{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T10:06:40Z","timestamp":1776334000831,"version":"3.51.2"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1007\/s11010-014-2112-5","type":"journal-article","created":{"date-parts":[[2014,5,31]],"date-time":"2014-05-31T14:58:27Z","timestamp":1401548307000},"page":"65-76","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Carvacrol modulates instability of xenobiotic metabolizing enzymes and downregulates the expressions of PCNA, MMP-2, and MMP-9 during diethylnitrosamine-induced hepatocarcinogenesis in rats"],"prefix":"10.1007","volume":"395","author":[{"given":"Jayakumar","family":"Subramaniyan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gokuladhas","family":"Krishnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajan","family":"Balan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divya","family":"MGJ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elamaran","family":"Ramasamy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenbhagaraman","family":"Ramalingam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramakrishnan","family":"Veerabathiran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Premkumar","family":"Thandavamoorthy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gopi Krishnan","family":"Mani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devaki","family":"Thiruvengadam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,6,1]]},"reference":[{"key":"2112_CR1","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1053\/j.gastro.2007.04.061","volume":"132","author":"HB El-Serag","year":"2007","unstructured":"El-Serag HB, Rudolph KL (2007) Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 132:2557\u20132576","journal-title":"Gastroenterology"},{"key":"2112_CR2","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1093\/carcin\/bgp263","volume":"31","author":"J Michael","year":"2010","unstructured":"Michael J, John Oliver DeLancey, Melissa M, Jemal Ahmedin, Elizabeth M (2010) The global burden of cancer: priorities for prevention. Carcinogenesis 31:100\u2013110","journal-title":"Carcinogenesis"},{"key":"2112_CR3","unstructured":"Loeppky RN (1994) Nitrosamine and Nitroso compound chemistry and biochemistry. ACS Symposium series 553. American Chemical Society, Washington, pp 1\u201312"},{"key":"2112_CR4","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1080\/15428119691014431","volume":"57","author":"BD Reh","year":"1996","unstructured":"Reh BD, Fajen JM (1996) Worker exposures to nitrosamines in a rubber vehicle sealing plant. Am Ind Hyg Assoc J 57:918\u2013923","journal-title":"Am Ind Hyg Assoc J"},{"key":"2112_CR5","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0163-7258(96)00062-9","volume":"71","author":"L Verna","year":"1996","unstructured":"Verna L, Whysner J, Williams GM (1996) N-nitrosodiethylamine mechanistic data and risk assessment: bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation. Pharm Ther 71:57\u201381","journal-title":"Pharm Ther"},{"issue":"6","key":"2112_CR6","first-page":"1839","volume":"4","author":"M Daisy Glory","year":"2011","unstructured":"Daisy Glory M, Devaki T (2011) Chrysin attenuates the instability of xenobiotic metabolizing and mitochondrial enzymes during diethyl nitrosamine induced liver carcinoma. J Pharm Res 4(6):1839\u20131842","journal-title":"J Pharm Res"},{"issue":"2","key":"2112_CR7","doi-asserted-by":"crossref","first-page":"S219","DOI":"10.1079\/BJN2002686","volume":"88","author":"JJ Rafter","year":"2002","unstructured":"Rafter JJ (2002) Scientific basis of biomarkers and benefits of functional foods for reduction of disease risk: cancer. Br J Nutr 88(2):S219\u2013S224","journal-title":"Br J Nutr"},{"key":"2112_CR8","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0955-2863(02)00251-6","volume":"14","author":"G Loo","year":"2003","unstructured":"Loo G (2003) Redox-sensitive mechanisms of phytochemical mediated inhibition of cancer cell proliferation. J Nutr Biochem 14:64\u201373","journal-title":"J Nutr Biochem"},{"key":"2112_CR9","first-page":"100","volume":"54","author":"CC Arcila-Lozano","year":"2004","unstructured":"Arcila-Lozano CC, Loarca-Pina G, Lecona-Uribe S, Gonzalez de Mejia E (2004) Oregano: properties, composition and biological activity. Arch Latinoam Nutr 54:100\u2013111","journal-title":"Arch Latinoam Nutr"},{"key":"2112_CR10","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.fitote.2004.05.002","volume":"75","author":"M Vincenzi De","year":"2004","unstructured":"De Vincenzi M, Stammati A, De Vincenzi A, Silano M (2004) Constituents of aromatic plants: carvacrol. Fitoterapia 75:801\u2013804","journal-title":"Fitoterapia"},{"key":"2112_CR11","doi-asserted-by":"crossref","first-page":"620","DOI":"10.4315\/0362-028X-63.5.620","volume":"63","author":"A Ultee","year":"2000","unstructured":"Ultee A, Slump RA, Steging G, Smid EJ (2000) Antimicrobial activity of carvacrol toward Bacillus cereus on rice. J Food Prot 63:620\u2013624","journal-title":"J Food Prot"},{"key":"2112_CR12","doi-asserted-by":"crossref","first-page":"8255","DOI":"10.1021\/jf049033e","volume":"52","author":"I Dadalioglu","year":"2004","unstructured":"Dadalioglu I, Evrendilek GA (2004) Chemical compositions and antibacterial effects of essential oils of Turkish oregano (Origanum minutiflorum), bay laurel (Laurus nobilis), Spanish lavender (Lavandula stoechas L.), and fennel (Foeniculum vulgare) on common foodborne pathogens. J Agric Food Chem 52:8255\u20138260","journal-title":"J Agric Food Chem"},{"key":"2112_CR13","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1248\/bpb.26.1725","volume":"26","author":"MH Alma","year":"2003","unstructured":"Alma MH, Mavi A, Yildirim A (2003) Screening chemical composition and in vitro antioxidant and antimicrobial activities of the essential oils from Origanum syriacum L. growing in Turkey. Biol Pharm Bul 26:1725\u20131729","journal-title":"Biol Pharm Bul"},{"key":"2112_CR14","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1055\/s-2000-9773","volume":"66","author":"G Ruberto","year":"2000","unstructured":"Ruberto G, Baratta MT, Deans SG, Dorman HJ (2000) Antioxidant and antimicrobial activity of Foeniculum vulgare and Crithmum maritimum essential oils. Planta Med 66:687\u2013693","journal-title":"Planta Med"},{"key":"2112_CR15","first-page":"84","volume":"10","author":"S Karkabounas","year":"1996","unstructured":"Karkabounas S, Sofis G, Evangelou A (1996) Implication of free radicals in platelet aggregation: antiplatelet effects of free radical scavengers ex vivo. Epith Klin Farmacol Farmakokin 10:84\u201391","journal-title":"Epith Klin Farmacol Farmakokin"},{"key":"2112_CR16","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0304-3835(97)04712-5","volume":"115","author":"A Evangelou","year":"1997","unstructured":"Evangelou A, Kalpouzos G, Karkabounas S (1997) Dose-related preventive and therapeutic effects of antioxidants and anticarcinogens on experimentally induced malignant tumors in wistar rats. Cancer Lett 115:105\u2013111","journal-title":"Cancer Lett"},{"key":"2112_CR17","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.phymed.2009.12.008","volume":"17","author":"KM Arunasree","year":"2010","unstructured":"Arunasree KM (2010) Anti-proliferative effects of carvacrol on a human metastatic breast cancer cell line, MDA-MB 231. Phytomedicine 17:581\u2013588. doi: 10.1016\/j.phymed.2009.12.008","journal-title":"Phytomedicine"},{"key":"2112_CR18","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1023\/B:CYTO.0000039917.60348.45","volume":"43","author":"AT Koparal","year":"2003","unstructured":"Koparal AT, Zeytinoglu M (2003) Effects of carvacrol on a human non-small cell lung cancer (NSCLC) cell line, A549. Cytotechnology 43:149\u2013154. doi: 10.1023\/B:CYTO.0000039917.60348.45","journal-title":"Cytotechnology"},{"key":"2112_CR19","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s11010-009-0151-0","volume":"331","author":"P Anandakumar","year":"2009","unstructured":"Anandakumar P, Kamaraj S, Jagan S, Ramakrishnan G, Naveenkumar C, Asokkumar S, Devaki T (2009) Capsaicin alleviates the imbalance in xenobiotic metabolizing enzymes and tumor markers during experimental lung tumorigenesis. Mol Cell Biochem 331:135\u2013143. doi: 10.1007\/s11010-009-0151-0","journal-title":"Mol Cell Biochem"},{"key":"2112_CR20","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265\u2013275","journal-title":"J Biol Chem"},{"key":"2112_CR21","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1016\/S0021-9258(20)82245-5","volume":"239","author":"T Omura","year":"1964","unstructured":"Omura T, Sato R (1964) The carbon monoxide-binding pigment of liver microsomes. II. Solubilization, purification, and properties. J Biol Chem 239:2379\u20132380","journal-title":"J Biol Chem"},{"key":"2112_CR22","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1016\/S0021-9258(19)73803-4","volume":"237","author":"AH Phillips","year":"1962","unstructured":"Phillips AH, Langdon RG (1962) Hepatic triphosphopyridine nucleotide-cytochrome c reductase: isolation, characterization, and kinetic studies. J Biol Chem 237:2652\u20132660","journal-title":"J Biol Chem"},{"key":"2112_CR23","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0021-9258(18)65247-0","volume":"221","author":"P Strittmatter","year":"1956","unstructured":"Strittmatter P, Velick SF (1956) A microsomal cytochrome reductase specific for diphosphopyridine nucleotide. J Biol Chem 221:277\u2013286","journal-title":"J Biol Chem"},{"key":"2112_CR24","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","volume":"249","author":"WH Habig","year":"1974","unstructured":"Habig WH, Pabst MJ, Jakoby WB (1974) Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 249:7130\u20137139","journal-title":"J Biol Chem"},{"key":"2112_CR25","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/0006-2952(83)90610-X","volume":"32","author":"KW Bock","year":"1983","unstructured":"Bock KW, Burchell B, Dutton GJ (1983) UDP-glucuronosyltransferase activities. Guidelines for consistent interim terminology and assay conditions. Biochem Pharmacol 32:953\u2013955","journal-title":"Biochem Pharmacol"},{"key":"2112_CR26","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/bjc.1978.162","volume":"38","author":"GM Macnab","year":"1978","unstructured":"Macnab GM, Urbanowicz JM, Kew MC (1978) Carcinoembryonic antigen in hepatocellular cancer. Br J Cancer 38:51\u201354","journal-title":"Br J Cancer"},{"key":"2112_CR27","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/jnci\/60.1.19","volume":"60","author":"S Sell","year":"1978","unstructured":"Sell S, Becker FF (1978) Alpha-Fetoprotein. J Natl Cancer Inst 60:19\u201326","journal-title":"J Natl Cancer Inst"},{"key":"2112_CR28","first-page":"107","volume":"140","author":"M Aubele","year":"1994","unstructured":"Aubele M, Biesterfeld S, Derenzini M (1994) Guidelines of AgNOR quantitation. Committee on AgNOR quantitation within the European Society of Pathology. Zentralbl Pathol 140:107\u2013108","journal-title":"Zentralbl Pathol"},{"key":"2112_CR29","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.ctrv.2007.01.008","volume":"33","author":"N Voorzanger-Rousselot","year":"2007","unstructured":"Voorzanger-Rousselot N, Garnero P (2007) Biochemical markers in oncology. Part I: molecular basis. Part II: clinical uses. Cancer Treat Rev 33:230\u2013283","journal-title":"Cancer Treat Rev"},{"key":"2112_CR30","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0959-8049(01)00350-1","volume":"38","author":"F Bray","year":"2002","unstructured":"Bray F, Sankila R, Ferlay J, Parkin DM (2002) Estimates of cancer incidence and mortality in Europe in 1995. Eur J Cancer 38:99\u2013166","journal-title":"Eur J Cancer"},{"key":"2112_CR31","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0169-5002(00)00205-1","volume":"32","author":"T Shibayama","year":"2001","unstructured":"Shibayama T, Ueoka H, Nishii K (2001) Complementary roles of pro-gastrin-releasing peptide (ProGRP) and neuron specific enolase (NSE) in diagnosis and prognosis of small-cell lung cancer (SCLC). Lung Cancer 32:61\u201369","journal-title":"Lung Cancer"},{"key":"2112_CR32","first-page":"165","volume":"23","author":"H Zheng","year":"2003","unstructured":"Zheng H, He BF, Luo RC (2003) Diagnostic value of combined detection of TPS, NSE and CEA in lung cancer. Di Yi Jun Yi Da Xue Xue Bao 23:165\u2013166","journal-title":"Di Yi Jun Yi Da Xue Xue Bao"},{"key":"2112_CR33","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1136\/thx.40.2.85","volume":"40","author":"T Esscher","year":"1985","unstructured":"Esscher T, Steinholtz L, Bergh J (1985) Neurone specific enolase: a useful diagnostic serum marker for small cell carcinoma of the lung. Thorax 40:85\u201390","journal-title":"Thorax"},{"key":"2112_CR34","first-page":"511","volume":"57","author":"DD Banker","year":"2003","unstructured":"Banker DD (2003) Viral hepatitis (Part-IV). Indian J Med Sci 57:511\u2013517","journal-title":"Indian J Med Sci"},{"key":"2112_CR35","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.cbi.2008.01.010","volume":"172","author":"P Srinivasan","year":"2008","unstructured":"Srinivasan P, Suchalatha S, Babu PV, Devi RS, Narayan S, Sabitha KE, Shyamala Devi CS (2008) Chemopreventive and therapeutic modulation of green tea polyphenols on drug metabolizing enzymes in 4-Nitroquinoline 1-oxide induced oral cancer. Chem Biol Interact 172:224\u2013234. doi: 10.1016\/j.cbi.2008.01.010","journal-title":"Chem Biol Interact"},{"key":"2112_CR36","first-page":"223","volume":"24","author":"R Subapriya","year":"2005","unstructured":"Subapriya R, Velmurugan B, Nagini S (2005) Modulation of xenobiotic-metabolizing enzymes by ethanolic neem leaf extract during hamster buccal pouch carcinogenesis. J Exp Clin Cancer Res 24:223\u2013230","journal-title":"J Exp Clin Cancer Res"},{"key":"2112_CR37","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1054\/drup.1999.0083","volume":"2","author":"LI McLellan","year":"1999","unstructured":"McLellan LI, Wolf CR (1999) Glutathione and glutathione-dependent enzymes in cancer drug resistance. Drug Resist Updat 2:153\u2013164","journal-title":"Drug Resist Updat"},{"key":"2112_CR38","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/ijc.1193","volume":"92","author":"Y Hiraku","year":"2001","unstructured":"Hiraku Y, Yamashita N, Nishiguchi M, Kawanishi S (2001) Catechol estrogens induce oxidative DNA damage and estradiol enhances cell proliferation. Int J Cancer 92:333\u2013337","journal-title":"Int J Cancer"},{"key":"2112_CR39","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3748\/wjg.v8.i3.385","volume":"8","author":"LX Qin","year":"2002","unstructured":"Qin LX, Tang ZY (2002) The prognostic molecular markers in hepatocellular carcinoma. World J Gastroenterol 8:385\u2013392","journal-title":"World J Gastroenterol"},{"key":"2112_CR40","first-page":"582","volume":"52","author":"JW Lamberti","year":"1977","unstructured":"Lamberti JW, Chapel JL (1977) Development and evaluation of a sex education program for medical students. J Med Educ 52:582\u2013586","journal-title":"J Med Educ"},{"key":"2112_CR41","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1002\/1097-0142(19940501)73:9<2268::AID-CNCR2820730906>3.0.CO;2-O","volume":"73","author":"IO Ng","year":"1994","unstructured":"Ng IO, Lai EC, Fan ST (1994) Prognostic significance of proliferating cell nuclear antigen expression in hepatocellular carcinoma. Cancer 73:2268\u20132274","journal-title":"Cancer"},{"key":"2112_CR42","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1016\/j.lfs.2005.11.015","volume":"78","author":"T Chakraborty","year":"2006","unstructured":"Chakraborty T, Chatterjee A, Saralaya MG (2006) Vanadium inhibits the development of 2-acetylaminofluorene-induced premalignant phenotype in a two-stage chemical rat hepatocarcinogenesis model. Life Sci 78:2839\u20132851","journal-title":"Life Sci"},{"key":"2112_CR43","doi-asserted-by":"crossref","first-page":"4531","DOI":"10.1073\/pnas.73.12.4531","volume":"73","author":"OJ Miller","year":"1976","unstructured":"Miller OJ, Miller DA, Dev VG (1976) Expression of human and suppression of mouse nucleolus organizer activity in mouse-human somatic cell hybrids. Proc Natl Acad Sci USA 73:4531\u20134535","journal-title":"Proc Natl Acad Sci USA"},{"key":"2112_CR44","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1177\/38.12.1701461","volume":"38","author":"FJ Moreno","year":"1990","unstructured":"Moreno FJ, Rodrigo RM, Garcia-Herdugo G (1990) AgNOR proteins and rDNA transcriptional activity in plant cells. J Histochem Cytochem 38:1879\u20131887","journal-title":"J Histochem Cytochem"},{"key":"2112_CR45","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s11010-008-9876-4","volume":"319","author":"S Jagan","year":"2008","unstructured":"Jagan S, Ramakrishnan G, Anandakumar P, Kamaraj S, Devaki T (2008) Antiproliferative potential of gallic acid against diethylnitrosamine-induced rat hepatocellular carcinoma. Mol Cell Biochem 319:51\u201359. doi: 10.1007\/s11010-008-9876-4","journal-title":"Mol Cell Biochem"},{"key":"2112_CR46","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/0952-7915(93)90109-6","volume":"5","author":"T Ishizaka","year":"1993","unstructured":"Ishizaka T, Mitsui H, Yanagida M (1993) Development of human mast cells from their progenitors. Curr Opin Immunol 5:937\u2013943","journal-title":"Curr Opin Immunol"},{"key":"2112_CR47","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.dld.2010.02.016","volume":"42","author":"H Francis","year":"2010","unstructured":"Francis H, Meininger CJ (2010) A review of mast cells and liver disease: what have we learned? Dig Liver Dis 42:529\u2013536. doi: 10.1016\/j.dld.2010.02.016","journal-title":"Dig Liver Dis"},{"key":"2112_CR48","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1002\/1097-0142(20000615)88:12<2686::AID-CNCR6>3.0.CO;2-6","volume":"88","author":"I Takanami","year":"2000","unstructured":"Takanami I, Takeuchi K, Naruke M (2000) Mast cell density is associated with angiogenesis and poor prognosis in pulmonary adenocarcinoma. Cancer 88:2686\u20132692","journal-title":"Cancer"},{"key":"2112_CR49","doi-asserted-by":"crossref","first-page":"9291","DOI":"10.1074\/jbc.M410396200","volume":"280","author":"E Tchougounova","year":"2005","unstructured":"Tchougounova E, Lundequist A, Fajardo I (2005) A key role for mast cell chymase in the activation of pro-matrix metalloprotease-9 and pro-matrix metalloprotease-2. J Biol Chem 280:9291\u20139296","journal-title":"J Biol Chem"},{"key":"2112_CR50","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nrc745","volume":"2","author":"M Egeblad","year":"2002","unstructured":"Egeblad M, Werb Z (2002) New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2:161\u2013174","journal-title":"Nat Rev Cancer"},{"key":"2112_CR51","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1126\/science.1067100","volume":"295","author":"LM Coussens","year":"2002","unstructured":"Coussens LM, Fingleton B, Matrisian LM (2002) Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science 295:2387\u20132392","journal-title":"Science"},{"key":"2112_CR52","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0092-8674(00)80108-7","volume":"86","author":"D Hanahan","year":"1996","unstructured":"Hanahan D, Folkman J (1996) Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86:353\u2013364","journal-title":"Cell"},{"key":"2112_CR53","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1093\/jnci\/89.17.1260","volume":"89","author":"AF Chambers","year":"1997","unstructured":"Chambers AF, Matrisian LM (1997) Changing views of the role of matrix metalloproteinases in metastasis. J Natl Cancer Inst 89:1260\u20131270","journal-title":"J Natl Cancer Inst"},{"key":"2112_CR54","first-page":"551","volume":"9","author":"JE Rundhaug","year":"2003","unstructured":"Rundhaug JE (2003) Matrix metalloproteinases, angiogenesis, and cancer: commentary re: A. C. Lockhart et al., Reduction of wound angiogenesis in patients treated with BMS-275291, a broad spectrum matrix metalloproteinase inhibitor. Clin Cancer Res 9:551\u2013554","journal-title":"Clin Cancer Res"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-014-2112-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11010-014-2112-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-014-2112-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T10:15:55Z","timestamp":1649153755000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11010-014-2112-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,1]]},"references-count":54,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["2112"],"URL":"https:\/\/doi.org\/10.1007\/s11010-014-2112-5","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,1]]}}}