{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T22:53:50Z","timestamp":1792882430550,"version":"4.5.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T00:00:00Z","timestamp":1513555200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology","doi-asserted-by":"publisher","award":["BT\/PR4268\/BRB\/10\/1016\/2011"],"award-info":[{"award-number":["BT\/PR4268\/BRB\/10\/1016\/2011"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s11010-017-3253-0","type":"journal-article","created":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T01:18:15Z","timestamp":1513559895000},"page":"79-88","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Apocynin prevents isoproterenol-induced cardiac hypertrophy in rat"],"prefix":"10.1007","volume":"445","author":[{"given":"Nikhat","family":"Saleem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anamika","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6833-9113","authenticated-orcid":false,"given":"Shyamal K.","family":"Goswami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,12,18]]},"reference":[{"key":"3253_CR1","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/nrm3495","volume":"14","author":"M Maillet","year":"2013","unstructured":"Maillet M, van Berlo JH, Molkentin JD (2013) Molecular basis of physiological heart growth: fundamental concepts and new players. Nat Rev Mol Cell Biol 14:38\u201348. \n                        https:\/\/doi.org\/10.1038\/nrm3495","journal-title":"Nat Rev Mol Cell Biol"},{"key":"3253_CR2","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.yjmcc.2016.06.001","volume":"97","author":"I Shimizu","year":"2016","unstructured":"Shimizu I, Minamino T (2016) Physiological and pathological cardiac hypertrophy. J Mol Cell Cardiol 97:245\u2013262. \n                        https:\/\/doi.org\/10.1016\/j.yjmcc.2016.06.001","journal-title":"J Mol Cell Cardiol"},{"key":"3253_CR3","doi-asserted-by":"publisher","first-page":"396","DOI":"10.3389\/fphys.2013.00396","volume":"4","author":"N Ferrara","year":"2014","unstructured":"Ferrara N, Komici K, Corbi G et al (2014) \u03b2-adrenergic receptor responsiveness in aging heart and clinical implications. Front Physiol 4:396. \n                        https:\/\/doi.org\/10.3389\/fphys.2013.00396","journal-title":"Front Physiol"},{"key":"3253_CR4","doi-asserted-by":"publisher","first-page":"265","DOI":"10.3389\/fphys.2013.00265","volume":"4","author":"M Ciccarelli","year":"2013","unstructured":"Ciccarelli M, Santulli G, Pascale V et al (2013) Adrenergic receptors and me: role in development of cardiovascular disease. Front Physiol 4:265. \n                        https:\/\/doi.org\/10.3389\/fphys.2013.00265","journal-title":"Front Physiol"},{"key":"3253_CR5","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/nrm1983","volume":"7","author":"J Heineke","year":"2006","unstructured":"Heineke J, Molkentin JD (2006) Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat Rev Mol Cell Biol 7:589\u2013600. \n                        https:\/\/doi.org\/10.1038\/nrm1983","journal-title":"Nat Rev Mol Cell Biol"},{"key":"3253_CR6","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.pharmthera.2012.06.006","volume":"135","author":"J Hou","year":"2012","unstructured":"Hou J, Kang YJ (2012) Regression of pathological cardiac hypertrophy: signaling pathways and therapeutic targets. Pharmacol Ther 135:337\u2013354. \n                        https:\/\/doi.org\/10.1016\/j.pharmthera.2012.06.006","journal-title":"Pharmacol Ther"},{"key":"3253_CR7","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1007\/s00204-015-1477-x","volume":"89","author":"YK Tham","year":"2015","unstructured":"Tham YK, Bernardo BC, Ooi JYY et al (2015) Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets. Arch Toxicol 89:1401\u20131438. \n                        https:\/\/doi.org\/10.1007\/s00204-015-1477-x","journal-title":"Arch Toxicol"},{"key":"3253_CR8","doi-asserted-by":"publisher","first-page":"2414","DOI":"10.1016\/j.bbadis.2013.07.023","volume":"1832","author":"E Dirkx","year":"2013","unstructured":"Dirkx E, da Costa Martins PA, De Windt LJ (2013) Regulation of fetal gene expression in heart failure. Biochim Biophys Acta 1832:2414\u20132424. \n                        https:\/\/doi.org\/10.1016\/j.bbadis.2013.07.023","journal-title":"Biochim Biophys Acta"},{"key":"3253_CR9","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1161\/CIRCRESAHA.114.300559","volume":"114","author":"Y-R Chen","year":"2014","unstructured":"Chen Y-R, Zweier JL (2014) Cardiac mitochondria and reactive oxygen species generation. Circ Res 114:524\u2013537. \n                        https:\/\/doi.org\/10.1161\/CIRCRESAHA.114.300559","journal-title":"Circ Res"},{"key":"3253_CR10","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.yjmcc.2014.02.002","volume":"73","author":"CM Sag","year":"2014","unstructured":"Sag CM, Santos CXC, Shah AM (2014) Redox regulation of cardiac hypertrophy. J Mol Cell Cardiol 73:103\u2013111. \n                        https:\/\/doi.org\/10.1016\/j.yjmcc.2014.02.002","journal-title":"J Mol Cell Cardiol"},{"key":"3253_CR11","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s10741-010-9186-2","volume":"16","author":"A Nabeebaccus","year":"2011","unstructured":"Nabeebaccus A, Zhang M, Shah AM (2011) NADPH oxidases and cardiac remodelling. Heart Fail Rev 16:5\u201312. \n                        https:\/\/doi.org\/10.1007\/s10741-010-9186-2","journal-title":"Heart Fail Rev"},{"key":"3253_CR12","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1089\/ars.2012.4550","volume":"18","author":"M Zhang","year":"2013","unstructured":"Zhang M, Perino A, Ghigo A et al (2013) NADPH oxidases in heart failure: poachers or gamekeepers? Antioxid Redox Signal 18:1024\u20131041. \n                        https:\/\/doi.org\/10.1089\/ars.2012.4550","journal-title":"Antioxid Redox Signal"},{"key":"3253_CR13","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.freeradbiomed.2010.04.030","volume":"49","author":"RP Brandes","year":"2010","unstructured":"Brandes RP, Weissmann N, Schr\u00f6der K (2010) NADPH oxidases in cardiovascular disease. Free Radic Biol Med 49:687\u2013706. \n                        https:\/\/doi.org\/10.1016\/j.freeradbiomed.2010.04.030","journal-title":"Free Radic Biol Med"},{"key":"3253_CR14","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1161\/CIRCRESAHA.111.243972","volume":"110","author":"B Lass\u00e8gue","year":"2012","unstructured":"Lass\u00e8gue B, San Mart\u00edn A, Griendling KK (2012) Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system. Circ Res 110:1364\u20131390. \n                        https:\/\/doi.org\/10.1161\/CIRCRESAHA.111.243972","journal-title":"Circ Res"},{"key":"3253_CR15","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/j.1755-5922.2011.00310.x","volume":"31","author":"J Streeter","year":"2013","unstructured":"Streeter J, Thiel W, Brieger K, Miller FJ (2013) Opportunity nox: the future of NADPH oxidases as therapeutic targets in cardiovascular disease. Cardiovasc Ther 31:125\u2013137. \n                        https:\/\/doi.org\/10.1111\/j.1755-5922.2011.00310.x","journal-title":"Cardiovasc Ther"},{"key":"3253_CR16","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s11010-017-3088-8","volume":"436","author":"N Saleem","year":"2017","unstructured":"Saleem N, Goswami SK (2017) Activation of adrenergic receptor in H9c2 cardiac myoblasts co-stimulates Nox2 and the derived ROS mediate the downstream responses. Mol Cell Biochem 436:167\u2013178. \n                        https:\/\/doi.org\/10.1007\/s11010-017-3088-8","journal-title":"Mol Cell Biochem"},{"key":"3253_CR17","doi-asserted-by":"publisher","first-page":"3159","DOI":"10.1038\/nprot.2006.378","volume":"1","author":"I Rahman","year":"2006","unstructured":"Rahman I, Kode A, Biswas SK (2006) Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method. Nat Protoc 1:3159\u20133165. \n                        https:\/\/doi.org\/10.1038\/nprot.2006.378","journal-title":"Nat Protoc"},{"key":"3253_CR18","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.redox.2015.05.005","volume":"5","author":"A Thakur","year":"2015","unstructured":"Thakur A, Alam MJ, Ajayakumar MR et al (2015) Norepinephrine-induced apoptotic and hypertrophic responses in H9c2 cardiac myoblasts are characterized by different repertoire of reactive oxygen species generation. Redox Biol 5:243\u2013252. \n                        https:\/\/doi.org\/10.1016\/j.redox.2015.05.005","journal-title":"Redox Biol"},{"key":"3253_CR19","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.yjmcc.2015.06.007","volume":"85","author":"M Grimm","year":"2015","unstructured":"Grimm M, Ling H, Willeford A et al (2015) CaMKII\u03b4 mediates \u03b2-adrenergic effects on RyR2 phosphorylation and SR Ca(2+) leak and the pathophysiological response to chronic \u03b2-adrenergic stimulation. J Mol Cell Cardiol 85:282\u2013291. \n                        https:\/\/doi.org\/10.1016\/j.yjmcc.2015.06.007","journal-title":"J Mol Cell Cardiol"},{"key":"3253_CR20","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1089\/ars.2013.5814","volume":"23","author":"S Altenh\u00f6fer","year":"2015","unstructured":"Altenh\u00f6fer S, Radermacher KA, Kleikers PWM et al (2015) Evolution of NADPH oxidase inhibitors: selectivity and mechanisms for target engagement. Antioxid Redox Signal 23:406\u2013427. \n                        https:\/\/doi.org\/10.1089\/ars.2013.5814","journal-title":"Antioxid Redox Signal"},{"key":"3253_CR21","doi-asserted-by":"publisher","first-page":"e110708","DOI":"10.1371\/journal.pone.0110708","volume":"9","author":"HM Ismail","year":"2014","unstructured":"Ismail HM, Scapozza L, Ruegg UT, Dorchies OM (2014) Diapocynin, a dimer of the NADPH oxidase inhibitor apocynin, reduces ROS production and prevents force loss in eccentrically contracting dystrophic muscle. PloS ONE 9:e110708. \n                        https:\/\/doi.org\/10.1371\/journal.pone.0110708","journal-title":"PloS ONE"},{"key":"3253_CR22","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1016\/j.redox.2017.05.001","volume":"12","author":"GS Youn","year":"2017","unstructured":"Youn GS, Cho H, Kim D et al (2017) Crosstalk between HDAC6 and Nox2-based NADPH oxidase mediates HIV-1 Tat-induced pro-inflammatory responses in astrocytes. Redox Biol 12:978\u2013986. \n                        https:\/\/doi.org\/10.1016\/j.redox.2017.05.001","journal-title":"Redox Biol"},{"key":"3253_CR23","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.cellsig.2015.11.013","volume":"28","author":"T Theccanat","year":"2016","unstructured":"Theccanat T, Philip JL, Razzaque AM et al (2016) Regulation of cellular oxidative stress and apoptosis by G protein-coupled receptor kinase-2; The role of NADPH oxidase 4. Cell Signal 28:190\u2013203. \n                        https:\/\/doi.org\/10.1016\/j.cellsig.2015.11.013","journal-title":"Cell Signal"},{"key":"3253_CR24","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1139\/y10-063","volume":"88","author":"J Liu","year":"2010","unstructured":"Liu J, Zhou J, An W et al (2010) Apocynin attenuates pressure overload-induced cardiac hypertrophy in rats by reducing levels of reactive oxygen species. Can J Physiol Pharmacol 88:745\u2013752. \n                        https:\/\/doi.org\/10.1139\/y10-063","journal-title":"Can J Physiol Pharmacol"},{"key":"3253_CR25","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1016\/j.freeradbiomed.2015.09.023","volume":"89","author":"P Diaz-Vivancos","year":"2015","unstructured":"Diaz-Vivancos P, de Simone A, Kiddle G, Foyer CH (2015) Glutathione\u2013linking cell proliferation to oxidative stress. Free Radic Biol Med 89:1154\u20131164. \n                        https:\/\/doi.org\/10.1016\/j.freeradbiomed.2015.09.023","journal-title":"Free Radic Biol Med"},{"key":"3253_CR26","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1016\/j.tiv.2014.04.017","volume":"28","author":"S Sentellas","year":"2014","unstructured":"Sentellas S, Morales-Ibanez O, Zanuy M, Albert\u00ed JJ (2014) GSSG\/GSH ratios in cryopreserved rat and human hepatocytes as a biomarker for drug induced oxidative stress. Toxicol Vitro Int J Publ Assoc BIBRA 28:1006\u20131015. \n                        https:\/\/doi.org\/10.1016\/j.tiv.2014.04.017","journal-title":"Toxicol Vitro Int J Publ Assoc BIBRA"},{"key":"3253_CR27","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1111\/j.1749-6632.2009.05100.x","volume":"1188","author":"H Taegtmeyer","year":"2010","unstructured":"Taegtmeyer H, Sen S, Vela D (2010) Return to the fetal gene program: a suggested metabolic link to gene expression in the heart. Ann N Y Acad Sci 1188:191\u2013198. \n                        https:\/\/doi.org\/10.1111\/j.1749-6632.2009.05100.x","journal-title":"Ann N Y Acad Sci"},{"key":"3253_CR28","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1016\/j.freeradbiomed.2011.07.008","volume":"51","author":"E Jindal","year":"2011","unstructured":"Jindal E, Goswami SK (2011) In cardiac myoblasts, cellular redox regulates FosB and Fra-1 through multiple cis-regulatory modules. Free Radic Biol Med 51:1512\u20131521. \n                        https:\/\/doi.org\/10.1016\/j.freeradbiomed.2011.07.008","journal-title":"Free Radic Biol Med"},{"key":"3253_CR29","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1097\/MAJ.0b013e3182249fcd","volume":"342","author":"DB Sawyer","year":"2011","unstructured":"Sawyer DB (2011) Oxidative stress in heart failure: what are we missing? Am J Med Sci 342:120\u2013124. \n                        https:\/\/doi.org\/10.1097\/MAJ.0b013e3182249fcd","journal-title":"Am J Med Sci"},{"key":"3253_CR30","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1016\/j.freeradbiomed.2012.07.010","volume":"53","author":"Y Zhang","year":"2012","unstructured":"Zhang Y, Tocchetti CG, Krieg T, Moens AL (2012) Oxidative and nitrosative stress in the maintenance of myocardial function. Free Radic Biol Med 53:1531\u20131540. \n                        https:\/\/doi.org\/10.1016\/j.freeradbiomed.2012.07.010","journal-title":"Free Radic Biol Med"},{"key":"3253_CR31","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.freeradbiomed.2014.07.046","volume":"76","author":"RP Brandes","year":"2014","unstructured":"Brandes RP, Weissmann N, Schr\u00f6der K (2014) Nox family NADPH oxidases: molecular mechanisms of activation. Free Radic Biol Med 76:208\u2013226. \n                        https:\/\/doi.org\/10.1016\/j.freeradbiomed.2014.07.046","journal-title":"Free Radic Biol Med"},{"key":"3253_CR32","doi-asserted-by":"publisher","first-page":"298020","DOI":"10.1155\/2014\/298020","volume":"2014","author":"BA \u2019t Hart","year":"2014","unstructured":"\u2019t Hart BA, Copray S, Philippens I (2014) Apocynin, a low molecular oral treatment for neurodegenerative disease. BioMed Res Int 2014:298020. \n                        https:\/\/doi.org\/10.1155\/2014\/298020","journal-title":"BioMed Res Int"},{"key":"3253_CR33","doi-asserted-by":"publisher","first-page":"301","DOI":"10.3389\/fncel.2016.00301","volume":"10","author":"R Rastogi","year":"2016","unstructured":"Rastogi R, Geng X, Li F, Ding Y (2016) NOX activation by subunit interaction and underlying mechanisms in disease. Front Cell Neurosci 10:301. \n                        https:\/\/doi.org\/10.3389\/fncel.2016.00301","journal-title":"Front Cell Neurosci"},{"key":"3253_CR34","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.2741\/e535","volume":"4","author":"A Simonyi","year":"2012","unstructured":"Simonyi A, Serfozo P, Lehmidi TM et al (2012) The neuroprotective effects of apocynin. Front Biosci Elite Ed 4:2183\u20132193","journal-title":"Front Biosci Elite Ed"},{"key":"3253_CR35","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.1124\/mol.106.028951","volume":"70","author":"X Liu","year":"2006","unstructured":"Liu X, Sun SQ, Hassid A, Ostrom RS (2006) cAMP inhibits transforming growth factor-beta-stimulated collagen synthesis via inhibition of extracellular signal-regulated kinase 1\/2 and Smad signaling in cardiac fibroblasts. Mol Pharmacol 70:1992\u20132003. \n                        https:\/\/doi.org\/10.1124\/mol.106.028951","journal-title":"Mol Pharmacol"},{"key":"3253_CR36","doi-asserted-by":"publisher","first-page":"e0152005","DOI":"10.1371\/journal.pone.0152005","volume":"11","author":"Q Yin","year":"2016","unstructured":"Yin Q, Yang C, Wu J et al (2016) Downregulation of \u03b2-adrenoceptors in isoproterenol-induced cardiac remodeling through HuR. PloS ONE 11:e0152005. \n                        https:\/\/doi.org\/10.1371\/journal.pone.0152005","journal-title":"PloS ONE"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11010-017-3253-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-017-3253-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-017-3253-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T07:59:37Z","timestamp":1530691177000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11010-017-3253-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,18]]},"references-count":36,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["3253"],"URL":"https:\/\/doi.org\/10.1007\/s11010-017-3253-0","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,18]]}}}