{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T15:48:33Z","timestamp":1778600913674,"version":"3.51.4"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T00:00:00Z","timestamp":1593993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T00:00:00Z","timestamp":1593993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1007\/s11010-020-03754-2","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T18:03:36Z","timestamp":1594058616000},"page":"1-8","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Silencing of long non-coding RNA CRNDE promotes autophagy and alleviates neonatal hypoxic-ischemic brain damage in rats"],"prefix":"10.1007","volume":"472","author":[{"given":"Chun-Hua","family":"Fu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang-Fang","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cai-Xia","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing-Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Zhi","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1855-4816","authenticated-orcid":false,"given":"Gao-Hua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,7,6]]},"reference":[{"key":"3754_CR1","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1080\/14737175.2017.1259567","volume":"17","author":"EP Yildiz","year":"2017","unstructured":"Yildiz EP, Ekici B, Tatli B (2017) Neonatal hypoxic ischemic encephalopathy: an update on disease pathogenesis and treatment. Expert Rev Neurother 17:449\u2013459. https:\/\/doi.org\/10.1080\/14737175.2017.1259567","journal-title":"Expert Rev Neurother"},{"key":"3754_CR2","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1038\/nature06639","volume":"451","author":"N Mizushima","year":"2008","unstructured":"Mizushima N, Levine B, Cuervo AM, Klionsky DJ (2008) Autophagy fights disease through cellular self-digestion. Nature 451:1069\u20131075. https:\/\/doi.org\/10.1038\/nature06639","journal-title":"Nature"},{"key":"3754_CR3","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.nbd.2008.07.022","volume":"32","author":"S Carloni","year":"2008","unstructured":"Carloni S, Buonocore G, Balduini W (2008) Protective role of autophagy in neonatal hypoxia-ischemia induced brain injury. Neurobiol Dis 32:329\u2013339. https:\/\/doi.org\/10.1016\/j.nbd.2008.07.022","journal-title":"Neurobiol Dis"},{"key":"3754_CR4","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1111\/jnc.13851","volume":"139","author":"Y Xu","year":"2016","unstructured":"Xu Y, Tian Y, Tian Y, Li X, Zhao P (2016) Autophagy activation involved in hypoxic-ischemic brain injury induces cognitive and memory impairment in neonatal rats. J Neurochem 139:795\u2013805. https:\/\/doi.org\/10.1111\/jnc.13851","journal-title":"J Neurochem"},{"key":"3754_CR5","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.expneurol.2017.12.008","volume":"301","author":"L Ye","year":"2018","unstructured":"Ye L, Feng Z, Doycheva D, Malaguit J, Dixon B, Xu N, Zhang JH, Tang J (2018) CpG-ODN exerts a neuroprotective effect via the TLR9\/pAMPK signaling pathway by activation of autophagy in a neonatal HIE rat model. Exp Neurol 301:70\u201380. https:\/\/doi.org\/10.1016\/j.expneurol.2017.12.008","journal-title":"Exp Neurol"},{"key":"3754_CR6","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1042\/BST20160376","volume":"45","author":"ZH Kwok","year":"2017","unstructured":"Kwok ZH, Tay Y (2017) Long noncoding RNAs: lincs between human health and disease. Biochem Soc Trans 45:805","journal-title":"Biochem Soc Trans"},{"key":"3754_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainresbull.2019.06.004","volume":"152","author":"H Fang","year":"2019","unstructured":"Fang H, Li HF, He MH, Yan JY, Yang M, Zhang FX, Wang RR, Wang QY, Zhang JP (2019) Long non-coding RNA MALAT1 sponges microRNA-429 to regulate apoptosis of hippocampal neurons in hypoxic-ischemic brain damage by regulating WNT1. Brain Res Bull 152:1\u201310. https:\/\/doi.org\/10.1016\/j.brainresbull.2019.06.004","journal-title":"Brain Res Bull"},{"key":"3754_CR8","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.28075","author":"XM Zhou","year":"2018","unstructured":"Zhou XM, Liu J, Wang Y, Zhang MH (2018) Silencing of long noncoding RNA MEG3 enhances cerebral protection of dexmedetomidine against hypoxic-ischemic brain damage in neonatal mice by binding to miR-129-5p. J Cell Biochem. https:\/\/doi.org\/10.1002\/jcb.28075","journal-title":"J Cell Biochem"},{"key":"3754_CR9","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.bbrc.2018.02.070","volume":"497","author":"RB Zhao","year":"2018","unstructured":"Zhao RB, Zhu LH, Shu JP, Qiao LX, Xia ZK (2018) GAS5 silencing protects against hypoxia\/ischemia-induced neonatal brain injury. Biochem Biophys Res Commun 497:285\u2013291. https:\/\/doi.org\/10.1016\/j.bbrc.2018.02.070","journal-title":"Biochem Biophys Res Commun"},{"key":"3754_CR10","doi-asserted-by":"publisher","first-page":"72833","DOI":"10.18632\/oncotarget.12023","volume":"7","author":"S Shen","year":"2016","unstructured":"Shen S, Liu H, Wang Y, Wang J, Ni X, Ai Z, Pan H, Liu H, Shao Y (2016) Long non-coding RNA CRNDE promotes gallbladder carcinoma carcinogenesis and as a scaffold of DMBT1 and C-IAP1 complexes to activating PI3K-AKT pathway. Oncotarget 7:72833\u201372844. https:\/\/doi.org\/10.18632\/oncotarget.12023","journal-title":"Oncotarget"},{"key":"3754_CR11","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1038\/mt.2016.71","volume":"24","author":"J Zheng","year":"2016","unstructured":"Zheng J, Liu X, Wang P, Xue Y, Ma J, Qu C, Liu Y (2016) CRNDE promotes malignant progression of glioma by attenuating miR-384\/PIWIL4\/STAT3 Axis. Mol Ther 24:1199\u20131215. https:\/\/doi.org\/10.1038\/mt.2016.71","journal-title":"Mol Ther"},{"key":"3754_CR12","doi-asserted-by":"publisher","first-page":"2332","DOI":"10.1080\/15384101.2019.1647024","volume":"18","author":"M Yi","year":"2019","unstructured":"Yi M, Dai X, Li Q, Xu X, Chen Y, Wang D (2019) Downregulated lncRNA CRNDE contributes to the enhancement of nerve repair after traumatic brain injury in rats. Cell Cycle 18:2332\u20132343. https:\/\/doi.org\/10.1080\/15384101.2019.1647024","journal-title":"Cell Cycle"},{"key":"3754_CR13","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1093\/jnen\/nlx052","volume":"76","author":"F Zhao","year":"2017","unstructured":"Zhao F, Qu Y, Zhu J, Zhang L, Huang L, Liu H, Li S, Mu D (2017) miR-30d-5p plays an important role in autophagy and apoptosis in developing rat brains after hypoxic-ischemic injury. J Neuropathol Exp Neurol 76:709\u2013719. https:\/\/doi.org\/10.1093\/jnen\/nlx052","journal-title":"J Neuropathol Exp Neurol"},{"key":"3754_CR14","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1007\/s00281-010-0220-1","volume":"32","author":"Y Ichimura","year":"2010","unstructured":"Ichimura Y, Komatsu M (2010) Selective degradation of p62 by autophagy. Semin Immunopathol 32:431\u2013436. https:\/\/doi.org\/10.1007\/s00281-010-0220-1","journal-title":"Semin Immunopathol"},{"key":"3754_CR15","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1177\/1947601911431081","volume":"2","author":"LD Graham","year":"2011","unstructured":"Graham LD, Pedersen SK, Brown GS, Ho T, Kassir Z, Moynihan AT, Vizgoft EK, Dunne R, Pimlott L, Young GP, Lapointe LC, Molloy PL (2011) Colorectal neoplasia differentially expressed (CRNDE), a novel gene with elevated expression in colorectal adenomas and adenocarcinomas. Genes Cancer 2:829\u2013840. https:\/\/doi.org\/10.1177\/1947601911431081","journal-title":"Genes Cancer"},{"key":"3754_CR16","doi-asserted-by":"publisher","first-page":"e2997","DOI":"10.1038\/cddis.2017.328","volume":"8","author":"J Ding","year":"2017","unstructured":"Ding J, Li J, Wang H, Tian Y, Xie M, He X, Ji H, Ma Z, Hui B, Wang K, Ji G (2017) Long noncoding RNA CRNDE promotes colorectal cancer cell proliferation via epigenetically silencing DUSP5\/CDKN1A expression. Cell Death Dis 8:e2997. https:\/\/doi.org\/10.1038\/cddis.2017.328","journal-title":"Cell Death Dis"},{"key":"3754_CR17","doi-asserted-by":"publisher","DOI":"10.3727\/096504019x15742472027401","author":"XH Sun","year":"2019","unstructured":"Sun XH, Fan WJ, An ZJ, Sun Y (2019) Inhibition of long non-coding RNA CRNDE increases chemosensitivity of medulloblastoma cells by targeting MiR-29c-3p. Oncol Res. https:\/\/doi.org\/10.3727\/096504019x15742472027401","journal-title":"Oncol Res"},{"key":"3754_CR18","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgz166","author":"X Bai","year":"2019","unstructured":"Bai X, Wang W, Zhao P, Wen J, Guo X, Shen T, Shen J, Yang X (2019) LncRNA CRNDE acts as an oncogene in cervical cancer through sponging miR-183 to regulate CCNB1 expression. Carcinogenesis. https:\/\/doi.org\/10.1093\/carcin\/bgz166","journal-title":"Carcinogenesis"},{"key":"3754_CR19","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.canlet.2015.03.027","volume":"367","author":"Y Wang","year":"2015","unstructured":"Wang Y, Wang Y, Li J, Zhang Y, Yin H, Han B (2015) CRNDE, a long-noncoding RNA, promotes glioma cell growth and invasion through mTOR signaling. Cancer Lett 367:122\u2013128. https:\/\/doi.org\/10.1016\/j.canlet.2015.03.027","journal-title":"Cancer Lett"},{"key":"3754_CR20","doi-asserted-by":"publisher","first-page":"4597","DOI":"10.1111\/jcmm.13781","volume":"22","author":"S Pop","year":"2018","unstructured":"Pop S, Enciu A-M, Necula LG, Tanase C (2018) Long non-coding RNAs in brain tumours: focus on recent epigenetic findings in glioma. J Cell Mol Med 22:4597\u20134610. https:\/\/doi.org\/10.1111\/jcmm.13781","journal-title":"J Cell Mol Med"},{"key":"3754_CR21","doi-asserted-by":"publisher","first-page":"846","DOI":"10.4161\/auto.28264","volume":"10","author":"V Ginet","year":"2014","unstructured":"Ginet V, Spiehlmann A, Rummel C, Rudinskiy N, Grishchuk Y, Luthi-Carter R, Clarke PGH, Truttmann AC, Puyal J (2014) Involvement of autophagy in hypoxic-excitotoxic neuronal death. Autophagy 10:846\u2013860. https:\/\/doi.org\/10.4161\/auto.28264","journal-title":"Autophagy"},{"key":"3754_CR22","doi-asserted-by":"publisher","first-page":"454","DOI":"10.2353\/ajpath.2008.070876","volume":"172","author":"M Koike","year":"2008","unstructured":"Koike M, Shibata M, Tadakoshi M, Gotoh K, Komatsu M, Waguri S, Kawahara N, Kuida K, Nagata S, Kominami E, Tanaka K, Uchiyama Y (2008) Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury. Am J Pathol 172:454\u2013469. https:\/\/doi.org\/10.2353\/ajpath.2008.070876","journal-title":"Am J Pathol"},{"key":"3754_CR23","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.redox.2015.06.016","volume":"6","author":"Q Lu","year":"2015","unstructured":"Lu Q, Harris VA, Kumar S, Mansour HM, Black SM (2015) Autophagy in neonatal hypoxia ischemic brain is associated with oxidative stress. Redox Biol 6:516\u2013523. https:\/\/doi.org\/10.1016\/j.redox.2015.06.016","journal-title":"Redox Biol"},{"key":"3754_CR24","doi-asserted-by":"publisher","first-page":"417","DOI":"10.4103\/1673-5374.202945","volume":"12","author":"LX Xu","year":"2017","unstructured":"Xu LX, Tang XJ, Yang YY, Li M, Jin MF, Miao P, Ding X, Wang Y, Li YH, Sun B, Feng X (2017) Neuroprotective effects of autophagy inhibition on hippocampal glutamate receptor subunits after hypoxia-ischemia-induced brain damage in newborn rats. Neural Regen Res 12:417\u2013424. https:\/\/doi.org\/10.4103\/1673-5374.202945","journal-title":"Neural Regen Res"},{"key":"3754_CR25","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1080\/15548627.2015.1132134","volume":"12","author":"C Xie","year":"2016","unstructured":"Xie C, Ginet V, Sun Y, Koike M, Zhou K, Li T, Li H, Li Q, Wang X, Uchiyama Y, Truttmann AC, Kroemer G, Puyal J, Blomgren K, Zhu C (2016) Neuroprotection by selective neuronal deletion of Atg7 in neonatal brain injury. Autophagy 12:410\u2013423. https:\/\/doi.org\/10.1080\/15548627.2015.1132134","journal-title":"Autophagy"},{"key":"3754_CR26","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.expneurol.2014.03.002","volume":"255","author":"S Carloni","year":"2014","unstructured":"Carloni S, Albertini MC, Galluzzi L, Buonocore G, Proietti F, Balduini W (2014) Increased autophagy reduces endoplasmic reticulum stress after neonatal hypoxia-ischemia: role of protein synthesis and autophagic pathways. Exp Neurol 255:103\u2013112. https:\/\/doi.org\/10.1016\/j.expneurol.2014.03.002","journal-title":"Exp Neurol"},{"key":"3754_CR27","doi-asserted-by":"publisher","first-page":"e2919","DOI":"10.1038\/cddis.2017.318","volume":"8","author":"D Cui","year":"2017","unstructured":"Cui D, Sun D, Wang X, Yi L, Kulikowicz E, Reyes M, Zhu J, Yang ZJ, Jiang W, Koehler RC (2017) Impaired autophagosome clearance contributes to neuronal death in a piglet model of neonatal hypoxic-ischemic encephalopathy. Cell Death Dis 8:e2919. https:\/\/doi.org\/10.1038\/cddis.2017.318","journal-title":"Cell Death Dis"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-020-03754-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-020-03754-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-020-03754-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T23:51:17Z","timestamp":1625529077000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11010-020-03754-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,6]]},"references-count":27,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["3754"],"URL":"https:\/\/doi.org\/10.1007\/s11010-020-03754-2","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,6]]},"assertion":[{"value":"31 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}