{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T04:20:51Z","timestamp":1793420451611,"version":"4.5.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2016,10,17]],"date-time":"2016-10-17T00:00:00Z","timestamp":1476662400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","award":["454262\/2014-0"],"award-info":[{"award-number":["454262\/2014-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","award":["482055\/2013-8"],"award-info":[{"award-number":["482055\/2013-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1007\/s11010-016-2843-6","type":"journal-article","created":{"date-parts":[[2016,10,17]],"date-time":"2016-10-17T14:58:49Z","timestamp":1476716329000},"page":"69-78","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Methionine and methionine sulfoxide treatment induces M1\/classical macrophage polarization and modulates oxidative stress and purinergic signaling parameters"],"prefix":"10.1007","volume":"424","author":[{"given":"Lien M.","family":"dos Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiane M.","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana H.","family":"Azambuja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila T.","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pathise S.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elita F.","family":"da Silveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalia S.","family":"Pedra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kennia","family":"Galdino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlus A. T.","family":"do Couto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayara S. P.","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rejane G.","family":"Tavares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roselia M.","family":"Spanevello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francieli M.","family":"Stefanello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizandra","family":"Braganhol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,10,17]]},"reference":[{"key":"2843_CR1","doi-asserted-by":"crossref","first-page":"1750S","DOI":"10.1093\/jn\/136.6.1750S","volume":"136","author":"JD Finkelstein","year":"2006","unstructured":"Finkelstein JD (2006) Inborn errors of sulfur-containing amino acid metabolism. J Nutr 136:1750S\u20131753S","journal-title":"J Nutr"},{"key":"2843_CR2","first-page":"2007","volume-title":"The metabolic and molecular bases of inherited disease","author":"SH Mudd","year":"2001","unstructured":"Mudd SH, Levy HL, Kraus JP (2001) Disorders of transsulfuration. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds) The metabolic and molecular bases of inherited disease, 8th edn. McGraw-Hill, New York, pp 2007\u20132056","edition":"8"},{"key":"2843_CR3","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0168-8278(00)80122-1","volume":"33","author":"MA Avila","year":"2000","unstructured":"Avila MA, Berasain C, Torres L, Mart\u00edn-Duce A, Corrales FJ, Yang H, Prieto J, Lu SC, Caballer\u00eda J, Rod\u00e9s J, Mato JM (2000) Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma. J Hepatol 33:907\u2013914","journal-title":"J Hepatol"},{"key":"2843_CR4","doi-asserted-by":"crossref","first-page":"5560","DOI":"10.1073\/pnas.091016398","volume":"98","author":"SC Lu","year":"2001","unstructured":"Lu SC, Alvarez L, Huang ZZ, Chen L, An W, Corrales FJ, Avila MA, Kanel G, Mato JM (2001) Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Proc Natl Acad Sci USA 98:5560\u20135565","journal-title":"Proc Natl Acad Sci USA"},{"key":"2843_CR5","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ymgme.2010.07.009","volume":"101","author":"J Fern\u00e1ndez-Irigoyen","year":"2010","unstructured":"Fern\u00e1ndez-Irigoyen J, Santamar\u00eda E, Chien YH, Hwu WL, Korman SH, Faghfoury H, Schulzr A, Hoganson GE, Stable SP, Allen RH, Wagner C, Mudd SH, Corrales FJ (2010) Enzymatic activity of methionine adenosyltransferase variants identified in patients with persistent hypermethioninemia. Mol Genet Metab 101:172\u2013177","journal-title":"Mol Genet Metab"},{"key":"2843_CR6","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0300-483X(00)00437-6","volume":"160","author":"DL Laskin","year":"2001","unstructured":"Laskin DL, Laskin JD (2001) Role of macrophages and inflammatory mediators in chemically induced toxicity. Toxicology 160:111\u2013118","journal-title":"Toxicology"},{"key":"2843_CR7","doi-asserted-by":"crossref","first-page":"6","DOI":"10.12703\/P6-13","volume":"6","author":"FO Martinez","year":"2014","unstructured":"Martinez FO, Gordon S (2014) The M1 and M2 paradigm of macrophage activation: time for reassessment. F1000Prime Rep 6:6\u201313","journal-title":"F1000Prime Rep"},{"key":"2843_CR8","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nri978","volume":"3","author":"S Gordon","year":"2003","unstructured":"Gordon S (2003) Alternative activation of macrophages. Nat Rev Immunol 3:23\u201325","journal-title":"Nat Rev Immunol"},{"key":"2843_CR9","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nri2448","volume":"8","author":"DM Mosser","year":"2008","unstructured":"Mosser DM, Edwards JP (2008) Exploring the full spectrum of macrophages activation. Nat Rev Immunol 8:958\u2013969","journal-title":"Nat Rev Immunol"},{"key":"2843_CR10","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1182\/blood-2009-07-231795","volume":"114","author":"A Mantovani","year":"2009","unstructured":"Mantovani A (2009) Orchestration of macrophage polarization. Blood 114:3135\u20133136","journal-title":"Blood"},{"key":"2843_CR11","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev.immunol.021908.132532","volume":"27","author":"FO Martinez","year":"2009","unstructured":"Martinez FO, Helming L, Gordon S (2009) Alternative activation of macrophages: an immunologic functional perspective. Annu Rev Immunol 27:451\u2013483","journal-title":"Annu Rev Immunol"},{"key":"2843_CR12","doi-asserted-by":"crossref","first-page":"520","DOI":"10.7150\/ijbs.8879","volume":"10","author":"YC Liu","year":"2014","unstructured":"Liu YC, Zou XB, Chai YF, Yao YM (2014) Macrophage polarization in inflammatory diseases. Int J Biol Sci 10:520\u2013529","journal-title":"Int J Biol Sci"},{"key":"2843_CR13","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.imbio.2010.05.027","volume":"215","author":"S Ley","year":"2010","unstructured":"Ley S, Weigert A, Brune B (2010) Neuromediators in inflammation\u2014a macrophage\/nerve connection. Immunobiology 215:674\u2013684","journal-title":"Immunobiology"},{"key":"2843_CR14","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1182\/blood.V97.3.587","volume":"97","author":"F Virgilio Di","year":"2001","unstructured":"Di Virgilio F, Chiozzi P, Ferrari D, Falzoni S, Sanz JM, Morrelli A, Falzoni S, Sanz JM, Morelli A, Torboli M, Bolognesi G, Baricordi OR (2001) Nucleotide receptors: an emerging family of regulatory molecules in blood cells. Blood 97:587\u2013600","journal-title":"Blood"},{"key":"2843_CR15","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.pharmthera.2005.04.013","volume":"112","author":"MJ Bours","year":"2006","unstructured":"Bours MJ, EL Swennen, Di Virgilio F, Cronstein BN, Dagnelie PC (2006) Adenosine 5\u2032-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther 112:358\u2013404","journal-title":"Pharmacol Ther"},{"key":"2843_CR16","doi-asserted-by":"crossref","first-page":"580","DOI":"10.3389\/fimmu.2014.00580","volume":"5","author":"BN Desai","year":"2014","unstructured":"Desai BN, Leitinger N (2014) Purinergic and calcium signaling in macrophage function and plasticity. Front Immunol 5:580","journal-title":"Front Immunol"},{"key":"2843_CR17","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1189\/jlb.0802418","volume":"73","author":"A Sala La","year":"2003","unstructured":"La Sala A, Ferrari D, Di Virgilio F, Idzko M, Norgauer J, Girolomoni G (2003) Alerting and tuning the immune response by extracellular nucleotides. J Leukoc Biol 73:339\u2013343","journal-title":"J Leukoc Biol"},{"key":"2843_CR18","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/ddr.10209","volume":"59","author":"I Lemaire","year":"2003","unstructured":"Lemaire I, Leduc N (2003) Purinergic P2X7 receptor function in lung alveolar macrophages: pharmacologic characterization and bidirectional regulation by Th1 and Th2 cytokines. Drug Dev Res 59:118\u2013127","journal-title":"Drug Dev Res"},{"key":"2843_CR19","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.molmed.2013.03.005","volume":"19","author":"L Antonioli","year":"2013","unstructured":"Antonioli L, Pacher P, Vizi ES, Hasko G (2013) CD39 and CD73 in immunity and inflammation. Trends Mol Med 19:355\u2013367","journal-title":"Trends Mol Med"},{"key":"2843_CR20","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.it.2003.11.003","volume":"25","author":"G Hasko","year":"2004","unstructured":"Hasko G, Cronstein BN (2004) Adenosine: an endogenous regulator of innate immunity. Trends Immunol 25:33\u201339","journal-title":"Trends Immunol"},{"key":"2843_CR21","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s11302-006-9003-5","volume":"2","author":"SC Robson","year":"2006","unstructured":"Robson SC, S\u00e9vigny J, Zimmermann H (2006) The E-NTPDase family of ectonucleotidases: structure function relationships and pathophysiological significance. Purinergic Signal 2:409\u2013430","journal-title":"Purinergic Signal"},{"issue":"2","key":"2843_CR22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00109-012-0991-z","volume":"91","author":"MS Longhi","year":"2013","unstructured":"Longhi MS, Robson SC, Bernstein SH, Serra S, Deaglio (2013) Biological functions of ecto-enzymes in regulating extracellular adenosine levels in neoplastic and inflammatory disease states. J Mol Med 91(2):165\u2013172","journal-title":"J Mol Med"},{"key":"2843_CR23","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1084\/jem.169.5.1543","volume":"169","author":"DJ Stuehr","year":"1989","unstructured":"Stuehr DJ, Nathan CF (1989) Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. J Exp Med 169:1543\u20131555","journal-title":"J Exp Med"},{"key":"2843_CR24","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0022-1759(94)90027-2","volume":"174","author":"IM Corraliza","year":"1994","unstructured":"Corraliza IM, Campo ML, Soler G, Modolell M (1994) Determination ofarginase activity in macrophages: a micromethod. J Immunol Methods 174:231\u2013235","journal-title":"J Immunol Methods"},{"key":"2843_CR25","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","volume":"105","author":"H Aebi","year":"1984","unstructured":"Aebi H (1984) Catalase in vitro. Methods Enzymol 105:121\u2013126","journal-title":"Methods Enzymol"},{"key":"2843_CR26","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","volume":"247","author":"HP Misra","year":"1972","unstructured":"Misra HP, Fridovich I (1972) The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 247:3170\u20133175","journal-title":"J Biol Chem"},{"key":"2843_CR27","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0076-6879(81)77046-0","volume":"77","author":"A Wendel","year":"1981","unstructured":"Wendel A (1981) Glutathione peroxidase. Methods Enzymol 77:325\u2013333","journal-title":"Methods Enzymol"},{"key":"2843_CR28","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0003-2697(86)90640-8","volume":"157","author":"KM Chan","year":"1986","unstructured":"Chan KM, Delfert D, Junger KD (1986) A direct colorimetric assay for Ca2+-stimulated ATPase activity. Anal Biochem 157:375\u2013380","journal-title":"Anal Biochem"},{"key":"2843_CR29","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254","journal-title":"Anal Biochem"},{"key":"2843_CR30","doi-asserted-by":"crossref","first-page":"632","DOI":"10.2353\/ajpath.2007.061213","volume":"171","author":"SM Jay","year":"2007","unstructured":"Jay SM, Skokos E, Laiwalla F, Krady MM, Kyriakides TR (2007) Foreign body giant cell formation is preceded by lamellipodia formation and can be attenuated by inhibition of Rac1 activation. Am J Pathol 171:632\u2013640","journal-title":"Am J Pathol"},{"issue":"4","key":"2843_CR31","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.2353\/ajpath.2008.070513","volume":"172","author":"SW Waldo","year":"2008","unstructured":"Waldo SW, Li Y, Buono C, Zhao B, Billings EM, Chang J, Kruth HS (2008) Heterogeneity of human macrophages in culture and in atherosclerotic plaques. Am J Pathol 172(4):1112\u20131126","journal-title":"Am J Pathol"},{"key":"2843_CR32","doi-asserted-by":"crossref","first-page":"17253","DOI":"10.1073\/pnas.1308887110","volume":"110","author":"FY McWhorter","year":"2013","unstructured":"McWhorter FY, Wang T, Nguyen P, Chung T, Liu WF (2013) Modulation of macrophage phenotype by cell shape. Proc Natl Acad Sci USA 110:17253\u201317258","journal-title":"Proc Natl Acad Sci USA"},{"key":"2843_CR33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneumeth.2006.07.029","volume":"160","author":"FM Stefanello","year":"2007","unstructured":"Stefanello FM, Matt\u00e9 S, Scherer EB, Wannmacher CMD, Wajner M, Wyse ATS (2007) Chemically induced model of hypermethioninemia in rats. J Neurosci Methods 160:1\u20134","journal-title":"J Neurosci Methods"},{"key":"2843_CR34","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.biochi.2009.04.018","volume":"91","author":"FM Stefanello","year":"2009","unstructured":"Stefanello FM, Matt\u00e9 C, Pederzolli CD, Kolling J, Mescka CP, Lamers ML, De Assis AM, Perry ML, Dos Santos MF, Dutra-Filho CS, Wyse AT (2009) Hypermethioninemia provokes oxidative damage and histological changes in liver of rats. Biochimie 91:961\u2013968","journal-title":"Biochimie"},{"key":"2843_CR35","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1023\/B:BOLI.0000009978.17777.33","volume":"26","author":"P Augoustides-Savvopoulou","year":"2003","unstructured":"Augoustides-Savvopoulou P, Luka Z, Karyda S, Stabler SP, Allen RH, Patsiaoura K, Wagner C, Mudd SH (2003) Glycine N-methyltransferase deficiency: a new patient with a novel mutation. J Inherit Metab Dis 26:745\u2013759","journal-title":"J Inherit Metab Dis"},{"key":"2843_CR36","doi-asserted-by":"crossref","first-page":"4090","DOI":"10.1093\/jn\/133.12.4090","volume":"133","author":"MK Ozias","year":"2003","unstructured":"Ozias MK, Schalinske KL (2003) All-trans-retinoic acid rapidly induces glycine N-methyltransferase in a dose-dependent manner and reduces circulating methionine and homocysteine levels in rats. J Nutr 133:4090\u20134094","journal-title":"J Nutr"},{"key":"2843_CR37","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0098-2997(01)00010-3","volume":"22","author":"HJ Forman","year":"2001","unstructured":"Forman HJ, Torres M (2001) Redox signaling in macrophages. Mol Asp Med 22:189\u2013216","journal-title":"Mol Asp Med"},{"key":"2843_CR38","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.jinf.2005.08.017","volume":"52","author":"CC Oliveira","year":"2006","unstructured":"Oliveira CC, Oliveira SM, Godoy LMF, Gabardo J, Buchi DF, Canova (2006) A Brazilian medical formulation, alters oxidative metabolism of mice macrophages. J Infect 52:420\u2013432","journal-title":"J Infect"},{"key":"2843_CR39","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1371\/journal.pone.0117398","volume":"10","author":"D Tyteca","year":"2015","unstructured":"Tyteca D, Nishino T, Debaix H, Van Der Smissen P, N\u2019Kuli F, Hoffmann D, Cnops Y, Rabolli V, Loo GV, Beyaert R, Huaux F, Devuyst O, Courtoy PJ (2015) Regulation of macrophage motility by the water channel aquaporin-1: crucial role of M0\/M2 phenotype switch. PloS One 10:2","journal-title":"PloS One"},{"key":"2843_CR40","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3389\/fimmu.2014.00402","volume":"5","author":"SS Bohlson","year":"2014","unstructured":"Bohlson SS, O\u2019Conner SD, Hulsebus HJ, Ho M-M, Fraser DA (2014) Complement, C1q, and C1q-related molecules regulate macrophage polarization. Front Immunol 5:402","journal-title":"Front Immunol"},{"key":"2843_CR41","doi-asserted-by":"crossref","first-page":"e31205","DOI":"10.1371\/journal.pone.0031205","volume":"7","author":"RF Zanin","year":"2012","unstructured":"Zanin RF, Braganhol E, Bergamin LS, Campesato LF, Filho AZ, Moreira JC, Morrone FB, S\u00e9vigny J, Schetinger MR, de Souza Wyse AT, Battastini AM (2012) Differential macrophage activation alters the expression profile of NTPDase and ecto-5\u2032-nucleotidase. PLoS One 7:e31205","journal-title":"PLoS One"},{"key":"2843_CR42","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1002\/eji.200939741","volume":"40","author":"SA L\u00e9vesque","year":"2010","unstructured":"L\u00e9vesque SA, Kukulski F, Enjyoji K, Robson SC, S\u00e9vigny J (2010) NTPDase1 governs P2X7-dependent functions in murine macrophages. Eur J Immunol 40:1473\u20131485","journal-title":"Eur J Immunol"},{"key":"2843_CR43","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1016\/j.freeradbiomed.2012.02.033","volume":"52","author":"H Yamada","year":"2012","unstructured":"Yamada H, Akahoshia N, Kamatad S, Hagiyad Y, Hishikia T, Nagahatac Y, Matsuurac T, Takanoc N, Morib M, Ishizakib Y, Izumib T, Kumagaie Y, Kasaharad T, Suematsua M, Ishii I (2012) Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine \u03b3-lyase, an animal model of cystathioninuria. Free Radic Biol Med 52:1716\u20131726","journal-title":"Free Radic Biol Med"},{"key":"2843_CR44","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.gene.2013.08.025","volume":"530","author":"K Hirabayashi","year":"2013","unstructured":"Hirabayashi K, Shiohara M, Yamada K, Sueki A, Ide Y, Takeuchi K, Hagimoto R, Kinoshita T, Yabuhara A, Mudd SH, Koike K (2013) Neurologically normal development of a patient with severe methionine adenosyltransferase I\/III deficiency after continuing dietary methionine restriction. Gene 530:104\u2013108","journal-title":"Gene"},{"key":"2843_CR45","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.fsi.2014.11.024","volume":"42","author":"M Machado","year":"2015","unstructured":"Machado M, Azeredo R, D\u00edaz-Rosales P, Afonso A, Peres H, Oliva-Teles A, Costas B (2015) Dietary tryptophan and methionine as modulators of European seabass (Dicentrarchus labrax) immune status and inflammatory response. Fish Shellfish Immunol 42:353\u2013362","journal-title":"Fish Shellfish Immunol"},{"key":"2843_CR46","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11010-013-1777-5","volume":"384","author":"MZ Costa","year":"2013","unstructured":"Costa MZ, Da Silva TM, Flores NP, Schmitz F, Da Silva Scherer EB, Viau CM, Saffi J, Barschak AG, De Souza Wyse AT, Spanevello RM, Stefanello FM (2013) Methionine and methionine sulfoxide alter parameters of oxidative stress in the liver of young rats: in vitro and in vivo studies. Mol Cell Biochem 384:21\u201328","journal-title":"Mol Cell Biochem"},{"key":"2843_CR47","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1172\/JCI118862","volume":"98","author":"ME Chamberlin","year":"1996","unstructured":"Chamberlin ME, Ubagai T, Mudd SH, Wilson WL, Leonard JV, Chou JY (1996) Demyelination of the brain is association with methionine adenosyltransferase I\/III deficiency. J Clin Investig 98:1021\u20131027","journal-title":"J Clin Investig"},{"key":"2843_CR48","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ymgme.2012.08.002","volume":"107","author":"M Furujo","year":"2012","unstructured":"Furujo M, Kinoshita M, Nagao M, Kubo T (2012) Methionine adenosyltransferase I\/III deficiency: neurological manifestations and relevance of S-adenosylmethionine. Mol Genet Metab 107:253\u2013256","journal-title":"Mol Genet Metab"},{"issue":"7","key":"2843_CR49","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s11033-016-4022-y","volume":"43","author":"X Wang","year":"2016","unstructured":"Wang X, Hai C (2016) Novel insights into redox system and the mechanism of redox regulation. Mol Biol Rep 43(7):607\u2013628","journal-title":"Mol Biol Rep"},{"key":"2843_CR50","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1523\/JNEUROSCI.18-02-00687.1998","volume":"18","author":"JY Keller","year":"1998","unstructured":"Keller JY, Kindy MS, Holtsberg FW, St. Clair DK, Yen HC, Germeyer A, Steiner SM, Bruce-Keller AJ, Hutchins JB, Mattson MP (1998) Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction. J Neurosci 18:687\u2013697","journal-title":"J Neurosci"},{"key":"2843_CR51","doi-asserted-by":"crossref","first-page":"29626","DOI":"10.1074\/jbc.M208665200","volume":"278","author":"Y Chovolou","year":"2003","unstructured":"Chovolou Y, Watjem W, Kampkotter A, Kahl R (2003) Resistance to tumor necrosis factor-\u03b1 (TNF-\u03b1)-induced apoptosis in rat hepatoma cells expressing TNF-\u03b1 is linked to low antioxidant enzyme expression. J Biol Chem 278:29626\u201329632","journal-title":"J Biol Chem"},{"key":"2843_CR52","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.smim.2013.01.002","volume":"24","author":"M Pelletier","year":"2013","unstructured":"Pelletier M, Lepow TS, Billingham LK, Murphy MP, Siegel RM (2013) New tricks from an old dog: mitochondrial redox signaling in cellular inflammation. Semin Immunol 24:384\u2013392","journal-title":"Semin Immunol"},{"key":"2843_CR53","first-page":"1","volume":"13","author":"Z Ghorbani","year":"2016","unstructured":"Ghorbani Z, Hajizadeh M, Hekmatdoost A (2016) Dietary supplementation in patients with alcoholic liver disease: a review on current evidence. Hepatobiliary Pancreat Dis Int 13:1\u20133","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"2843_CR54","doi-asserted-by":"crossref","first-page":"622","DOI":"10.3390\/ijms17050622","volume":"17","author":"P Stiuso","year":"2016","unstructured":"Stiuso P, Bagarolo ML, Ilisso CP, Vanacore D, Martino E, Caraglia M, Porcelli M, Cacciapuoti G (2016) Protective effect of tyrosol and S-adenosylmethionine against ethanol-induced oxidative stress of Hepg2 cells involves sirtuin 1, P53 and Erk1\/2 signaling. Int J Mol Sci 17:622","journal-title":"Int J Mol Sci"},{"key":"2843_CR55","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/emm.2016.35","volume":"48","author":"SY Yoon","year":"2016","unstructured":"Yoon SY, Hong GH, Kwon HS, Park S, Park SY, Shin B, Kim TB, Moon HB, Cho YS (2016) S-Adenosylmethionine reduces airway inflammation and fibrosis in a murine model of chronic severe asthma via suppression of oxidative stress. Exp Mol Med 48:236","journal-title":"Exp Mol Med"},{"key":"2843_CR56","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1074\/jbc.M006781200","volume":"276","author":"M Solle","year":"2001","unstructured":"Solle M, Labasi J, Perregaux DG, Stam E, Petrushova N, Koller BH, Griffiths RJ, Gabel CA (2001) Altered cytokine production in mice lacking P2X(7) receptors. J Biol Chem 276:125\u2013132","journal-title":"J Biol Chem"},{"key":"2843_CR57","doi-asserted-by":"crossref","first-page":"59778","DOI":"10.1371\/journal.pone.0059778","volume":"8","author":"H Sakaki","year":"2013","unstructured":"Sakaki H, Tsukimoto M, Harada H, Moriyama Y, Kojima S (2013) Autocrine regulation of macrophage activation via exocytosis of ATP and activation of P2Y11 receptor. PLoS One 8:59778","journal-title":"PLoS One"},{"issue":"1","key":"2843_CR58","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s12035-014-8983-3","volume":"53","author":"FC Vuaden","year":"2016","unstructured":"Vuaden FC, Savio LE, Rico EP, Mussulini BH, Rosemberg DB, de Oliveira DL, Bogo MR, Bonan CD, Wyse AT (2016) Methionine exposure alters glutamate uptake and adenine nucleotide hydrolysis in the Zebrafish brain. Mol Neurobiol 53(1):200\u2013209","journal-title":"Mol Neurobiol"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-016-2843-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11010-016-2843-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-016-2843-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T14:55:38Z","timestamp":1657464938000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11010-016-2843-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,17]]},"references-count":58,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["2843"],"URL":"https:\/\/doi.org\/10.1007\/s11010-016-2843-6","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,17]]}}}