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Significant differences were found in the susceptibility of these cell lines to all stilbenes, including RSV. The THP-1 cells were more resistant to cytotoxic activity of these compounds than HL-60 cells. Among the tested stilbenes, 3,4,4\u02b9-tri-MS and 3,4,2\u02b9,4\u02b9-tetra-MS exhibited higher cytotoxicity toward both cell lines than RSV and the other methoxy stilbenes. This activity might be related to cell cycle arrest at the G2\/M phase and induction of apoptosis. In this regard, 3,4,4\u02b9-tri-MS and 3,4,2\u02b9,4\u02b9-tetra-MS at highest concentrations increased the p53 protein level particularly in HL-60 cells. Moreover, treatment with these derivatives increased the ratio of the proapoptotic Bax protein to the antiapoptotic Bcl-xl protein, suggesting the induction of apoptosis through the intrinsic mitochondrial pathway in both cell lines. Further studies are required to fully elucidate the mechanism of these activities.<\/jats:p>","DOI":"10.1007\/s11010-020-03837-0","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T16:02:59Z","timestamp":1596211379000},"page":"113-123","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effect of methoxy stilbenes\u2014analogs of resveratrol\u2014on the viability and induction of cell cycle arrest and apoptosis in human myeloid leukemia cells"],"prefix":"10.1007","volume":"474","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3821-9759","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Zieli\u0144ska-Przyjemska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz","family":"Kaczmarek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violetta","family":"Krajka-Ku\u017aniak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Wierzchowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanda","family":"Baer-Dubowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,31]]},"reference":[{"key":"3837_CR1","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/s41698-017-0038-6","volume":"1","author":"AY Berman","year":"2017","unstructured":"Berman AY, Motechin RA, Wiesenfeld MY, Holz MK (2017) The therapeutic potential of resveratrol: a review of clinical trials. 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