{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:18:52Z","timestamp":1760300332616,"version":"3.37.3"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"crossref","award":["81471522","81671536","81871223"],"award-info":[{"award-number":["81471522","81671536","81871223"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Nature Science Foundation of Guangdong Province of China","award":["2014A030313482"],"award-info":[{"award-number":["2014A030313482"]}]},{"name":"Guangdong Provincial Science and Technology Project","award":["2016A020218015"],"award-info":[{"award-number":["2016A020218015"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1007\/s11010-019-03678-6","type":"journal-article","created":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T14:02:33Z","timestamp":1577887353000},"page":"187-197","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["MicroRNA-9119 regulates cell viability of granulosa cells in polycystic ovarian syndrome via mediating Dicer expression"],"prefix":"10.1007","volume":"465","author":[{"given":"Yang","family":"Ding","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8569-8775","authenticated-orcid":false,"given":"Zhiling","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,1,1]]},"reference":[{"key":"3678_CR1","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1016\/j.fertnstert.2014.04.024","volume":"101","author":"T Imbar","year":"2014","unstructured":"Imbar T, Eisenberg I (2014) Regulatory role of microRNAs in ovarian function. Fertil Steril 101:1524\u20131530","journal-title":"Fertil Steril"},{"key":"3678_CR2","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1757-2215-5-8","volume":"5","author":"J Baley","year":"2012","unstructured":"Baley J, Li J (2012) MicroRNAs and ovarian function. J Ovarian Res 5:8","journal-title":"J Ovarian Res"},{"key":"3678_CR3","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1210\/jc.2003-031122","volume":"89","author":"R Azziz","year":"2004","unstructured":"Azziz R, Sanchez LA, Knochenhauer ES et al (2004) Androgen excess in women: experience with over 1000 consecutive patients. J Clin Endocrinol Metab 89:453\u2013462","journal-title":"J Clin Endocrinol Metab"},{"key":"3678_CR4","doi-asserted-by":"publisher","first-page":"4237","DOI":"10.1210\/jc.2006-0178","volume":"91","author":"R Azziz","year":"2006","unstructured":"Azziz R, Carmina E, Dewailly D et al (2006) Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline. J Clin Endocrinol Metab 91:4237\u20134245","journal-title":"J Clin Endocrinol Metab"},{"key":"3678_CR5","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1111\/j.1365-2605.2005.00623.x","volume":"29","author":"S Franks","year":"2006","unstructured":"Franks S, McCarthy MI, Hardy K (2006) Development of polycystic ovary syndrome: involvement of genetic and environmental factors. Int J Androl 29: 278\u201385; (discussion 286\u2013290).","journal-title":"Int J Androl"},{"key":"3678_CR6","doi-asserted-by":"publisher","first-page":"98","DOI":"10.3390\/jcm7050098","volume":"7","author":"T Fujii","year":"2018","unstructured":"Fujii T, Shimada K, Nakai T et al (2018) MicroRNAs in smoking-related carcinogenesis: biomarkers, functions, and therapy. J Clin Med 7:98","journal-title":"J Clin Med"},{"key":"3678_CR7","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.molmed.2014.06.005","volume":"20","author":"J Hayes","year":"2014","unstructured":"Hayes J, Peruzzi PP, Lawler S (2014) MicroRNAs in cancer: biomarkers, functions and therapy. Trends Mol Med 20:460\u2013469","journal-title":"Trends Mol Med"},{"key":"3678_CR8","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/ncb1596","volume":"9","author":"H Valadi","year":"2007","unstructured":"Valadi H, Ekstr\u00f6m K, Bossios A et al (2007) Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 9:654","journal-title":"Nat Cell Biol"},{"key":"3678_CR9","doi-asserted-by":"publisher","first-page":"10513","DOI":"10.1073\/pnas.0804549105","volume":"105","author":"PS Mitchell","year":"2008","unstructured":"Mitchell PS, Parkin RK, Kroh EM et al (2008) Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci 105:10513\u201310518","journal-title":"Proc Natl Acad Sci"},{"key":"3678_CR10","doi-asserted-by":"publisher","first-page":"E1835","DOI":"10.1210\/jc.2013-2218","volume":"98","author":"M Murri","year":"2013","unstructured":"Murri M, Insenser M, Fern\u00e1ndez-Dur\u00e1n E et al (2013) Effects of polycystic ovary syndrome (PCOS), sex hormones, and obesity on circulating miRNA-21, miRNA-27b, miRNA-103, and miRNA-155 expression. J Clin Endocrinol Metab 98:E1835\u2013E1844","journal-title":"J Clin Endocrinol Metab"},{"key":"3678_CR11","doi-asserted-by":"publisher","first-page":"85","DOI":"10.15171\/bi.2016.12","volume":"6","author":"M Salimi-Asl","year":"2016","unstructured":"Salimi-Asl M, Mozdarani H, Kadivar M (2016) Up-regulation of miR-21 and 146a expression and increased DNA damage frequency in a mouse model of polycystic ovary syndrome (PCOS). BioImpacts: BI 6: 85.","journal-title":"BioImpacts: BI"},{"key":"3678_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1757-2215-6-36","volume":"6","author":"MM Hossain","year":"2013","unstructured":"Hossain MM, Cao M, Wang Q et al (2013) Altered expression of miRNAs in a dihydrotestosterone-induced rat PCOS model. J Ovarian Res 6:1","journal-title":"J Ovarian Res"},{"key":"3678_CR13","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.7150\/ijbs.12611","volume":"11","author":"Y Guan","year":"2015","unstructured":"Guan Y, Yao H, Wang J et al (2015) NF-\u03baB-DICER-miRs axis regulates TNF-\u03b1 expression in responses to endotoxin stress. Int J Biol Sci 11:1257","journal-title":"Int J Biol Sci"},{"key":"3678_CR14","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.mce.2009.09.021","volume":"315","author":"L Lei","year":"2010","unstructured":"Lei L, Jin S, Gonzalez G et al (2010) The regulatory role of Dicer in folliculogenesis in mice. Mol Cell Endocrinol 315:63\u201373","journal-title":"Mol Cell Endocrinol"},{"key":"3678_CR15","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1093\/humrep\/des463","volume":"28","author":"NK Stepto","year":"2013","unstructured":"Stepto NK, Cassar S, Joham AE et al (2013) Women with polycystic ovary syndrome have intrinsic insulin resistance on euglycaemic-hyperinsulaemic clamp. Hum Reprod 28:777\u2013784","journal-title":"Hum Reprod"},{"key":"3678_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12958-019-0505-8","volume":"17","author":"T He","year":"2019","unstructured":"He T, Sun Y, Zhang Y et al (2019) MicroRNA-200b and microRNA-200c are up-regulated in PCOS granulosa cell and inhibit KGN cell proliferation via targeting PTEN. Reprod Biol Endocrinol 17:1\u20138","journal-title":"Reprod Biol Endocrinol"},{"key":"3678_CR17","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1158\/2326-6066.CIR-14-0112","volume":"2","author":"Y Xia","year":"2014","unstructured":"Xia Y, Shen S, Verma IM (2014) NF-kappaB, an active player in human cancers. Cancer Immunol Res 2:823\u2013830","journal-title":"Cancer Immunol Res"},{"key":"3678_CR18","doi-asserted-by":"publisher","first-page":"6781","DOI":"10.1038\/sj.onc.1209944","volume":"25","author":"S Gerondakis","year":"2006","unstructured":"Gerondakis S, Grumont R, Gugasyan R et al (2006) Unravelling the complexities of the NF-kappaB signalling pathway using mouse knockout and transgenic models. Oncogene 25:6781\u20136799","journal-title":"Oncogene"},{"key":"3678_CR19","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1111\/bju.12488","volume":"114","author":"DP Nguyen","year":"2014","unstructured":"Nguyen DP, Li J, Yadav SS et al (2014) Recent insights into NF-kappaB signalling pathways and the link between inflammation and prostate cancer. BJU Int 114:168\u2013176","journal-title":"BJU Int"},{"key":"3678_CR20","doi-asserted-by":"publisher","first-page":"2083","DOI":"10.1007\/s00018-013-1545-4","volume":"71","author":"C Gasparini","year":"2014","unstructured":"Gasparini C, Celeghini C, Monasta L et al (2014) NF-kappaB pathways in hematological malignancies. Cell Mol Life Sci 71:2083\u20132102","journal-title":"Cell Mol Life Sci"},{"key":"3678_CR21","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.canlet.2010.10.015","volume":"332","author":"A Arlt","year":"2013","unstructured":"Arlt A, Muerkoster SS, Schafer H (2013) Targeting apoptosis pathways in pancreatic cancer. Cancer Lett 332:346\u2013358","journal-title":"Cancer Lett"},{"key":"3678_CR22","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1038\/nrc2889","volume":"10","author":"M Gyrd-Hansen","year":"2010","unstructured":"Gyrd-Hansen M, Meier P (2010) IAPs: from caspase inhibitors to modulators of NF-\u03baB, inflammation and cancer. Nat Rev Cancer 10:561","journal-title":"Nat Rev Cancer"},{"key":"3678_CR23","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1146\/annurev.immunol.14.1.649","volume":"14","author":"S Albert","year":"1996","unstructured":"Albert S, Baldwin J (1996) THE NF-\u03baB AND I\u03baB PROTEINS: New Discoveries and Insights. Annu Rev Immunol 14:649\u2013681","journal-title":"Annu Rev Immunol"},{"key":"3678_CR24","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/nsmb729","volume":"11","author":"MA Carmell","year":"2004","unstructured":"Carmell MA, Hannon GJ (2004) RNase III enzymes and the initiation of gene silencing. Nat Struct Mol Biol 11:214","journal-title":"Nat Struct Mol Biol"},{"key":"3678_CR25","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.cub.2007.01.050","volume":"17","author":"Z Jin","year":"2007","unstructured":"Jin Z, Xie T (2007) Dcr-1 maintains Drosophila ovarian stem cells. Curr Biol 17:539\u2013544","journal-title":"Curr Biol"},{"key":"3678_CR26","doi-asserted-by":"publisher","first-page":"15918","DOI":"10.1074\/jbc.M110.178798","volume":"286","author":"R Sun","year":"2011","unstructured":"Sun R, Zhang Y, Lv Q et al (2011) Toll-like receptor 3 (TLR3) induces apoptosis via death receptors and mitochondria by up-regulating the transactivating p63 isoform \u03b1 (TAP63\u03b1). J Biol Chem 286:15918\u201315928","journal-title":"J Biol Chem"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-019-03678-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11010-019-03678-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-019-03678-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T00:20:50Z","timestamp":1609374050000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11010-019-03678-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,1]]},"references-count":26,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["3678"],"URL":"https:\/\/doi.org\/10.1007\/s11010-019-03678-6","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"type":"print","value":"0300-8177"},{"type":"electronic","value":"1573-4919"}],"subject":[],"published":{"date-parts":[[2020,1,1]]},"assertion":[{"value":"4 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 January 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Every procedure was approved by the Animal Care and Use Committee of the First Affiliated Hospital of Shantou University Medical College.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}