{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T17:37:05Z","timestamp":1776706625203,"version":"3.51.2"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:00:00Z","timestamp":1566432000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:00:00Z","timestamp":1566432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"JSPS KAKENHI","award":["17K07184"],"award-info":[{"award-number":["17K07184"]}]},{"DOI":"10.13039\/100007428","name":"Naito Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1007\/s11010-019-03606-8","type":"journal-article","created":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T07:02:32Z","timestamp":1566457352000},"page":"25-31","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["A novel compound, ferulic acid-bound resveratrol, induces the tumor suppressor gene p15 and inhibits the three-dimensional proliferation of colorectal cancer cells"],"prefix":"10.1007","volume":"462","author":[{"given":"Yuuga","family":"Sawata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiji","family":"Matsukawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Doi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Tsunoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagisa","family":"Arikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natsumi","family":"Matsunaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichiro","family":"Ohnuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senji","family":"Shirasawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yojiro","family":"Kotake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,8,22]]},"reference":[{"key":"3606_CR1","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1038\/nrm859","volume":"3","author":"LE O\u2019Brien","year":"2002","unstructured":"O\u2019Brien LE, Zegers MM, Mostov KE (2002) Building epithelial architecture: insights from three-dimensional culture models. Nat Rev Mol Cell Biol 3:531\u2013537. \nhttps:\/\/doi.org\/10.1038\/nrm859","journal-title":"Nat Rev Mol Cell Biol"},{"key":"3606_CR2","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/nrm1858","volume":"7","author":"LG Griffith","year":"2006","unstructured":"Griffith LG, Swartz MA (2006) Capturing complex 3D tissue physiology in vitro. Nat Rev Mol Cell Biol 7:211\u2013224. \nhttps:\/\/doi.org\/10.1038\/nrm1858","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5","key":"3606_CR3","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1593\/neo.10170","volume":"12","author":"T Tsunoda","year":"2010","unstructured":"Tsunoda T, Takashima Y, Fujimoto T, Koyanagi M, Yoshida Y, Doi K, Tanaka Y, Kuroki M, Sasazuki T, Shirasawa S (2010) Three-dimensionally specific inhibition of DNA repair-related genes by activated KRAS in colon crypt model. Neoplasia 12(5):397\u2013404","journal-title":"Neoplasia"},{"key":"3606_CR4","doi-asserted-by":"publisher","first-page":"478","DOI":"10.2203\/dose-response.09-015.Mukherjee","volume":"8","author":"S Mukherjee","year":"2010","unstructured":"Mukherjee S, Dudley JI, Das DK (2010) Dose-dependency of resveratrol in providing health benefits. Dose Response 8:478\u2013500","journal-title":"Dose Response"},{"key":"3606_CR5","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.jnutbio.2005.01.017","volume":"16","author":"P Signorelli","year":"2005","unstructured":"Signorelli P, Ghidoni R (2005) Resveratrol as an anticancer nutrient: molecular basis, open questions and promises. J Nutr Biochem 16:449\u2013466. \nhttps:\/\/doi.org\/10.1016\/j.jnutbio.2005.01.017","journal-title":"J Nutr Biochem"},{"key":"3606_CR6","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.fct.2013.07.021","volume":"61","author":"A Carrizzo","year":"2013","unstructured":"Carrizzo A, Forte M, Damato A, Trimarco V, Salzano F, Bartolo M, Maciag A, Puca AA, Vecchione C (2013) Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases. Food Chem Toxicol 61:215\u2013226. \nhttps:\/\/doi.org\/10.1016\/j.fct.2013.07.021","journal-title":"Food Chem Toxicol"},{"issue":"8","key":"3606_CR7","first-page":"4551","volume":"34","author":"T Tsunoda","year":"2014","unstructured":"Tsunoda T, Ishikura S, Doi K, Matsuzaki H, Iwaihara Y, Shirasawa S (2014) Resveratrol induces luminal apoptosis of human colorectal cancer HCT116 cells in three-dimensional culture. Anticancer Res 34(8):4551\u20134555","journal-title":"Anticancer Res"},{"issue":"8","key":"3606_CR8","first-page":"4453","volume":"35","author":"T Tsunoda","year":"2015","unstructured":"Tsunoda T, Ishikura S, Doi K, Iwaihara Y, Hidesima H, Luo H, Hirose Y, Shirasawa S (2015) Establishment of a three-dimensional floating cell culture system for screening drugs targeting KRAS-mediated signaling molecules. Anticancer Res 35(8):4453\u20134459","journal-title":"Anticancer Res"},{"issue":"1\u20132","key":"3606_CR9","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s11010-017-3191-x","volume":"442","author":"H Okamoto","year":"2018","unstructured":"Okamoto H, Matsukawa T, Doi S, Tsunoda T, Sawata Y, Naemura M, Ohnuki K, Shirasawa S, Kotake Y (2018) A novel resveratrol derivative selectively inhibits the proliferation of colorectal cancer cells with KRAS mutation. Mol Cell Biochem 442(1\u20132):39\u201345","journal-title":"Mol Cell Biochem"},{"key":"3606_CR10","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1101\/gad.13.12.1501","volume":"13","author":"CJ Sherr","year":"1999","unstructured":"Sherr CJ, Roberts JM (1999) CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 13:1501\u20131512","journal-title":"Genes Dev"},{"key":"3606_CR11","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1126\/science.274.5293.1672","volume":"274","author":"CJ Sherr","year":"1996","unstructured":"Sherr CJ (1996) Cancer cell cycles. Science 274:1672\u20131677","journal-title":"Science"},{"key":"3606_CR12","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1126\/science.8465203","volume":"260","author":"S Shirasawa","year":"1993","unstructured":"Shirasawa S, Furuse M, Yokoyama N, Sasazuki T (1993) Altered growth of human colon cancer cell lines disrupted at activated Ki-ras. Science 260:85\u201388","journal-title":"Science"},{"key":"3606_CR13","unstructured":"Doi S, Kishi A, Matsukawa T, Nojima M, Matsui T, Yamada Y, Yamada I (2015) A novel resveratrol derivative. Japan. Patent 5703887"},{"key":"3606_CR14","unstructured":"Kishi A, Matsukawa T, Doi S, Nojima M, Matsui T, Yamada Y, Yamada I (2015) A novel resveratrol derivative. Japan. Patent 5673091"},{"key":"3606_CR15","unstructured":"Doi S, Matsukawa T, Kishi A, Nojima M, Matsui T, Yamada Y, Yamada I (2015) A novel resveratrol derivative. Japan. Patent 5728972"},{"key":"3606_CR16","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1101\/gad.1499407","volume":"21","author":"Y Kotake","year":"2007","unstructured":"Kotake Y, Cao R, Viatour P, Sage J, Zhang Y, Xiong Y (2007) pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene. Genes Dev 21:49\u201354. \nhttps:\/\/doi.org\/10.1101\/gad.1499407","journal-title":"Genes Dev"},{"key":"3606_CR17","doi-asserted-by":"publisher","first-page":"81","DOI":"10.21873\/anticanres.11292","volume":"37","author":"Y Kotake","year":"2017","unstructured":"Kotake Y, Goto T, Naemura M, Inoue Y, Okamoto H, Tahara K (2017) Long noncoding RNA PANDA positively regulates proliferation of osteosarcoma cells. Anticancer Res 37:81\u201385. \nhttps:\/\/doi.org\/10.21873\/anticanres.11292","journal-title":"Anticancer Res"},{"key":"3606_CR18","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1080\/01635581.2011.538486","volume":"63","author":"B Janicke","year":"2011","unstructured":"Janicke B, Hegardt C, Krogh M, Onning G, Akesson B, Cirenajwis HM, Oredsson SM (2011) The antiproliferative effect of dietary fiber phenolic compounds ferulic acid and p-coumaric acid on the cell cycle of Caco-2 cells. Nutr Cancer 63:611\u2013622. \nhttps:\/\/doi.org\/10.1080\/01635581.2011.538486","journal-title":"Nutr Cancer"},{"key":"3606_CR19","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1038\/371257a0","volume":"371","author":"GJ Hannon","year":"1994","unstructured":"Hannon GJ, Beach D (1994) p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature 371:257\u2013261. \nhttps:\/\/doi.org\/10.1038\/371257a0","journal-title":"Nature"},{"key":"3606_CR20","doi-asserted-by":"publisher","first-page":"35053","DOI":"10.1074\/jbc.274.49.35053","volume":"274","author":"JN Rich","year":"1999","unstructured":"Rich JN, Zhang M, Datto MB, Bigner DD, Wang XF (1999) Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines. J Biol Chem 274:35053\u201335058","journal-title":"J Biol Chem"},{"key":"3606_CR21","doi-asserted-by":"publisher","first-page":"5178","DOI":"10.1093\/emboj\/19.19.5178","volume":"19","author":"XH Feng","year":"2000","unstructured":"Feng XH, Lin X, Derynck R (2000) Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta. EMBO J 19:5178\u20135193. \nhttps:\/\/doi.org\/10.1093\/emboj\/19.19.5178","journal-title":"EMBO J"},{"key":"3606_CR22","doi-asserted-by":"publisher","first-page":"1956","DOI":"10.1038\/onc.2010.568","volume":"30","author":"Y Kotake","year":"2011","unstructured":"Kotake Y, Nakagawa T, Kitagawa K, Suzuki S, Liu N, Kitagawa M, Xiong Y (2011) Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15(INK4B) tumor suppressor gene. Oncogene 30:1956\u20131962. \nhttps:\/\/doi.org\/10.1038\/onc.2010.568","journal-title":"Oncogene"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-019-03606-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11010-019-03606-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-019-03606-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T23:39:03Z","timestamp":1597966743000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11010-019-03606-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,22]]},"references-count":22,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["3606"],"URL":"https:\/\/doi.org\/10.1007\/s11010-019-03606-8","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,22]]},"assertion":[{"value":"17 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The resveratrol derivatives (UHA023, UHA024, and UHA025) used in this study were provided by UHA Mikakuto Co., Ltd. Taiji Matsukawa and Satoshi Doi are employees of UHA Mikakuto Co., Ltd. The authors have no conflict of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}