{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:52:16Z","timestamp":1790016736652,"version":"4.0.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T00:00:00Z","timestamp":1535932800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"The Scientific and Technological Research Project in Henan Province","award":["162102210297"],"award-info":[{"award-number":["162102210297"]}]},{"name":"The Scientific and Technological Research Project in Henan Province","award":["172102110034"],"award-info":[{"award-number":["172102110034"]}]},{"name":"Major Scientific and Technological Project in Henan Province","award":["141100110800"],"award-info":[{"award-number":["141100110800"]}]},{"name":"Key Research Projects of Higher Education in Henan province","award":["17A230011"],"award-info":[{"award-number":["17A230011"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1007\/s11010-018-3436-3","type":"journal-article","created":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T08:21:14Z","timestamp":1535962874000},"page":"111-119","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Stimulation role of epinephrine in transcription of the melatonin synthesis key enzyme AANAT in the pineal gland of broilers"],"prefix":"10.1007","volume":"453","author":[{"given":"Yongfen","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,9,3]]},"reference":[{"key":"3436_CR1","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.2174\/1567205014666170523092858","volume":"14","author":"M Munch","year":"2017","unstructured":"Munch M, Schmieder M, Bieler K, Goldbach R, Fuhrmann T, Zumstein N, Vonmoos P, Scartezzini JL, Wirz-Justice A, Cajochen C (2017) Bright light delights: effects of daily light exposure on emotions, rest-activity cycles, sleep and melatonin secretion in severely demented patients. Curr Alzheimer Res 14:1063\u20131075. https:\/\/doi.org\/10.2174\/1567205014666170523092858","journal-title":"Curr Alzheimer Res"},{"issue":"1","key":"3436_CR2","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/j.1600-079X.2008.00602.x","volume":"46","author":"JT Kang","year":"2009","unstructured":"Kang JT, Koo OJ, Kwon DK, Park HJ, Jang G, Kang SK, Lee BC (2009) Effects of melatonin on in vitro maturation of porcine oocyte and expression of melatonin receptor RNA in cumulus and granulosa cells. J Pineal Res 46(1):22\u201328. https:\/\/doi.org\/10.1111\/j.1600-079x.2008.00602.x","journal-title":"J Pineal Res"},{"key":"3436_CR3","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/173675","author":"J Jaworek","year":"2012","unstructured":"Jaworek J, Szklarczyk J, Jaworek AK, Nawrot-Porabka K, Leja-Szpak A, Bonior J, Kot M (2012) Protective effect of melatonin on acute pancreatitis. Int J Inflam. https:\/\/doi.org\/10.1155\/2012\/173675","journal-title":"Int J Inflam"},{"issue":"13","key":"3436_CR4","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1007\/s00018-008-8001-x","volume":"65","author":"R Hardeland","year":"2008","unstructured":"\u00a0Hardeland R (2008) Melatonin, hormone of darkness and more: occurrence, control mechanisms, actions and bioactive metabolites. Cell Mol Life Sci 65(13):2001\u20132018. https:\/\/doi.org\/10.1007\/s00018-008-8001-x","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"3436_CR5","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.acthis.2008.03.004","volume":"112","author":"K Stebelov\u00e1","year":"2010","unstructured":"Stebelov\u00e1 K, Anttila K, M\u00e4ntt\u00e4ri S, Saarela S, Zeman M (2010) Immunohistochemical definition of MT2 receptors and melatonin in the gastrointestinal tissues of rat. Acta Histochemica 112(1):26\u201333. https:\/\/doi.org\/10.1016\/j.acthis.2008.03.004","journal-title":"Acta Histochemica"},{"issue":"1\u20132","key":"3436_CR6","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/S0006-8993(01)02936-5","volume":"918","author":"Y Isobe","year":"2001","unstructured":"Isobe Y, Fujioi J, Nishino H (2001) Circadian rhythm of melatonin release in pineal gland culture: arg-vasopressin inhibits melatonin release. Brain Res 918(1\u20132):67\u201373. https:\/\/doi.org\/10.1016\/s0006-8993(01)02936-5","journal-title":"Brain Res"},{"issue":"3950","key":"3436_CR7","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1126\/science.169.3950.1093","volume":"169","author":"DC Klein","year":"1970","unstructured":"Klein DC, Weller JL (1970) Indole metabolism in the pineal gland: a circadian rhythm in N-acetyltransferase. Sci 169(3950):1093-1095. https:\/\/doi.org\/10.1126\/science.169.3950.1093","journal-title":"Sci"},{"issue":"4","key":"3436_CR8","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1177\/074873001129002033","volume":"16","author":"JH Stehle","year":"2001","unstructured":"Stehle JH, von Gall C, Schomerus C, Korf HW (2001) Of rodents and ungulates and melatonin: creating a uniform code for darkness by different signaling mechanisms. J Biol Rhythms 16(4):312\u2013325. https:\/\/doi.org\/10.1177\/074873001129002033","journal-title":"J Biol Rhythms"},{"issue":"6","key":"3436_CR9","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.1046\/j.1471-4159.2000.0742315.x","volume":"74","author":"M Zatz","year":"2000","unstructured":"Zatz M, Gastel JA, Heath JR, Klein DC (2000) Chick Pineal Melatonin Synthesiss : light and cyclic AMP control abundance of serotonin N-acetyltransferase protein. J Neurochem 74(6):2315\u20132321. https:\/\/doi.org\/10.1046\/j.1471-4159.2000.0742315.x","journal-title":"J Neurochem"},{"key":"3436_CR10","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/S0014-2999(01)01250-X","volume":"430","author":"E Rey","year":"2001","unstructured":"Rey E, Hernandez-Diaz FJ, Abreu P, Alonso R, Tabares L (2001) Dopamine induces intracellular Ca2+ signals mediated by alpha1B-adrenoceptors in rat pineal cells. Euro J Pharmacol 430:9\u201317. https:\/\/doi.org\/10.1016\/s0014-2999(01)01250-x","journal-title":"Euro J Pharmacol"},{"key":"3436_CR11","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/0006-8993(88)91553-3","volume":"450","author":"M Zatz","year":"1988","unstructured":"Zatz M, Mullen DA (1988) Norepinephrine, acting via adenylate cyclase, inhibits melatonin output but does not phase-shift the pacemaker in cultured chick pineal cells. Brain Res 450:137\u2013143. https:\/\/doi.org\/10.1016\/0006-8993(88)91553-3","journal-title":"Brain Res"},{"issue":"2","key":"3436_CR12","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0031-6997(24)01449-2","volume":"52","author":"D Vaudry","year":"2000","unstructured":"Vaudry D, Gonzalez BJ, Basille M, Yon L, Fournier A, Vaudry H (2000) Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions. Pharmacol Rev 52(2):269\u2013324","journal-title":"Pharmacol Rev"},{"issue":"4","key":"3436_CR13","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1034\/j.1600-079X.2001.300406.x","volume":"30","author":"MT Albarran","year":"2001","unstructured":"Albarran MT, Lopez-Burillo S, Pablos MI, Reiter RJ, Agapito MT (2001) Endogenous rhythms of melatonin, total antioxidant status and superoxide dismutase activity in several tissues of chick and their inhibition by light. J Pineal Res 30(4):227\u2013233. https:\/\/doi.org\/10.1034\/j.1600-079x.2001.300406.x","journal-title":"J Pineal Res"},{"issue":"2","key":"3436_CR14","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1080\/09291010701324715","volume":"39","author":"C Claudia","year":"2008","unstructured":"Claudia C, Lucia F, Estela M, Morten M, Lilian P (2008) Daily rhythms of norepinephrine, \u03b21-adrenoceptor mRNA, serotonin, arylalkylamine N-acetyltransferase mRNA, arylalkylamine N-acetyltransferase and hydroxyindol-O-methyltransferase activities, and melatonin in the pineal gland of viscacha. Biol Rhythm Res 39(2):93\u2013107. https:\/\/doi.org\/10.1080\/09291010701324715","journal-title":"Biol Rhythm Res"},{"issue":"2","key":"3436_CR15","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1124\/pr.55.2.2","volume":"55","author":"V Simonneaux","year":"2003","unstructured":"Simonneaux V, Ribelayga C (2003) Generation of the melatonin endocrine message in mammals: a review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters. Pharmacol Rev 55(2):325\u2013395. https:\/\/doi.org\/10.1124\/pr.55.2.2","journal-title":"Pharmacol Rev"},{"key":"3436_CR16","doi-asserted-by":"publisher","unstructured":"Peliciari-Garcia RA, Andrade-Silva J, Cipolla-Neto J, Carvalho CR (2013) Leptin modulates norepinephrine-mediated melatonin synthesis in cultured rat pineal gland. Biomed Res Int 2013:546516. https:\/\/doi.org\/10.1155\/2013\/546516","DOI":"10.1155\/2013\/546516"},{"issue":"42","key":"3436_CR17","doi-asserted-by":"publisher","first-page":"32991","DOI":"10.1074\/jbc.M005671200","volume":"275","author":"NW Chong","year":"2000","unstructured":"Chong NW, Bernard M, Klein DC (2000) Characterization of the chicken serotonin N-acetyltransferase gene. Activation via clock gene heterodimer\/E box interaction. J biol chem 275(42):32991\u201332998. https:\/\/doi.org\/10.1074\/jbc.m005671200","journal-title":"J biol chem"},{"issue":"8","key":"3436_CR18","doi-asserted-by":"publisher","first-page":"2966","DOI":"10.1210\/en.2014-1232","volume":"155","author":"K Rohde","year":"2014","unstructured":"Rohde K, Rovsing L, Ho AK, Moller M, Rath MF (2014) Circadian dynamics of the cone-rod homeobox (CRX) transcription factor in the rat pineal gland and its role in regulation of arylalkylamine N-acetyltransferase (AANAT). Endocrinol 155 (8):2966\u20132975. https:\/\/doi.org\/10.1210\/en.2014-1232","journal-title":"Endocrinol"},{"issue":"1","key":"3436_CR19","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.snb.2010.10.041","volume":"153","author":"RN Goyal","year":"2011","unstructured":"Goyal RN, Aziz MA, Oyama M, Chatterjee S, Rana ARS (2011) Nanogold based electrochemical sensor for determination of norepinephrine in biological fluids. Sens Actuators B: Chem 153(1):232\u2013238. https:\/\/doi.org\/10.1016\/j.snb.2010.10.041","journal-title":"Sens Actuators B: Chem"},{"issue":"2","key":"3436_CR20","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.snb.2009.01.022","volume":"137","author":"S Shahrokhian","year":"2009","unstructured":"Shahrokhian S, Ghalkhani M, Amini MK (2009) Application of carbon-paste electrode modified with iron phthalocyanine for voltammetric determination of epinephrine in the presence of ascorbic acid and uric acid. Sens Actuators B: Chem 137(2):669\u2013675. https:\/\/doi.org\/10.1016\/j.snb.2009.01.022","journal-title":"Sens Actuators B: Chem"},{"key":"3436_CR21","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/0006-8993(88)91339-X","volume":"438","author":"M Zatz","year":"1988","unstructured":"Zatz M, Mullen Da Fau - Moskal JR, Moskal JR (1988) Photoendocrine transduction in cultured chick pineal cells: effects of light, dark, and potassium on the melatonin rhythm. Brain Res 438:199\u2013215. https:\/\/doi.org\/10.1016\/0006-8993(88)91339-x","journal-title":"Brain Res"},{"issue":"4","key":"3436_CR22","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2\u2212\u0394\u0394CT Method. Methods 25(4):402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods"},{"issue":"2","key":"3436_CR23","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1093\/cvr\/cvu258","volume":"105","author":"AM Wengrowski","year":"2015","unstructured":"Wengrowski AM, Wang X, Tapa S, Posnack NG, Mendelowitz D, Kay MW (2015) Optogenetic release of norepinephrine from cardiac sympathetic neurons alters mechanical and electrical function. Cardiovasc Res 105(2):143\u2013150. https:\/\/doi.org\/10.1093\/cvr\/cvu258","journal-title":"Cardiovasc Res"},{"issue":"1","key":"3436_CR24","doi-asserted-by":"publisher","first-page":"55","DOI":"10.2141\/jpsa.35.55","volume":"35","author":"Z Fu","year":"2008","unstructured":"Fu Z, Kato H, Sugahara K, Kubo T (2008) Circadian Rhythm of Pineal Melatonin in Silky Chicks. Jan Poult Sci 35(1):55\u201359. https:\/\/doi.org\/10.2141\/jpsa.35.55","journal-title":"Jan Poult Sci"},{"key":"3436_CR25","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.electacta.2014.01.160","volume":"125","author":"Yadav SK Rosy","year":"2014","unstructured":"\u00a0Rosy, Yadav SK, Agrawal B, Oyama M, Goyal RN (2014) Graphene modified Palladium sensor for electrochemical analysis of norepinephrine in pharmaceuticals and biological fluids. Electrochimica Acta 125:622\u2013629. https:\/\/doi.org\/10.1016\/j.electacta.2014.01.160","journal-title":"Electrochimica Acta"},{"key":"3436_CR26","doi-asserted-by":"publisher","first-page":"911","DOI":"10.2116\/analsci.30.911","volume":"30","author":"HH Nadiki","year":"2014","unstructured":"Nadiki HH, Noroozifar M, Khorasani-Motlagh M (2014) Development of glassy carbon electrode modified with ruthenium red-multiwalled carbon nanotubes for simultaneous determination of epinephrine and acetaminophen. Anal sci 30:911\u2013918. https:\/\/doi.org\/10.2116\/analsci.30.911","journal-title":"Anal sci"},{"key":"3436_CR27","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1007\/s00228-015-1873-4","volume":"71","author":"NG Harps\u00f8e","year":"2015","unstructured":"Harps\u00f8e NG, Andersen LPH, G\u00f6genur I, Rosenberg J (2015) Clinical pharmacokinetics of melatonin: a systematic review. Eur J Clin Pharmacol 71:901\u2013909. https:\/\/doi.org\/10.1007\/s00228-015-1873-4","journal-title":"Eur J Clin Pharmacol."},{"key":"3436_CR28","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1254\/jjp.81.29","volume":"81","author":"M Wang","year":"1999","unstructured":"Wang M, Yokotani K, Nakamura K, Murakami Y, Okada S, Osumi Y (1999) Melatonin inhibits the central sympatho-adrenomedullary outflow in rats. Jan J Pharmacol 81:29\u201333. https:\/\/doi.org\/10.1254\/jjp.81.29","journal-title":"Jan J Pharmacol"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11010-018-3436-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-018-3436-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-018-3436-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T20:05:25Z","timestamp":1751832325000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11010-018-3436-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,3]]},"references-count":28,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["3436"],"URL":"https:\/\/doi.org\/10.1007\/s11010-018-3436-3","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,3]]},"assertion":[{"value":"29 December 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 September 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All applicable international, national, and\/or institutional guidelines for the care and use of animals were followed.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}