{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:20:48Z","timestamp":1790817648961,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2013,11,28]],"date-time":"2013-11-28T00:00:00Z","timestamp":1385596800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1007\/s11010-013-1905-2","type":"journal-article","created":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T12:16:31Z","timestamp":1385554591000},"page":"135-147","source":"Crossref","is-referenced-by-count":22,"title":["The action of p-synephrine on hepatic carbohydrate metabolism and respiration occurs via both Ca2+-mobilization and cAMP production"],"prefix":"10.1007","volume":"388","author":[{"given":"Andrea Luiza","family":"de Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurandir Fernando","family":"Comar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anacharis Babeto","family":"de S\u00e1-Nakanishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosane Marina","family":"Peralta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelar","family":"Bracht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,11,28]]},"reference":[{"key":"1905_CR1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s13105-011-0078-2","volume":"67","author":"J Mercarder","year":"2011","unstructured":"Mercarder J, Wanecq E, Chen J, Carp\u00e9n\u00e9 C (2011) Isopropylnorsynephrine is a stronger lipolytic agent in human adipocytes than synephrine and other amines present in Citrus aurantium. J Physiol Biochem 67:443\u2013452","journal-title":"J Physiol Biochem"},{"key":"1905_CR2","first-page":"69","volume":"29","author":"A Fugh-Berman","year":"2004","unstructured":"Fugh-Berman A, Myers A (2004) Citrus aurantium, an ingredient of dietary supplements marketed for weight loss: current status of clinical and basic research. Exp Biol Med 29:689\u2013704","journal-title":"Exp Biol Med"},{"key":"1905_CR3","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1016\/j.fct.2008.04.037","volume":"46","author":"MD Arbo","year":"2008","unstructured":"Arbo MD, Larentis ER, Linck VM, Aboy AL, Pimentel AL, Henriques AT, Dallegrave E, Garcia SC, Leal MB, Limberger RP (2008) Concentrations of p-synephrine in fruits and leaves of Citrus species (Rutaceae) and the acute toxicity testing of Citrus aurantium extract and p-synephrine. Food Chem Toxicol 46:2770\u20132775","journal-title":"Food Chem Toxicol"},{"key":"1905_CR4","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0031-9422(00)85799-4","volume":"8","author":"TA Wheaton","year":"1969","unstructured":"Wheaton TA, Stewart I (1969) Biosynthesis of synephrine in citrus. Phytochemistry 8:85\u201392","journal-title":"Phytochemistry"},{"key":"1905_CR5","doi-asserted-by":"crossref","first-page":"547","DOI":"10.3177\/jnsv.53.547","volume":"53","author":"T Tsujita","year":"2007","unstructured":"Tsujita T, Takaku T (2007) Lipolysis induced by segment wall extract from Satsuma mandarin orange (Citrus unshu Mark). J Nutr Sci Vitaminol 53:547\u2013551","journal-title":"J Nutr Sci Vitaminol"},{"key":"1905_CR6","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0304-3940(96)12895-0","volume":"214","author":"DK Song","year":"1996","unstructured":"Song DK, Suh HW, Jung JS, Wie MB, Son KH, Kim YH (1996) Antidepressant-like effects of p-synephrine in mouse models of immobility tests. Neurosci Lett 214:107\u2013110","journal-title":"Neurosci Lett"},{"key":"1905_CR7","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1476-5381.1988.tb11449.x","volume":"93","author":"CM Brown","year":"1988","unstructured":"Brown CM, McGrath JC, Midgley JM, Muir AGB, O\u2032Brien JW, Thonoor CM, Williams CM, Wilson VG (1988) Activities of octopamine and synephrine stereoisomers on \u03b1-adrenoceptors. Br J Pharmacol 93:417\u2013429","journal-title":"Br J Pharmacol"},{"key":"1905_CR8","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/PL00005357","volume":"359","author":"C Carp\u00e9n\u00e9","year":"1999","unstructured":"Carp\u00e9n\u00e9 C, Galitzky J, Fontana E, Atgi\u00e9 C, Lafontan M, Berlan M (1999) Selective activation of \u03b23-adrenoceptors by octopamine: comparative studies in mammalian fat cells. Naunyn Schmiedeberg\u2019s Arch Pharmacol 359:310\u2013321","journal-title":"Naunyn Schmiedeberg\u2019s Arch Pharmacol"},{"key":"1905_CR9","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1254\/jphs.09077FP","volume":"111","author":"T Hibino","year":"2009","unstructured":"Hibino T, Yuzurihara M, Kase Y, Takeda A (2009) Synephrine, a component of Evodiae fructus, constricts isolated rat aorta via adrenergic and serotonergic receptors. J Pharmacol Sci 111:73\u201381","journal-title":"J Pharmacol Sci"},{"key":"1905_CR10","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/S0367-326X(99)00093-3","volume":"70","author":"G Calapai","year":"1999","unstructured":"Calapai G, Firenzuoli F, Saitta A, Squadrito F, Arlotta MR, Constantino G, Inferrera G (1999) Antiobesity and cardiovascular toxic effects of Citrus aurantium extracts in the rat: a preliminary report. Fitoterapia 70:586\u2013592","journal-title":"Fitoterapia"},{"key":"1905_CR11","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.bbrc.2012.01.085","volume":"418","author":"NY Hong","year":"2012","unstructured":"Hong NY, Cui ZG, Kang HK, Lee DH, Lee YK, Park DB (2012) p-Synephrine stimulates glucose consumption via AMPK in L6 skeletal muscle cells. Biochem Biophys Res Commun 418:720\u2013724","journal-title":"Biochem Biophys Res Commun"},{"key":"1905_CR12","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1111\/j.1365-2125.2008.03144.x","volume":"65","author":"CA Haller","year":"2008","unstructured":"Haller CA, Duan M, Jacob P III, Benowitz N (2008) Human pharmacology of a performance-enhancing dietary supplement under resting and exercise conditions. Br J Clin Pharmacol 65:833\u2013840","journal-title":"Br J Clin Pharmacol"},{"key":"1905_CR13","doi-asserted-by":"crossref","first-page":"5854","DOI":"10.3390\/molecules17055854","volume":"17","author":"JS Peixoto","year":"2012","unstructured":"Peixoto JS, Comar JF, Moreira CT, Soares AA, Oliveira AL, Bracht A, Peralta RM (2012) Effects of Citrus aurantium (bitter orange) fruit extracts and p-synephrine on metabolic fluxes in the rat liver. Molecules 17:5854\u20135869","journal-title":"Molecules"},{"key":"1905_CR14","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/B978-1-4832-3161-7.50048-3","volume-title":"Control of energy metabolism","author":"R Scholz","year":"1965","unstructured":"Scholz R, B\u00fccher T (1965) Hemoglobin-free perfusion of rat liver. In: Chance B, Estabrook RW, Williamson JR (eds) Control of energy metabolism. Academic Press, New York, pp 393\u2013414"},{"key":"1905_CR15","first-page":"275","volume-title":"M\u00e9todos de laborat\u00f3rio em bioqu\u00edmica","author":"A Bracht","year":"2003","unstructured":"Bracht A, Ishii-Iwamoto EL, Kelmer-Bracht AM (2003) O estudo do me-tabolismo no f\u00edgado em perfus\u00e3o. In: Bracht A, Ishii-Iwamoto EL (eds) M\u00e9todos de laborat\u00f3rio em bioqu\u00edmica. Editora Manole, S\u00e3o Paulo, pp 275\u2013289"},{"key":"1905_CR16","volume-title":"Methods of enzymatic analysis","author":"HU Bergmeyer","year":"1974","unstructured":"Bergmeyer HU (1974) Methods of enzymatic analysis. Verlag Chemie, Weinheim"},{"key":"1905_CR17","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1034\/j.1600-0773.2003.930307.x","volume":"93","author":"JF Comar","year":"2003","unstructured":"Comar JF, Suzuki-Kemmelmeier F, Bracht A (2003) The action of oxybutynin on haemodynamics and metabolism in the perfused rat liver. Basic Clin Pharmacol Toxicol 93:147\u2013152","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"1905_CR18","first-page":"1","volume":"9","author":"A Bracht","year":"2002","unstructured":"Bracht A, Kouyoumdjian M, Ishii-Iwamoto EL, Borges DR (2002) Indicator injections and pressure monitoring as complementary tools for investigating microcirculatory changes in the liver. Trends Comp Biochem Physiol 9:1\u201316","journal-title":"Trends Comp Biochem Physiol"},{"key":"1905_CR19","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/0006-2952(92)90414-E","volume":"44","author":"NS Yamamoto","year":"1992","unstructured":"Yamamoto NS, Ishii-Iwamoto EL, Bracht A (1992) Activation of glyco-genolysis by methotrexate. Influence of calcium and inhibitors of hormone action. Biochem Pharmacol 44:781\u2013787","journal-title":"Biochem Pharmacol"},{"key":"1905_CR20","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.regpep.2005.03.005","volume":"129","author":"A Polato-Schmeisch","year":"2005","unstructured":"Polato-Schmeisch A, Oliveira DS, Ide LT, Suzuki-Kemmelmeier F, Bracht A (2005) Zonation of the metabolic action of vasopressin in the bivascularly perfused rat liver. Reg Peptides 129:233\u2013243","journal-title":"Reg Peptides"},{"key":"1905_CR21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj2960001","volume":"296","author":"FL Bygrave","year":"1993","unstructured":"Bygrave FL, Benedetti A (1993) Calcium: its modulation in liver by cross-talk between the actions of glucagon and calcium-mobilizing agonists. Biochem J 296:1\u201314","journal-title":"Biochem J"},{"key":"1905_CR22","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1159\/000324274","volume":"87","author":"N Haga","year":"2011","unstructured":"Haga N, Aikawa K, Shishido K, Yanagida T, Kushida N, Takahashi N, Yazaki J, Yamaguchi O (2011) Effect of long-term prazosin and yohimbine administration on c-Fos expression in spinal neurons: inhibitory effect of alpha-1 and alpha-2 adrenoceptors on afferents from the lower urinary tract. Urol Inter 87:230\u2013237","journal-title":"Urol Inter"},{"key":"1905_CR23","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00213-011-2632-6","volume":"222","author":"AM Landau","year":"2012","unstructured":"Landau AM, Doudet DJ, Jakobsen S (2012) Amphetamine challenge de-creases yohimbine binding to \u03b1-2 adrenoceptors in Landrace pig brain. Psychopharmacology 222:155\u2013163","journal-title":"Psychopharmacology"},{"key":"1905_CR24","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1582-4934.2010.01015.x","volume":"15","author":"J Machackova","year":"2011","unstructured":"Machackova J, Sanganalmath SK, Elimban V, Dhalla NS (2011) \u03b2-Adrenergic blockade attenuates cardiac dysfunction and myofibrillar remodelling in congestive heart failure. J Cell Mol Med 15:545\u2013554","journal-title":"J Cell Mol Med"},{"key":"1905_CR25","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0006-2952(97)00303-1","volume":"54","author":"J Constantin","year":"1997","unstructured":"Constantin J, Suzuki-Kemmelmeier F, Yamamoto NS, Bracht A (1997) Production, uptake and metabolic effects of cyclic AMP in the bivascularly perfused rat liver. Biochem Pharmacol 54:1115\u20131125","journal-title":"Biochem Pharmacol"},{"key":"1905_CR26","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/s11897-011-0064-6","volume":"8","author":"C Gauthier","year":"2011","unstructured":"Gauthier C, Rozec B, Manoury B, Baalligand JL (2011) Beta-3 adrenoceptors as new therapeutic targets for cardiovascular pathologies. Curr Heart Fail Rep 8:184\u2013192","journal-title":"Curr Heart Fail Rep"},{"key":"1905_CR27","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.1432-1033.1969.tb00593.x","volume":"9","author":"LA Menahan","year":"1969","unstructured":"Menahan LA, Wieland O (1969) The role of endogenous lipid in gluconeogenesis and ketogenesis of perfused rat liver. Eur J Biochem 9:182\u2013188","journal-title":"Eur J Biochem"},{"key":"1905_CR28","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0014-5793(86)80875-4","volume":"205","author":"S Soboll","year":"1986","unstructured":"Soboll S, Scholz R (1986) Control of energy metabolism by glucagon and adrenaline in perfused rat liver. FEBS Lett 205:109\u2013112","journal-title":"FEBS Lett"},{"key":"1905_CR29","first-page":"193","volume":"64","author":"RB Bazotte","year":"1989","unstructured":"Bazotte RB, Constantin J, Curi R, Kemmelmeier FS, Hell NS, Bracht A (1989) The sensitivity of glycogenolysis to glucagon, epinephrine and cyanide in livers from rats in different metabolic conditions. Res Commun Chem Pathol Pharmacol 64:193\u2013203","journal-title":"Res Commun Chem Pathol Pharmacol"},{"key":"1905_CR30","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0306-3623(94)00161-F","volume":"26","author":"EA Nascimento","year":"1995","unstructured":"Nascimento EA, Yamamoto NS, Bracht A, Ishii-Iwamoto EL (1995) Naproxen inhibits hepatic glycogenolysis induced by Ca2+-dependent agents. Gen Pharmacol 26:211\u2013218","journal-title":"Gen Pharmacol"},{"key":"1905_CR31","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/S0731-7085(02)00153-X","volume":"29","author":"F Pellati","year":"2002","unstructured":"Pellati F, Benvenuti S, Melegari M, Firenzuoli F (2002) Determination of adrenergic agonists from extracts and herbal products of Citrus aurantium L. var. amara by LC. J Pharm Biomed Anal 29:1113\u20131119","journal-title":"J Pharm Biomed Anal"},{"key":"1905_CR32","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1016\/S0021-9258(19)68124-X","volume":"257","author":"PH Reinhart","year":"1982","unstructured":"Reinhart PH, Taylor WM, Bygrave FL (1982) Studies on alpha-adrenergic-induced respiration and glycogenolysis in perfused rat liver. J Biol Chem 257:1906\u20131912","journal-title":"J Biol Chem"},{"key":"1905_CR33","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0014-2999(98)00404-X","volume":"352","author":"C Tonello","year":"1998","unstructured":"Tonello C, Dioni L, Briscini L, Nisoli E, Carruba MO (1998) SR59230A blocks \u03b23-adrenoceptor-linked modulation of uncoupling protein-1 and leptin in rat brown adipocytes. Eur J Pharmacol 352:125\u2013129","journal-title":"Eur J Pharmacol"},{"key":"1905_CR34","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.phrs.2009.01.002","volume":"59","author":"MG Ursino","year":"2009","unstructured":"Ursino MG, Vasina V, Raschi E, Crema F, De Ponti F (2009) The \u03b23-adrenoceptor as a therapeutic target: current perspectives. Pharmacol Res 59:221\u2013234","journal-title":"Pharmacol Res"},{"key":"1905_CR35","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1002\/hep.23222","volume":"50","author":"J Trebicka","year":"2009","unstructured":"Trebicka J, Hennenberg M, Prosting AS, Laleman W, Klein S, Granzow M, Nevens F, Zaagsma J, Heller J, Sauerbruch T (2009) Role of \u03b23-adrenoceptors for intrahepatic resistance and portal hypertension in liver cirrhosis. Hepatology 50:1924\u20131935","journal-title":"Hepatology"},{"key":"1905_CR36","doi-asserted-by":"crossref","first-page":"482973","DOI":"10.1155\/2011\/482973","volume":"2011","author":"SJ Stohs","year":"2011","unstructured":"Stohs SJ, Preuss HG, Shara M (2011) A review of the receptor-binding properties of p-synephrine as related to its pharmacological effects. Oxid Med Cell Longev 2011:482973","journal-title":"Oxid Med Cell Longev"},{"issue":"11","key":"1905_CR37","doi-asserted-by":"crossref","first-page":"21858","DOI":"10.3390\/ijms141121858","volume":"14","author":"AL Oliveira de","year":"2013","unstructured":"de Oliveira AL, de Paula MN, Comar JF, Vilela VR, Peralta RM, Bracht A (2013) Adrenergic metabolic and hemodynamic effects of octopamine in the liver. Int J Mol Sci 14(11):21858\u201321872","journal-title":"Int J Mol Sci"},{"key":"1905_CR38","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/bjp.2008.124","volume":"154","author":"JR Docherty","year":"2008","unstructured":"Docherty JR (2008) Pharmacology of stimulants prohibited by the world anti-doping agency (WADA). Br J Pharmacol 154:606\u2013622","journal-title":"Br J Pharmacol"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-013-1905-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11010-013-1905-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-013-1905-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T20:21:51Z","timestamp":1647548511000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11010-013-1905-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,28]]},"references-count":38,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["1905"],"URL":"https:\/\/doi.org\/10.1007\/s11010-013-1905-2","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,28]]}}}