{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:57:40Z","timestamp":1787320660809,"version":"build-2736575974"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T00:00:00Z","timestamp":1491350400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31170934"],"award-info":[{"award-number":["31170934"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31271050"],"award-info":[{"award-number":["31271050"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271717"],"award-info":[{"award-number":["81271717"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1007\/s11010-017-3016-y","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T12:42:58Z","timestamp":1491396178000},"page":"61-77","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Tbx18-dependent differentiation of brown adipose tissue-derived stem cells toward cardiac pacemaker cells"],"prefix":"10.1007","volume":"433","author":[{"given":"Lei","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Jun","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Sheng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Juan","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan-Sen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Quan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Qun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,4,5]]},"reference":[{"key":"3016_CR1","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nrcardio.2011.120","volume":"8","author":"MR Rosen","year":"2011","unstructured":"Rosen MR, Robinson RB, Brink PR, Cohen IS (2011) The road to biological pacing. Nat Rev Cardiol 8:656\u2013666","journal-title":"Nat Rev Cardiol"},{"key":"3016_CR2","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/cvr\/cvs120","volume":"94","author":"ML Bakker","year":"2012","unstructured":"Bakker ML, Boink GJ, Boukens BJ, Verkerk AO, van den Boogaard M, den Haan AD, Hoogaars WM, Buermans HP, de Bakker JM, Seppen J, Tan HL, Moorman AF, \u2018t Hoen PA, Christoffels VM (2012) T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells. Cardiovasc Res 94:439\u2013449","journal-title":"Cardiovasc Res"},{"key":"3016_CR3","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nbt.2465","volume":"31","author":"N Kapoor","year":"2013","unstructured":"Kapoor N, Liang W, Marban E, Cho HC (2013) Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18. Nat Biotechnol 31:54\u201362","journal-title":"Nat Biotechnol"},{"key":"3016_CR4","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1161\/CIRCRESAHA.113.301283","volume":"113","author":"A Scavone","year":"2013","unstructured":"Scavone A, Capilupo D, Mazzocchi N, Crespi A, Zoia S, Campostrini G, Bucchi A, Milanesi R, Baruscotti M, Benedetti S, Antonini S, Messina G, DiFrancesco D, Barbuti A (2013) Embryonic stem cell-derived CD166 + precursors develop into fully functional sinoatrial-like cells. Circ Res 113:389\u2013398","journal-title":"Circ Res"},{"key":"3016_CR5","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1161\/CIRCULATIONAHA.110.971721","volume":"122","author":"A Kleger","year":"2010","unstructured":"Kleger A, Seufferlein T, Malan D, Tischendorf M, Storch A, Wolheim A, Latz S, Protze S, Porzner M, Proepper C, Brunner C, Katz SF, Varma Pusapati G, Bullinger L, Franz WM, Koehntop R, Giehl K, Spyrantis A, Wittekindt O, Lin Q, Zenke M, Fleischmann BK, Wartenberg M, Wobus AM, Boeckers TM, Liebau S (2010) Modulation of calcium-activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker-like cells. Circulation 122:1823\u20131836","journal-title":"Circulation"},{"key":"3016_CR6","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/cbin.10194","volume":"38","author":"S Amin","year":"2014","unstructured":"Amin S, Banijamali SE, Tafazoli-Shadpour M, Shokrgozar MA, Dehghan MM, Haghighipour N, Mahdian R, Bayati V, Abbasnia P (2014) Comparing the effect of equiaxial cyclic mechanical stimulation on GATA4 expression in adipose-derived and bone marrow-derived mesenchymal stem cells. Cell Biol Int 38:219\u2013227","journal-title":"Cell Biol Int"},{"key":"3016_CR7","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0003-4975(02)04568-X","volume":"75","author":"S Rangappa","year":"2003","unstructured":"Rangappa S, Fen C, Lee EH, Bongso A, Sim EK (2003) Transformation of adult mesenchymal stem cells isolated from the fatty tissue into cardiomyocytes. Ann Thorac Surg 75: 775\u2013779","journal-title":"Ann Thorac Surg"},{"key":"3016_CR8","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1161\/01.RES.0000109792.43271.47","volume":"94","author":"V Planat-B\u00e9nard","year":"2004","unstructured":"Planat-B\u00e9nard V, Menard C, Andr\u00e9 M, Puceat M, Perez A, Garcia-Verdugo JM, P\u00e9nicaud L, Casteilla L (2004) Spontaneous cardiomyocyte differentiation from adipose tissue stroma cells. Circ Res 94:223\u2013229","journal-title":"Circ Res"},{"key":"3016_CR9","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.bbrc.2006.01.181","volume":"342","author":"Y Yamada","year":"2006","unstructured":"Yamada Y, Wang X, Yokoyama S, Fukuda N, Takakura N (2006) Cardiac progenitor cells in brown adipose tissue repaired damaged myocardium. Biochem Biophys Res Commun 342:662\u2013670","journal-title":"Biochem Biophys Res Commun"},{"key":"3016_CR10","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.bbrc.2012.07.022","volume":"424","author":"W Chang","year":"2012","unstructured":"Chang W, Lim S, Song BW, Lee CY, Park MS, Chung YA, Yoon C, Lee SY, Ham O, Park JH, Choi E, Maeng LS, Hwang KC (2012) Phorbol myristate acetate differentiates human adipose-derived mesenchymal stem cells into functional cardiogenic cells. Biochem Biophys Res Commun 424:740\u2013746","journal-title":"Biochem Biophys Res Commun"},{"key":"3016_CR11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11010-010-0523-5","volume":"344","author":"MS Jin","year":"2010","unstructured":"Jin MS, Shi S, Zhang Y, Yan Y, Sun XD, Liu W, Liu HW (2010) Icariin-mediated differentiation of mouse adipose-derived stem cells into cardiomyocytes. Mol Cell Biochem 344:1\u20139","journal-title":"Mol Cell Biochem"},{"key":"3016_CR12","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1111\/j.1582-4934.2010.01009.x","volume":"14","author":"YS Choi","year":"2010","unstructured":"Choi YS, Dusting GJ, Stubbs S, Arunothayaraj S, Han XL, Collas P, Morrison WA, Dilley RJ (2010) Differentiation of human adipose-derived stem cells into beating cardiomyocytes. J Cell Mol Med 14:878\u2013889","journal-title":"J Cell Mol Med"},{"key":"3016_CR13","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.ijcard.2007.11.068","volume":"133","author":"WC Lee","year":"2009","unstructured":"Lee WC, Sepulveda JL, Rubin JP, Marra KG (2009) Cardiomyogenic differentiation potential of human adipose precursor cells. Int J Cardiol 133:399\u2013401","journal-title":"Int J Cardiol"},{"key":"3016_CR14","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.bbrc.2007.01.095","volume":"354","author":"YH Song","year":"2007","unstructured":"Song YH, Gehmert S, Sadat S, Pinkernell K, Bai X, Matthias N, Alt E (2007) VEGF is critical for spontaneous differentiation of stem cells into cardiomyocytes. Biochem Biophys Res Commun 354:999\u20131003","journal-title":"Biochem Biophys Res Commun"},{"key":"3016_CR15","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1253\/circj.CJ-15-0400","volume":"79","author":"T Takahashi","year":"2015","unstructured":"Takahashi T, Nagai T, Kanda M, Liu ML, Kondo N, Naito AT, Ogura T, Nakaya H, Lee JK, Komuro I, Kobayashi Y (2015) Regeneration of the cardiac conduction system by adipose tissue-derived stem cells. Circ J 79:2703\u20132712","journal-title":"Circ J"},{"key":"3016_CR16","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ymeth.2008.03.006","volume":"45","author":"BA Bunnell","year":"2008","unstructured":"Bunnell BA, Flaat M, Gagliardi C, Patel B, Ripoll C (2008) Adipose-derived stem cells: isolation, expansion and differentiation. Methods 45:115\u2013120","journal-title":"Methods"},{"key":"3016_CR17","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1002\/stem.57","volume":"27","author":"J Savage","year":"2009","unstructured":"Savage J, Conley AJ, Blais A, Skerjanc IS (2009) SOX15 and SOX7 differentially regulate the myogenic program in P19 cells. Stem Cells 27:1231\u20131243","journal-title":"Stem Cells"},{"key":"3016_CR18","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1056\/NEJMoa0810780","volume":"360","author":"AM Cypess","year":"2009","unstructured":"Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, Kolodny GM, Kahn CR (2009) Identification and importance of brown adipose tissue in adult humans. N Engl J Med 360:1509\u20131517","journal-title":"N Engl J Med"},{"key":"3016_CR19","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1056\/NEJMoa0808949","volume":"360","author":"KA Virtanen","year":"2009","unstructured":"Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, Niemi T, Taittonen M, Laine J, Savisto NJ, Enerb\u00e4ck S, Nuutila P (2009) Functional brown adipose tissue in healthy adults. N Engl J Med 360:1518\u20131525","journal-title":"N Engl J Med"},{"key":"3016_CR20","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3109\/07853890.2010.535557","volume":"43","author":"S Cinti","year":"2011","unstructured":"Cinti S (2011) Between brown and white: novel aspects of adipocyte differentiation. Ann Med 43:104\u2013115","journal-title":"Ann Med"},{"key":"3016_CR21","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/cvr\/cvp267","volume":"85","author":"M Jumabay","year":"2010","unstructured":"Jumabay M, Zhang R, Yao Y, Goldhaber JI, Bostrom KI (2010) Spontaneously beating cardiomyocytes derived from white mature adipocytes. Cardiovasc Res 85:17\u201327","journal-title":"Cardiovasc Res"},{"key":"3016_CR22","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.yjmcc.2007.06.012","volume":"43","author":"NJ Palpant","year":"2007","unstructured":"Palpant NJ, Yasuda S, MacDougald O, Metzger JM (2007) Non-canonical Wnt signaling enhances differentiation of Sca1+\/c-kit + adipose-derived murine stromal vascular cells into spontaneously beating cardiac myocytes. J Mol Cell Cardiol 43:362\u2013370","journal-title":"J Mol Cell Cardiol"},{"key":"3016_CR23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.cps.2005.08.004","volume":"33","author":"SS Tholpady","year":"2006","unstructured":"Tholpady SS, Llull R, Ogle RC, Rubin JP, Futrell JW, Katz AJ (2006) Adipose tissue: stem cells and beyond. Clin Plast Surg 33:55\u201362","journal-title":"Clin Plast Surg"},{"key":"3016_CR24","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3389\/fcell.2014.00042","volume":"2","author":"C Dromard","year":"2014","unstructured":"Dromard C, Barreau C, Andr\u00e9 M, Berger-M\u00fcller S, Casteilla L, Planat-Benard V (2014) Mouse adipose tissue stromal cells give rise to skeletal and cardiomyogenic cell sub-populations. Front Cell Dev Biol 2:42","journal-title":"Front Cell Dev Biol"},{"key":"3016_CR25","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1242\/jcs.03029","volume":"119","author":"G Di Rocco","year":"2006","unstructured":"Di Rocco G, Iachininoto MG, Tritarelli A, Straino S, Zacheo A, Germani A, Crea F, Capogrossi MC (2006) Myogenic potential of adipose-tissue-derived cells. J Cell Sci 119:2945\u20132952","journal-title":"J Cell Sci"},{"key":"3016_CR26","doi-asserted-by":"crossref","first-page":"701","DOI":"10.3727\/096368912X655127","volume":"22","author":"SJ Huang","year":"2013","unstructured":"Huang SJ, Fu RH, Shyu WC, Liu SP, Jong GP, Chiu YW, Wu HS, Tsou YA, Cheng CW, Lin SZ (2013) Adipose-derived stem cells: isolation, characterization, and differentiation potential. Cell Transplant 22:701\u2013709","journal-title":"Cell Transplant"},{"key":"3016_CR27","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ijcard.2009.08.021","volume":"147","author":"C Wiese","year":"2011","unstructured":"Wiese C, Nikolova T, Zahanich I, Sulzbacher S, Fuchs J, Yamanaka S, Graf E, Ravens U, Boheler KR, Wobus AM (2011) Differentiation induction of mouse embryonic stem cells into sinus node-like cells by suramin. Int J Cardiol 147:95\u2013111","journal-title":"Int J Cardiol"},{"key":"3016_CR28","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1161\/CIRCRESAHA.109.205419","volume":"106","author":"VM Christoffels","year":"2010","unstructured":"Christoffels VM, Smits GJ, Kispert A, Moorman AF (2010) Development of the pacemaker tissues of the heart. Circ Res 106:240\u2013254","journal-title":"Circ Res"},{"key":"3016_CR29","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1007\/s00018-007-6518-z","volume":"64","author":"WM Hoogaars","year":"2007","unstructured":"Hoogaars WM, Barnett P, Moorman AF, Christoffels VM (2007) T-box factors determine cardiac design. Cell Mol Life Sci 64:646\u2013660","journal-title":"Cell Mol Life Sci"},{"key":"3016_CR30","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1161\/CIRCRESAHA.108.187062","volume":"104","author":"C Wiese","year":"2009","unstructured":"Wiese C, Grieskamp T, Airik R, Mommersteeg MT, Gardiwal A, de Gier-de Vries C, Schuster-Gossler K, Moorman AF, Kispert A, Christoffels VM (2009) Formation of the sinus node head and differentiation of sinus node myocardium are independently regulated by Tbx18 and Tbx3. Circ Res 104:388\u2013397","journal-title":"Circ Res"},{"key":"3016_CR31","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.3892\/ijmm.2016.2736","volume":"38","author":"M Yang","year":"2016","unstructured":"Yang M, Zhang GG, Wang T, Wang X, Tang YH, Huang H, Barajas-Martinez H, Hu D, Huang CX (2016) TBX18 gene induces adipose-derived stem cells to differentiate into pacemaker-like cells in the myocardial microenvironment. Int J Mol Med 38:1403\u20131410","journal-title":"Int J Mol Med"},{"key":"3016_CR32","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1101\/gad.416007","volume":"21","author":"WM Hoogaars","year":"2007","unstructured":"Hoogaars WM, Engel A, Brons JF, Verkerk AO, de Lange FJ, Wong LY, Bakker ML, Clout DE, Wakker V, Barnett P, Ravesloot JH, Moorman AF, Verheijck EE, Christoffels VM (2007) Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria. Genes Dev 21:1098\u20131112","journal-title":"Genes Dev"},{"key":"3016_CR33","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1161\/CIRCULATIONAHA.106.637819","volume":"115","author":"RJ Blaschke","year":"2007","unstructured":"Blaschke RJ, Hahurij ND, Kuijper S, Just S, Wisse LJ, Deissler K, Maxelon T, Anastassiadis K, Spitzer J, Hardt SE, Sch\u00f6ler H, Feitsma H, Rottbauer W, Blum M, Meijlink F, Rappold G, Gittenberger-de Groot AC (2007) Targeted mutation reveals essential functions of the homeodomain transcription factor Shox2 in sinoatrial and pacemaking development. Circulation 115:1830\u20131838","journal-title":"Circulation"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11010-017-3016-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-017-3016-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-017-3016-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T13:27:26Z","timestamp":1568986046000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11010-017-3016-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,5]]},"references-count":33,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["3016"],"URL":"https:\/\/doi.org\/10.1007\/s11010-017-3016-y","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,5]]}}}