.06.012","journal-title":"J Nutr Biochem"},{"key":"1870_CR13","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s00213-012-2675-3","volume":"222","author":"J Trevisan da Rocha","year":"2012","unstructured":"Trevisan da Rocha J, Mozzaquatro Gai B, Pinton S, Sampaio TB, Nogueira CW, Zeni G (2012) Effects of diphenyl diselenide on depressive-like behavior in ovariectomized mice submitted to subchronic stress: involvement of the serotonergic system. Psychopharmacology 222:709\u2013719. doi: 10.1007\/s00213-012-2675-3","journal-title":"Psychopharmacology"},{"key":"1870_CR14","doi-asserted-by":"crossref","first-page":"e39382","DOI":"10.1371\/journal.pone.0039382","volume":"7","author":"S Kumari","year":"2012","unstructured":"Kumari S, Mehta SL, Li PA (2012) Glutamate induces mitochondrial dynamic imbalance and autophagy activation: preventive effects of selenium. PLoS ONE 7:e39382. doi: 10.1371\/journal.pone.0039382PONE-D-12-01177","journal-title":"PLoS ONE"},{"key":"1870_CR15","doi-asserted-by":"crossref","first-page":"e47910","DOI":"10.1371\/journal.pone.0047910","volume":"7","author":"N Mendelev","year":"2012","unstructured":"Mendelev N, Mehta SL, Idris H, Kumari S, Li PA (2012) Selenite stimulates mitochondrial biogenesis signaling and enhances mitochondrial functional performance in murine hippocampal neuronal cells. PLoS One 7:e47910. doi: 10.1371\/journal.pone.0047910PONE-D-12-09198","journal-title":"PLoS One"},{"key":"1870_CR16","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.ijdevneu.2010.07.225","volume":"28","author":"V Glaser","year":"2010","unstructured":"Glaser V, Nazari EM, Muller YM, Feksa L, Wannmacher CM, Rocha JB, de Bem AF, Farina M, Latini A (2010) Effects of inorganic selenium administration in methylmercury-induced neurotoxicity in mouse cerebral cortex. Int J Dev Neurosci 28:631\u2013637. doi: 10.1016\/j.ijdevneu.2010.07.225","journal-title":"Int J Dev Neurosci"},{"key":"1870_CR17","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1159\/000112110","volume":"16","author":"V Dave","year":"1994","unstructured":"Dave V, Mullaney KJ, Goderie S, Kimelberg HK, Aschner M (1994) Astrocytes as mediators of methylmercury neurotoxicity: effects on d-aspartate and serotonin uptake. Dev Neurosci 16:222\u2013231","journal-title":"Dev Neurosci"},{"key":"1870_CR18","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.envres.2006.02.003","volume":"102","author":"JL Franco","year":"2006","unstructured":"Franco JL, Teixeira A, Meotti FC, Ribas CM, Stringari J, Garcia Pomblum SC, Moro AM, Bohrer D, Bairros AV, Dafre AL, Santos AR, Farina M (2006) Cerebellar thiol status and motor deficit after lactational exposure to methylmercury. Environ Res 102:22\u201328. doi: 10.1016\/j.envres.2006.02.003","journal-title":"Environ Res"},{"key":"1870_CR19","author":"R Paula Martins de","year":"2013","unstructured":"de Paula Martins R, Glaser V, da Luz Scheffer D, de Paula Ferreira PM, Wannmacher CM, Farina M, de Oliveira PA, Prediger RD, Latini A (2013) Platelet oxygen consumption as a peripheral blood marker of brain energetics in a mouse model of severe neurotoxicity. J Bioenerg Biomembr. doi: 10.1007\/s10863-013-9499-7","journal-title":"J Bioenerg Biomembr"},{"key":"1870_CR20","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.neuroscience.2005.05.013","volume":"135","author":"A Latini","year":"2005","unstructured":"Latini A, Rodriguez M, Borba Rosa R, Scussiato K, Leipnitz G, de Assis DR, da Costa Ferreira G, Funchal C, Jacques-Silva MC, Buzin L, Giugliani R, Cassina A, Radi R, Wajner M (2005) 3-Hydroxyglutaric acid moderately impairs energy metabolism in brain of young rats. Neuroscience 135:111\u2013120. doi: 10.1016\/j.neuroscience.2005.05.013","journal-title":"Neuroscience"},{"key":"1870_CR21","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0065-1281(97)80022-0","volume":"99","author":"AL Paul De","year":"1997","unstructured":"De Paul AL, Pons P, Aoki A, Torres AI (1997) Heterogeneity of pituitary lactotrophs: immunocytochemical identification of functional subtypes. Acta Histochem 99:277\u2013289. doi: 10.1016\/S0065-1281(97)80022-0","journal-title":"Acta Histochem"},{"key":"1870_CR22","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.abb.2006.06.025","volume":"453","author":"AQ Santos dos","year":"2006","unstructured":"dos Santos AQ, Nardin P, Funchal C, de Almeida LM, Jacques-Silva MC, Wofchuk ST, Goncalves CA, Gottfried C (2006) Resveratrol increases glutamate uptake and glutamine synthetase activity in C6 glioma cells. Arch Biochem Biophys 453:161\u2013167. doi: 10.1016\/j.abb.2006.06.025","journal-title":"Arch Biochem Biophys"},{"key":"1870_CR23","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265\u2013275","journal-title":"J Biol Chem"},{"key":"1870_CR24","first-page":"51","volume":"34C","author":"G Santin","year":"2012","unstructured":"Santin G, Piccolini VM, Barni S, Veneroni P, Giansanti V, Dal Bo V, Bernocchi G, Bottone MG (2012) Mitochondrial fusion: a mechanism of cisplatin-induced resistance in neuroblastoma cells? Neurotoxicology 34C:51\u201360. doi: 10.1016\/j.neuro.2012.10.011","journal-title":"Neurotoxicology"},{"key":"1870_CR25","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.brainresbull.2008.11.001","volume":"79","author":"AS Freitas de","year":"2009","unstructured":"de Freitas AS, Funck VR, Rotta Mdos S, Bohrer D, Morschbacher V, Puntel RL, Nogueira CW, Farina M, Aschner M, Rocha JB (2009) Diphenyl diselenide, a simple organoselenium compound, decreases methylmercury-induced cerebral, hepatic and renal oxidative stress and mercury deposition in adult mice. Brain Res Bull 79:77\u201384. doi: 10.1016\/j.brainresbull.2008.11.001","journal-title":"Brain Res Bull"},{"key":"1870_CR26","author":"V Glaser","year":"2013","unstructured":"Glaser V, Moritz B, Schmitz A, Dafr\u00e9 AL, Nazari EM, Rauh M\u00fcller YM, Feksa L, Straliotto MR, de Bem AF, Farina M, da Rocha JB, Latini A (2013) Protective effects of diphenyl diselenide in a mouse model of brain toxicity. Chem Biol Interact. doi: 10.1016\/j.cbi.2013.08.002","journal-title":"Chem Biol Interact"},{"key":"1870_CR27","doi-asserted-by":"crossref","first-page":"7699","DOI":"10.3390\/molecules15117699","volume":"15","author":"AS Freitas de","year":"2010","unstructured":"de Freitas AS, Wagner C, Haigert Sudati J, Alves D, Oliveira Porci\u00fancula L, Kade IJ, Rocha JB (2010) Diphenyl diselenide and analogs are substrates of cerebral rat thioredoxin reductase: a pathway for their neuroprotective effects. Molecules 15:7699\u201376714","journal-title":"Molecules"},{"key":"1870_CR28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neulet.2011.07.050","volume":"503","author":"AS Freitas de","year":"2011","unstructured":"de Freitas AS, Rocha JB (2011) Diphenyl diselenide and analogs are substrates of cerebral rat thioredoxin reductase: a pathway for their neuroprotective effects. Neurosci Lett 503:1\u20135. doi: 10.1016\/j.neulet.2011.07.050","journal-title":"Neurosci Lett"},{"key":"1870_CR29","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.neuro.2006.05.007","volume":"27","author":"MC Newland","year":"2006","unstructured":"Newland MC, Reed MN, LeBlanc A, Donlin WD (2006) Brain and blood mercury and selenium after chronic and developmental exposure to methylmercury. Neurotoxicology 27:710\u2013720. doi: 10.1016\/j.neuro.2006.05.007","journal-title":"Neurotoxicology"},{"key":"1870_CR30","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0009-2797(77)90069-2","volume":"17","author":"SC Fang","year":"1977","unstructured":"Fang SC (1977) Interaction of selenium and mercury in the rat. Chem Biol Interact 17:25\u201340","journal-title":"Chem Biol Interact"},{"key":"1870_CR31","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/0091-3057(80)90277-4","volume":"13","author":"A Naganuma","year":"1980","unstructured":"Naganuma A, Imura N (1980) Changes in distribution of mercury and selenium in soluble fractions of rabbit tissues after simultaneous administration. Pharmacol Biochem Behav 13:537\u2013544","journal-title":"Pharmacol Biochem Behav"},{"key":"1870_CR32","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.atherosclerosis.2008.02.030","volume":"201","author":"AF Bem de","year":"2008","unstructured":"de Bem AF, Farina M, Portella Rde L, Nogueira CW, Dinis TC, Laranjinha JA, Almeida LM, Rocha JB (2008) Diphenyl diselenide, a simple glutathione peroxidase mimetic, inhibits human LDL oxidation in vitro. Atherosclerosis 201:92\u2013100. doi: 10.1016\/j.atherosclerosis.2008.02.030","journal-title":"Atherosclerosis"},{"key":"1870_CR33","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.etap.2005.07.017","volume":"21","author":"L Savegnago","year":"2006","unstructured":"Savegnago L, Trevisan M, Alves D, Rocha JB, Nogueira CW, Zeni G (2006) Antisecretory and antiulcer effects of diphenyl diselenide. Environ Toxicol Pharmacol 21:86\u201392. doi: 10.1016\/j.etap.2005.07.017","journal-title":"Environ Toxicol Pharmacol"},{"key":"1870_CR34","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1007\/s00204-007-0209-2","volume":"81","author":"N Mori","year":"2007","unstructured":"Mori N, Yasutake A, Hirayama K (2007) Comparative study of activities in reactive oxygen species production\/defense system in mitochondria of rat brain and liver, and their susceptibility to methylmercury toxicity. Arch Toxicol 81:769\u2013776. doi: 10.1007\/s00204-007-0209-2","journal-title":"Arch Toxicol"},{"key":"1870_CR35","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0968-0004(00)01735-7","volume":"26","author":"VP Skulachev","year":"2001","unstructured":"Skulachev VP (2001) Mitochondrial filaments and clusters as intracellular power-transmitting cables. Trends Biochem Sci 26:23\u201329","journal-title":"Trends Biochem Sci"},{"key":"1870_CR36","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.cell.2010.02.026","volume":"141","author":"H Chen","year":"2010","unstructured":"Chen H, Vermulst M, Wang YE, Chomyn A, Prolla TA, McCaffery JM, Chan DC (2010) Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations. Cell 141:280\u2013289. doi: 10.1016\/j.cell.2010.02.026","journal-title":"Cell"},{"key":"1870_CR37","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/90116","volume":"28","author":"T Ono","year":"2001","unstructured":"Ono T, Isobe K, Nakada K, Hayashi JI (2001) Human cells are protected from mitochondrial dysfunction by complementation of DNA products in fused mitochondria. Nat Genet 28:272\u2013275. doi: 10.1038\/9011690116","journal-title":"Nat Genet"},{"key":"1870_CR38","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.ijdevneu.2010.07.225","volume":"28","author":"V Glaser","year":"2010","unstructured":"Glaser V, Nazari EM, Muller YM, Feksa L, Wannmacher CM, Rocha JB, de Bem AF, Farina M, Latini A (2010) Effects of inorganic selenium administration in methylmercury-induced neurotoxicity in mouse cerebral cortex. Int J Dev Neurosci 28:631\u2013637. doi: 10.1016\/j.ijdevneu.2010.07.225","journal-title":"Int J Dev Neurosci"},{"key":"1870_CR39","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/BF00697390","volume":"61","author":"J O\u2019Kusky","year":"1983","unstructured":"O\u2019Kusky J (1983) Methylmercury poisoning of the developing nervous system: morphological changes in neuronal mitochondria. Acta Neuropathol 61:116\u2013122","journal-title":"Acta Neuropathol"},{"key":"1870_CR40","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0006-8993(70)90332-X","volume":"18","author":"JJ Pysh","year":"1970","unstructured":"Pysh JJ (1970) Mitochondrial changes in rat inferior colliculus during postnatal development: an electron microscopic study. Brain Res 18:325\u2013342","journal-title":"Brain Res"},{"key":"1870_CR41","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.brainresbull.2006.05.002","volume":"70","author":"ME Burger","year":"2006","unstructured":"Burger ME, Fachinetto R, Wagner C, Perottoni J, Pereira RP, Zeni G, Rocha JB (2006) Effects of diphenyl-diselenide on orofacial dyskinesia model in rats. Brain Res Bull 70:165\u2013170. doi: 10.1016\/j.brainresbull.2006.05.002","journal-title":"Brain Res Bull"},{"key":"1870_CR42","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1007\/s00204-011-0720-3","volume":"85","author":"CW Nogueira","year":"2011","unstructured":"Nogueira CW, Rocha JB (2011) Toxicology and pharmacology of selenium: emphasis on synthetic organoselenium compounds. Arch Toxicol 85:1313\u20131359. doi: 10.1007\/s00204-011-0720-3","journal-title":"Arch Toxicol"},{"key":"1870_CR43","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.etap.2013.01.004","volume":"35","author":"ML Jin","year":"2013","unstructured":"Jin ML, Park SY, Kim YH, Park G, Lee SJ (2013) Acanthopanax senticosus exerts neuroprotective effects through HO-1 signaling in hippocampal and microglial cells. Environ Toxicol Pharmacol 35:335\u2013346. doi: 10.1016\/j.etap.2013.01.004","journal-title":"Environ Toxicol Pharmacol"},{"key":"1870_CR44","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neulet.2013.03.038","volume":"543","author":"W Wang","year":"2013","unstructured":"Wang W, Wang WP, Zhang GL, Wu YF, Xie T, Kan MC, Fang HB, Wang HC (2013) Activation of Nrf2-ARE signal pathway in hippocampus of amygdala kindling rats. Neurosci Lett 543:58\u201363. doi: 10.1016\/j.neulet.2013.03.038","journal-title":"Neurosci Lett"},{"key":"1870_CR45","doi-asserted-by":"crossref","first-page":"22925","DOI":"10.1074\/jbc.M414635200","volume":"280","author":"AY Shih","year":"2005","unstructured":"Shih AY, Imbeault S, Barakauskas V, Erb H, Jiang L, Li P, Murphy TH (2005) Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo. J Biol Chem 280:22925\u201322936. doi: 10.1074\/jbc.M414635200","journal-title":"J Biol Chem"},{"key":"1870_CR46","doi-asserted-by":"crossref","first-page":"10321","DOI":"10.1523\/JNEUROSCI.4014-05.2005","volume":"25","author":"AY Shih","year":"2005","unstructured":"Shih AY, Li P, Murphy TH (2005) A small-molecule-inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo. J Neurosci 25:10321\u201310335. doi: 10.1523\/JNEUROSCI.4014-05.2005","journal-title":"J Neurosci"},{"key":"1870_CR47","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.neulet.2005.09.065","volume":"393","author":"J Zhao","year":"2006","unstructured":"Zhao J, Kobori N, Aronowski J, Dash PK (2006) Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents. Neurosci Lett 393:108\u2013112. doi: 10.1016\/j.neulet.2005.09.065","journal-title":"Neurosci Lett"},{"key":"1870_CR48","doi-asserted-by":"crossref","first-page":"10240","DOI":"10.1523\/JNEUROSCI.1683-07.2007","volume":"27","author":"J Zhao","year":"2007","unstructured":"Zhao J, Moore AN, Redell JB, Dash PK (2007) Enhancing expression of Nrf2-driven genes protects the blood brain barrier after brain injury. J Neurosci 27:10240\u201310248. doi: 10.1523\/JNEUROSCI.1683-07.2007","journal-title":"J Neurosci"},{"key":"1870_CR49","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1146\/annurev.pharmtox.46.120604.141046","volume":"47","author":"TW Kensler","year":"2007","unstructured":"Kensler TW, Wakabayashi N, Biswal S (2007) Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol 47:89\u2013116. doi: 10.1146\/annurev.pharmtox.46.120604.141046","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"1870_CR50","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1161\/01.RES.0000338597.71702.ad","volume":"103","author":"CA Piantadosi","year":"2008","unstructured":"Piantadosi CA, Carraway MS, Babiker A, Suliman HB (2008) Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1. Circ Res 103:1232\u20131240. doi: 10.1161\/01.RES.0000338597.71702.ad","journal-title":"Circ Res"},{"key":"1870_CR51","doi-asserted-by":"crossref","first-page":"16374","DOI":"10.1074\/jbc.M110.207738","volume":"286","author":"CA Piantadosi","year":"2011","unstructured":"Piantadosi CA, Withers CM, Bartz RR, MacGarvey NC, Fu P, Sweeney TE, Welty-Wolf KE, Suliman HB (2011) Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression. J Biol Chem 286:16374\u201316385. doi: 10.1074\/jbc.M110.207738","journal-title":"J Biol Chem"},{"key":"1870_CR52","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.2174\/1381612033453730","volume":"9","author":"J Alam","year":"2003","unstructured":"Alam J, Cook JL (2003) Transcriptional regulation of the heme oxygenase-1 gene via the stress response element pathway. Curr Pharm Des 9:2499\u20132511","journal-title":"Curr Pharm Des"},{"key":"1870_CR53","doi-asserted-by":"crossref","first-page":"6388","DOI":"10.1016\/S0021-9258(18)63477-5","volume":"244","author":"R Tenhunen","year":"1969","unstructured":"Tenhunen R, Marver HS, Schmid R (1969) Microsomal heme oxygenase. Characterization of the enzyme. J Biol Chem 244:6388\u20136394","journal-title":"J Biol Chem"},{"key":"1870_CR54","doi-asserted-by":"crossref","first-page":"16093","DOI":"10.1073\/pnas.252626999","volume":"99","author":"DE Baranano","year":"2002","unstructured":"Baranano DE, Rao M, Ferris CD, Snyder SH (2002) Biliverdin reductase: a major physiologic cytoprotectant. Proc Natl Acad Sci USA 99:16093\u201316098. doi: 10.1073\/pnas.252626999","journal-title":"Proc Natl Acad Sci USA"},{"key":"1870_CR55","doi-asserted-by":"crossref","first-page":"16916","DOI":"10.1074\/jbc.M410690200","volume":"280","author":"KM Connor","year":"2005","unstructured":"Connor KM, Subbaram S, Regan KJ, Nelson KK, Mazurkiewicz JEB, Barthlomew PJ, Aplin AE, Tai YT, Aquirre-Ghiso J, Flores SC, Melendez JA (2005) Mitochondrial H2O2 regulates the angiogenic phenotype via PTEN oxidation. J Biol Chem 280:16916\u201316924","journal-title":"J Biol Chem"},{"key":"1870_CR56","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1242\/jcs.03318","volume":"120","author":"HB Suliman","year":"2007","unstructured":"Suliman HB, Carraway MS, Tatro LG, Piantadosi CA (2007) A new activating role for CO in cardiac mitochondrial biogenesis. J Cell Sci 120:299\u2013308","journal-title":"J Cell Sci"},{"key":"1870_CR57","first-page":"3730","volume":"117","author":"HB Suliman","year":"2007","unstructured":"Suliman HB, Carraway MS, Ali AS, Reynolds CM, KE W-W, Piantadosi CA (2007) The CO\/HO system reverses inhibition of mitochondrial biogenesis and prevents murine doxorubicin cardiomyopathy. J Clin Invest 117:3730\u20133741","journal-title":"J Clin Invest"},{"key":"1870_CR58","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.neuro.2010.05.012","volume":"31","author":"V Glaser","year":"2010","unstructured":"Glaser V, Leipnitz G, Straliotto MR, Oliveira J, dos Santos VV, Wannmacher CM, de Bem AF, Rocha JB, Farina M, Latini A (2010) Oxidative stress-mediated inhibition of brain creatine kinase activity by methylmercury. Neurotoxicology 31:454\u2013460. doi: 10.1016\/j.neuro.2010.05.012","journal-title":"Neurotoxicology"},{"key":"1870_CR59","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1432-1033.1986.tb09420.x","volume":"154","author":"H Inoue","year":"1986","unstructured":"Inoue H, Noguchi T, Tanaka T (1986) Complete amino acid sequence of rat l-type pyruvate kinase deduced from the cDNA sequence. Eur J Biochem 154:465\u2013469","journal-title":"Eur J Biochem"},{"key":"1870_CR60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2006.04.005","volume":"162","author":"AF Bem de","year":"2006","unstructured":"de Bem AF, de Lima Portella R, Perottoni J, Becker E, Bohrer D, Paixao MW, Nogueira CW, Zeni G, Rocha JB (2006) Changes in biochemical parameters in rabbits blood after oral exposure to diphenyl diselenide for long periods. Chem Biol Interact 162:1\u201310. doi: 10.1016\/j.cbi.2006.04.005","journal-title":"Chem Biol Interact"},{"key":"1870_CR61","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1742-7843.2007.00073.x","volume":"101","author":"AF Bem de","year":"2007","unstructured":"de Bem AF, de Lima Portella R, Farina M, Perottoni J, Paixao MW, Nogueira CW, Teixeira Rocha JB (2007) Low toxicity of diphenyl diselenide in rabbits: a long-term study. Basic Clin Pharmacol Toxicol 101:47\u201355. doi: 10.1111\/j.1742-7843.2007.00073.x","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"1870_CR62","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0378-4274(03)00090-0","volume":"143","author":"FC Meotti","year":"2003","unstructured":"Meotti FC, Borges VC, Zeni G, Rocha JB, Nogueira CW (2003) Potential renal and hepatic toxicity of diphenyl diselenide, diphenyl ditelluride and Ebselen for rats and mice. Toxicol Lett 143:9\u201316","journal-title":"Toxicol Lett"},{"key":"1870_CR63","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0300-483X(02)00423-7","volume":"183","author":"CW Nogueira","year":"2003","unstructured":"Nogueira CW, Meotti FC, Curte E, Pilissao C, Zeni G, Rocha JB (2003) Investigations into the potential neurotoxicity induced by diselenides in mice and rats. Toxicology 183:29\u201337","journal-title":"Toxicology"},{"key":"1870_CR64","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1097\/00006123-199802000-00038","volume":"42","author":"I Saito","year":"1998","unstructured":"Saito I, Asano T, Sano K, Takakura K, Abe H, Yoshimoto T, Kikuchi H, Ohta T, Ishibashi S (1998) Neuroprotective effect of an antioxidant, ebselen, in patients with delayed neurological deficits after aneurysmal subarachnoid hemorrhage. Neurosurgery 42:269\u2013277 discussion 277-8","journal-title":"Neurosurgery"},{"key":"1870_CR65","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1023\/A:1014903127672","volume":"27","author":"CW Nogueira","year":"2002","unstructured":"Nogueira CW, Rotta LN, Zeni G, Souza DO, Rocha JB (2002) Exposure to ebselen changes glutamate uptake and release by rat brain synaptosomes. Neurochem Res 27:283\u2013288","journal-title":"Neurochem Res"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-013-1870-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11010-013-1870-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-013-1870-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T20:09:12Z","timestamp":1648584552000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11010-013-1870-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,13]]},"references-count":65,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["1870"],"URL":"https:\/\/doi.org\/10.1007\/s11010-013-1870-9","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,13]]}}}