{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:04:10Z","timestamp":1787771050191,"version":"build-2784847793"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2014,8,23]],"date-time":"2014-08-23T00:00:00Z","timestamp":1408752000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1007\/s11010-014-2199-8","type":"journal-article","created":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T08:39:22Z","timestamp":1408696762000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Hepatic stellate cell is activated by microRNA-181b via PTEN\/Akt pathway"],"prefix":"10.1007","volume":"398","author":[{"given":"Jianjian","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cunzao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peihong","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bicheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fujun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,8,23]]},"reference":[{"issue":"5","key":"2199_CR1","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/S0168-8278(98)80269-9","volume":"29","author":"E Olaso","year":"1998","unstructured":"Olaso E, Friedman SL (1998) Molecular regulation of hepatic fibrogenesis. J Hepatol 29(5):836\u2013847","journal-title":"J Hepatol"},{"issue":"9","key":"2199_CR2","doi-asserted-by":"crossref","first-page":"e24568","DOI":"10.1371\/journal.pone.0024568","volume":"6","author":"M Kwiecinski","year":"2011","unstructured":"Kwiecinski M, Noetel A, Elfimova N, Trebicka J, Schievenbusch S, Strack I, Molnar L, von Brandenstein M, Tox U, Nischt R, Coutelle O, Dienes HP, Odenthal M (2011) Hepatocyte growth factor (HGF) inhibits collagen I and IV synthesis in hepatic stellate cells by miRNA-29 induction. PLoS ONE 6(9):e24568. doi: 10.1371\/journal.pone.0024568","journal-title":"PLoS ONE"},{"issue":"5","key":"2199_CR3","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.biopha.2013.03.014","volume":"67","author":"J Wei","year":"2013","unstructured":"Wei J, Feng L, Li Z, Xu G, Fan X (2013) MicroRNA-21 activates hepatic stellate cells via PTEN\/Akt signaling. Biomed Pharmacother 67(5):387\u2013392. doi: 10.1016\/j.biopha.2013.03.014","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"2199_CR4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1152\/physrev.00013.2007","volume":"88","author":"SL Friedman","year":"2008","unstructured":"Friedman SL (2008) Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev 88(1):125\u2013172. doi: 10.1152\/physrev.00013.2007","journal-title":"Physiol Rev"},{"issue":"1\u20132","key":"2199_CR5","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/S0014-5793(01)02656-4","volume":"502","author":"S Dooley","year":"2001","unstructured":"Dooley S, Delvoux B, Streckert M, Bonzel L, Stopa M, ten Dijke P, Gressner AM (2001) Transforming growth factor beta signal transduction in hepatic stellate cells via Smad2\/3 phosphorylation, a pathway that is abrogated during in vitro progression to myofibroblasts. TGFbeta signal transduction during transdifferentiation of hepatic stellate cells. FEBS Lett 502(1\u20132):4\u201310","journal-title":"FEBS Lett"},{"issue":"1","key":"2199_CR6","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.cell.2005.06.036","volume":"122","author":"CM Croce","year":"2005","unstructured":"Croce CM, Calin GA (2005) miRNAs, cancer, and stem cell division. Cell 122(1):6\u20137. doi: 10.1016\/j.cell.2005.06.036","journal-title":"Cell"},{"issue":"2","key":"2199_CR7","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","volume":"116","author":"DP Bartel","year":"2004","unstructured":"Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116(2):281\u2013297","journal-title":"Cell"},{"issue":"4","key":"2199_CR8","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.febslet.2009.01.034","volume":"583","author":"J Ji","year":"2009","unstructured":"Ji J, Zhang J, Huang G, Qian J, Wang X, Mei S (2009) Over-expressed microRNA-27a and 27b influence fat accumulation and cell proliferation during rat hepatic stellate cell activation. FEBS Lett 583(4):759\u2013766. doi: 10.1016\/j.febslet.2009.01.034","journal-title":"FEBS Lett"},{"issue":"4","key":"2199_CR9","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.jhep.2008.11.025","volume":"50","author":"CJ Guo","year":"2009","unstructured":"Guo CJ, Pan Q, Li DG, Sun H, Liu BW (2009) miR-15b and miR-16 are implicated in activation of the rat hepatic stellate cell: an essential role for apoptosis. J Hepatol 50(4):766\u2013778. doi: 10.1016\/j.jhep.2008.11.025","journal-title":"J Hepatol"},{"issue":"1","key":"2199_CR10","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/hep.25613","volume":"56","author":"AM Lakner","year":"2012","unstructured":"Lakner AM, Steuerwald NM, Walling TL, Ghosh S, Li T, McKillop IH, Russo MW, Bonkovsky HL, Schrum LW (2012) Inhibitory effects of microRNA 19b in hepatic stellate cell-mediated fibrogenesis. Hepatology 56(1):300\u2013310. doi: 10.1002\/hep.25613","journal-title":"Hepatology"},{"key":"2199_CR11","author":"J Zheng","year":"2013","unstructured":"Zheng J, Wu C, Lin Z, Guo Y, Shi L, Dong P, Lu Z, Gao S, Liao Y, Chen B, Yu F (2013) Curcumin up-regulates phosphatase and tensin homologue deleted on chromosome 10 through microRNA-mediated control of DNA methylation\u2014a novel mechanism suppressing liver fibrosis. FEBS J. doi: 10.1111\/febs.12574","journal-title":"FEBS J"},{"issue":"1","key":"2199_CR12","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.bbrc.2012.03.025","volume":"421","author":"B Wang","year":"2012","unstructured":"Wang B, Li W, Guo K, Xiao Y, Wang Y, Fan J (2012) miR-181b promotes hepatic stellate cells proliferation by targeting p27 and is elevated in the serum of cirrhosis patients. Biochem Biophys Res Commun 421(1):4\u20138. doi: 10.1016\/j.bbrc.2012.03.025","journal-title":"Biochem Biophys Res Commun"},{"key":"2199_CR13","doi-asserted-by":"crossref","unstructured":"Yao QY, Xu BL, Wang JY, Liu HC, Zhang SC, Tu CT (2012) Inhibition by curcumin of multiple sites of the transforming growth factor-beta1 signalling pathway ameliorates the progression of liver fibrosis induced by carbon tetrachloride in rats. BMC Complement Altern Med 12(156). doi: 10.1186\/1472-6882-12-156","DOI":"10.1186\/1472-6882-12-156"},{"issue":"1","key":"2199_CR14","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3892\/ijmm.2013.1356","volume":"32","author":"J Zheng","year":"2013","unstructured":"Zheng J, Lin Z, Dong P, Lu Z, Gao S, Chen X, Wu C, Yu F (2013) Activation of hepatic stellate cells is suppressed by microRNA-150. Int J Mol Med 32(1):17\u201324. doi: 10.3892\/ijmm.2013.1356","journal-title":"Int J Mol Med"},{"issue":"6","key":"2199_CR15","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","volume":"3","author":"TD Schmittgen","year":"2008","unstructured":"Schmittgen TD, Livak KJ (2008) Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 3(6):1101\u20131108","journal-title":"Nat Protoc"},{"issue":"1","key":"2199_CR16","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1136\/gut.2004.042127","volume":"54","author":"L Xu","year":"2005","unstructured":"Xu L, Hui AY, Albanis E, Arthur MJ, O\u2019Byrne SM, Blaner WS, Mukherjee P, Friedman SL, Eng FJ (2005) Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis. Gut 54(1):142\u2013151. doi: 10.1136\/gut.2004.042127","journal-title":"Gut"},{"issue":"3","key":"2199_CR17","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1055\/s-2001-17556","volume":"21","author":"D Schuppan","year":"2001","unstructured":"Schuppan D, Ruehl M, Somasundaram R, Hahn EG (2001) Matrix as a modulator of hepatic fibrogenesis. Semin Liver Dis 21(3):351\u2013372. doi: 10.1055\/s-2001-17556","journal-title":"Semin Liver Dis"},{"issue":"1","key":"2199_CR18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.taap.2012.06.022","volume":"264","author":"EB Bian","year":"2012","unstructured":"Bian EB, Huang C, Ma TT, Tao H, Zhang H, Cheng C, Lv XW, Li J (2012) DNMT1-mediated PTEN hypermethylation confers hepatic stellate cell activation and liver fibrogenesis in rats. Toxicol Appl Pharmacol 264(1):13\u201322. doi: 10.1016\/j.taap.2012.06.022","journal-title":"Toxicol Appl Pharmacol"},{"issue":"1","key":"2199_CR19","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/febs.12574","volume":"281","author":"J Zheng","year":"2014","unstructured":"Zheng J, Wu C, Lin Z, Guo Y, Shi L, Dong P, Lu Z, Gao S, Liao Y, Chen B, Yu F (2014) Curcumin up-regulates phosphatase and tensin homologue deleted on chromosome 10 through microRNA-mediated control of DNA methylation\u2014a novel mechanism suppressing liver fibrosis. FEBS J 281(1):88\u2013103. doi: 10.1111\/febs.12574","journal-title":"FEBS J"},{"issue":"Suppl 1","key":"2199_CR20","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1111\/j.1440-1746.2006.04659.x","volume":"22","author":"CJ Parsons","year":"2007","unstructured":"Parsons CJ, Takashima M, Rippe RA (2007) Molecular mechanisms of hepatic fibrogenesis. J Gastroenterol Hepatol 22(Suppl 1):S79\u2013S84. doi: 10.1111\/j.1440-1746.2006.04659.x","journal-title":"J Gastroenterol Hepatol"},{"issue":"12","key":"2199_CR21","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1016\/j.cellsig.2012.07.023","volume":"24","author":"Y He","year":"2012","unstructured":"He Y, Huang C, Zhang SP, Sun X, Long XR, Li J (2012) The potential of microRNAs in liver fibrosis. Cell Signal 24(12):2268\u20132272. doi: 10.1016\/j.cellsig.2012.07.023","journal-title":"Cell Signal"},{"issue":"5","key":"2199_CR22","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/labinvest.2008.20","volume":"88","author":"J Lin","year":"2008","unstructured":"Lin J, Chen A (2008) Activation of peroxisome proliferator-activated receptor-gamma by curcumin blocks the signaling pathways for PDGF and EGF in hepatic stellate cells. Lab Investig 88(5):529\u2013540. doi: 10.1038\/labinvest.2008.20","journal-title":"Lab Investig"},{"issue":"8","key":"2199_CR23","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s00535-009-0073-3","volume":"44","author":"M Takashima","year":"2009","unstructured":"Takashima M, Parsons CJ, Ikejima K, Watanabe S, White ES, Rippe RA (2009) The tumor suppressor protein PTEN inhibits rat hepatic stellate cell activation. J Gastroenterol 44(8):847\u2013855. doi: 10.1007\/s00535-009-0073-3","journal-title":"J Gastroenterol"},{"issue":"3","key":"2199_CR24","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.bcp.2009.09.013","volume":"79","author":"H Liu","year":"2010","unstructured":"Liu H, Li H, Guo L, Li M, Li C, Wang S, Jiang W, Liu X, McNutt MA, Li G (2010) Mechanisms involved in phosphatidylinositol 3-kinase pathway mediated up-regulation of the mu opioid receptor in lymphocytes. Biochem Pharmacol 79(3):516\u2013523. doi: 10.1016\/j.bcp.2009.09.013","journal-title":"Biochem Pharmacol"},{"issue":"14","key":"2199_CR25","doi-asserted-by":"crossref","first-page":"13374","DOI":"10.1074\/jbc.M409444200","volume":"280","author":"E Gabele","year":"2005","unstructured":"Gabele E, Reif S, Tsukada S, Bataller R, Yata Y, Morris T, Schrum LW, Brenner DA, Rippe RA (2005) The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. J Biol Chem 280(14):13374\u201313382. doi: 10.1074\/jbc.M409444200","journal-title":"J Biol Chem"},{"issue":"22","key":"2199_CR26","doi-asserted-by":"crossref","first-page":"13375","DOI":"10.1074\/jbc.273.22.13375","volume":"273","author":"T Maehama","year":"1998","unstructured":"Maehama T, Dixon JE (1998) The tumor suppressor, PTEN\/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 273(22):13375\u201313378","journal-title":"J Biol Chem"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-014-2199-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11010-014-2199-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-014-2199-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T05:48:55Z","timestamp":1565761735000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11010-014-2199-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,23]]},"references-count":26,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["2199"],"URL":"https:\/\/doi.org\/10.1007\/s11010-014-2199-8","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,23]]}}}