{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:53:39Z","timestamp":1769820819583,"version":"3.49.0"},"reference-count":101,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T00:00:00Z","timestamp":1609718400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T00:00:00Z","timestamp":1609718400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1007\/s11010-020-03961-x","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T20:03:55Z","timestamp":1609790635000},"page":"1489-1504","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Influence of integrins on thrombus formation: a road leading to the unravelling of DVT"],"prefix":"10.1007","volume":"476","author":[{"given":"Nilanjana","family":"Ghosh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0748-8769","authenticated-orcid":false,"given":"Iti","family":"Garg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swati","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhuvnesh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,4]]},"reference":[{"issue":"1","key":"3961_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1172\/JCI114957","volume":"87","author":"E Ruoslahti","year":"1991","unstructured":"Ruoslahti E (1991) Integrins. J Clin Invest 87(1):1\u20135","journal-title":"J Clin Invest"},{"issue":"4","key":"3961_CR2","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1083\/jcb.106.4.1359","volume":"106","author":"RS Piotrowicz","year":"1988","unstructured":"Piotrowicz RS, Orchekowski RP, Nugent DJ, Yamada KY, Kunicki TJ (1988) Glycoprotein Ic-IIa functions as an activation-independent fibronectin receptor on human platelets. J Cell Biol 106(4):1359\u20131364","journal-title":"J Cell Biol"},{"issue":"2","key":"3961_CR3","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/0092-8674(86)90744-0","volume":"46","author":"JW Tamkun","year":"1986","unstructured":"Tamkun JW, DeSimone DW, Fonda D, Patel RS, Buck C, Horwitz AF, Hynes RO (1986) Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin. Cell 46(2):271\u2013282","journal-title":"Cell"},{"key":"3961_CR4","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1146\/annurev.pharmtox.44.101802.121440","volume":"44","author":"T Holbro","year":"2004","unstructured":"Holbro T, Hynes NE (2004) ErbB receptors: directing key signaling networks throughout life. Annu Rev Pharmacol Toxicol 44:195\u2013217","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"3961_CR5","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1111\/j.1600-065X.1990.tb00565.x","volume":"114","author":"RS Larson","year":"1990","unstructured":"Larson RS, Springer TA (1990) Structure and function of leukocyte integrins. Immunol Rev 114:181\u2013217","journal-title":"Immunol Rev"},{"issue":"24","key":"3961_CR6","doi-asserted-by":"publisher","first-page":"15138","DOI":"10.1074\/jbc.273.24.15138","volume":"273","author":"C Lu","year":"1998","unstructured":"Lu C, Oxvig C, Springer TA (1998) The structure of the \u03b2-propeller domain and C-terminal region of the integrin \u03b1M subunit dependence on \u03b2 subunit association and prediction of domains. J Biol Chem 273(24):15138\u201315147","journal-title":"J Biol Chem"},{"issue":"3","key":"3961_CR7","doi-asserted-by":"publisher","first-page":"a004994","DOI":"10.1101\/cshperspect.a004994","volume":"3","author":"ID Campbell","year":"2011","unstructured":"Campbell ID, Humphries MJ (2011) Integrin structure, activation, and interactions. Cold Spring Harb Perspect Biol 3(3):a004994","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"11","key":"3961_CR8","doi-asserted-by":"publisher","first-page":"3865","DOI":"10.1002\/j.1460-2075.1992.tb05479.x","volume":"11","author":"D Gullberg","year":"1992","unstructured":"Gullberg D, Gehlsen KR, Turner DC, Ahlen K, Zijenah LS, Barnes MJ, Rubin K (1992) Analysis of alpha 1 beta 1, alpha 2 beta 1 and alpha 3 beta 1 integrins in cell \u2013 collagen interactions: identification of conformation dependent alpha 1 beta 1 binding sites in collagen type I. EMBO J 11(11):3865\u20133873","journal-title":"EMBO J"},{"issue":"2","key":"3961_CR9","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/0014-4827(90)90194-F","volume":"190","author":"D Gullberg","year":"1990","unstructured":"Gullberg D, Turner DC, Borg TK, Terracio L, Rubin K (1990) Different \u03b21-integrin collagen receptors on rat hepatocytes and cardiac fibroblasts. Exp Cell Res 190(2):254\u2013264","journal-title":"Exp Cell Res"},{"issue":"2","key":"3961_CR10","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/0092-8674(91)90191-Z","volume":"67","author":"JA Schiro","year":"1991","unstructured":"Schiro JA, Chan BM, Roswit WT, Kassner PD, Pentland AP, Hemler ME et al (1991) Integrin \u03b12\u03b21 (VLA-2) mediates reorganization and contraction of collagen matrices by human cells. Cell 67(2):403\u2013410","journal-title":"Cell"},{"issue":"1","key":"3961_CR11","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1006\/dbio.2001.0363","volume":"237","author":"CF Tiger","year":"2001","unstructured":"Tiger CF, Fougerousse F, Grundstr\u00f6m G, Velling T, Gullberg D (2001) \u03b111\u03b21 integrin is a receptor for interstitial collagens involved in cell migration and collagen reorganization on mesenchymal nonmuscle cells. Dev Biol 237(1):116\u2013129","journal-title":"Dev Biol"},{"key":"3961_CR12","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.ceb.2005.08.010","volume":"5","author":"MH Ginsberg","year":"2005","unstructured":"Ginsberg MH, Partridge A, Shattil SJ (2005) Integrin regulation. Curr Opin Cell Biol 5:509\u2013516","journal-title":"Curr Opin Cell Biol"},{"issue":"6","key":"3961_CR13","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/S0092-8674(02)00971-6","volume":"110","author":"RO Hynes","year":"2002","unstructured":"Hynes RO (2002) Integrins: bidirectional, allosteric signaling machines. Cell 110(6):673\u2013687","journal-title":"Cell"},{"issue":"24","key":"3961_CR14","first-page":"21749","volume":"277","author":"DA Calderwood","year":"2002","unstructured":"Calderwood DA, Yan B, de Pereda JM, Alvarez BG, Fujioka Y, Liddington RC, Ginsberg MH (2002) The phosphotyrosine binding-like domain of talin activates integrins. J BiolChem 277(24):21749\u201321758","journal-title":"J BiolChem"},{"issue":"10","key":"3961_CR15","doi-asserted-by":"publisher","first-page":"6118","DOI":"10.1074\/jbc.M709527200","volume":"283","author":"M Bouaouina","year":"2008","unstructured":"Bouaouina M, Lad Y, Calderwood DA (2008) The N-terminal domains of talin cooperate with the phosphotyrosine binding-like domain to activate \u03b21 and \u03b23 integrins. J Biol Chem 283(10):6118\u20136125","journal-title":"J Biol Chem"},{"key":"3961_CR16","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1111\/j.1538-7836.2009.03370.x","volume":"1","author":"B Nieswandt","year":"2009","unstructured":"Nieswandt B, Varga-Szabo D, Elvers M (2009) Integrins in platelet activation. J Thromb Haemost Suppl 1:206\u2013209","journal-title":"J Thromb Haemost Suppl"},{"key":"3961_CR17","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1242\/jcs.01014","volume":"117","author":"DA Calderwood","year":"2004","unstructured":"Calderwood DA (2004) Integrin activation. J Cell Sci 117:657\u2013666","journal-title":"J Cell Sci"},{"issue":"13","key":"3961_CR18","doi-asserted-by":"publisher","first-page":"3113","DOI":"10.1084\/jem.20071827","volume":"204","author":"B Nieswandt","year":"2007","unstructured":"Nieswandt B, Moser M, Pleines I, Varga-Szabo D, Monkley S, Critchley D, F\u00e4ssler R (2007) Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo. J Exp Med 204(13):3113\u20133118","journal-title":"J Exp Med"},{"issue":"8","key":"3961_CR19","doi-asserted-by":"publisher","first-page":"2250","DOI":"10.1172\/JCI31024","volume":"117","author":"BG Petrich","year":"2007","unstructured":"Petrich BG, Fogelstrand P, Partridge AW, Yousefi N, Ablooglu AJ, Shattil SJ, Ginsberg MH (2007) The antithrombotic potential of selective blockade of talin-dependent integrin \u03b1 IIb \u03b2 3 (platelet GPIIb\u2013IIIa) activation. J Clin Invest 117(8):2250\u20132259","journal-title":"J Clin Invest"},{"issue":"2","key":"3961_CR20","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1172\/JCI5487","volume":"103","author":"KM Hodivala-Dilke","year":"1999","unstructured":"Hodivala-Dilke KM, McHugh KP, Tsakiris DA, Rayburn H, Crowley D, Ullman-Culler\u00e9 M et al (1999) \u03b23-integrin\u2013deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. J Clin Invest 103(2):229\u2013238","journal-title":"J Clin Invest"},{"issue":"12","key":"3961_CR21","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1038\/embor.2008.202","volume":"9","author":"H Larjava","year":"2008","unstructured":"Larjava H, Plow EF, Wu C (2008) Kindlins: essential regulators of integrin signalling and cell\u2013matrix adhesion. EMBO Rep 9(12):1203\u20131208","journal-title":"EMBO Rep"},{"issue":"4","key":"3961_CR22","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1038\/nrm2871","volume":"11","author":"SJ Shattil","year":"2010","unstructured":"Shattil SJ, Kim C, Ginsberg MH (2010) The final steps of integrin activation: the end game. Nat Rev Mol Cell Biol 11(4):288\u2013300","journal-title":"Nat Rev Mol Cell Biol"},{"key":"3961_CR23","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1101\/gad.1758709","volume":"23","author":"KR Legate","year":"2009","unstructured":"Legate KR, Wickstr\u00f6m SA, F\u00e4ssler R (2009) Genetic and cell biological analysis of integrin outside-in signaling. Genes Dev 23:397\u2013418","journal-title":"Genes Dev"},{"issue":"10","key":"3961_CR24","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/S0960-9822(02)00810-2","volume":"12","author":"AC Mackinnon","year":"2002","unstructured":"Mackinnon AC, Qadota H, Norman KR, Moerman DG, Williams BD (2002) C. elegans PAT-4\/ILK functions as an adaptor protein within integrin adhesion complexes. Curr Biol 12(10):787\u2013797","journal-title":"Curr Biol"},{"issue":"7","key":"3961_CR25","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1007\/s13238-010-0089-8","volume":"1","author":"L Tao","year":"2010","unstructured":"Tao L, Zhang Y, Xi X, Kieffer N (2010) Recent advances in the understanding of the molecular mechanisms regulating platelet integrin \u03b1IIb\u03b23 activation. Protein Cell 1(7):627\u2013637","journal-title":"Protein Cell"},{"key":"3961_CR26","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1101\/gad.469408","volume":"22","author":"E Montanez","year":"2008","unstructured":"Montanez E, Ussar S, Schifferer M, B\u00f6sl M, Zent R, Moser M, F\u00e4ssler R (2008) Kindlin-2 controls bidirectional signaling of integrins. Genes Dev 22:1325\u20131330","journal-title":"Genes Dev"},{"issue":"8","key":"3961_CR27","doi-asserted-by":"publisher","first-page":"6824","DOI":"10.1074\/jbc.M307978200","volume":"279","author":"S Kloeker","year":"2004","unstructured":"Kloeker S, Major MB, Calderwood DA, Ginsberg MH, Jones DA, Beckerle MC (2004) The Kindler syndrome protein is regulated by transforming growth factor-\u03b2 and involved in integrin-mediated adhesion. J Biol Chem 279(8):6824\u20136833","journal-title":"J Biol Chem"},{"issue":"1","key":"3961_CR28","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S0092-8674(03)00163-6","volume":"113","author":"Y Tu","year":"2003","unstructured":"Tu Y, Wu S, Shi X, Chen K, Wu C (2003) Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation. Cell 113(1):37\u201347","journal-title":"Cell"},{"key":"3961_CR29","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/nm1722","volume":"3","author":"M Moser","year":"2008","unstructured":"Moser M, Nieswandt B, Ussar S, Pozgajova M, F\u00e4ssler R (2008) Kindlin-3 is essential for integrin activation and platelet aggregation. Nat Med 3:325\u2013330","journal-title":"Nat Med"},{"issue":"5929","key":"3961_CR30","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1126\/science.1163865","volume":"324","author":"M Moser","year":"2009","unstructured":"Moser M, Legate KR, Zent R, F\u00e4ssler R (2009) The tail of integrins, talin, and kindlins. Science 324(5929):895\u2013899","journal-title":"Science"},{"issue":"3","key":"3961_CR31","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1182\/blood-2005-03-1308","volume":"107","author":"Z Li","year":"2006","unstructured":"Li Z, Zhang G, Feil R, Han J, Du X (2006) Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin \u03b1IIb\u03b23. Blood 107(3):965\u2013972","journal-title":"Blood"},{"issue":"17","key":"3961_CR32","doi-asserted-by":"publisher","first-page":"5265","DOI":"10.1093\/nar\/18.17.5265","volume":"18","author":"SM Robbins","year":"1990","unstructured":"Robbins SM, Suttorp VV, Weeks G, Spiegelman GB (1990) A ras-related gene from the lower eukaryote Dictyostelium that is highly conserved relative to the human rap genes. Nucleic Acids Res 18(17):5265\u20135269","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"3961_CR33","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/0092-8674(91)90066-8","volume":"67","author":"IK Hariharan","year":"1991","unstructured":"Hariharan IK, Carthew RW, Rubin GM (1991) The Drosophila roughened mutation: activation of a rap homolog disrupts eye development and interferes with cell determination. Cell 67(4):717\u2013722","journal-title":"Cell"},{"issue":"1-2","key":"3961_CR34","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1002\/dvg.1020120123","volume":"12","author":"SM Robbins","year":"1991","unstructured":"Robbins SM, Khosla M, Thiery R, Weeks G, Spiegelman GB (1991) Ras-related genes in Dictyosteliumdiscoideum. Dev Genet 12(1-2):147\u2013153","journal-title":"Dev Genet"},{"issue":"21","key":"3961_CR35","doi-asserted-by":"publisher","first-page":"2512","DOI":"10.1161\/01.CIR.0000017264.66561.3D","volume":"105","author":"J D\u00edez","year":"2002","unstructured":"D\u00edez J, Querejeta R, L\u00f3pez B, Gonz\u00e1lez A, Larman M, Mart\u00ednez Ubago JL (2002) Losartan-dependent regression of myocardial fibrosis is associated with reduction of left ventricular chamber stiffness in hypertensive patients. Circulation 105(21):2512\u20132517","journal-title":"Circulation"},{"issue":"suppl_D","key":"3961_CR36","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1093\/eurheartj\/13.suppl_D.24","volume":"13","author":"CG Brilla","year":"1992","unstructured":"Brilla CG, Maisch B, Weber KT (1992) Myocardial collagen matrix remodelling in arterial hypertension. Eur Heart J 13(suppl_D):24\u201332","journal-title":"Eur Heart J"},{"issue":"1","key":"3961_CR37","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.cardiores.2004.08.020","volume":"65","author":"P Camelliti","year":"2005","unstructured":"Camelliti P, Borg TK, Kohl P (2005) Structural and functional characterisation of cardiac fibroblasts. Cardiovasc Res 65(1):40\u201351","journal-title":"Cardiovasc Res"},{"issue":"3","key":"3961_CR38","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1172\/JCI22973","volume":"115","author":"M Chrzanowska-Wodnicka","year":"2005","unstructured":"Chrzanowska-Wodnicka M, Smyth SS, Schoenwaelder SM, Fischer TH, White GC (2005) Rap1b is required for normal platelet function and hemostasis in mice. J Clin Invest 115(3):680\u2013687","journal-title":"J Clin Invest"},{"issue":"2","key":"3961_CR39","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.devcel.2008.12.007","volume":"16","author":"M Ieda","year":"2009","unstructured":"Ieda M, Tsuchihashi T, Ivey KN, Ross RS, Hong TT, Shaw RM, Srivastava D (2009) Cardiac fibroblasts regulate myocardial proliferation through \u03b21 integrin signaling. Dev Cell 16(2):233\u2013244","journal-title":"Dev Cell"},{"key":"3961_CR40","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/s00441-002-0567-2","volume":"309","author":"C Lopez-Sanchez","year":"2002","unstructured":"Lopez-Sanchez C, Climent V, Schoenwolf GC, Alvarez IS, Garcia-Martinez V (2002) Induction of cardiogenesis by Hensen\u2019s node and fibroblast growth factors. Cell Tissue Res 309:237\u2013249","journal-title":"Cell Tissue Res"},{"key":"3961_CR41","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s00395-005-0529-4","volume":"100","author":"A Kamkin","year":"2005","unstructured":"Kamkin A, Kiseleva I, Lozinsky I, Scholz H (2005) Electrical interaction of mechanosensitive fibroblasts and myocytes in the heart. Basic Res Cardiol 100:337\u2013345","journal-title":"Basic Res Cardiol"},{"issue":"9","key":"3961_CR42","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1016\/j.amjmed.2008.03.046","volume":"121","author":"A Aneja","year":"2008","unstructured":"Aneja A, Tang WW, Bansilal S, Garcia MJ, Farkouh ME (2008) Diabetic cardiomyopathy: insights into pathogenesis, diagnostic challenges, and therapeutic options. Am J Med 121(9):748\u2013757","journal-title":"Am J Med"},{"key":"3961_CR43","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.matbio.2015.05.006","volume":"47","author":"B Hinz","year":"2015","unstructured":"Hinz B (2015) The extracellular matrix and transforming growth factor-\u03b21: tale of a strained relationship. Matrix Biol 47:54\u201365","journal-title":"Matrix Biol"},{"issue":"3","key":"3961_CR44","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1016\/S0008-6363(98)00305-8","volume":"41","author":"A Nicoletti","year":"1999","unstructured":"Nicoletti A, Michel JB (1999) Cardiac fibrosis and inflammation: interaction with hemodynamic and hormonal factors. Cardiovasc Res 41(3):532\u2013543","journal-title":"Cardiovasc Res"},{"issue":"5","key":"3961_CR45","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1002\/jcp.24261","volume":"228","author":"MM Barczyk","year":"2013","unstructured":"Barczyk MM, Lu N, Popova SN, Bolstad AI, Gullberg D (2013) \u03b111\u03b21 integrin-mediated MMP-13-dependent collagen lattice contraction by fibroblasts: evidence for integrin-coordinated collagen proteolysis. J Cell Physiol 228(5):1108\u20131119","journal-title":"J Cell Physiol"},{"issue":"14","key":"3961_CR46","doi-asserted-by":"publisher","first-page":"10434","DOI":"10.1074\/jbc.M109.078766","volume":"285","author":"S Carracedo","year":"2010","unstructured":"Carracedo S, Lu N, Popova SN, Jonsson R, Eckes B, Gullberg D (2010) The fibroblast integrin \u03b111\u03b21 is induced in a mechanosensitive manner involving activin A and regulates myofibroblast differentiation. J Biol Chem 285(14):10434\u201310445","journal-title":"J Biol Chem"},{"issue":"1","key":"3961_CR47","doi-asserted-by":"publisher","first-page":"H96","DOI":"10.1152\/ajpheart.00918.2015","volume":"311","author":"RA Civitarese","year":"2016","unstructured":"Civitarese RA, Talior-Volodarsky I, Desjardins JF, Kabir G, Switzer J, Mitchell M et al (2016) The \u03b111 integrin mediates fibroblast\u2013extracellular matrix\u2013cardiomyocyte interactions in health and disease. Am J Physiol Heart Circ Physiol 311(1):H96\u2013H106","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"6","key":"3961_CR48","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1161\/01.RES.83.6.594","volume":"83","author":"H Kai","year":"1998","unstructured":"Kai H, Muraishi A, Sugiu Y, Nishi H, Seki Y, Kuwahara F et al (1998) Expression of proto-oncogenes and gene mutation of sarcomeric proteins in patients with hypertrophic cardiomyopathy. Circ Res 83(6):594\u2013601","journal-title":"Circ Res"},{"issue":"6","key":"3961_CR49","doi-asserted-by":"publisher","first-page":"H2291","DOI":"10.1152\/ajpheart.00749.2005","volume":"289","author":"AM Samarel","year":"2005","unstructured":"Samarel AM (2005) Costameres, focal adhesions, and cardiomyocyte mechanotransduction. Am J Physiol Heart Circ Physiol 289(6):H2291\u2013H2301","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"4","key":"3961_CR50","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/S0008-6363(00)00140-1","volume":"47","author":"N Maitra","year":"2000","unstructured":"Maitra N, Flink IL, Bahl JJ, Morkin E (2000) Expression of \u03b1 and \u03b2 integrins during terminal differentiation of cardiomyocytes. Cardiovasc Res 47(4):715\u2013725","journal-title":"Cardiovasc Res"},{"key":"3961_CR51","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.yjmcc.2003.11.007","volume":"3","author":"F Bouzeghrane","year":"2004","unstructured":"Bouzeghrane F, Mercure C, Reudelhuber TL, Thibault G (2004) \u03b18\u03b21 integrin is upregulated in myofibroblasts of fibrotic and scarring myocardium. J Mol Cell Cardiol 3:343\u2013353","journal-title":"J Mol Cell Cardiol"},{"issue":"3","key":"3961_CR52","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/S0002-9440(10)65334-5","volume":"154","author":"PD Arora","year":"1999","unstructured":"Arora PD, Narani N, McCulloch CA (1999) The compliance of collagen gels regulates transforming growth factor-\u03b2 induction of \u03b1-smooth muscle actin in fibroblasts. Am J Pathol 154(3):871\u2013882","journal-title":"Am J Pathol"},{"issue":"8902","key":"3961_CR53","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/S0140-6736(94)90007-8","volume":"343","author":"E Topol","year":"1994","unstructured":"Topol E, Califf R, Weisman H, Ellis S, Tcheng J, Worley S et al (1994) Randomised trial of coronary intervention with antibody against platelet IIb\/IIIa integrin for reduction of clinical restenosis: results at six months. Lancet 343(8902):881\u2013886","journal-title":"Lancet"},{"issue":"7","key":"3961_CR54","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1172\/JCI119307","volume":"99","author":"BS Coller","year":"1997","unstructured":"Coller BS (1997) Platelet GPIIb\/IIIa antagonists: the first anti-integrin receptor therapeutics. J Clin Invest 99(7):1467\u20131471","journal-title":"J Clin Invest"},{"issue":"14","key":"3961_CR55","doi-asserted-by":"publisher","first-page":"12384","DOI":"10.1074\/jbc.M208544200","volume":"278","author":"VJ Thannickal","year":"2003","unstructured":"Thannickal VJ, Lee DY, White ES, Cui Z, Larios JM, Chacon R et al (2003) Myofibroblast differentiation by transforming growth factor-\u03b21 is dependent on cell adhesion and integrin signaling via focal adhesion kinase. J Biol Chem 278(14):12384\u201312389","journal-title":"J Biol Chem"},{"issue":"7","key":"3961_CR56","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1016\/0735-1097(95)00391-6","volume":"26","author":"NS Kleiman","year":"1995","unstructured":"Kleiman NS, Raizner AE, Jordan R, Wang AL, Norton D, Mace KF et al (1995) Differential inhibition of platelet aggregation induced by adenosine diphosphate or a thrombin receptor-activating peptide in patients treated with bolus chimeric 7E3 Fab: implications for inhibition of the internal pool of GPIIb\/IIIa receptors. J Am Coll Cardiol 26(7):1665\u20131671","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"3961_CR57","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1016\/j.ahj.2003.09.003","volume":"146","author":"DJ Kereiakes","year":"2003","unstructured":"Kereiakes DJ (2003) Inflammation as a therapeutic target: a unique role for abciximab. Am Heart J 146(4):S1\u2013S4","journal-title":"Am Heart J"},{"issue":"7","key":"3961_CR58","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1097\/00019501-200211000-00002","volume":"13","author":"R Blindt","year":"2002","unstructured":"Blindt R, Bosserhoff AK, Krott N, Vogt F, Hanrath P, Demircan L, vom Dahl J (2002) Decrease of vascular smooth muscle cell locomotion by abciximab, but not tirofiban: a possible role of different affinity to alpha v beta 3 integrins. Coron Artery Dis 13(7):357\u2013364","journal-title":"Coron Artery Dis"},{"issue":"19","key":"3961_CR59","doi-asserted-by":"publisher","first-page":"2468","DOI":"10.1001\/jama.285.19.2468","volume":"285","author":"JC O\u2019Shea","year":"2001","unstructured":"O\u2019Shea JC, Hafley GE, Greenberg S, Hasselblad V, Lorenz TJ, Kitt MM et al (2001) Platelet glycoprotein IIb\/IIIa integrin blockade with eptifibatide in coronary stent intervention: the ESPRIT trial: a randomized controlled trial. JAMA 285(19):2468\u20132473","journal-title":"JAMA"},{"issue":"5 Suppl","key":"3961_CR60","doi-asserted-by":"publisher","first-page":"S332","DOI":"10.1097\/00003246-200205001-00025","volume":"30","author":"JR Leclerc","year":"2002","unstructured":"Leclerc JR (2002) Platelet glycoprotein IIb\/IIIa antagonists: lessons learned from clinical trials and future directions. Crit Care Med 30(5 Suppl):S332\u2013S340","journal-title":"Crit Care Med"},{"issue":"4","key":"3961_CR61","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1517\/17425255.1.4.727","volume":"1","author":"LK Jennings","year":"2005","unstructured":"Jennings LK (2005) Current strategies with eptifibatide and other antiplatelet agents in percutaneous coronary intervention and acute coronary syndromes. Expert Opin Drug Metab Toxicol 1(4):727\u2013737","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"8","key":"3961_CR62","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1161\/01.CIR.98.8.734","volume":"98","author":"SJ Brener","year":"1998","unstructured":"Brener SJ, Barr LA, Burchenal JEB, Katz S, George BS, Jones AA et al (1998) Randomized, placebo-controlled trial of platelet glycoprotein IIb\/IIIa blockade with primary angioplasty for acute myocardial infarction. Circulation 98(8):734\u2013741","journal-title":"Circulation"},{"key":"3961_CR63","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1056\/NEJM199912233412601","volume":"341","author":"CL Grines","year":"1999","unstructured":"Grines CL, Cox DA, Stone GW, Garcia E, Mattos LA, Giambartolomei A et al (1999) Coronary angioplasty with or without stent implantation for acute myocardial infarction. N Engl J Med 341:1949\u20131956","journal-title":"N Engl J Med"},{"issue":"1","key":"3961_CR64","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1161\/CIRCULATIONAHA.105.170815","volume":"113","author":"SC Smith Jr","year":"2006","unstructured":"Smith SC Jr (2006) American College of Cardiology\/American Heart Association Task Force on Practice Guidelines; American College of Cardiology\/American Heart Association\/Society for Cardiovascular Angiography and Interventions Writing Committee to update the 2001 guidelines for percutaneous coronary intervention. ACC\/AHA\/SCAI 2005 guideline update for percutaneous coronary intervention-summary article: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (ACC\/AHA\/SCAI). Circulation 113(1):156\u2013175","journal-title":"Circulation"},{"issue":"8","key":"3961_CR65","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1016\/S0006-2952(00)00444-5","volume":"60","author":"TN Yoganathan","year":"2000","unstructured":"Yoganathan TN, Costello P, Chen X, Jabali M, Yan J, Leung D et al (2000) Integrin-linked kinase (ILK): a \u201chot\u201d therapeutic target. Biochem Pharmacol 60(8):1115\u20131119","journal-title":"Biochem Pharmacol"},{"issue":"23","key":"3961_CR66","doi-asserted-by":"publisher","first-page":"2762","DOI":"10.1161\/hc4801.100792","volume":"104","author":"X Zhang","year":"2001","unstructured":"Zhang X, Hu K, Li CY (2001) Protection against oxidized low-density lipoprotein\u2013induced vascular endothelial cell death by integrin-linked kinase. Circulation 104(23):2762\u20132766","journal-title":"Circulation"},{"key":"3961_CR67","doi-asserted-by":"publisher","first-page":"9481","DOI":"10.1038\/s41598-018-25994-5","volume":"8","author":"CC Fang","year":"2018","unstructured":"Fang CC, Chou TH, Huang JW, Lee CC, Chen SC (2018) The small molecule inhibitor QLT-0267 decreases the production of fibrin-induced inflammatory cytokines and prevents post-surgical peritoneal adhesions. Sci Rep 8:9481","journal-title":"Sci Rep"},{"issue":"8","key":"3961_CR68","first-page":"1228","volume":"117","author":"ZC Zhang","year":"2004","unstructured":"Zhang ZC, Li SJ, Yang YZ, Chen RZ, Ge JB, Chen HZ (2004) Microarray analysis of extracellular matrix genes expression in myocardium of mouse with Coxsackie virus B3 myocarditis. Chin Med J 117(8):1228\u20131231","journal-title":"Chin Med J"},{"issue":"6654","key":"3961_CR69","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1038\/40187","volume":"389","author":"M Uehata","year":"1997","unstructured":"Uehata M, Ishizaki T, Satoh H, Ono T, Kawahara T, Morishita T, Tamakawa H, Yamagami K, Inui J, Maekawa M, Narumiya S (1997) Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 389(6654):990\u2013994","journal-title":"Nature"},{"issue":"18","key":"3961_CR70","doi-asserted-by":"publisher","first-page":"2234","DOI":"10.1161\/01.CIR.0000127939.16111.58","volume":"109","author":"T Hattori","year":"2004","unstructured":"Hattori T, Shimokawa H, Higashi M, Hiroki J, Mukai Y, Tsutsui H et al (2004) Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice. Circulation 109(18):2234\u20132239","journal-title":"Circulation"},{"key":"3961_CR71","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1161\/01.RES.0000176970.22603.8d","volume":"97","author":"E Qvigstad","year":"2005","unstructured":"Qvigstad E, Sjaastad I, Brattelid T, Nunn C, Swift F, Birkeland JAK et al (2005) Dual serotonergic regulation of ventricular contractile force through 5-HT2A and 5-HT4 receptors induced in the acute failing heart. Circ Res 97:268\u2013276","journal-title":"Circ Res"},{"issue":"5","key":"3961_CR72","first-page":"976","volume":"57","author":"T Ishizaki","year":"2000","unstructured":"Ishizaki T, Uehata M, Tamechika I, Keel J, Nonomura K, Maekawa M, Narumiya S (2000) Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol 57(5):976\u2013983","journal-title":"Mol Pharmacol"},{"issue":"3","key":"3961_CR73","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1097\/01.fjc.0000134775.76636.3f","volume":"44","author":"K Inokuchi","year":"2004","unstructured":"Inokuchi K, Ito A, Fukumoto Y, Matoba T, Shiose A, Nishida T et al (2004) Usefulness of fasudil, a Rho-kinase inhibitor, to treat intractable severe coronary spasm after coronary artery bypass surgery. J Cardiovasc Pharmacol 44(3):275\u2013277","journal-title":"J Cardiovasc Pharmacol"},{"issue":"5","key":"3961_CR74","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1161\/01.RES.83.5.490","volume":"83","author":"C Guijarro","year":"1998","unstructured":"Guijarro C, Blanco-Colio LM, Ortego M, Alonso C, Ortiz A, Plaza JJ et al (1998) 3-Hydroxy-3-methylglutaryl coenzyme a reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture. Circ Res 83(5):490\u2013500","journal-title":"Circ Res"},{"issue":"1","key":"3961_CR75","first-page":"151","volume":"215","author":"A Kern","year":"1993","unstructured":"Kern A, Eble J, Golbik R, K\u00fchn K (1993) Interaction of type IV collagen with the isolated integrins \u03b11\u03b21 and \u03b12\u03b21.Eur. J Biochem 215(1):151\u2013159","journal-title":"J Biochem"},{"issue":"42","key":"3961_CR76","doi-asserted-by":"publisher","first-page":"26006","DOI":"10.1016\/S0021-9258(18)47151-7","volume":"269","author":"T Kamata","year":"1994","unstructured":"Kamata T, Takada Y (1994) Direct binding of collagen to the I domain of integrin alpha 2 beta 1 (VLA-2, CD49b\/CD29) in a divalent cation-independent manner. J Biol Chem 269(42):26006\u201326010","journal-title":"J Biol Chem"},{"issue":"11","key":"3961_CR77","doi-asserted-by":"publisher","first-page":"8255","DOI":"10.1074\/jbc.275.11.8255","volume":"275","author":"P Nykvist","year":"2000","unstructured":"Nykvist P, Tu H, Ivaska J, K\u00e4pyl\u00e4 J, Pihlajaniemi T, Heino J (2000) Distinct recognition of collagen subtypes by \u03b11\u03b21 and \u03b12\u03b21 integrins \u03b11\u03b21 mediates cell adhesion to type Xiii collagen. J Biol Chem 275(11):8255\u20138261","journal-title":"J Biol Chem"},{"issue":"3","key":"3961_CR78","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1111\/j.1432-1033.1994.0975b.x","volume":"225","author":"M Pfaff","year":"1994","unstructured":"Pfaff M, G\u00f6hring W, Brown JC, Timpl R (1994) Binding of purified collagen receptors (\u03b11\u03b21, \u03b12\u03b21) and RGD-dependent integrins to laminins and laminin fragments. Eur J Biochem 225(3):975\u2013984","journal-title":"Eur J Biochem"},{"issue":"Pt 4","key":"3961_CR79","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1242\/jcs.114.4.811","volume":"114","author":"F Decline","year":"2001","unstructured":"Decline F, Rousselle P (2001) Keratinocyte migration requires alpha2beta1 integrin-mediated interaction with the laminin 5 gamma2 chain. J Cell Sci 114(Pt 4):811\u2013823","journal-title":"J Cell Sci"},{"issue":"7","key":"3961_CR80","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1111\/j.1538-7836.2005.01432.x","volume":"3","author":"RB Zotz","year":"2005","unstructured":"Zotz RB, Winkelmann BR, M\u00fcller C, Boehm BO, M\u00e4rz W, Scharf RE (2005) Association of polymorphisms of platelet membrane integrins \u03b1IIb\u03b23 (HPA-1b\/PlA2) and \u03b12\u03b21 (\u03b12807TT) with premature myocardial infarction. J Thromb Haemost 3(7):1522\u20131529","journal-title":"J Thromb Haemost"},{"issue":"21","key":"3961_CR81","first-page":"6116","volume":"62","author":"Y Funahashi","year":"2002","unstructured":"Funahashi Y, Sugi NH, Semba T, Yamamoto Y, Hamaoka S, Tsukahara-Tamai N et al (2002) Sulfonamide derivative, E7820, is a unique angiogenesis inhibitor suppressing an expression of integrin \u03b12 subunit on endothelium. Cancer Res 62(21):6116\u20136123","journal-title":"Cancer Res"},{"issue":"4","key":"3961_CR82","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1158\/1078-0432.CCR-0109-03","volume":"10","author":"T Semba","year":"2004","unstructured":"Semba T, Funahashi Y, Ono N, Yamamoto Y, Sugi NH, Asada M et al (2004) An angiogenesis inhibitor E7820 shows broad-spectrum tumor growth inhibition in a xenograft model: possible value of integrin \u03b12 on platelets as a biological marker. Clin Cancer Res 10(4):1430\u20131438","journal-title":"Clin Cancer Res"},{"issue":"2","key":"3961_CR83","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/0092-8674(94)90337-9","volume":"76","author":"TA Springer","year":"1994","unstructured":"Springer TA (1994) Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76(2):301\u2013314","journal-title":"Cell"},{"issue":"2","key":"3961_CR84","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/nrd1637","volume":"4","author":"JH Noseworthy","year":"2005","unstructured":"Noseworthy JH, Kirkpatrick P (2005) Natalizumab. Nat Rev Drug Discov 4(2):101\u2013102","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"3961_CR85","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3233\/HAB-1997-8102","volume":"8","author":"OJ L\u00e9ger","year":"1997","unstructured":"L\u00e9ger OJ, Yednock TA, Tanner L, Horner HC, Hines DK, Keen S et al (1997) Humanization of a mouse antibody against human alpha-4 integrin: a potential therapeutic for the treatment of multiple sclerosis. Hum Antibodies 8(1):3\u201316","journal-title":"Hum Antibodies"},{"issue":"4","key":"3961_CR86","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1002\/ijc.10958","volume":"104","author":"O Stoeltzing","year":"2003","unstructured":"Stoeltzing O, Liu W, Reinmuth N, Fan F, Parry GC, Parikh AA et al (2003) Inhibition of integrin \u03b15\u03b21 function with a small peptide (ATN-161) plus continuous 5-FU infusion reduces colorectal liver metastases and improves survival in mice. Int J Cancer 104(4):496\u2013503","journal-title":"Int J Cancer"},{"issue":"18","key":"3961_CR87","doi-asserted-by":"publisher","first-page":"6471","DOI":"10.1073\/pnas.84.18.6471","volume":"84","author":"DA Cheresh","year":"1987","unstructured":"Cheresh DA (1987) Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor. Proc Natl Acad Sci U S A 84(18):6471\u20136475","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"3961_CR88","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1172\/JCI118808","volume":"98","author":"S Stromblad","year":"1996","unstructured":"Stromblad S, Becker JC, Yebra M, Brooks PC, Cheresh DA (1996) Suppression of p53 activity and p21WAF1'C'P1 expression by vascular cell integrin a& during angiogenesis. J Clin Invest 98(2):426\u2013433","journal-title":"J Clin Invest"},{"issue":"7","key":"3961_CR89","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1016\/0092-8674(94)90007-8","volume":"79","author":"PC Brooks","year":"1994","unstructured":"Brooks PC, Montgomery AM, Rosenfeld M, Reisfeld RA, Hu T, Klier G, Cheresh DA (1994) Integrin \u03b1v\u03b23 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 79(7):1157\u20131164","journal-title":"Cell"},{"issue":"5158","key":"3961_CR90","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1126\/science.7512751","volume":"264","author":"B Pc","year":"1994","unstructured":"Pc B, Clark RA, Cheresh DA (1994) Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science. 264(5158):569\u2013571","journal-title":"Science."},{"issue":"4","key":"3961_CR91","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1172\/JCI118227","volume":"96","author":"PC Brooks","year":"1995","unstructured":"Brooks PC, Str\u00f6mblad S, Klemke R, Visscher D, Sarkar FH, Cheresh DA (1995) Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin. J Clin Invest 96(4):1815\u20131822","journal-title":"J Clin Invest"},{"issue":"Pt 3","key":"3961_CR92","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1042\/bj3170817","volume":"317","author":"C Marcinkiewicz","year":"1996","unstructured":"Marcinkiewicz C, Rosenthal LA, Mosser DM, Kunicki TJ, Niewiarowski S (1996) Immunological characterization of eristostatin and echistatin binding sites on \u03b1IIb \u03b23 and \u03b1V\u03b23 integrins. Biochem J 317(Pt 3):817\u2013825","journal-title":"Biochem J"},{"key":"3961_CR93","unstructured":"Guidance on the use of glycoprotein IIb\/IIIa inhibitors in the treatment of acute coronary syndromes. National Institute for Clinical Excellence, 2000. https:\/\/www.nice.org.uk\/guidance\/ta47\/resources\/guidance-on-the-use-of-glycoprotein-iibiiia-inhibitors-in-the-treatment-of-acute-coronary-syndromes-pdf-2294582158789"},{"key":"3961_CR94","doi-asserted-by":"publisher","first-page":"2477","DOI":"10.1161\/01.CIR.100.25.2477","volume":"100","author":"SP Marso","year":"1999","unstructured":"Marso SP, Lincoff AM, Ellis SG, Bhatt DL, Tanguay JF, Kleiman NS et al (1999) Optimizing the percutaneous interventional outcomes for patients with diabetes mellitus: results of the EPISTENT (Evaluation of platelet IIb\/IIIa inhibitor for stenting trial) diabetic substudy. Circulation. 100:2477\u20132484","journal-title":"Circulation."},{"issue":"9310","key":"3961_CR95","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/S0140-6736(02)08022-4","volume":"359","author":"A Kastrati","year":"2002","unstructured":"Kastrati A, Mehilli J, Dirschinger J, Schricke U, Neverve J, Pache J et al (2002) Myocardial salvage after coronary stenting plus abciximab versus fibrinolysis plus abciximab in patients with acute myocardial infarction: a randomised trial. Lancet. 359(9310):920\u2013925","journal-title":"Lancet."},{"issue":"23","key":"3961_CR96","doi-asserted-by":"publisher","first-page":"2520","DOI":"10.1093\/eurheartj\/ehi620","volume":"26","author":"Admiral Investigators","year":"2005","unstructured":"Admiral Investigators (2005) Three-year duration of benefit from abciximab in patients receiving stents for acute myocardial infarction in the randomized double-blind ADMIRAL study. Eur Heart J 26(23):2520\u20132523","journal-title":"Eur Heart J"},{"issue":"56","key":"3961_CR97","doi-asserted-by":"publisher","first-page":"8024","DOI":"10.1038\/sj.onc.1203258","volume":"18","author":"DK Lynch","year":"1999","unstructured":"Lynch DK, Ellis CA, Edwards PA, Hiles ID (1999) Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism. Oncogene. 18(56):8024\u20138032","journal-title":"Oncogene."},{"issue":"3","key":"3961_CR98","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1128\/MMBR.63.3.725-734.1999","volume":"63","author":"GR Nemerow","year":"1999","unstructured":"Nemerow GR, Stewart PL (1999) Role of \u03b1v integrins in adenovirus cell entry and gene delivery. Microbiol Mol Biol Rev 63(3):725\u2013734","journal-title":"Microbiol Mol Biol Rev"},{"issue":"2-3","key":"3961_CR99","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1017\/cts.2019.382","volume":"3","author":"S Vootukuri","year":"2019","unstructured":"Vootukuri S et al (2019) Preclinical studies of RUC-4, a novel platelet \u03b1IIb\u03b23 antagonist, in non-human primates and with human platelets. J Clin Transl Sci 3(2-3):65\u201374","journal-title":"J Clin Transl Sci"},{"issue":"Supplement_1","key":"3961_CR100","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1182\/blood-2019-124548","volume":"134","author":"OS Bentur","year":"2019","unstructured":"Bentur OS, Coller BS (2019) In vitro effects of the novel platelet \u03b1IIb\u03b23 receptor antagonist RUC-4 on the verifynow assays: potential for point-of-care monitoring of RUC-4 therapy. Blood 134(Supplement_1):166","journal-title":"Blood"},{"key":"3961_CR101","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/978-1-4939-8612-5_13","volume":"1821","author":"P Simons","year":"2018","unstructured":"Simons P et al (2018) Small-volume flow cytometry-based multiplex analysis of the activity of small GTPases. Rho GTPases. Methods Mol Biol 1821:177\u2013195","journal-title":"Methods Mol Biol"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-020-03961-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11010-020-03961-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-020-03961-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T14:00:27Z","timestamp":1674828027000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11010-020-03961-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,4]]},"references-count":101,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["3961"],"URL":"https:\/\/doi.org\/10.1007\/s11010-020-03961-x","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,4]]},"assertion":[{"value":"7 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors have declared that no competing interests exist.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}