{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T18:59:25Z","timestamp":1772132365506,"version":"3.50.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"key project of the National Natural Science Foundation","award":["No. 81230042"],"award-info":[{"award-number":["No. 81230042"]}]},{"name":"National Key Project of Scientific and Technical Supporting Programs Funded by Ministry of Science & Technology of China","award":["No. 2012BAI11B03"],"award-info":[{"award-number":["No. 2012BAI11B03"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1007\/s11010-015-2644-3","type":"journal-article","created":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T04:36:07Z","timestamp":1451882167000},"page":"109-118","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Galangin inhibits hypertrophic scar formation via ALK5\/Smad2\/3 signaling pathway"],"prefix":"10.1007","volume":"413","author":[{"given":"Yifan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengzhou","family":"Shan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingfeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,1,4]]},"reference":[{"key":"2644_CR1","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1111\/exd.12419","volume":"23","author":"LJ van den Broek","year":"2014","unstructured":"van den Broek LJ, Limandjaja GC, Niessen FB, Gibbs S (2014) Human hypertrophic and keloid scar models: principles, limitations and future challenges from a tissue engineering perspective. Exp Dermatol 23:382\u2013386. doi:\n                    10.1111\/exd.12419","journal-title":"Exp Dermatol"},{"key":"2644_CR2","doi-asserted-by":"publisher","first-page":"817","DOI":"10.2217\/rme.14.54","volume":"9","author":"ER Zielins","year":"2014","unstructured":"Zielins ER, Atashroo DA, Maan ZN, Duscher D, Walmsley GG, Hu M, Senarath-Yapa K, McArdle A, Tevlin R, Wearda T, Paik KJ, Duldulao C, Hong WX, Gurtner GC, Longaker MT (2014) Wound healing: an update. Regen Med 9:817\u2013830. doi:\n                    10.2217\/rme.14.54","journal-title":"Regen Med"},{"key":"2644_CR3","doi-asserted-by":"publisher","first-page":"565","DOI":"10.6061\/clinics\/2014(08)11","volume":"69","author":"FB Rabello","year":"2014","unstructured":"Rabello FB, Souza CD, Farina Junior JA (2014) Update on hypertrophic scar treatment. Clinics (Sao Paulo) 69:565\u2013573","journal-title":"Clinics (Sao Paulo)"},{"key":"2644_CR4","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1111\/j.1365-2133.2011.10492.x","volume":"165","author":"C Vrijman","year":"2011","unstructured":"Vrijman C, van Drooge AM, Limpens J, Bos JD, van der Veen JP, Spuls PI, Wolkerstorfer A (2011) Laser and intense pulsed light therapy for the treatment of hypertrophic scars: a systematic review. Br J Dermatol 165:934\u2013942. doi:\n                    10.1111\/j.1365-2133.2011.10492.x","journal-title":"Br J Dermatol"},{"key":"2644_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jaad.2011.05.055","volume":"66","author":"C Profyris","year":"2012","unstructured":"Profyris C, Tziotzios C, Do Vale I (2012) Cutaneous scarring: pathophysiology, molecular mechanisms, and scar reduction therapeutics: part I. The molecular basis of scar formation. J Am Acad Dermatol 66:1\u201310. doi:\n                    10.1016\/j.jaad.2011.05.055","journal-title":"J Am Acad Dermatol"},{"key":"2644_CR6","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s12079-013-0195-5","volume":"7","author":"Z Zhu","year":"2013","unstructured":"Zhu Z, Ding J, Shankowsky HA, Tredget EE (2013) The molecular mechanism of hypertrophic scar. J Cell Commun Signal 7:239\u2013252. doi:\n                    10.1007\/s12079-013-0195-5","journal-title":"J Cell Commun Signal"},{"key":"2644_CR7","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1038\/nature07039","volume":"453","author":"GC Gurtner","year":"2008","unstructured":"Gurtner GC, Werner S, Barrandon Y, Longaker MT (2008) Wound repair and regeneration. Nature 453:314\u2013321. doi:\n                    10.1038\/nature07039","journal-title":"Nature"},{"key":"2644_CR8","doi-asserted-by":"publisher","first-page":"301","DOI":"10.2147\/ccid.s50046","volume":"7","author":"IA Darby","year":"2014","unstructured":"Darby IA, Laverdet B, Bonte F, Desmouliere A (2014) Fibroblasts and myofibroblasts in wound healing. Clin Cosmet Investig Dermatol 7:301\u2013311. doi:\n                    10.2147\/ccid.s50046","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"2644_CR9","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1038\/nm.2574","volume":"18","author":"VW Wong","year":"2012","unstructured":"Wong VW, Rustad KC, Akaishi S, Sorkin M, Glotzbach JP, Januszyk M, Nelson ER, Levi K, Paterno J, Vial IN, Kuang AA, Longaker MT, Gurtner GC (2012) Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling. Nat Med 18:148\u2013152. doi:\n                    10.1038\/nm.2574","journal-title":"Nat Med"},{"key":"2644_CR10","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.intimp.2014.04.014","volume":"21","author":"EO Santos","year":"2014","unstructured":"Santos EO, Kabeya LM, Figueiredo-Rinhel AS, Marchi LF, Andrade MF, Piatesi F, Paoliello-Paschoalato AB, Azzolini AE, Lucisano-Valim YM (2014) Flavonols modulate the effector functions of healthy individuals\u2019 immune complex-stimulated neutrophils: a therapeutic perspective for rheumatoid arthritis. Int Immunopharmacol 21:102\u2013111. doi:\n                    10.1016\/j.intimp.2014.04.014","journal-title":"Int Immunopharmacol"},{"key":"2644_CR11","doi-asserted-by":"publisher","first-page":"607","DOI":"10.3109\/13880209.2012.757327","volume":"51","author":"S Kumar","year":"2013","unstructured":"Kumar S, Alagawadi KR (2013) Anti-obesity effects of galangin, a pancreatic lipase inhibitor in cafeteria diet fed female rats. Pharm Biol 51:607\u2013613. doi:\n                    10.3109\/13880209.2012.757327","journal-title":"Pharm Biol"},{"key":"2644_CR12","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s12935-015-0168-2","volume":"15","author":"ST Chien","year":"2015","unstructured":"Chien ST, Shi MD, Lee YC, Te CC, Shih YW (2015) Galangin, a novel dietary flavonoid, attenuates metastatic feature via PKC\/ERK signaling pathway in TPA-treated liver cancer HepG2 cells. Cancer Cell Int 15:15. doi:\n                    10.1186\/s12935-015-0168-2","journal-title":"Cancer Cell Int"},{"key":"2644_CR13","doi-asserted-by":"publisher","first-page":"13403","DOI":"10.3390\/molecules171113403","volume":"17","author":"S Li","year":"2012","unstructured":"Li S, Wu C, Zhu L, Gao J, Fang J, Li D, Fu M, Liang R, Wang L, Cheng M, Yang H (2012) By improving regional cortical blood flow, attenuating mitochondrial dysfunction and sequential apoptosis galangin acts as a potential neuroprotective agent after acute ischemic stroke. Molecules 17:13403\u201313423. doi:\n                    10.3390\/molecules171113403","journal-title":"Molecules"},{"key":"2644_CR14","doi-asserted-by":"publisher","first-page":"165","DOI":"10.4062\/biomolther.2014.130","volume":"23","author":"SR Madduma Hewage","year":"2015","unstructured":"Madduma Hewage SR, Piao MJ, Kim KC, Cha JW, Han X, Choi YH, Chae S, Hyun JW (2015) Galangin (3,5,7-trihydroxyflavone) shields human keratinocytes from ultraviolet B-induced oxidative stress. Biomol Ther (Seoul) 23:165\u2013173. doi:\n                    10.4062\/biomolther.2014.130","journal-title":"Biomol Ther (Seoul)"},{"key":"2644_CR15","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.fct.2014.03.021","volume":"68","author":"JK Choi","year":"2014","unstructured":"Choi JK, Kim SH (2014) Inhibitory effect of galangin on atopic dermatitis-like skin lesions. Food Chem Toxicol 68:135\u2013141. doi:\n                    10.1016\/j.fct.2014.03.021","journal-title":"Food Chem Toxicol"},{"key":"2644_CR16","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.etap.2013.04.004","volume":"36","author":"X Wang","year":"2013","unstructured":"Wang X, Gong G, Yang W, Li Y, Jiang M, Li L (2013) Antifibrotic activity of galangin, a novel function evaluated in animal liver fibrosis model. Environ Toxicol Pharmacol 36:288\u2013295. doi:\n                    10.1016\/j.etap.2013.04.004","journal-title":"Environ Toxicol Pharmacol"},{"key":"2644_CR17","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.gene.2012.10.069","volume":"513","author":"J Kosla","year":"2013","unstructured":"Kosla J, Dvorak M, Cermak V (2013) Molecular analysis of the TGF-beta controlled gene expression program in chicken embryo dermal myofibroblasts. Gene 513:90\u2013100. doi:\n                    10.1016\/j.gene.2012.10.069","journal-title":"Gene"},{"key":"2644_CR18","doi-asserted-by":"publisher","first-page":"3563","DOI":"10.1074\/jbc.M114.601872","volume":"290","author":"CF Woeller","year":"2015","unstructured":"Woeller CF, O\u2019Loughlin CW, Roztocil E, Feldon SE, Phipps RP (2015) Salinomycin and other polyether ionophores are a new class of antiscarring agent. J Biol Chem 290:3563\u20133575. doi:\n                    10.1074\/jbc.M114.601872","journal-title":"J Biol Chem"},{"key":"2644_CR19","doi-asserted-by":"publisher","first-page":"5353","DOI":"10.1093\/emboj\/16.17.5353","volume":"16","author":"A Nakao","year":"1997","unstructured":"Nakao A, Imamura T, Souchelnytskyi S, Kawabata M, Ishisaki A, Oeda E, Tamaki K, Hanai J, Heldin CH, Miyazono K, ten Dijke P (1997) TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4. EMBO J 16:5353\u20135362. doi:\n                    10.1093\/emboj\/16.17.5353","journal-title":"EMBO J"},{"key":"2644_CR20","doi-asserted-by":"publisher","first-page":"3250","DOI":"10.1096\/fj.07-8218com","volume":"21","author":"S Aarabi","year":"2007","unstructured":"Aarabi S, Bhatt KA, Shi Y, Paterno J, Chang EI, Loh SA, Holmes JW, Longaker MT, Yee H, Gurtner GC (2007) Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis. FASEB J 21:3250\u20133261. doi:\n                    10.1096\/fj.07-8218com","journal-title":"FASEB J"},{"key":"2644_CR21","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/sj.jid.5700613","volume":"127","author":"B Hinz","year":"2007","unstructured":"Hinz B (2007) Formation and function of the myofibroblast during tissue repair. J Investig Dermatol 127:526\u2013537. doi:\n                    10.1038\/sj.jid.5700613","journal-title":"J Investig Dermatol"},{"key":"2644_CR22","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1038\/nm.2807","volume":"18","author":"TA Wynn","year":"2012","unstructured":"Wynn TA, Ramalingam TR (2012) Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nat Med 18:1028\u20131040. doi:\n                    10.1038\/nm.2807","journal-title":"Nat Med"},{"key":"2644_CR23","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1016\/S0092-8674(00)80303-7","volume":"89","author":"H Hayashi","year":"1997","unstructured":"Hayashi H, Abdollah S, Qiu Y, Cai J, Xu YY, Grinnell BW, Richardson MA, Topper JN, Gimbrone MA Jr, Wrana JL, Falb D (1997) The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling. Cell 89:1165\u20131173","journal-title":"Cell"},{"key":"2644_CR24","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/37284","volume":"390","author":"CH Heldin","year":"1997","unstructured":"Heldin CH, Miyazono K, ten Dijke P (1997) TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 390:465\u2013471. doi:\n                    10.1038\/37284","journal-title":"Nature"},{"key":"2644_CR25","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1038\/jid.2012.486","volume":"133","author":"XJ Liu","year":"2013","unstructured":"Liu XJ, Xu MJ, Fan ST, Wu Z, Li J, Yang XM, Wang YH, Xu J, Zhang ZG (2013) Xiamenmycin attenuates hypertrophic scars by suppressing local inflammation and the effects of mechanical stress. J Investig Dermatol 133:1351\u20131360. doi:\n                    10.1038\/jid.2012.486","journal-title":"J Investig Dermatol"},{"key":"2644_CR26","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1111\/dsu.12346","volume":"39","author":"JA Ledon","year":"2013","unstructured":"Ledon JA, Savas J, Franca K, Chacon A, Nouri K (2013) Intralesional treatment for keloids and hypertrophic scars: a review. Dermatol Surg 39:1745\u20131757. doi:\n                    10.1111\/dsu.12346","journal-title":"Dermatol Surg"},{"key":"2644_CR27","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1001\/archfaci.8.6.362","volume":"8","author":"D Leventhal","year":"2006","unstructured":"Leventhal D, Furr M, Reiter D (2006) Treatment of keloids and hypertrophic scars: a meta-analysis and review of the literature. Arch Facial Plast Surg 8:362\u2013368. doi:\n                    10.1001\/archfaci.8.6.362","journal-title":"Arch Facial Plast Surg"},{"key":"2644_CR28","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1046\/j.1524-4725.1999.98257.x","volume":"25","author":"RS English","year":"1999","unstructured":"English RS, Shenefelt PD (1999) Keloids and hypertrophic scars. Dermatol Surg 25:631\u2013638","journal-title":"Dermatol Surg"},{"key":"2644_CR29","doi-asserted-by":"publisher","first-page":"113","DOI":"10.2119\/molmed.2009.00153","volume":"17","author":"GG Gauglitz","year":"2011","unstructured":"Gauglitz GG, Korting HC, Pavicic T, Ruzicka T, Jeschke MG (2011) Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies. Mol Med 17:113\u2013125. doi:\n                    10.2119\/molmed.2009.00153","journal-title":"Mol Med"},{"key":"2644_CR30","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/j.1067-1927.2005.130102.x","volume":"13","author":"A Desmouliere","year":"2005","unstructured":"Desmouliere A, Chaponnier C, Gabbiani G (2005) Tissue repair, contraction, and the myofibroblast. Wound Repair Regen 13:7\u201312. doi:\n                    10.1111\/j.1067-1927.2005.130102.x","journal-title":"Wound Repair Regen"},{"key":"2644_CR31","doi-asserted-by":"publisher","first-page":"4494","DOI":"10.1021\/jm0400247","volume":"47","author":"F Gellibert","year":"2004","unstructured":"Gellibert F, Woolven J, Fouchet MH, Mathews N, Goodland H, Lovegrove V, Laroze A, Nguyen VL, Sautet S, Wang R, Janson C, Smith W, Krysa G, Boullay V, De Gouville AC, Huet S, Hartley D (2004) Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors. J Med Chem 47:4494\u20134506. doi:\n                    10.1021\/jm0400247","journal-title":"J Med Chem"},{"key":"2644_CR32","first-page":"1880","volume":"16","author":"J Sapitro","year":"2010","unstructured":"Sapitro J, Dunmire JJ, Scott SE, Sutariya V, Geldenhuys WJ, Hewit M, Yue BY, Nakamura H (2010) Suppression of transforming growth factor-beta effects in rabbit subconjunctival fibroblasts by activin receptor-like kinase 5 inhibitor. Mol Vis 16:1880\u20131892","journal-title":"Mol Vis"},{"key":"2644_CR33","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/ki.2013.82","volume":"84","author":"N Shen","year":"2013","unstructured":"Shen N, Lin H, Wu T, Wang D, Wang W, Xie H, Zhang J, Feng Z (2013) Inhibition of TGF-beta1-receptor posttranslational core fucosylation attenuates rat renal interstitial fibrosis. Kidney Int 84:64\u201377. doi:\n                    10.1038\/ki.2013.82","journal-title":"Kidney Int"},{"key":"2644_CR34","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.yexmp.2006.12.003","volume":"83","author":"H Higashiyama","year":"2007","unstructured":"Higashiyama H, Yoshimoto D, Kaise T, Matsubara S, Fujiwara M, Kikkawa H, Asano S, Kinoshita M (2007) Inhibition of activin receptor-like kinase 5 attenuates bleomycin-induced pulmonary fibrosis. Exp Mol Pathol 83:39\u201346. doi:\n                    10.1016\/j.yexmp.2006.12.003","journal-title":"Exp Mol Pathol"},{"key":"2644_CR35","doi-asserted-by":"publisher","first-page":"4171","DOI":"10.18632\/oncotarget.2878","volume":"6","author":"JH Park","year":"2015","unstructured":"Park JH, Ryu SH, Choi EK, Ahn SD, Park E, Choi KC, Lee SW (2015) SKI2162, an inhibitor of the TGF-beta type I receptor (ALK5), inhibits radiation-induced fibrosis in mice. Oncotarget 6:4171\u20134179","journal-title":"Oncotarget"},{"key":"2644_CR36","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-014-0476-5","author":"Y Shang","year":"2015","unstructured":"Shang Y, Yu D, Hao L (2015) Liposome\u2013adenoviral hTERT-siRNA knockdown in fibroblasts from keloids reduce telomere length and fibroblast growth. Cell Biochem Biophys. doi:\n                    10.1007\/s12013-014-0476-5","journal-title":"Cell Biochem Biophys"},{"key":"2644_CR37","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1038\/jid.2014.84","volume":"134","author":"YW Wang","year":"2014","unstructured":"Wang YW, Liou NH, Cherng JH, Chang SJ, Ma KH, Fu E, Liu JC, Dai NT (2014) siRNA-targeting transforming growth factor-beta type I receptor reduces wound scarring and extracellular matrix deposition of scar tissue. J Investig Dermatol 134:2016\u20132025. doi:\n                    10.1038\/jid.2014.84","journal-title":"J Investig Dermatol"},{"key":"2644_CR38","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1038\/jid.2013.396","volume":"134","author":"M Aoki","year":"2014","unstructured":"Aoki M, Miyake K, Ogawa R, Dohi T, Akaishi S, Hyakusoku H, Shimada T (2014) siRNA knockdown of tissue inhibitor of metalloproteinase-1 in keloid fibroblasts leads to degradation of collagen type I. J Investig Dermatol 134:818\u2013826. doi:\n                    10.1038\/jid.2013.396","journal-title":"J Investig Dermatol"},{"key":"2644_CR39","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.colsurfb.2015.05.006","volume":"132","author":"A Dehshahri","year":"2015","unstructured":"Dehshahri A, Sadeghpour H (2015) Surface decorations of poly(amidoamine) dendrimer by various pendant moieties for improved delivery of nucleic acid materials. Colloids Surf B Biointerfaces 132:85\u2013102. doi:\n                    10.1016\/j.colsurfb.2015.05.006","journal-title":"Colloids Surf B Biointerfaces"}],"updated-by":[{"DOI":"10.1007\/s11010-020-03702-0","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T00:00:00Z","timestamp":1583452800000}}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-015-2644-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11010-015-2644-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-015-2644-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-015-2644-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T21:26:24Z","timestamp":1600291584000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11010-015-2644-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,4]]},"references-count":39,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["2644"],"URL":"https:\/\/doi.org\/10.1007\/s11010-015-2644-3","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s11010-020-03702-0","asserted-by":"object"}]},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,4]]},"assertion":[{"value":"2 August 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 December 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2020","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"In the original article, Figs.\ufffd\ufffd3b, 4a, c and 5d were published incorrectly. The correct version of the figures are provided in this correction.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2020","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"In the original article, Figs.\ufffd\ufffd3b, 4a, c and 5d were published incorrectly. The correct version of the figures are provided in this correction.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Ethical approval was given by the Animal Care and Use Committee of Shanghai Jiao Tong University.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}