{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T23:13:22Z","timestamp":1769728402309,"version":"3.49.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,1,3]],"date-time":"2021-01-03T00:00:00Z","timestamp":1609632000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,3]],"date-time":"2021-01-03T00:00:00Z","timestamp":1609632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600897"],"award-info":[{"award-number":["81600897"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771109"],"award-info":[{"award-number":["81771109"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901031"],"award-info":[{"award-number":["81901031"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1007\/s11010-020-03995-1","type":"journal-article","created":{"date-parts":[[2021,1,3]],"date-time":"2021-01-03T14:02:38Z","timestamp":1609682558000},"page":"1351-1364","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Downregulated hypoxia-inducible factor 1\u03b1 improves myoblast differentiation under hypoxic condition in mouse genioglossus"],"prefix":"10.1007","volume":"476","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1560-0108","authenticated-orcid":false,"given":"Yun","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqi","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxin","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuehua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8849-361X","authenticated-orcid":false,"given":"Qiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,3]]},"reference":[{"key":"3995_CR1","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1378\/chest.122.4.1400","volume":"122","author":"M McGuire","year":"2002","unstructured":"McGuire M, MacDermott M, Bradford A (2002) The effects of chronic episodic hypercapnic hypoxia on rat upper airway muscle contractile properties and fiber-type distribution. Chest 122:1400\u20131406","journal-title":"Chest"},{"key":"3995_CR2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.resp.2005.04.001","volume":"147","author":"A Bradford","year":"2005","unstructured":"Bradford A, McGuire M, O'Halloran KD (2005) Does episodic hypoxia affect upper airway dilator muscle function? Implications for the pathophysiology of obstructive sleep apnoea. Respir Physiol Neurobiol 147:223\u2013234","journal-title":"Respir Physiol Neurobiol"},{"key":"3995_CR3","doi-asserted-by":"crossref","first-page":"4304","DOI":"10.1073\/pnas.90.9.4304","volume":"90","author":"GL Wang","year":"1993","unstructured":"Wang GL, Semenza GL (1993) General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc Natl Acad Sci USA 90:4304\u20134308","journal-title":"Proc Natl Acad Sci USA"},{"key":"3995_CR4","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1152\/physrev.00015.2007","volume":"88","author":"DG Allen","year":"2008","unstructured":"Allen DG, Lamb GD, Westerblad H (2008) Skeletal muscle fatigue: cellular mechanisms. Physiol Rev 88:287\u2013332","journal-title":"Physiol Rev"},{"key":"3995_CR5","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1096\/fj.04-2215fje","volume":"19","author":"D Volonte","year":"2005","unstructured":"Volonte D, Liu Y, Galbiati F (2005) The modulation of caveolin-1 expression controls satellite cell activation during muscle repair. FASEB J 19:237\u2013239","journal-title":"FASEB J"},{"key":"3995_CR6","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ydbio.2017.03.004","volume":"424","author":"MA Berberoglu","year":"2017","unstructured":"Berberoglu MA, Gallagher TL, Morrow ZT, Talbot JC, Hromowyk KJ, Tenente IM, Langenau DM, Amacher SL (2017) Satellite-like cells contribute to pax7-dependent skeletal muscle repair in adult zebrafish. Dev Biol 424:162\u2013180","journal-title":"Dev Biol"},{"key":"3995_CR7","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.semcdb.2017.11.010","volume":"72","author":"JM Hern\u00e1ndez-Hern\u00e1ndez","year":"2017","unstructured":"Hern\u00e1ndez-Hern\u00e1ndez JM, Garc\u00eda-Gonz\u00e1lez EG, Brun CE, Rudnicki MA (2017) The myogenic regulatory factors, determinants of muscle development, cell identity and regeneration. Semin Cell Dev Biol 72:10\u201318","journal-title":"Semin Cell Dev Biol"},{"key":"3995_CR8","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.semcdb.2017.11.011","volume":"72","author":"PS Zammit","year":"2017","unstructured":"Zammit PS (2017) Function of the myogenic regulatory factors Myf5, MyoD, Myogenin and MRF4 in skeletal muscle, satellite cells and regenerative myogenesis. Semin Cell Dev Biol 72:19\u201332","journal-title":"Semin Cell Dev Biol"},{"key":"3995_CR9","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12951-017-0284-3","volume":"15","author":"AD Ducray","year":"2017","unstructured":"Ducray AD, Felser A, Zielinski J, Bittner A, B\u00fcrgi JV, Nuoffer J, Frenz M, Mevissen M (2017) Effects of silica nanoparticle exposure on mitochondrial function during neuronal differentiation. J Nanobiotechnol 15:49","journal-title":"J Nanobiotechnol"},{"key":"3995_CR10","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.biocel.2014.07.015","volume":"54","author":"A Wanet","year":"2014","unstructured":"Wanet A, Remacle N, Najar M, Sokal E, Arnould T, Najimi M, Renard P (2014) Mitochondrial remodeling in hepatic differentiation and dedifferentiation. Int J Biochem Cell Biol 54:174\u2013185","journal-title":"Int J Biochem Cell Biol"},{"key":"3995_CR11","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1007\/s00125-016-3919-2","volume":"59","author":"X Wang","year":"2016","unstructured":"Wang X, Feng Z, Wang X, Yang L, Han S, Cao K, Xu J, Zhao L, Zhang Y, Ji L (2016) O-GlcNAcase deficiency suppresses skeletal myogenesis and insulin sensitivity in mice through the modulation of mitochondrial homeostasis. Diabetologia 59:1287\u20131296","journal-title":"Diabetologia"},{"key":"3995_CR12","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/845379","author":"E Barbieri","year":"2011","unstructured":"Barbieri E, Battistelli M, Casadei L et al (2011) Morphofunctional and biochemical approaches for studying mitochondrial changes during myoblasts differentiation. J Aging Res. https:\/\/doi.org\/10.4061\/2011\/845379","journal-title":"J Aging Res"},{"key":"3995_CR13","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s11010-010-0668-2","volume":"349","author":"A Wagatsuma","year":"2011","unstructured":"Wagatsuma A, Kotake N, Yamada S (2011) Muscle regeneration occurs to coincide with mitochondrial biogenesis. Mol Cell Biochem 349:139\u2013147","journal-title":"Mol Cell Biochem"},{"key":"3995_CR14","doi-asserted-by":"crossref","first-page":"C1119","DOI":"10.1152\/ajpcell.00463.2005","volume":"290","author":"CS Kraft","year":"2006","unstructured":"Kraft CS, LeMoine CM, Lyons CN, Michaud D, Mueller CR, Moyes CD (2006) Control of mitochondrial biogenesis during myogenesis. Am J Physiol Cell Physiol 290:C1119\u20131127","journal-title":"Am J Physiol Cell Physiol"},{"key":"3995_CR15","doi-asserted-by":"crossref","first-page":"E802","DOI":"10.1152\/ajpendo.00343.2001","volume":"282","author":"S Duguez","year":"2002","unstructured":"Duguez S, F\u00e9asson L, Denis C, Freyssenet D (2002) Mitochondrial biogenesis during skeletal muscle regeneration. Am J Physiol Endocrinol Metab 282:E802\u2013809","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"3995_CR16","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1172\/JCI67227","volume":"123","author":"NB Ruderman","year":"2013","unstructured":"Ruderman NB, Carling D, Prentki M, Cacicedo JM (2013) AMPK, insulin resistance, and the metabolic syndrome. J Clin Invest 123:2764\u20132772","journal-title":"J Clin Invest"},{"key":"3995_CR17","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1194\/jlr.R025882","volume":"53","author":"RA Srivastava","year":"2012","unstructured":"Srivastava RA, Pinkosky SL, Filippov S, Hanselman JC, Cramer CT, Newton RS (2012) AMP-activated protein kinase: an emerging drug target to regulate imbalances in lipid and carbohydrate metabolism to treat cardio- metabolic diseases. J Lipid Res 53:2490\u20132514","journal-title":"J Lipid Res"},{"key":"3995_CR18","doi-asserted-by":"crossref","first-page":"360","DOI":"10.2337\/db14-0508","volume":"64","author":"S Pirkmajer","year":"2015","unstructured":"Pirkmajer S, Kulkarni SS, Tom RZ, Ross FA, Hawley SA, Hardie DG, Zierah JR, Chibalin AV (2015) Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation. Diabetes 64:360\u2013369","journal-title":"Diabetes"},{"key":"3995_CR19","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.brainres.2019.02.030","volume":"1714","author":"D Ma","year":"2019","unstructured":"Ma D, Liu X, Liu J, Li M, Chen L, Gao M, Xu W, Yang Y (2019) Long-term liraglutide ameliorates nigrostriatal impairment via regulating AMPK\/PGC-1a signaling in diabetic mice. Brain Res 1714:126\u2013132","journal-title":"Brain Res"},{"key":"3995_CR20","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1007\/s12603-018-1015-7","volume":"22","author":"Y Yu","year":"2018","unstructured":"Yu Y, Zhao Y, Teng F, Li J, Guan Y, Xu J, Lv X, Guan F, Zhang M, Chen L (2018) Berberine improves cognitive deficiency and muscular dysfunction via activation of the AMPK\/SIRT1\/PGC-1a pathway in skeletal muscle from naturally aging rats. J Nutr Health Aging 22:710\u2013717","journal-title":"J Nutr Health Aging"},{"key":"3995_CR21","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1016\/j.tetlet.2011.03.002","volume":"52","author":"C Zhong","year":"2011","unstructured":"Zhong C, Zhu J, Sun X et al (2011) Concise total syntheses of (\u00b1) isopaucifloral F, (\u00b1) quadrangularin A, and (\u00b1) pallidol. Tetrahedron Lett 52:2815\u20132817","journal-title":"Tetrahedron Lett"},{"key":"3995_CR22","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10616-008-9143-2","volume":"56","author":"M Agnello","year":"2008","unstructured":"Agnello M, Morici G, Rinaldi AM (2008) A method for measuring mitochondrial mass and activity. Cytotechnology 56:145\u2013149","journal-title":"Cytotechnology"},{"key":"3995_CR23","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1242\/dev.079665","volume":"139","author":"W Liu","year":"2012","unstructured":"Liu W, Wen Y, Bi P, Lai X, Liu XS, Liu X, Kuang S (2012) Hypoxia promotes satellite cell self-renewal and enhances the efficiency of myoblast transplantation. Development 139:2857\u20132865","journal-title":"Development"},{"key":"3995_CR24","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s00424-013-1336-7","volume":"466","author":"T Chaillou","year":"2014","unstructured":"Chaillou T, Koulmann N, Meunier A, Pugni\u00e8re P, McCarthy JJ, Beaudry M, Bigard X (2014) Ambient hypoxia enhances the loss of muscle mass after extensive injury. Pflugers Arch 466:587\u2013598","journal-title":"Pflugers Arch"},{"key":"3995_CR25","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s11010-010-0622-3","volume":"347","author":"A Wagatsuma","year":"2011","unstructured":"Wagatsuma A, Kotake N, Yamada S (2011) Spatial and temporal expression of hypoxia-inducible factor-1alpha during myogenesis in vivo and in vitro. Mol Cell Biochem 347:145\u2013155","journal-title":"Mol Cell Biochem"},{"key":"3995_CR26","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/jcp.20539","volume":"207","author":"P Seyer","year":"2006","unstructured":"Seyer P, Grandemange S, Busson M, Carazo A, Gamal\u00e9ri F, Pessemesse L, Casas F, Cabello G, Wrutniak-Cabello C (2006) Mitochondrial activity regulates myoblast differentiation by control of c-Myc expression. J Cell Physiol 207:75\u201386","journal-title":"J Cell Physiol"},{"key":"3995_CR27","doi-asserted-by":"crossref","first-page":"e0153729","DOI":"10.1371\/journal.pone.0153729","volume":"11","author":"LJ Wang","year":"2016","unstructured":"Wang LJ, Xu XY, Kang LN, Xiang WP (2016) Bone marrow mesenchymal stem cells attenuate mitochondria damage induced by hypoxia in mouse trophoblasts. PLoS ONE 11:e0153729","journal-title":"PLoS ONE"},{"key":"3995_CR28","doi-asserted-by":"crossref","first-page":"464","DOI":"10.4103\/1673-5374.266058","volume":"15","author":"Y Yang","year":"2020","unstructured":"Yang Y, Ye G, Zhang YL, He HW, Yu BQ, Hong YM, Wei Y, Xin Li (2020) Transfer of mitochondria from mesenchymal stem cells derived from induced pluripotent stem cells attenuates hypoxia-ischemia-induced mitochondrial dysfunction in PC12 cells. Neural Regen Res 15:464\u2013472","journal-title":"Neural Regen Res"},{"key":"3995_CR29","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1007\/s00125-011-2135-3","volume":"54","author":"C Handschin","year":"2011","unstructured":"Handschin C (2011) Peroxisome proliferator-activated receptor \u03b3 coactivator 1\u03b2 (PGC-1\u03b2) improves skeletal muscle mitochondrial function and insulin sensitivity. Diabetologia 54:1270\u20131272","journal-title":"Diabetologia"},{"key":"3995_CR30","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cmet.2006.12.003","volume":"5","author":"Z Arany","year":"2007","unstructured":"Arany Z, Lebrasseur N, Morris C, Smith E, Yang W, Ma Y, Chin S, Spiegelman BM (2007) The transcriptional coactivator PGC-1beta drives the formation of oxidative type IIX fibers in skeletal muscle. Cell Metab 5:35\u201346","journal-title":"Cell Metab"},{"key":"3995_CR31","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.ccr.2007.04.001","volume":"11","author":"H Zhang","year":"2007","unstructured":"Zhang H, Gao P, Fukuda R, Kumar G, Krishnamachary B, Zeller KI, Dang CV, Semenza GL (2007) HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell 11:407\u2013420","journal-title":"Cancer Cell"},{"key":"3995_CR32","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.bbamcr.2010.09.019","volume":"1813","author":"RC Scarpulla","year":"2011","unstructured":"Scarpulla RC (2011) Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network. Biochim Biophys Acta 1813:1269\u20131278","journal-title":"Biochim Biophys Acta"},{"key":"3995_CR33","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1113\/expphysiol.2006.034736","volume":"92","author":"CU Niesler","year":"2007","unstructured":"Niesler CU, Myburgh KH, Moore F (2007) The changing AMPK expression profile in differentiating mouse skeletal muscle myoblast cells helps confer increasing resistance to apoptosis. Exp Physiol 92:207\u2013217","journal-title":"Exp Physiol"},{"key":"3995_CR34","doi-asserted-by":"crossref","first-page":"4517","DOI":"10.1128\/MCB.01078-13","volume":"33","author":"X Fu","year":"2013","unstructured":"Fu X, Zhao J, Zhu M, Foretz M, Viollet B, Dodson MV, Du M (2013) AMP-activated protein kinase alpha1 but not alpha2 catalytic subunit potentiates myogenin expression and myogenesis. Mol Cell Biol 33:4517\u20134525","journal-title":"Mol Cell Biol"},{"key":"3995_CR35","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1128\/MCB.05124-11","volume":"31","author":"PT Mungai","year":"2011","unstructured":"Mungai PT, Waypa GB, Jairaman A, Prakriya M, Dokic D, Ball MK, Schumacker PT (2011) Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels. Mol Cell Biol 31:3531\u20133545","journal-title":"Mol Cell Biol"},{"key":"3995_CR36","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.3892\/or.2013.2628","volume":"30","author":"L Wang","year":"2013","unstructured":"Wang L, Liu Q, Li F, Qiu J, Fan H, Ma H, Zhu Y, Wu L, Han X, Yang Z, Jiang H, Wei J, Xia H (2013) Apoptosis induced by PGC-1beta in breast cancer cells is mediated by the mTOR pathway. Oncol Rep 30:1631\u20131638","journal-title":"Oncol Rep"},{"key":"3995_CR37","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.fitote.2014.10.006","volume":"99","author":"AK Rawat","year":"2014","unstructured":"Rawat AK, Korthikunta V, Gautam S, Pal S, Tadigoppula N, Tamrakar AK, Srivastava AK (2014) 4-Hydroxyisoleucine improves insulin resistance by promoting mitochondrial biogenesis and act through AMPK and Akt dependent pathway. Fitoterapia 99:307\u2013317","journal-title":"Fitoterapia"},{"key":"3995_CR38","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1042\/BJ20111829","volume":"444","author":"I Martinez-Reyes","year":"2012","unstructured":"Martinez-Reyes I, S\u00e1nchez-Arag\u00f3 M, Cuezva JM (2012) AMPK and GCN2-ATF4 signal the repression of mitochondria in colon cancer cells. Biochem J 444:249\u2013259","journal-title":"Biochem J"},{"key":"3995_CR39","doi-asserted-by":"crossref","first-page":"4743","DOI":"10.1016\/j.bbagen.2013.06.004","volume":"1830","author":"CC Hsu","year":"2013","unstructured":"Hsu CC, Wang CH, Wu LC, Hsia CY, Chi CW, Yin PH, Chang CJ, Sung MT, Wei YH, Lu SH, Lee HC (2013) Mitochondrial dysfunction represses HIF-1alpha protein synthesis through AMPK activation in human hepatoma HepG2 cells. Biochim Biophys Acta 1830:4743\u20134751","journal-title":"Biochim Biophys Acta"},{"key":"3995_CR40","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jsbmb.2013.12.006","volume":"140","author":"Y Lu","year":"2014","unstructured":"Lu Y, Liu Y, Li Y (2014) Comparison of natural estrogens and synthetic derivative on genioglossus function and estrogen receptors expression in rats with chronic intermittent hypoxia. J Steroid Biochem Mol Biol 140:71\u201379","journal-title":"J Steroid Biochem Mol Biol"},{"key":"3995_CR41","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.bbagen.2011.09.007","volume":"1810","author":"M Vucetic","year":"2011","unstructured":"Vucetic M, Otasevic V, Korac A, Stancic A, Jankovic A, Markelic M, Golic I, Velickovic K, Buzadzic B, Korac B (2011) Interscapular brown adipose tissue metabolic reprogramming during cold acclimation: interplay of HIF-1alpha and AMPKalpha. Biochim Biophys Acta 1810:1252\u20131261","journal-title":"Biochim Biophys Acta"},{"key":"3995_CR42","doi-asserted-by":"crossref","first-page":"E4458","DOI":"10.1073\/pnas.1411199111","volume":"111","author":"AB Hwang","year":"2014","unstructured":"Hwang AB, Ryu EA, Artan M, Chang HW, Kabir MH, Nam HJ, Lee D, Yang JS, Kim S, Mair WB, Lee C, Lee SS, Lee SJ (2014) Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in caenorhabditis elegans. Proc Natl Acad Sci USA 111:E4458\u20134467","journal-title":"Proc Natl Acad Sci USA"},{"key":"3995_CR43","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.exger.2018.07.012","volume":"111","author":"L Toniolo","year":"2018","unstructured":"Toniolo L, Fusco P, Formoso L, Mazzi A, Canato M, Reggiani C, Giacomello E (2018) Resveratrol treatment reduces the appearance of tubular aggregates and improves the resistance to fatigue in aging mice skeletal muscles. Exp Gerontol 111:170\u2013179","journal-title":"Exp Gerontol"},{"key":"3995_CR44","doi-asserted-by":"crossref","first-page":"6187","DOI":"10.1113\/jphysiol.2012.240077","volume":"590","author":"T Yamada","year":"2012","unstructured":"Yamada T, Ivarsson N, Hern\u00e1ndez A, Fahlstr\u00f6m A, Cheng AJ, Zhang SJ, Bruton JD, Ulfhake B, Westerblad H (2012) Impaired mitochondrial respiration and decreased fatigue resistance followed by severe muscle weakness in skeletal muscle of mitochondrial DNA mutator mice. J Physiol 590:6187\u20136197","journal-title":"J Physiol"},{"issue":"Suppl 1","key":"3995_CR45","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.5213\/inj.1938046.023","volume":"23","author":"SS Park","year":"2019","unstructured":"Park SS, Park HS, Jeong H, Kwak HB, No MH, Heo JW, Yoo SZ, Kim TW (2019) Treadmill exercise ameliorates chemotherapy-induced muscle weakness and central fatigue by enhancing mitochondrial function and inhibiting apoptosis. Int Neurourol J 23(Suppl 1):S32\u201339","journal-title":"Int Neurourol J"},{"key":"3995_CR46","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1096\/fj.14-250449","volume":"28","author":"L Lantier","year":"2014","unstructured":"Lantier L, Fentz J, Mounier R, Leclerc J, Treebak JT, Pehm\u00f8ller C, Sanz N, Sakakibara I, Saint-Amand E, Rimbaud S, Maire P, Marette A, Ventura-Clapier R, Ferry A, Wojtaszewski JF, Foretz M, Viollet B (2014) AMPK controls exercise endurance, mitochondrial oxidative capacity, and skeletal muscle integrity. FASEB J 28:3211\u20133224","journal-title":"FASEB J"},{"key":"3995_CR47","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.brainresbull.2016.02.011","volume":"121","author":"D Wan","year":"2016","unstructured":"Wan D, Zhou Y, Wang K, Hou Y, Hou R, Ye X (2016) Resveratrol provides neuroprotection by inhibiting phosphodiesterases and regulating the cAMP\/AMPK\/SIRT1 pathway after stroke in rats. Brain Res Bull 121:255\u2013262","journal-title":"Brain Res Bull"},{"key":"3995_CR48","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1016\/j.metabol.2015.07.010","volume":"64","author":"RD Hamidie","year":"2015","unstructured":"Hamidie RD, Yamada T, Ishizawa R, Saito Y, Masuda K (2015) Curcumin treatment enhances the effect of exercise on mitochondrial biogenesis in skeletal muscle by increasing cAMP levels. Metabolism 64:1334\u20131347","journal-title":"Metabolism"},{"key":"3995_CR49","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.cmet.2012.04.003","volume":"15","author":"NL Price","year":"2012","unstructured":"Price NL, Gomes AP, Ling AJY (2012) SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab 15:675\u2013690","journal-title":"Cell Metab"},{"key":"3995_CR50","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.18632\/aging.101910","volume":"11","author":"Y Huang","year":"2019","unstructured":"Huang Y, Zhu X, Chen K, Lang H, Zhang Y, Hou P, Ran L, Zhou M, Zheng J, Yi L, Mi M, Zhang Q (2019) Resveratrol prevents sarcopenic obesity by reversing mitochondrial dysfunction and oxidative stress via the PKA\/LKB1\/AMPK pathway. Aging (Albany NY) 11:2217\u20132240","journal-title":"Aging (Albany NY)"},{"key":"3995_CR51","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1128\/MCB.06160-11","volume":"32","author":"C Bardella","year":"2012","unstructured":"Bardella C, Olivero M, Lorenzato A, Geuna M, Adam J, O\u2019Flaherty L, Rustin P, Tomlinson I, Pollard PJ, Renzo MF (2012) Cells lacking the fumarase tumor suppressor are protected from apoptosis through a hypoxia-inducible factor-independent, AMPK-dependent mechanism. Mol Cell Biol 32:3081\u20133094","journal-title":"Mol Cell Biol"},{"key":"3995_CR52","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.joen.2013.02.001","volume":"39","author":"Q Zhou","year":"2013","unstructured":"Zhou Q, Liu H, Sun Q, Zhang L, Lin H, Yuan G, Zhang L, Chen Z (2013) Adenosine monophosphate-activated protein kinase\/mammalian target of rapamycin-dependent autophagy protects human dental pulp cells against hypoxia. J Endod 39:768\u2013773","journal-title":"J Endod"},{"key":"3995_CR53","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/aps.2014.17","volume":"35","author":"LL Xuan","year":"2014","unstructured":"Xuan LL, Shi J, Yao CS, Bai JY, Qu F, Zhang JL, Hou Q (2014) Vam3, a resveratrol dimer, inhibits cigarette smoke-induced cell apoptosis in lungs by improving mitochondrial function. Acta Pharmacol Sin 35:779\u2013791","journal-title":"Acta Pharmacol Sin"},{"key":"3995_CR54","doi-asserted-by":"crossref","first-page":"e78019","DOI":"10.1371\/journal.pone.0078019","volume":"8","author":"KM Weixel","year":"2013","unstructured":"Weixel KM, Marciszyn A, Alzamora R, Li H, Fischer O, Edinger RS, Hallows KR, Johnson JP (2013) Resveratrol inhibits the epithelial sodium channel via phopshoinositides and AMP-activated protein kinase in kidney collecting duct cells. PLoS ONE 8:e78019","journal-title":"PLoS ONE"},{"key":"3995_CR55","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1083\/jcb.200712110","volume":"182","author":"H Ren","year":"2008","unstructured":"Ren H, Yin P, Duan C (2008) IGFBP-5 regulates muscle cell differentiation by binding to IGF-II and switching on the IGF-II auto-regulation loop. J Cell Biol 182:979\u2013991","journal-title":"J Cell Biol"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-020-03995-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11010-020-03995-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-020-03995-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T18:13:28Z","timestamp":1614622408000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11010-020-03995-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,3]]},"references-count":55,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["3995"],"URL":"https:\/\/doi.org\/10.1007\/s11010-020-03995-1","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,3]]},"assertion":[{"value":"22 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by Animal Welfare and Ethics Group, Department of Laboratory Animal Science at Fudan University. Norms regarding the ethical treatment of animals were strictly followed during the whole operation. Euthanasia was done rapidly and painlessly to ensure that the animals do not suffer at any stage of the experiment.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}