{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:13:54Z","timestamp":1791825234090,"version":"4.3.4"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2014,3,9]],"date-time":"2014-03-09T00:00:00Z","timestamp":1394323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1007\/s11010-014-2006-6","type":"journal-article","created":{"date-parts":[[2014,3,8]],"date-time":"2014-03-08T08:05:45Z","timestamp":1394265945000},"page":"225-232","source":"Crossref","is-referenced-by-count":140,"title":["Oxidative stress in rheumatoid arthritis patients: relationship to diseases activity"],"prefix":"10.1007","volume":"391","author":[{"given":"Mirjana","family":"Veselinovic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nevena","family":"Barudzic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Vuletic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Zivkovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Tomic-Lucic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragan","family":"Djuric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Jakovljevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,3,9]]},"reference":[{"key":"2006_CR1","first-page":"E427","volume":"14","author":"HS Smith","year":"2011","unstructured":"Smith HS, Smith AR, Seidner P (2011) Painful rheumatoid arthritis. Pain Physician 14:E427\u2013E458","journal-title":"Pain Physician"},{"key":"2006_CR2","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1056\/NEJMra1004965","volume":"365","author":"IB McInnes","year":"2011","unstructured":"McInnes IB, Schett G (2011) The pathogenesis of rheumatoid arthritis. N Engl J Med 365:2205\u20132219","journal-title":"N Engl J Med"},{"key":"2006_CR3","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1742-4658.2005.05103.x","volume":"273","author":"C Chinopoulos","year":"2006","unstructured":"Chinopoulos C, Adam-Vizi V (2006) Calcium, mitochondria and oxidative stress in neuronal pathology. Novel aspects of an enduring theme. FEBS J 273:433\u2013450","journal-title":"FEBS J"},{"key":"2006_CR4","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1093\/rheumatology\/kes193","volume":"51","author":"LK Stamp","year":"2012","unstructured":"Stamp LK, Khalilova I, Tarr JM, Senthilmohan R, Turner R, Haigh RC, Winyard PG, Kettle AJ (2012) Myeloperoxidase and oxidative stress in rheumatoid arthritis. Rheumatology (Oxford) 51:1796\u20131803","journal-title":"Rheumatology (Oxford)"},{"key":"2006_CR5","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1365-2249.2008.03634.x","volume":"152","author":"LI Filippin","year":"2008","unstructured":"Filippin LI, Vercelino R, Marroni NP, Xavier RM (2008) Redox signalling and the inflammatory response in rheumatoid arthritis. Clin Exp Immunol 152:415\u2013422","journal-title":"Clin Exp Immunol"},{"key":"2006_CR6","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1042\/BST0391226","volume":"39","author":"PG Winyard","year":"2011","unstructured":"Winyard PG, Ryan B, Eggleton P, Nissim A, Taylor E, Lo Faro ML, Burkholz T, Szab\u00f3-Taylor KE, Fox B, Viner N, Haigh RC, Benjamin N, Jones AM, Whiteman M (2011) Measurement and meaning of markers of reactive species of oxygen, nitrogen and sulfur in healthy human subjects and patients with inflammatory joint disease. Biochem Soc Trans 39:1226\u20131232","journal-title":"Biochem Soc Trans"},{"key":"2006_CR7","first-page":"7","volume":"45","author":"K Hadjigogos","year":"2003","unstructured":"Hadjigogos K (2003) The role of free radicals in the pathogenesis of rheumatoid arthritis. Panminerva Med 45:7\u201313","journal-title":"Panminerva Med"},{"issue":"1","key":"2006_CR8","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1756-185X.2009.01375.x","volume":"12","author":"P Vasanthi","year":"2009","unstructured":"Vasanthi P, Nalini G, Rajasekhar G (2009) Status of oxidative stress in rheumatoid arthritis. Int J Rheum Dis 12(1):29\u201333","journal-title":"Int J Rheum Dis"},{"issue":"3","key":"2006_CR9","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/ar3045","volume":"12","author":"G Nagy","year":"2010","unstructured":"Nagy G, Koncz A, Telarico T, Fernandez D, Ersek B, Buz\u00e1s E, Perl A (2010) Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus. Arthritis Res Ther 12(3):210","journal-title":"Arthritis Res Ther"},{"key":"2006_CR10","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s002960100105","volume":"20","author":"O Onur","year":"2001","unstructured":"Universidade Federal do Rio Grande do Sul, Onur O, Akinci AS, Akbiyik F, Unsal I (2001) Elevated levels of nitrate in rheumatoid arthritis. Rheumatol Int 20:154\u2013158","journal-title":"Rheumatol Int"},{"key":"2006_CR11","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0009-8981(03)00324-3","volume":"336","author":"JW Choi","year":"2003","unstructured":"Choi JW (2003) Nitric oxide production is increased in patients with rheumatoid arthritis but does not correlate with laboratory parameters of disease activity. Clin Chim Acta 336:83\u201387","journal-title":"Clin Chim Acta"},{"key":"2006_CR12","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/PL00011172","volume":"19","author":"MY Cimen","year":"2000","unstructured":"Cimen MY, Cimen OB, Kacmaz M, Ozturk HS, Yorgancioglu R, Durak I (2000) Oxidant\/antioxidant status of the erythrocytes from patients with rheumatoid arthritis. Clin Rheumatol 19:275\u2013277","journal-title":"Clin Rheumatol"},{"key":"2006_CR13","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1006\/bbrc.2000.2503","volume":"270","author":"M Nivsarkar","year":"2000","unstructured":"Nivsarkar M (2000) Improvement in circulating superoxide dismutase levels: role of nonsteroidal anti-inflammatory drugs in rheumatoid arthritis. Biochem Biophys Res Commun 270:714\u2013716","journal-title":"Biochem Biophys Res Commun"},{"key":"2006_CR14","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.jbspin.2007.02.002","volume":"74","author":"V Afonso","year":"2007","unstructured":"Afonso V, Champy R, Mitrovic D, Collin P, Lomri A (2007) Reactive oxygen species and superoxide dismutases: role in joint diseases. Joint Bone Spine 74:324\u2013329","journal-title":"Joint Bone Spine"},{"key":"2006_CR15","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","volume":"31","author":"FC Arnett","year":"1988","unstructured":"Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS et al (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315\u2013324","journal-title":"Arthritis Rheum"},{"key":"2006_CR16","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1136\/ard.2010.138461","volume":"69","author":"D Aletaha","year":"2010","unstructured":"Aletaha D, Neogi T, SIlman A, Funovits J, Felson DT et al (2010) 2010 rheumatoid arthritis classification criteria: an America college of rhuematology\/European League against Rheumatism collaborative initiative. Ann Rheum Dis 69:1580\u20131588","journal-title":"Ann Rheum Dis"},{"key":"2006_CR17","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/art.1780380107","volume":"38","author":"ML Prevoo","year":"1995","unstructured":"Prevoo ML, van\u2019t Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, van Riel PL (1995) Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 38:44\u201348","journal-title":"Arthritis Rheum"},{"issue":"12","key":"2006_CR18","doi-asserted-by":"crossref","first-page":"4041","DOI":"10.1007\/s00296-011-2135-0","volume":"32","author":"M Hirao","year":"2012","unstructured":"Hirao M, Yamasaki N, Oze H, Ebina K, Nampei A, Kawato Y, Shi K, Yoshikawa H, Nishimoto N, Hashimoto J (2012) Serum level of oxidative stress marker is dramatically low in patients with rheumatoid arthritis treated with tocilizumab. Rheumatol Int 32(12):4041\u20134045","journal-title":"Rheumatol Int"},{"issue":"7","key":"2006_CR19","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.3899\/jrheum.111401","volume":"39","author":"G Hjeltnes","year":"2012","unstructured":"Hjeltnes G, Hollan I, F\u00f8rre \u00d8, Wiik A, Lyberg T, Mikkelsen K, Agewall S (2012) Relations of serum COMP to cardiovascular risk factors and endothelial function in patients with rheumatoid arthritis treated with methotrexate and TNF-\u03b1 inhibitors. J Rheumatol 39(7):1341\u20131347","journal-title":"J Rheumatol"},{"key":"2006_CR20","first-page":"123","volume-title":"Handbook of methods for oxygen radical research","author":"C Auclair","year":"1985","unstructured":"Auclair C, Voisin E (1985) Nitroblue tetrazolium reduction. In: Greenvvald RA (ed) Handbook of methods for oxygen radical research. CRC Press, Boka Raton, pp 123\u2013132"},{"key":"2006_CR21","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0022-1759(80)90340-3","volume":"38","author":"E Pick","year":"1980","unstructured":"Pick E, Keisari Y (1980) A simple colorimetric method for the measurement of hydrogen peroxide produced by cells in culture. J Immunol Methods 38:161\u2013170","journal-title":"J Immunol Methods"},{"key":"2006_CR22","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","volume":"126","author":"LC Green","year":"1982","unstructured":"Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR (1982) Analysis of nitrate, nitrite and [15N] nitrate in biological fluids. Anal Biochem 126:131\u2013138","journal-title":"Anal Biochem"},{"key":"2006_CR23","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351\u2013358","journal-title":"Anal Biochem"},{"issue":"22","key":"2006_CR24","doi-asserted-by":"crossref","first-page":"6056","DOI":"10.1016\/S0021-9258(18)63505-7","volume":"244","author":"JM McCord","year":"1969","unstructured":"McCord JM, Fridovich I (1969) The utility of superoxide dismutase in studying free radical reactions. I. Radicals generated by the interaction of sulfite, dimethyl sulfoxide, and oxygen. J Biol Chem 244(22):6056\u20136063","journal-title":"J Biol Chem"},{"key":"2006_CR25","first-page":"105","volume-title":"Red cell metabolism, a manual of biochemical methods","author":"E Beutler","year":"1982","unstructured":"Beutler E (1982) Catalase. In: Beutler E (ed) Red cell metabolism, a manual of biochemical methods. Grune and Stratton, New York, pp 105\u2013106"},{"key":"2006_CR26","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","volume":"247","author":"HP Misra","year":"1972","unstructured":"Misra HP, Fridovich I (1972) The role of superoxide-anion in the autooxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 247:3170\u20133175","journal-title":"J Biol Chem"},{"key":"2006_CR27","first-page":"112","volume-title":"Red cell metabolism: a manual of biochemical methods","author":"E Beutler","year":"1975","unstructured":"Beutler E (1975) Reduced glutathione\u2014GSH. In: Beutler E (ed) Red cell metabolism: a manual of biochemical methods. Grane and Straton, New York, pp 112\u2013114"},{"key":"2006_CR28","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s00296-001-0163-x","volume":"21","author":"S Taysi","year":"2002","unstructured":"Taysi S, Polat F, Gul M, Sari RA, Bakan E (2002) Lipid peroxidation, some extracellular anti-oxidants, and anti-oxidant enzymes in serum of patients with rheumatoid arthritis. Rheumatol Int 21:200\u2013204","journal-title":"Rheumatol Int"},{"issue":"4","key":"2006_CR29","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/cbf.1257","volume":"24","author":"G Baskol","year":"2006","unstructured":"Baskol G, Demir H, Baskol M, Kilic E, Ates F, Karakukcu C, Ustdal M (2006) Investigation of protein oxidation and lipid peroxidation in patients with rheumatoid arthritis. Cell Biochem Funct 24(4):307\u2013311","journal-title":"Cell Biochem Funct"},{"key":"2006_CR30","first-page":"230","volume":"23","author":"Y Ueki","year":"1996","unstructured":"Ueki Y, Miyake S, Tominaga Y, Eguchi K (1996) Increased nitric oxide levels in patients with rheumatoid arthritis. J Rheumatol 23:230\u2013236","journal-title":"J Rheumatol"},{"key":"2006_CR31","first-page":"2529","volume":"30","author":"TN Pham","year":"2003","unstructured":"Pham TN, Rahman P, Tobin YM, Khraishi MM, Hamilton SF, Alderdice C, Richardson VJ (2003) Elevated serum nitric oxide levels in patients with inflammatory arthritis associated with co-expression of inducible nitricoxide synthase and protein kinase C-eta in peripheral blood monocyte derived macrophages. J Rheumatol 30:2529\u20132534","journal-title":"J Rheumatol"},{"key":"2006_CR32","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S0161-5890(01)00113-4","volume":"38","author":"T Jikimoto","year":"2002","unstructured":"Jikimoto T, Nishikubo Y, Koshiba M et al (2002) Thioredoxin as a biomarker for oxidative stress in patients with rheumatoid arthritis. Mol Immunol 38:765\u2013772","journal-title":"Mol Immunol"},{"issue":"12","key":"2006_CR33","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.3109\/10715762.2012.727991","volume":"46","author":"S Kundu","year":"2012","unstructured":"Kundu S, Ghosh P, Datta S, Ghosh A, Chattopadhyay S, Chatterjee M (2012) Oxidative stress as a potential biomarker for determining disease activity in patients with rheumatoid arthritis. Free Radical Res 46(12):1482\u20131489","journal-title":"Free Radical Res"},{"issue":"4","key":"2006_CR34","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1756-185X.2011.01630.x","volume":"14","author":"SZ Hassan","year":"2011","unstructured":"Hassan SZ, Gheita TA, Kenawy SA, Fahim AT, El-Sorougy IM, Abdou MS (2011) Oxidative stress in systemic lupus erythematosus and rheumatoid arthritis patients: relationship to disease manifestations and activity. Int J Rheum Dis 14(4):325\u2013331","journal-title":"Int J Rheum Dis"},{"key":"2006_CR35","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.clinbiochem.2006.10.006","volume":"40","author":"O Altindag","year":"2007","unstructured":"Altindag O, Karakoc M, Kocyigit A, Celik H, Soran N (2007) Increased DNA damage and oxidative stress in patients with rheumatoid arthritis. Clin Biochem 40:167\u2013171","journal-title":"Clin Biochem"},{"key":"2006_CR36","first-page":"178","volume":"118","author":"F Karatas","year":"2003","unstructured":"Karatas F, Ozates I, Canatan H, Halifeoglu I, Karatepe M, Colakt R (2003) Antioxidant status and lipid peroxidation in patients with rheumatoid arthritis. Indian J Med Res 118:178\u2013181","journal-title":"Indian J Med Res"},{"issue":"4","key":"2006_CR37","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/BF02602957","volume":"26","author":"I Mazzetti","year":"1996","unstructured":"Mazzetti I, Grigolo B, Borz\u00ec RM, Meliconi R, Facchini A (1996) Serum copper\/zinc superoxide dismutase levels in patients with rheumatoid arthritis. Int J Clin Lab Res 26(4):245\u2013249","journal-title":"Int J Clin Lab Res"},{"issue":"2","key":"2006_CR38","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s10067-007-0746-3","volume":"27","author":"B Kalpakcioglu","year":"2008","unstructured":"Kalpakcioglu B, Senel K (2008) The interrelation of glutathione reductase, catalase, glutathione peroxidase, superoxide dismutase, and glucose-6-phosphate in the pathogenesis of rheumatoid arthritis. Clin Rheumatol 27(2):141\u2013145","journal-title":"Clin Rheumatol"},{"key":"2006_CR39","first-page":"2245","volume":"29","author":"ME Leo De","year":"2002","unstructured":"De Leo ME, Tranghese A, Passantino M, Mordente A, Lizzio MM, Galeotti T, Zoli A (2002) Manganese superoxide dismutase, glutathione peroxidase, and total radical trapping antioxidant capacity in active rheumatoid arthritis. J Rheumatol 29:2245\u20132246","journal-title":"J Rheumatol"},{"issue":"11","key":"2006_CR40","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1007\/s10067-012-2046-9","volume":"31","author":"GA Jacobson","year":"2012","unstructured":"Jacobson GA, Ives SJ, Narkowicz C, Jones G (2012) Plasma glutathione peroxidase (GSH-Px) concentration is elevated in rheumatoid arthritis: a case-control study. Clin Rheumatol 31(11):1543\u20131547","journal-title":"Clin Rheumatol"},{"issue":"2","key":"2006_CR41","first-page":"330","volume":"15","author":"I Zelen","year":"2010","unstructured":"Zelen I, Djurdjevic P, Popovic S, Stojanovic M, Jakovljevic V, Radivojevic S, Baskic D, Arsenijevic N (2010) Antioxidant enzymes activities and plasma levels of oxidative stress markers in B-chronic lymphocytic leukemia patients. J BUON 15(2):330\u2013336","journal-title":"J BUON"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-014-2006-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11010-014-2006-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-014-2006-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T07:21:56Z","timestamp":1648538516000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11010-014-2006-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,9]]},"references-count":41,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["2006"],"URL":"https:\/\/doi.org\/10.1007\/s11010-014-2006-6","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,9]]}}}