{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:42:35Z","timestamp":1786981355446,"version":"build-2736575974"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2016,12,26]],"date-time":"2016-12-26T00:00:00Z","timestamp":1482710400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1007\/s11010-016-2905-9","type":"journal-article","created":{"date-parts":[[2016,12,26]],"date-time":"2016-12-26T05:28:13Z","timestamp":1482730093000},"page":"133-143","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["IFN-\u03b3 regulates xanthine oxidase-mediated iNOS-independent oxidative stress in maneb- and paraquat-treated rat polymorphonuclear leukocytes"],"prefix":"10.1007","volume":"427","author":[{"given":"Deepali","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chetna","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,12,26]]},"reference":[{"key":"2905_CR1","first-page":"19","volume":"53","author":"C Singh","year":"2007","unstructured":"Singh C, Ahmad I, Kumar A (2007) Pesticides and metals induced Parkinson\u2019s disease: involvement of free radicals and oxidative stress. Cell Mol Biol 53:19\u201328","journal-title":"Cell Mol Biol"},{"key":"2905_CR2","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3109\/10715762.2014.899694","volume":"48","author":"T Blanco-Ayala","year":"2014","unstructured":"Blanco-Ayala T, Anderica-Romero AC, Pedraza-Chaverri J (2014) New insights into antioxidant strategies against paraquat toxicity. Free Radic Res 48:623\u2013640","journal-title":"Free Radic Res"},{"key":"2905_CR3","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1046\/j.1471-4159.2003.01525.x","volume":"84","author":"J Zhang","year":"2003","unstructured":"Zhang J, Fitsanakis VA, Gu G, Jing D, Ao M, Amarnath V, Montine TJ (2003) Manganese ethylene-bis-dithiocarbamate and selective dopaminergic neurodegeneration in rat: a link through mitochondrial dysfunction. J Neurochem 84:336\u2013346","journal-title":"J Neurochem"},{"key":"2905_CR4","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.bbadis.2013.03.019","volume":"1832","author":"A Dixit","year":"2013","unstructured":"Dixit A, Srivastava G, Verma D, Mishra M, Prakash O, Singh MP (2013) Minocycline, levodopa and MnTMPyP induced changes in the mitochondrial proteome profile of MPTP and maneb and paraquat mice models of Parkinson\u2019s disease. Biochim Biophys Acta 1832:1227\u20131240","journal-title":"Biochim Biophys Acta"},{"key":"2905_CR5","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1046\/j.1471-4159.2003.01773.x","volume":"85","author":"BK Barlow","year":"2003","unstructured":"Barlow BK, Thiruchelvam MJ, Bennice L, Cory-Slechta DA, Ballatori N, Richfield EK (2003) Increased synaptosomal dopamine content and brain concentration of paraquat produced by selective dithiocarbamates. J Neurochem 85:1075\u20131086","journal-title":"J Neurochem"},{"key":"2905_CR6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.brainres.2006.01.060","volume":"1081","author":"S Patel","year":"2006","unstructured":"Patel S, Singh V, Kumar A, Gupta YK, Singh MP (2006) Status of antioxidant defense system and expression of toxicant responsive genes in striatum of maneb- and paraquat-induced Parkinson\u2019s disease phenotype in mouse: mechanism of neurodegeneration. Brain Res 1081:9\u201318","journal-title":"Brain Res"},{"key":"2905_CR7","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.neuro.2006.07.009","volume":"27","author":"LM Domico","year":"2006","unstructured":"Domico LM, Zeevalk GD, Bernard LP, Cooper KR (2006) Acute neurotoxic effects of mancozeb and maneb in mesencephalic neuronal cultures are associated with mitochondrial dysfunction. Neurotoxicology 27:816\u2013825","journal-title":"Neurotoxicology"},{"key":"2905_CR8","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1089\/ars.2012.5149","volume":"20","author":"M Mittal","year":"2014","unstructured":"Mittal M, Siddiqui MR, Tran K, Reddy SP, Malik AB (2014) Reactive oxygen species in inflammation and tissue injury. Antioxid Redox Signal 20:1126\u20131167","journal-title":"Antioxid Redox Signal"},{"key":"2905_CR9","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1093\/clinids\/11.Supplement_7.S1532","volume":"11","author":"DW Sawyer","year":"1989","unstructured":"Sawyer DW, Donowitz GR, Mandell GL (1989) Polymorphonuclear neutrophils: an effective antimicrobial force. Rev Infect Dis 11:1532\u20131544","journal-title":"Rev Infect Dis"},{"key":"2905_CR10","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1080\/10715760802513733","volume":"42","author":"I Ahmad","year":"2008","unstructured":"Ahmad I, Kumar A, Shukla S, Pandey HP, Singh C (2008) The involvement of nitric oxide in maneb- and paraquat-induced oxidative stress in rat polymorphonuclear leukocytes. Free Radic Res 42:849\u2013862","journal-title":"Free Radic Res"},{"key":"2905_CR11","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1007\/s13105-014-0359-7","volume":"70","author":"P Tripathi","year":"2014","unstructured":"Tripathi P, Singh A, Agrawal S, Prakash O, Singh MP (2014) Cypermethrin alters the status of oxidative stress in the peripheral blood: relevance to Parkinsonism. J Physiol Biochem 70:915\u2013924","journal-title":"J Physiol Biochem"},{"key":"2905_CR12","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cbi.2015.02.012","volume":"231","author":"A Kumar","year":"2015","unstructured":"Kumar A, Shukla S, Chauhan AK, Singh D, Pandey HP, Singh C (2015) The manganese-salen compound EUK-134 and N-acetyl cysteine rescue from zinc- and paraquat-induced toxicity in rat polymorphonuclear leukocytes. Chem Biol Interact 231:18\u201326","journal-title":"Chem Biol Interact"},{"key":"2905_CR13","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s11010-014-2062-y","volume":"393","author":"I Ahmad","year":"2014","unstructured":"Ahmad I, Shukla S, Singh D, Chauhan AK, Kumar V, Singh BK, Patel DK, Pandey HP, Singh C (2014) CYP2E1-mediated oxidative stress regulates HO-1 and GST expression in maneb- and paraquat-treated rat polymorphonuclear leukocytes. Mol Cell Biochem 393:209\u2013222","journal-title":"Mol Cell Biochem"},{"key":"2905_CR14","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.pestbp.2015.03.007","volume":"123","author":"S Shukla","year":"2015","unstructured":"Shukla S, Singh D, Kumar V, Chauhan AK, Singh S, Ahmad I, Pandey HP, Singh C (2015) NADPH oxidase mediated maneb- and paraquat-induced oxidative stress in rat polymorphs: crosstalk with mitochondrial dysfunction. Pestic Biochem Physiol 123:74\u201386","journal-title":"Pestic Biochem Physiol"},{"key":"2905_CR15","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1161\/01.RES.85.5.437","volume":"85","author":"UEG Ekelund","year":"1999","unstructured":"Ekelund UEG, Harrison RW, Shokek O, Thakkar RN, Tunin RS, Senzaki H, Kass DA, Marb\u00e1n E, Hare JM (1999) Intravenous allopurinol decreases myocardial oxygen consumption and increases mechanical efficiency in dogs with pacing-induced heart failure. Circ Res 85:437\u2013445","journal-title":"Circ Res"},{"key":"2905_CR16","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.freeradbiomed.2010.03.024","volume":"49","author":"M Romagnoli","year":"2010","unstructured":"Romagnoli M, Gomez-Cabrera MC, Perrelli MG, Biasi F, Pallardo FV, Sastre J, Poli G, Vina J (2010) Xanthine oxidase-induced oxidative stress causes activation of NF-\u03baB and inflammation in the liver of type I diabetic rats. Free Radic Biol Med 49:171\u2013177","journal-title":"Free Radic Biol Med"},{"key":"2905_CR17","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1177\/147323001003800209","volume":"38","author":"JW Zhang","year":"2010","unstructured":"Zhang JW, Lv GC, Zhao Y (2010) The significance of the measurement of serum xanthine oxidase and oxidation markers in patients with acute organophosphorus pesticide poisoning. J Int Med Res 38:458\u2013465","journal-title":"J Int Med Res"},{"key":"2905_CR18","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/0003-9861(91)90187-N","volume":"288","author":"YM Kitazawa","year":"1991","unstructured":"Kitazawa YM, Matsubara NT, Tanaka T (1991) The role of xanthine oxidase in paraquat intoxication. Arch Biochem Biophys 288:220\u2013224","journal-title":"Arch Biochem Biophys"},{"key":"2905_CR19","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.neuro.2007.04.008","volume":"28","author":"LM Domico","year":"2007","unstructured":"Domico LM, Cooper KR, Bernard LP, Zeevalk GD (2007) Reactive oxygen species generation by the ethylene-bis-dithiocarbamate (EBDC) fungicide mancozeb and its contribution to neuronal toxicity in mesencephalic cells. Neurotoxicology 28:1079\u20131091","journal-title":"Neurotoxicology"},{"key":"2905_CR20","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000441091","volume":"131","author":"B Gondouin","year":"2015","unstructured":"Gondouin B, Jourde-Chiche N, Sallee M, Dou L, Cerini C, Loundou A, Morange S, Berland Y, Burtey S, Brunet P, Guieu R, Dussol B (2015) Plasma xanthine oxidase activity is predictive of cardiovascular disease in patients with chronic kidney disease, independently of uric acid levels. Nephron 131:167\u2013174","journal-title":"Nephron"},{"key":"2905_CR21","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1161\/HYPERTENSIONAHA.115.06344","volume":"67","author":"RL MacIsaac","year":"2016","unstructured":"MacIsaac RL, Salatzki J, Higgins P, Walters MR, Padmanabhan S, Dominiczak AF, Touyz RM, Dawson J (2016) Allopurinol and cardiovascular outcomes in adults with hypertension. Hypertension 67:535\u2013540","journal-title":"Hypertension"},{"key":"2905_CR22","doi-asserted-by":"crossref","first-page":"15944","DOI":"10.1073\/pnas.0404136101","volume":"101","author":"SK Khan","year":"2004","unstructured":"Khan SK, Lee K, Minhas KM, Gonzalez DR, Raju SV, Tejani AD, Li D, Berkowitz DE, Hare JM (2004) Neuronal nitric oxide synthase negatively regulates xanthine oxidoreductase inhibition of cardiac excitation-contraction coupling. Proc Natl Acad Sci USA 101:15944\u201315948","journal-title":"Proc Natl Acad Sci USA"},{"key":"2905_CR23","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1161\/01.RES.0000155331.09458.A7","volume":"96","author":"S Kinugawa","year":"2005","unstructured":"Kinugawa S, Huang H, Wang Z, Kaminski PM, Wolin MS, Hintze TH (2005) A defect of neuronal nitric oxide synthase increases xanthine oxidase-derived superoxide anion and attenuates the control of myocardial oxygen consumption by nitric oxide derived from endothelial nitric oxide synthase. Circ Res 96:355\u2013362","journal-title":"Circ Res"},{"key":"2905_CR24","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.pupt.2005.01.002","volume":"18","author":"Y Komaki","year":"2005","unstructured":"Komaki Y, Sugiura H, Koarai A, Tomaki M, Ogawa H, Akita T, Hattori T, Ichinose M (2005) Cytokine-mediated xanthine oxidase up regulation in chronic obstructive pulmonary disease\u2019s airways. Pulm Pharmacol Ther 18:297\u2013302","journal-title":"Pulm Pharmacol Ther"},{"key":"2905_CR25","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s11010-013-1780-x","volume":"384","author":"NK Singhal","year":"2013","unstructured":"Singhal NK, Chauhan AK, Jain SK, Shanker R, Singh C, Singh MP (2013) Silymarin- and melatonin-mediated changes in the expression of selected genes in pesticides-induced Parkinsonism. Mol Cell Biochem 384:47\u201358","journal-title":"Mol Cell Biochem"},{"key":"2905_CR26","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1007\/s11064-010-0176-5","volume":"35","author":"SP Gupta","year":"2010","unstructured":"Gupta SP, Patel S, Yadav S, Singh AK, Singh S, Singh MP (2010) Involvement of nitric oxide in maneb- and paraquat-induced Parkinson\u2019s disease phenotype in mouse: is there any link with lipid peroxidation? Neurochem Res 35:1206\u20131213","journal-title":"Neurochem Res"},{"key":"2905_CR27","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cbi.2012.10.027","volume":"201","author":"I Ahmad","year":"2013","unstructured":"Ahmad I, Shukla S, Kumar A, Singh BK, Kumar V, Chauhan AK, Singh D, Pandey HP, Singh C (2013) Biochemical and molecular mechanisms of N-acetyl cysteine and siymarin-mediated protection against maneb- and paraquat-induced hepatotoxicity in rats. Chem Biol Interact 201:9\u201318","journal-title":"Chem Biol Interact"},{"key":"2905_CR28","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/j.1749-6632.1994.tb36766.x","volume":"723","author":"H Berisha","year":"1994","unstructured":"Berisha H, Pakbaz H, Absood A, Foda HD, Said SI (1994) Nitric oxide mediates oxidant tissue injury caused by paraquat and xanthine oxidase. Ann NY Acad Sci 723:422\u2013425","journal-title":"Ann NY Acad Sci"},{"key":"2905_CR29","first-page":"296","volume":"66","author":"M Maqbool","year":"2011","unstructured":"Maqbool M, Vidyadaran S, George E, Ramasamy R (2011) Optimization of laboratory procedures for isolating human peripheral blood derived neutrophils. Med J Malays 66:296\u2013299","journal-title":"Med J Malays"},{"key":"2905_CR30","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-016-9857-7","author":"BK Singh","year":"2016","unstructured":"Singh BK, Kumar V, Chauhan AK, Dwivedi A, Singh S, Kumar A, Singh D, Patel DK, Ray RS, Jain SK, Singh C (2016) Neuronal nitric oxide synthase negatively regulates zinc-induced nigrostriatal dopaminergic neurodegeneration. Mol Neurobiol. doi: 10.1007\/s12035-016-9857-7","journal-title":"Mol Neurobiol"},{"key":"2905_CR31","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MA Bradford","year":"1976","unstructured":"Bradford MA (1976) Rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254","journal-title":"Anal Biochem"},{"key":"2905_CR32","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1093\/toxsci\/kfr058","volume":"121","author":"J Roede","year":"2011","unstructured":"Roede J, Hansen MH, Go YM, Jones DP (2011) Maneb and paraquat-mediated neurotoxicity: involvement of peroxiredoxin\/thioredoxin system. Toxicol Sci 121:368\u2013375","journal-title":"Toxicol Sci"},{"key":"2905_CR33","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.cbi.2010.09.023","volume":"188","author":"I Ahmad","year":"2010","unstructured":"Ahmad I, Shukla S, Kumar A, Singh BK, Patel DK, Pandey HP, Singh C (2010) Maneb and paraquat-induced modulation of toxicant responsive genes in the rat liver: comparison with polymorphonuclear leukocytes. Chem Biol Interact 188:566\u2013579","journal-title":"Chem Biol Interact"},{"key":"2905_CR34","doi-asserted-by":"crossref","first-page":"472","DOI":"10.3390\/biom5020472","volume":"5","author":"A Weidinger","year":"2015","unstructured":"Weidinger A, Kozlov AV (2015) Biological activities of reactive oxygen and nitrogen species: oxidative stress versus signal transduction. Biomolecules 5:472\u2013484","journal-title":"Biomolecules"},{"key":"2905_CR35","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9478-6","author":"AK Chauhan","year":"2015","unstructured":"Chauhan AK, Mittra N, Kumar V, Patel DK, Singh C (2015) Inflammation and B-cell lymphoma-2 associated X protein regulate zinc-induced apoptotic degeneration of rat nigrostriatal dopaminergic neurons. Mol Neurobiol. doi: 10.1007\/s12035-015-9478-6","journal-title":"Mol Neurobiol"},{"key":"2905_CR36","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1172\/JCI115563","volume":"89","author":"GP Dupont","year":"1992","unstructured":"Dupont GP, Huecksteadt TP, Marshall BC, Ryan US, Michael JR, Hoidal JR (1992) Regulation of xanthine dehydrogenase and xanthine oxidase activity and gene expression in cultured rat pulmonary endothelial cells. J Clin Investig 89:197\u2013202","journal-title":"J Clin Investig"},{"key":"2905_CR37","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0304-4165(98)00028-2","volume":"1381","author":"S Page","year":"1998","unstructured":"Page S, Powell D, Benboubetra M, Stevens CR, Blake DR, Selase F, Wolstenholme AJ, Harrison R (1998) Xanthine oxidoreductase in human mammary epithelial cells: activation in response to inflammatory cytokines. Biochim Biophys Acta 1381:191\u2013202","journal-title":"Biochim Biophys Acta"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-016-2905-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11010-016-2905-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-016-2905-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T19:39:56Z","timestamp":1568662796000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11010-016-2905-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,26]]},"references-count":37,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["2905"],"URL":"https:\/\/doi.org\/10.1007\/s11010-016-2905-9","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,26]]}}}