{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T21:32:45Z","timestamp":1769117565064,"version":"3.49.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T00:00:00Z","timestamp":1530576000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Ministry of Chemicals and Fertilizers, Govt. of India"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1007\/s11010-018-3394-9","type":"journal-article","created":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T16:28:55Z","timestamp":1530635335000},"page":"69-78","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Attenuation of type-1 diabetes-induced cardiovascular dysfunctions by direct thrombin inhibitor in rats: a mechanistic study"],"prefix":"10.1007","volume":"451","author":[{"given":"Yogesh","family":"Bulani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishnamoorthy","family":"Srinivasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyam Sunder","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,7,3]]},"reference":[{"key":"3394_CR1","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/0002-9149(72)90595-4","volume":"30","author":"S Rubler","year":"1972","unstructured":"Rubler S, Dlugash J, Yuceoglu YZ, Kumral T, Branwood AW, Grishman A (1972) New type of cardiomyopathy associated with diabetic glomerulosclerosis. Am J Cardiol 30:595\u2013602","journal-title":"Am J Cardiol"},{"key":"3394_CR2","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.thromres.2008.07.017","volume":"123","author":"E Sola","year":"2009","unstructured":"Sola E, Navarro S, Medina P, Vaya A, Estelles A, Hernandez-Mijares A, Espana F (2009) Activated protein C levels in obesity and weight loss influence. Thromb Res 123:697\u2013700","journal-title":"Thromb Res"},{"key":"3394_CR3","doi-asserted-by":"publisher","first-page":"5321","DOI":"10.1210\/jc.2003-030508","volume":"88","author":"M Romano","year":"2003","unstructured":"Romano M, Guagnano MT, Pacini G, Vigneri S, Falco A, Marinopiccoli M, Manigrasso MR, Basili S, Davi G (2003) Association of inflammation markers with impaired insulin sensitivity and coagulative activation in obese healthy women. J Clin Endocrinol Metab 88:5321\u20135326","journal-title":"J Clin Endocrinol Metab"},{"key":"3394_CR4","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/0735-1097(95)00518-8","volume":"27","author":"I Aoki","year":"1996","unstructured":"Aoki I, Shimoyama K, Aoki N, Homori M, Yanagisawa A, Nakahara K, Kawai Y, Kitamura SI, Ishikawa K (1996) Platelet-dependent thrombin generation in patients with diabetes mellitus: effects of glycemic control on coagulability in diabetes. J Am Coll Cardiol 27:560\u2013566","journal-title":"J Am Coll Cardiol"},{"key":"3394_CR5","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/S0049-3848(03)00338-4","volume":"111","author":"G Ersoz","year":"2003","unstructured":"Ersoz G, Yakaryilmaz A, Turan B (2003) Effect of sodium selenite treatment on platelet aggregation of streptozotocin-induced diabetic rats. Thromb Res 111:363\u2013367","journal-title":"Thromb Res"},{"key":"3394_CR6","doi-asserted-by":"publisher","first-page":"27","DOI":"10.5551\/jat1994.4.27","volume":"4","author":"M Okazaki","year":"1997","unstructured":"Okazaki M, Zhang H, Tsuji M, Morio Y, Oguchi K (1997) Blood coagulability and fibrinolysis in streptozotocin-induced diabetic rats. J Atheroscler Thromb 4:27\u201333","journal-title":"J Atheroscler Thromb"},{"key":"3394_CR7","doi-asserted-by":"publisher","first-page":"C1429","DOI":"10.1152\/ajpcell.1998.274.6.C1429","volume":"274","author":"O Dery","year":"1998","unstructured":"Dery O, Corvera CU, Steinhoff M, Bunnett NW (1998) Proteinase-activated receptors: novel mechanisms of signaling by serine proteases. Am J Physiol 274:C1429\u2013C1452","journal-title":"Am J Physiol"},{"key":"3394_CR8","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1161\/01.RES.86.10.1054","volume":"86","author":"A Sabri","year":"2000","unstructured":"Sabri A, Muske G, Zhang H, Pak E, Darrow A, Andrade-Gordon P, Steinberg SF (2000) Signaling properties and functions of two distinct cardiomyocyte protease-activated receptors. Circ Res 86:1054\u20131061","journal-title":"Circ Res"},{"key":"3394_CR9","doi-asserted-by":"publisher","first-page":"11714","DOI":"10.1074\/jbc.M213091200","volume":"278","author":"A Sabri","year":"2003","unstructured":"Sabri A, Guo J, Elouardighi H, Darrow AL, Andrade-Gordon P, Steinberg SF (2003) Mechanisms of protease-activated receptor-4 actions in cardiomyocytes. Role of Src tyrosine kinase. J Biol Chem 278:11714\u201311720","journal-title":"J Biol Chem"},{"key":"3394_CR10","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1536\/ihj.13-351","volume":"55","author":"L Kitasato","year":"2014","unstructured":"Kitasato L, Yamaoka-Tojo M, Hashikata T, Ishii S, Kameda R, Shimohama T, Tojo T, Ako J (2014) Factor Xa in mouse fibroblasts may induce fibrosis more than thrombin. Int Heart J 55:357\u2013361","journal-title":"Int Heart J"},{"key":"3394_CR11","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1161\/01.RES.0000035242.96310.45","volume":"91","author":"A Sabri","year":"2002","unstructured":"Sabri A, Short J, Guo J, Steinberg SF (2002) Protease-activated receptor-1-mediated DNA synthesis in cardiac fibroblast is via epidermal growth factor receptor transactivation: distinct PAR-1 signaling pathways in cardiac fibroblasts and cardiomyocytes. Circ Res 91:532\u2013539","journal-title":"Circ Res"},{"key":"3394_CR12","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.jacbts.2016.05.002","volume":"1","author":"C Jumeau","year":"2016","unstructured":"Jumeau C, Rupin A, Chieng-Yane P, Mougenot N, Zahr N, David-Dufilho M, Hatem SN (2016) Direct Thrombin Inhibitors Prevent Left Atrial Remodeling Associated With Heart Failure in Rats. JACC Basic Transl Sci 1:328\u2013339","journal-title":"JACC Basic Transl Sci"},{"key":"3394_CR13","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1210\/en.2009-0661","volume":"151","author":"M Mihara","year":"2010","unstructured":"Mihara M, Aihara K, Ikeda Y, Yoshida S, Kinouchi M, Kurahashi K, Fujinaka Y, Akaike M, Matsumoto T (2010) Inhibition of thrombin action ameliorates insulin resistance in type 2 diabetic db\/db mice. Endocrinology 151:513\u2013519","journal-title":"Endocrinology"},{"key":"3394_CR14","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1016\/j.ajpath.2012.06.011","volume":"181","author":"KM Kassel","year":"2012","unstructured":"Kassel KM, Sullivan BP, Cui W, Copple BL, Luyendyk JP (2012) Therapeutic administration of the direct thrombin inhibitor argatroban reduces hepatic inflammation in mice with established fatty liver disease. Am J Pathol 181:1287\u20131295","journal-title":"Am J Pathol"},{"key":"3394_CR15","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s10557-017-6732-3","volume":"31","author":"Y Bulani","year":"2017","unstructured":"Bulani Y, Sharma SS (2017) Argatroban attenuates diabetic cardiomyopathy in rats by reducing fibrosis, inflammation, apoptosis, and protease-activated receptor expression. Cardiovasc Drugs Ther 31:255\u2013267. https:\/\/doi.org\/10.1007\/s10557-017-6732-3","journal-title":"Cardiovasc Drugs Ther"},{"key":"3394_CR16","doi-asserted-by":"publisher","first-page":"936","DOI":"10.2337\/diab.37.7.936","volume":"37","author":"N Afzal","year":"1988","unstructured":"Afzal N, Ganguly PK, Dhalla KS, Pierce GN, Singal PK, Dhalla NS (1988) Beneficial effects of verapamil in diabetic cardiomyopathy. Diabetes 37:936\u2013942","journal-title":"Diabetes"},{"key":"3394_CR17","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1038\/sj.bjp.0704131","volume":"133","author":"G Miric","year":"2001","unstructured":"Miric G, Dallemagne C, Endre Z, Margolin S, Taylor SM, Brown L (2001) Reversal of cardiac and renal fibrosis by pirfenidone and spironolactone in streptozotocin-diabetic rats. Br J Pharmacol 133:687\u2013694","journal-title":"Br J Pharmacol"},{"key":"3394_CR18","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1038\/nprot.2008.138","volume":"3","author":"P Pacher","year":"2008","unstructured":"Pacher P, Nagayama T, Mukhopadhyay P, Batkai S, Kass DA (2008) Measurement of cardiac function using pressure-volume conductance catheter technique in mice and rats. Nat Protoc 3:1422\u20131434","journal-title":"Nat Protoc"},{"key":"3394_CR19","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265\u2013275","journal-title":"J Biol Chem"},{"key":"3394_CR20","doi-asserted-by":"publisher","first-page":"H125","DOI":"10.1152\/ajpheart.00165.2009","volume":"297","author":"T Radovits","year":"2009","unstructured":"Radovits T, Korkmaz S, Loganathan S, Barnucz E, Bomicke T, Arif R, Karck M, Szabo G (2009) Comparative investigation of the left ventricular pressure-volume relationship in rat models of type 1 and type 2 diabetes mellitus. Am J Physiol Heart Circ Physiol 297:H125\u2013H133","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"3394_CR21","doi-asserted-by":"publisher","first-page":"H1137","DOI":"10.1152\/ajpheart.2001.281.3.H1137","volume":"281","author":"Y Zhong","year":"2001","unstructured":"Zhong Y, Ahmed S, Grupp IL, Matlib MA (2001) Altered SR protein expression associated with contractile dysfunction in diabetic rat hearts. Am J Physiol Heart Circ Physiol 281:H1137\u2013H1147","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"3394_CR22","first-page":"E798","volume":"277","author":"X Liu","year":"1999","unstructured":"Liu X, Wang J, Takeda N, Binaglia L, Panagia V, Dhalla NS (1999) Changes in cardiac protein kinase C activities and isozymes in streptozotocin-induced diabetes. Am J Physiol 277:E798\u2013E804","journal-title":"Am J Physiol"},{"key":"3394_CR23","doi-asserted-by":"publisher","first-page":"3103","DOI":"10.1111\/bph.12656","volume":"171","author":"S Satheesan","year":"2014","unstructured":"Satheesan S, Figarola JL, Dabbs T, Rahbar S, Ermel R (2014) Effects of a new advanced glycation inhibitor, LR-90, on mitigating arterial stiffening and improving arterial elasticity and compliance in a diabetic rat model: aortic impedance analysis. Br J Pharmacol 171:3103\u20133114","journal-title":"Br J Pharmacol"},{"key":"3394_CR24","doi-asserted-by":"publisher","first-page":"300","DOI":"10.3181\/00379727-208-43860","volume":"208","author":"MJ Katovich","year":"1995","unstructured":"Katovich MJ, Hanley K, Strubbe G, Wright BE (1995) Effects of streptozotocin-induced diabetes and insulin treatment on blood pressure in the male rat. Proc Soc Exp Biol Med 208:300\u2013306","journal-title":"Proc Soc Exp Biol Med"},{"key":"3394_CR25","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1196\/annals.1372.007","volume":"1084","author":"FC Howarth","year":"2006","unstructured":"Howarth FC, Al-Shamsi N, Al-Qaydi M, Al-Mazrouei M, Qureshi A, Chandranath SI, Kazzam E, Adem A (2006) Effects of brain natriuretic peptide on contraction and intracellular Ca2+ in ventricular myocytes from the streptozotocin-induced diabetic rat. Ann N Y Acad Sci 1084:155\u2013165","journal-title":"Ann N Y Acad Sci"},{"key":"3394_CR26","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/j.cardiores.2006.11.033","volume":"73","author":"Z Xia","year":"2007","unstructured":"Xia Z, Kuo KH, Nagareddy PR, Wang F, Guo Z, Guo T, Jiang J, McNeill JH (2007) N-acetylcysteine attenuates PKCbeta2 overexpression and myocardial hypertrophy in streptozotocin-induced diabetic rats. Cardiovasc Res 73:770\u2013782","journal-title":"Cardiovasc Res"},{"key":"3394_CR27","doi-asserted-by":"publisher","first-page":"2298","DOI":"10.1161\/CIRCULATIONAHA.107.692764","volume":"116","author":"R Pawlinski","year":"2007","unstructured":"Pawlinski R, Tencati M, Hampton CR, Shishido T, Bullard TA, Casey LM, Andrade-Gordon P, Kotzsch M, Spring D, Luther T, Abe J, Pohlman TH, Verrier ED, Blaxall BC, Mackman N (2007) Protease-activated receptor-1 contributes to cardiac remodeling and hypertrophy. Circulation 116:2298\u20132306","journal-title":"Circulation"},{"key":"3394_CR28","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1016\/S0002-9440(10)62525-4","volume":"159","author":"DC Howell","year":"2001","unstructured":"Howell DC, Goldsack NR, Marshall RP, McAnulty RJ, Starke R, Purdy G, Laurent GJ, Chambers RC (2001) Direct thrombin inhibition reduces lung collagen, accumulation, and connective tissue growth factor mRNA levels in bleomycin-induced pulmonary fibrosis. Am J Pathol 159:1383\u20131395","journal-title":"Am J Pathol"},{"key":"3394_CR29","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1038\/nrm3619","volume":"14","author":"M Xin","year":"2013","unstructured":"Xin M, Olson EN, Bassel-Duby R (2013) Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair. Nat Rev Mol Cell Biol 14:529\u2013541","journal-title":"Nat Rev Mol Cell Biol"},{"key":"3394_CR30","doi-asserted-by":"publisher","first-page":"4540","DOI":"10.1096\/fj.12-213496","volume":"26","author":"AN Snead","year":"2012","unstructured":"Snead AN, Insel PA (2012) Defining the cellular repertoire of GPCRs identifies a profibrotic role for the most highly expressed receptor, protease-activated receptor 1, in cardiac fibroblasts. FASEB J 26:4540\u20134547","journal-title":"FASEB J"},{"key":"3394_CR31","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1093\/eurheartj\/ehw119","volume":"38","author":"HM Spronk","year":"2017","unstructured":"Spronk HM, De Jong AM, Verheule S, De Boer HC, Maass AH, Lau DH, Rienstra M, van Hunnik A, Kuiper M, Lumeij S, Zeemering S, Linz D, Kamphuisen PW, Ten Cate H, Crijns HJ, Van Gelder IC, van Zonneveld AJ, Schotten U (2017) Hypercoagulability causes atrial fibrosis and promotes atrial fibrillation. Eur Heart J 38:38\u201350","journal-title":"Eur Heart J"},{"key":"3394_CR32","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1177\/1074248413485434","volume":"18","author":"DL Sonin","year":"2013","unstructured":"Sonin DL, Wakatsuki T, Routhu KV, Harmann LM, Petersen M, Meyer J, Strande JL (2013) Protease-activated receptor 1 inhibition by SCH79797 attenuates left ventricular remodeling and profibrotic activities of cardiac fibroblasts. J Cardiovasc Pharmacol Ther 18:460\u2013475","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"3394_CR33","doi-asserted-by":"publisher","first-page":"242","DOI":"10.4103\/1673-5374.199011","volume":"12","author":"JN Yang","year":"2017","unstructured":"Yang JN, Chen J, Xiao M (2017) A protease-activated receptor 1 antagonist protects against global cerebral ischemia\/reperfusion injury after asphyxial cardiac arrest in rabbits. Neural Regen Res 12:242\u2013249","journal-title":"Neural Regen Res"},{"key":"3394_CR34","doi-asserted-by":"publisher","first-page":"2595","DOI":"10.3892\/mmr.2017.6303","volume":"15","author":"S Zhang","year":"2017","unstructured":"Zhang S, Liu Y, Wang Z, Liu J, Gu Z, Xu Q, Su L (2017) PAR1-mediated c-Jun activation promotes heat stress-induced early stage apoptosis of human umbilical vein endothelial cells. Mol Med Rep 15:2595\u20132603","journal-title":"Mol Med Rep"},{"key":"3394_CR35","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1093\/cvr\/cvp305","volume":"85","author":"N Mariappan","year":"2010","unstructured":"Mariappan N, Elks CM, Sriramula S, Guggilam A, Liu Z, Borkhsenious O, Francis J (2010) NF-kappaB-induced oxidative stress contributes to mitochondrial and cardiac dysfunction in type II diabetes. Cardiovasc Res 85:473\u2013483","journal-title":"Cardiovasc Res"},{"key":"3394_CR36","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.2337\/diab.47.8.1318","volume":"47","author":"Y Nishio","year":"1998","unstructured":"Nishio Y, Kashiwagi A, Taki H, Shinozaki K, Maeno Y, Kojima H, Maegawa H, Haneda M, Hidaka H, Yasuda H, Horiike K, Kikkawa R (1998) Altered activities of transcription factors and their related gene expression in cardiac tissues of diabetic rats. Diabetes 47:1318\u20131325","journal-title":"Diabetes"},{"key":"3394_CR37","doi-asserted-by":"publisher","first-page":"e94228","DOI":"10.1371\/journal.pone.0094228","volume":"9","author":"R Padiya","year":"2014","unstructured":"Padiya R, Chowdhury D, Borkar R, Srinivas R, Pal Bhadra M, Banerjee SK (2014) Garlic attenuates cardiac oxidative stress via activation of PI3K\/AKT\/Nrf2-Keap1 pathway in fructose-fed diabetic rat. PLoS ONE 9:e94228","journal-title":"PLoS ONE"},{"key":"3394_CR38","doi-asserted-by":"publisher","first-page":"618","DOI":"10.2337\/db13-1896","volume":"64","author":"H Suzuki","year":"2015","unstructured":"Suzuki H, Kayama Y, Sakamoto M, Iuchi H, Shimizu I, Yoshino T, Katoh D, Nagoshi T, Tojo K, Minamino T, Yoshimura M, Utsunomiya K (2015) Arachidonate 12\/15-lipoxygenase-induced inflammation and oxidative stress are involved in the development of diabetic cardiomyopathy. Diabetes 64:618\u2013630","journal-title":"Diabetes"},{"key":"3394_CR39","doi-asserted-by":"publisher","first-page":"H1036","DOI":"10.1152\/ajpheart.00340.2014","volume":"307","author":"CM Thomas","year":"2014","unstructured":"Thomas CM, Yong QC, Rosa RM, Seqqat R, Gopal S, Casarini DE, Jones WK, Gupta S, Baker KM, Kumar R (2014) Cardiac-specific suppression of NF-kappaB signaling prevents diabetic cardiomyopathy via inhibition of the renin-angiotensin system. Am J Physiol Heart Circ Physiol 307:H1036\u2013H1045","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"3394_CR40","doi-asserted-by":"publisher","unstructured":"Lorenzo O, Picatoste B, Ares-Carrasco S, Ramirez E, Egido J, Tunon J (2011) Potential role of nuclear factor kappaB in diabetic cardiomyopathy. Mediators Inflamm 2011. https:\/\/doi.org\/10.1155\/2011\/652097","DOI":"10.1155\/2011\/652097"},{"key":"3394_CR41","doi-asserted-by":"publisher","first-page":"48","DOI":"10.3389\/fimmu.2015.00048","volume":"6","author":"KL Lannan","year":"2015","unstructured":"Lannan KL, Sahler J, Kim N, Spinelli SL, Maggirwar SB, Garraud O, Cognasse F, Blumberg N, Phipps RP (2015) Breaking the mold: transcription factors in the anucleate platelet and platelet-derived microparticles. Front Immunol 6:48","journal-title":"Front Immunol"},{"key":"3394_CR42","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.3892\/ijmm.2015.2136","volume":"35","author":"SJ Jin","year":"2015","unstructured":"Jin SJ, Liu Y, Deng SH, Liao LH, Lin TL, Ning Q, Luo XP (2015) Neuroprotective effects of activated protein C on intrauterine inflammation-induced neonatal white matter injury are associated with the downregulation of fibrinogen-like protein 2\/fibroleukin prothrombinase and the inhibition of pro-inflammatory cytokine expression. Int J Mol Med 35:1199\u20131212","journal-title":"Int J Mol Med"},{"key":"3394_CR43","doi-asserted-by":"publisher","first-page":"2278","DOI":"10.1016\/j.ajpath.2011.07.015","volume":"179","author":"KM Kassel","year":"2011","unstructured":"Kassel KM, Owens AP 3rd, Rockwell CE, Sullivan BP, Wang R, Tawfik O, Li G, Guo GL, Mackman N, Luyendyk JP (2011) Protease-activated receptor 1 and hematopoietic cell tissue factor are required for hepatic steatosis in mice fed a Western diet. Am J Pathol 179:2278\u20132289","journal-title":"Am J Pathol"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11010-018-3394-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-018-3394-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-018-3394-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T22:46:15Z","timestamp":1661553975000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11010-018-3394-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,3]]},"references-count":43,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["3394"],"URL":"https:\/\/doi.org\/10.1007\/s11010-018-3394-9","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,3]]},"assertion":[{"value":"5 August 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"There is no conflict of interest associated with this publication.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}