{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:57:58Z","timestamp":1793051878429,"version":"4.5.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2020,5,23]],"date-time":"2020-05-23T00:00:00Z","timestamp":1590192000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,5,23]],"date-time":"2020-05-23T00:00:00Z","timestamp":1590192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1007\/s11010-020-03760-4","type":"journal-article","created":{"date-parts":[[2020,5,23]],"date-time":"2020-05-23T13:02:39Z","timestamp":1590238959000},"page":"175-188","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Trehalose attenuates TGF-\u03b21-induced fibrosis of hSCFs by activating autophagy"],"prefix":"10.1007","volume":"470","author":[{"given":"Nianxuan","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangbo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyi","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinke","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3389-8211","authenticated-orcid":false,"given":"Yao","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,23]]},"reference":[{"key":"3760_CR1","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.preteyeres.2007.12.002","volume":"27","author":"S Saika","year":"2008","unstructured":"Saika S, Yamanaka O, Sumioka T, Miyamoto T, Miyazaki K, Okada Y, Kitano A, Shirai K, Tanaka S, Ikeda K (2008) Fibrotic disorders in the eye: targets of gene therapy. Prog Retin Eye Res 27:177\u2013196. https:\/\/doi.org\/10.1016\/j.preteyeres.2007.12.002","journal-title":"Prog Retin Eye Res"},{"key":"3760_CR2","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1159\/000055620","volume":"32","author":"K Jinza","year":"2000","unstructured":"Jinza K, Saika S, Kin K, Ohnishi Y (2000) Relationship between formation of a filtering bleb and an intrascleral aqueous drainage route after trabeculectomy: evaluation using ultrasound biomicroscopy. Ophthal Res 32:240\u2013243. https:\/\/doi.org\/10.1159\/000055620","journal-title":"Ophthal Res"},{"key":"3760_CR3","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1016\/s0002-9440(10)63562-6","volume":"163","author":"JT Daniels","year":"2003","unstructured":"Daniels JT, Schultz GS, Blalock TD, Garrett Q, Grotendorst GR, Dean NM, Khaw PT (2003) Mediation of transforming growth factor-beta(1)-stimulated matrix contraction by fibroblasts: a role for connective tissue growth factor in contractile scarring. Am J Pathol 163:2043\u20132052. https:\/\/doi.org\/10.1016\/s0002-9440(10)63562-6","journal-title":"Am J Pathol"},{"key":"3760_CR4","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.ophtha.2017.08.028","volume":"125","author":"M Zada","year":"2018","unstructured":"Zada M, Pattamatta U, White A (2018) Modulation of fibroblasts in conjunctival wound healing. Ophthalmology 125:179\u2013192. https:\/\/doi.org\/10.1016\/j.ophtha.2017.08.028","journal-title":"Ophthalmology"},{"key":"3760_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1749-6632.2003.tb03205.x","volume":"995","author":"AB Roberts","year":"2003","unstructured":"Roberts AB, Russo A, Felici A, Flanders KC (2003) Smad3: a key player in pathogenetic mechanisms dependent on TGF-beta. Ann N Y Acad Sci 995:1\u201310. https:\/\/doi.org\/10.1111\/j.1749-6632.2003.tb03205.x","journal-title":"Ann N Y Acad Sci"},{"key":"3760_CR6","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1167\/iovs.08-2282","volume":"50","author":"O Yamanaka","year":"2009","unstructured":"Yamanaka O, Miyazaki K, Kitano A, Saika S, Nakajima Y, Ikeda K (2009) Suppression of injury-induced conjunctiva scarring by peroxisome proliferator-activated receptor \u03b3 gene transfer in mice. Invest Ophthalmol Vis Sci 50:187\u2013193. https:\/\/doi.org\/10.1167\/iovs.08-2282","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3760_CR7","first-page":"841","volume":"12","author":"O Yamanaka","year":"2006","unstructured":"Yamanaka O, Ikeda K, Saika S, Miyazaki K, Ooshima A, Ohnishi Y (2006) Gene transfer of Smad7 modulates injury-induced conjunctival wound healing in mice. Mol Vis 12:841\u2013851","journal-title":"Mol Vis"},{"key":"3760_CR8","doi-asserted-by":"publisher","first-page":"3069","DOI":"10.1167\/iovs.18-24258","volume":"59","author":"A Futakuchi","year":"2018","unstructured":"Futakuchi A, Inoue T, Wei FY, Inoue-Mochita M, Fujimoto T, Tomizawa K, Tanihara H (2018) YAP\/TAZ are essential for TGF-b2\u2013mediated conjunctival fibrosis. Invest Ophthalmol Vis Sci 59:3069\u20133078. https:\/\/doi.org\/10.1167\/iovs.18-24258","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3760_CR9","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.jtos.2019.01.008","volume":"17","author":"LM Martin","year":"2019","unstructured":"Martin LM, Jeyabalan N, Tripathi R, Panigrahi T, Johnson PJ, Ghosh A, Mohan RR (2019) Autophagy in corneal health and disease: a concise review. Ocul Surf 17:186\u2013197. https:\/\/doi.org\/10.1016\/j.jtos.2019.01.008","journal-title":"Ocul Surf"},{"key":"3760_CR10","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.7150\/ijbs.16245","volume":"12","author":"P Chai","year":"2016","unstructured":"Chai P, Ni H, Zhang H, Fan X (2016) The evolving functions of autophagy in ocular health: a double-edged sword. Int J Biol Sci 12:1332\u20131340. https:\/\/doi.org\/10.7150\/ijbs.16245","journal-title":"Int J Biol Sci"},{"key":"3760_CR11","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.cell.2004.11.046","volume":"120","author":"JJ Lum","year":"2005","unstructured":"Lum JJ, Bauer DE, Kong M, Harris MH, Li C, Lindsten T, Thompson CB (2005) Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120:237\u2013248. https:\/\/doi.org\/10.1016\/j.cell.2004.11.046","journal-title":"Cell"},{"key":"3760_CR12","doi-asserted-by":"publisher","first-page":"117175","DOI":"10.1016\/j.lfs.2019.117175","volume":"242","author":"HL Ye","year":"2020","unstructured":"Ye HL, Zhang JW, Chen XZ, Wu PB, Chen L, Zhang G (2020) Ursodeoxycholic acid alleviates experimental liver fibrosis involving inhibition of autophagy. Life Sci 242:117175. https:\/\/doi.org\/10.1016\/j.lfs.2019.117175","journal-title":"Life Sci"},{"key":"3760_CR13","doi-asserted-by":"publisher","first-page":"E1078","DOI":"10.3390\/cells8091078","volume":"8","author":"J Cosin-Roger","year":"2019","unstructured":"Cosin-Roger J, Canet F, Macias-Ceja DC, Gisbert-Ferr\u00e1ndiz L, Ortiz-Masi\u00e1 D, Esplugues JV, Al\u00f3s R, Navarro F, Barrachina MD, Calatayud S (2019) Autophagy stimulation as a potential strategy against intestinal fibrosis. Cells 8:E1078. https:\/\/doi.org\/10.3390\/cells8091078","journal-title":"Cells"},{"key":"3760_CR14","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1038\/s41385-019-0146-4","volume":"12","author":"R Mathur","year":"2019","unstructured":"Mathur R, Alam MM, Zhao XF, Liao Y, Shen J, Morgan S, Huang T, Lee H, Lee E, Huang Y, Zhu X (2019) Induction of autophagy in Cx3cr1+ mononuclear cells limits IL-23\/IL-22 axis-mediated intestinal fibrosis. Mucosal Immunol 12:612\u2013623. https:\/\/doi.org\/10.1038\/s41385-019-0146-4","journal-title":"Mucosal Immunol"},{"key":"3760_CR15","doi-asserted-by":"publisher","first-page":"152764","DOI":"10.1016\/j.phymed.2018.11.024","volume":"58","author":"L Wang","year":"2019","unstructured":"Wang L, Yuan D, Zheng J, Wu X, Wang J, Liu X, He Y, Zhang C, Liu C, Wang T, Zhou Z (2019) Chikusetsu saponin IVa attenuates isoprenaline-induced myocardial fibrosis in mice through activation autophagy mediated by AMPK\/mTOR\/ULK1 signaling. Phytomedicine 58:152764. https:\/\/doi.org\/10.1016\/j.phymed.2018.11.024","journal-title":"Phytomedicine"},{"key":"3760_CR16","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1007\/s00109-019-01757-1","volume":"97","author":"S Li","year":"2019","unstructured":"Li S, Peng F, Gong W, Wu J, Wang Y, Xu Z, Liu W, Li H, Yin B, Zhang Y, Chen S, Luo C, Li P, Chen Y, Huang Q, Zhou W, Long H (2019) Dimethylaminomicheliolide ameliorates peritoneal fibrosis through the activation of autophagy. J Mol Med (Berl) 97:659\u2013674. https:\/\/doi.org\/10.1007\/s00109-019-01757-1","journal-title":"J Mol Med (Berl)"},{"key":"3760_CR17","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/s41419-019-1820-x","volume":"10","author":"C Hill","year":"2019","unstructured":"Hill C, Li J, Liu D, Conforti F, Brereton CJ, Yao L, Zhou Y, Alzetani A, Chee SJ, Marshall BG, Fletcher SV, Hancock D, Ottensmeier CH, Steele AJ, Downward J, Richeldi L, Lu X, Davies DE, Jones MG, Wang Y (2019) Autophagy inhibition-mediated epithelial\u2013mesenchymal transition augments local myofibroblast differentiation in pulmonary fibrosis. Cell Death Dis 10:591. https:\/\/doi.org\/10.1038\/s41419-019-1820-x","journal-title":"Cell Death Dis"},{"key":"3760_CR18","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.7150\/thno.29682","volume":"9","author":"S Du","year":"2019","unstructured":"Du S, Li C, Lu Y, Lei X, Zhang Y, Li S, Liu F, Chen Y, Weng D, Chen J (2019) Dioscin alleviates crystalline silica-induced pulmonary inflammation and fibrosis through promoting alveolar macrophage autophagy. Theranostics 9:1878\u20131892. https:\/\/doi.org\/10.7150\/thno.29682","journal-title":"Theranostics"},{"key":"3760_CR19","doi-asserted-by":"publisher","first-page":"2743","DOI":"10.1167\/iovs.18-26526","volume":"60","author":"F Zhang","year":"2019","unstructured":"Zhang F, Liu K, Cao M, Qu J, Zhou D, Pan Z, Duan X, Zhou Y (2019) Rosiglitazone treatment prevents postoperative fibrosis in a rabbit model of glaucoma filtration surgery. Invest Ophthalmol Vis Sci 60:2743\u20132752. https:\/\/doi.org\/10.1167\/iovs.18-26526","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3760_CR20","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/nature25178","volume":"553","author":"J Collins","year":"2018","unstructured":"Collins J, Robinson C, Danhof H, Knetsch CW, van Leeuwen HC, Lawley TD, Auchtung JM, Britton RA (2018) Dietary trehalose enhances virulence of epidemic Clostridium difficile. Nature 553:291\u2013294. https:\/\/doi.org\/10.1038\/nature25178","journal-title":"Nature"},{"key":"3760_CR21","doi-asserted-by":"publisher","first-page":"E42","DOI":"10.3390\/nu11010042","volume":"11","author":"LF Chou","year":"2019","unstructured":"Chou LF, Cheng YL, Hsieh CY, Lin CY, Yang HY, Chen YC, Hung CC, Tian YC, Yang CW, Chang MY (2019) Effect of trehalose supplementation on autophagy and cystogenesis in a mouse model of polycystic kidney disease. Nutrients 11:E42. https:\/\/doi.org\/10.3390\/nu11010042","journal-title":"Nutrients"},{"key":"3760_CR22","doi-asserted-by":"publisher","first-page":"551","DOI":"10.2174\/1389450115666140225104705","volume":"15","author":"E Emanuele","year":"2014","unstructured":"Emanuele E (2014) Can trehalose prevent neurodegeneration? Insights from experimental studies. Curr Drug Targets 15:551\u2013557. https:\/\/doi.org\/10.2174\/1389450115666140225104705","journal-title":"Curr Drug Targets"},{"key":"3760_CR23","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1038\/s41419-018-0749-9","volume":"9","author":"HJ Lee","year":"2018","unstructured":"Lee HJ, Yoon YS, Lee SJ (2018) Mechanism of neuroprotection by trehalose: controversy surrounding autophagy induction. Cell Death Dis 9:712. https:\/\/doi.org\/10.1038\/s41419-018-0749-9","journal-title":"Cell Death Dis"},{"key":"3760_CR24","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.18632\/aging.100962","volume":"8","author":"RE Kaplon","year":"2016","unstructured":"Kaplon RE, Hill SD, Bispham NZ, Santos-Parker JR, Nowlan MJ, Snyder LL, Chonchol M, LaRocca TJ, McQueen MB, Seals DR (2016) Oral trehalose supplementation improves resistance artery endothelial function in healthy middle-aged and older adults. Aging 8:1167\u20131183. https:\/\/doi.org\/10.18632\/aging.100962","journal-title":"Aging"},{"key":"3760_CR25","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1080\/15548627.2018.1434373","volume":"14","author":"TD Evans","year":"2018","unstructured":"Evans TD, Jeong SJ, Zhang X, Sergin I, Razani B (2018) TFEB and trehalose drive the macrophage autophagy-lysosome system to protect against atherosclerosis. Autophagy 14:724\u2013726. https:\/\/doi.org\/10.1080\/15548627.2018.1434373","journal-title":"Autophagy"},{"key":"3760_CR26","doi-asserted-by":"publisher","first-page":"4691417","DOI":"10.1155\/2018\/4691417","volume":"2018","author":"K Fondi","year":"2018","unstructured":"Fondi K, Wozniak PA, Schmidl D, Bata AM, Witkowska KJ, Popa-Cherecheanu A, Schmetterer L, Garh\u00f6fer G (2018) Effect of hyaluronic acid\/trehalose in two different formulations on signs and symptoms in patients with moderate to severe dry eye disease. J Ophthalmol 2018:4691417. https:\/\/doi.org\/10.1155\/2018\/4691417","journal-title":"J Ophthalmol"},{"key":"3760_CR27","doi-asserted-by":"publisher","first-page":"595","DOI":"10.2147\/TCRM.S77091","volume":"11","author":"JC Pinto-Bonilla","year":"2015","unstructured":"Pinto-Bonilla JC, Del Olmo-Jimeno A, Llovet-Osuna F, Hern\u00e1ndez-Galilea E (2015) A randomized crossover study comparing trehalose\/hyaluronate eyedrops and standard treatment: patient satisfaction in the treatment of dry eye syndrome. Ther Clin Risk Manag 11:595\u2013603. https:\/\/doi.org\/10.2147\/TCRM.S77091","journal-title":"Ther Clin Risk Manag"},{"key":"3760_CR28","doi-asserted-by":"publisher","first-page":"6524","DOI":"10.1002\/jcp.26583","volume":"233","author":"K Hosseinpour-Moghaddam","year":"2018","unstructured":"Hosseinpour-Moghaddam K, Caraglia M, Sahebkar A (2018) Autophagy induction by trehalose: molecular mechanisms and therapeutic impacts. J Cell Physiol 233:6524\u20136543. https:\/\/doi.org\/10.1002\/jcp.26583","journal-title":"J Cell Physiol"},{"key":"3760_CR29","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1016\/j.jacc.2018.02.066","volume":"71","author":"S Sciarretta","year":"2018","unstructured":"Sciarretta S, Yee D, Nagarajan N, Bianchi F, Saito T, Valenti V, Tong M, Del Re DP, Vecchione C, Schirone L, Forte M, Rubattu S, Shirakabe A, Boppana VS, Volpe M, Frati G, Zhai P, Sadoshima J (2018) Trehalose-induced activation of autophagy improves cardiac remodeling after myocardial infarction. J Am Coll Cardiol 71:1999\u20132010. https:\/\/doi.org\/10.1016\/j.jacc.2018.02.066","journal-title":"J Am Coll Cardiol"},{"key":"3760_CR30","doi-asserted-by":"publisher","first-page":"8318","DOI":"10.1021\/acs.nanolett.9b03968","volume":"19","author":"S Ruan","year":"2019","unstructured":"Ruan S, Xie R, Qin L, Yu M, Xiao W, Hu C, Yu W, Qian Z, Ouyang L, He Q, Gao H (2019) Aggregable nanoparticles-enabled chemotherapy and autophagy inhibition combined with anti-PD-L1 antibody for improved glioma treatment. Nano Lett 19:8318\u20138332. https:\/\/doi.org\/10.1021\/acs.nanolett.9b03968","journal-title":"Nano Lett"},{"key":"3760_CR31","doi-asserted-by":"publisher","first-page":"109339","DOI":"10.1016\/j.biopha.2019.109339","volume":"118","author":"LQ Liu","year":"2019","unstructured":"Liu LQ, Wang SB, Shao YF, Shi JN, Wang W, Chen WY, Ye ZQ, Jiang JY, Fang QX, Zhang GB, Xuan ZX (2019) Hydroxychloroquine potentiates the anti-cancer effect of bevacizumab on glioblastoma via the inhibition of autophagy. Biomed Pharmacother 118:109339. https:\/\/doi.org\/10.1016\/j.biopha.2019.109339","journal-title":"Biomed Pharmacother"},{"key":"3760_CR32","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s40360-017-0136-7","volume":"18","author":"A Ulla","year":"2017","unstructured":"Ulla A, Mohamed MK, Sikder B, Rahman AT, Sumi FA, Hossain M, Reza HM, Rahman GMS, Alam MA (2017) Coenzyme Q10 prevents oxidative stress and fibrosis in isoprenaline induced cardiac remodeling in aged rats. BMC Pharmacol Toxicol 18:29. https:\/\/doi.org\/10.1186\/s40360-017-0136-7","journal-title":"BMC Pharmacol Toxicol"},{"key":"3760_CR33","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.semnephrol","volume":"32","author":"ME Choi","year":"2012","unstructured":"Choi ME, Ding Y, Kim SI (2012) TGF-\u03b2 signaling via TAK1 pathway: role in kidney fibrosis. Semin Nephrol 32:244\u2013252. https:\/\/doi.org\/10.1016\/j.semnephrol","journal-title":"Semin Nephrol"},{"key":"3760_CR34","doi-asserted-by":"publisher","first-page":"3563","DOI":"10.1172\/JCI62339","volume":"122","author":"L Song","year":"2012","unstructured":"Song L, Liu L, Wu Z, Li Y, Ying Z, Lin C, Wu J, Hu B, Cheng SY, Li M, Li J (2012) TGF-\u03b2 induces miR-182 to sustain NF-\u03baB activation in glioma subsets. J Clin Invest 122:3563\u20133578. https:\/\/doi.org\/10.1172\/JCI62339","journal-title":"J Clin Invest"},{"key":"3760_CR35","doi-asserted-by":"publisher","first-page":"2213","DOI":"10.1002\/ijc.31605","volume":"143","author":"W Wu","year":"2018","unstructured":"Wu W, Chen F, Cui X, Yang L, Chen J, Zhao J, Huang D, Liu J, Yang L, Zeng J, Zeng Z, Pan Y, Su F, Cai J, Ying Z, Zhao Q, Song E, Su S (2018) LncRNA NKILA suppresses TGF-\u03b2-induced epithelial-mesenchymal transition by blocking NF-\u03baB signaling in breast cancer. Int J Cancer 143:2213\u20132224. https:\/\/doi.org\/10.1002\/ijc.31605","journal-title":"Int J Cancer"},{"key":"3760_CR36","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1038\/s41467-017-00859-z","volume":"8","author":"AC Newman","year":"2017","unstructured":"Newman AC, Kemp AJ, Drabsch Y, Behrends C, Wilkinson S (2017) Autophagy acts through TRAF3 and RELB to regulate gene expression via antagonism of SMAD proteins. Nat Commun 8:1537. https:\/\/doi.org\/10.1038\/s41467-017-00859-z","journal-title":"Nat Commun"},{"key":"3760_CR37","doi-asserted-by":"publisher","first-page":"402","DOI":"10.3389\/fphar.2018.00402","volume":"9","author":"W Zheng","year":"2018","unstructured":"Zheng W, Qian Y, Chen S, Ruan H, Fan C (2018) Rapamycin protects against peritendinous fibrosis through activation of autophagy. Front Pharmacol 9:402. https:\/\/doi.org\/10.3389\/fphar.2018.00402","journal-title":"Front Pharmacol"},{"key":"3760_CR38","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1111\/j.1872-034X.2012.01111.x","volume":"43","author":"J Chang","year":"2013","unstructured":"Chang J, Hisamatsu T, Shimamura K, Yoneno K, Adachi M, Naruse H, Igarashi T, Higuchi H, Matsuoka K, Kitazume MT, Ando S, Kamada N, Kanai T, Hibi T (2013) Activated hepatic stellate cells mediate the differentiation of macrophages. Hepatol Res 43:658\u2013669. https:\/\/doi.org\/10.1111\/j.1872-034X.2012.01111.x","journal-title":"Hepatol Res"},{"key":"3760_CR39","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1002\/hep.26016","volume":"57","author":"E Liaskou","year":"2013","unstructured":"Liaskou E, Zimmermann HW, Li KK, Oo YH, Suresh S, Stamataki Z, Qureshi O, Lalor PF, Shaw J, Syn WK, Curbishley SM, Adams DH (2013) Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics. Hepatology 57:385\u2013398. https:\/\/doi.org\/10.1002\/hep.26016","journal-title":"Hepatology"},{"key":"3760_CR40","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1211\/jpp\/61.11.0013","volume":"61","author":"S Kumar","year":"2009","unstructured":"Kumar S, Enjamoori R, Jaiswal A, Ray R, Seth S, Maulik SK (2009) Catecholamine-induced myocardial fibrosis and oxidative stress is attenuated by Terminalia arjuna (Roxb.). J Pharm Pharmacol 61:1529\u20131536. https:\/\/doi.org\/10.1211\/jpp\/61.11.0013","journal-title":"J Pharm Pharmacol"},{"key":"3760_CR41","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s10911-010-9177-x","volume":"15","author":"ES Radisky","year":"2010","unstructured":"Radisky ES, Radisky DC (2010) Matrix metalloproteinase-induced epithelial\u2013mesenchymal transition in breast cancer. J Mamm Gland Biol Neoplasia 15:201\u2013212. https:\/\/doi.org\/10.1007\/s10911-010-9177-x","journal-title":"J Mamm Gland Biol Neoplasia"},{"key":"3760_CR42","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1002\/ijc.28165","volume":"133","author":"AK Dilly","year":"2013","unstructured":"Dilly AK, Ekambaram P, Guo Y, Cai Y, Tucker SC, Fridman R, Kandouz M, Honn KV (2013) Platelet-type 12-lipoxygenase induces MMP9 expression and cellular invasion via activation of PI3K\/Akt\/NF-\u03baB. Int J Cancer 133:1784\u20131791. https:\/\/doi.org\/10.1002\/ijc.28165","journal-title":"Int J Cancer"},{"key":"3760_CR43","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s00239-014-9645-9","volume":"79","author":"JC Arg\u00fcelles","year":"2014","unstructured":"Arg\u00fcelles JC (2014) Why can\u2019t vertebrates synthesize trehalose? J Mol Evol 79:111\u2013116. https:\/\/doi.org\/10.1007\/s00239-014-9645-9","journal-title":"J Mol Evol"},{"key":"3760_CR44","doi-asserted-by":"publisher","first-page":"3793","DOI":"10.3390\/ijms10093793","volume":"10","author":"G Iturriaga","year":"2009","unstructured":"Iturriaga G, Su\u00e1rez R, Nova-Franco B (2009) Trehalose metabolism: from osmoprotection to signaling. Int J Mol Sci 10:3793\u20133810. https:\/\/doi.org\/10.3390\/ijms10093793","journal-title":"Int J Mol Sci"},{"key":"3760_CR45","doi-asserted-by":"publisher","first-page":"3761","DOI":"10.1128\/AEM.71.7.3761-3769.2005","volume":"71","author":"JE Purvis","year":"2005","unstructured":"Purvis JE, Yomano LP, Ingram LO (2005) Enhanced trehalose production improves growth of Escherichia coli under osmotic stress. Appl Environ Microbiol 71:3761\u20133769. https:\/\/doi.org\/10.1128\/AEM.71.7.3761-3769.2005","journal-title":"Appl Environ Microbiol"},{"key":"3760_CR46","doi-asserted-by":"publisher","first-page":"24261","DOI":"10.1074\/jbc.M101487200","volume":"276","author":"N Benaroudj","year":"2001","unstructured":"Benaroudj N, Lee DH, Goldberg AL (2001) Trehalose accumulation during cellular stress protects cells and cellular proteins from damage by oxygen radicals. J Biol Chem 276:24261\u201324267. https:\/\/doi.org\/10.1074\/jbc.M101487200","journal-title":"J Biol Chem"},{"key":"3760_CR47","doi-asserted-by":"publisher","first-page":"17R","DOI":"10.1093\/glycob\/cwg047","volume":"13","author":"AD Elbein","year":"2003","unstructured":"Elbein AD, Pan YT, Pastuszak I, Carroll D (2003) New insights on trehalose: a multifunctional molecule. Glycobiology 13:17R\u201327R. https:\/\/doi.org\/10.1093\/glycob\/cwg047","journal-title":"Glycobiology"},{"key":"3760_CR48","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/s0065-2318(08)60266-8","volume":"30","author":"AD Elbein","year":"1974","unstructured":"Elbein AD (1974) The metabolism of alpha, alpha-trehalose. Adv Carbohydr Chem Biochem 30:227\u2013256. https:\/\/doi.org\/10.1016\/s0065-2318(08)60266-8","journal-title":"Adv Carbohydr Chem Biochem"},{"key":"3760_CR49","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1038\/nm985","volume":"10","author":"M Tanaka","year":"2004","unstructured":"Tanaka M, Machida Y, Niu S, Ikeda T, Jana NR, Doi H, Kurosawa M, Nekooki M, Nukina N (2004) Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease. Nat Med 10:148\u2013154. https:\/\/doi.org\/10.1038\/nm985","journal-title":"Nat Med"},{"key":"3760_CR50","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.neuro.2014.07.006","volume":"44","author":"S Sarkar","year":"2014","unstructured":"Sarkar S, Chigurupati S, Raymick J, Mann D, Bowyer JF, Schmitt T, Beger RD, Hanig JP, Schmued LC, Paule MG (2014) Neuroprotective effect of the chemical chaperone, trehalose in a chronic MPTP-induced Parkinson\u2019s disease mouse model. Neurotoxicology 44:250\u2013262. https:\/\/doi.org\/10.1016\/j.neuro.2014.07.006","journal-title":"Neurotoxicology"},{"key":"3760_CR51","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/s1097-2765(00)80064-7","volume":"1","author":"MA Singer","year":"1998","unstructured":"Singer MA, Lindquist S (1998) Multiple effects of trehalose on protein folding in vitro and in vivo. Mol Cell 1:639\u2013648. https:\/\/doi.org\/10.1016\/s1097-2765(00)80064-7","journal-title":"Mol Cell"},{"key":"3760_CR52","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/s0009-3084(02)00177-9","volume":"122","author":"JH Crowe","year":"2003","unstructured":"Crowe JH, Tablin F, Wolkers WF, Gousset K, Tsvetkova NM, Ricker J (2003) Stabilization of membranes in human platelets freeze-dried with trehalose. Chem Phys Lipids 122:41\u201352. https:\/\/doi.org\/10.1016\/s0009-3084(02)00177-9","journal-title":"Chem Phys Lipids"},{"key":"3760_CR53","doi-asserted-by":"publisher","first-page":"114916","DOI":"10.1016\/j.taap.2020.114916","volume":"391","author":"F Lu","year":"2020","unstructured":"Lu F, Sun X, Xu X, Jiang X (2020) SILAC-based proteomic profiling of the suppression of TGF-\u03b21-induced lung fibroblast-to-myofibroblast differentiation by trehalose. Toxicol Appl Pharmacol 391:114916. https:\/\/doi.org\/10.1016\/j.taap.2020.114916","journal-title":"Toxicol Appl Pharmacol"},{"key":"3760_CR54","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1292\/jvms.10-0342","volume":"73","author":"H Fujino","year":"2011","unstructured":"Fujino H, Lee S, Suzuki S, Chung UI, Mochizuki M, Nishimura R, Sasaki N (2011) Trehalose may prevent postsurgical adhesions in a rabbit model of hysterotomy. J Vet Med Sci 73:931\u2013935. https:\/\/doi.org\/10.1292\/jvms.10-0342","journal-title":"J Vet Med Sci"},{"key":"3760_CR55","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.jss.2014.03.077","volume":"191","author":"A Ohata","year":"2014","unstructured":"Ohata A, Tamura N, Iwata K, Abe N, Doi K, Saito Y, Katoh M, Nojima H (2014) Trehalose solution protects mesothelium and reduces bowel adhesions. J Surg Res 191:224\u2013230. https:\/\/doi.org\/10.1016\/j.jss.2014.03.077","journal-title":"J Surg Res"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-020-03760-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-020-03760-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-020-03760-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T23:06:46Z","timestamp":1621724806000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11010-020-03760-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,23]]},"references-count":55,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["3760"],"URL":"https:\/\/doi.org\/10.1007\/s11010-020-03760-4","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,23]]},"assertion":[{"value":"12 February 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 May 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}