{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T21:51:46Z","timestamp":1773784306459,"version":"3.50.1"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T00:00:00Z","timestamp":1611187200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T00:00:00Z","timestamp":1611187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100011054","name":"International Society of Hypertension","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100011054","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Association of African Universities","award":["AAU\/2017\/2018"],"award-info":[{"award-number":["AAU\/2017\/2018"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s11010-020-04031-y","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T18:02:56Z","timestamp":1611252176000},"page":"1861-1870","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Acetate causes renoprotection like androgen and mineralocorticoid receptors blockade in testosterone-exposed pregnant rats"],"prefix":"10.1007","volume":"476","author":[{"given":"Taofeek O.","family":"Usman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oluwaseun A.","family":"Adeyanju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel D.","family":"Areola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olufunto O.","family":"Badmus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibukun P.","family":"Oyeyipo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kehinde S.","family":"Olaniyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adewumi O.","family":"Oyabambi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1036-0662","authenticated-orcid":false,"given":"Lawrence A.","family":"Olatunji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,21]]},"reference":[{"key":"4031_CR1","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.ejogrb.2005.07.007","volume":"126","author":"E Salamalekis","year":"2006","unstructured":"Salamalekis E, Bakas P, Vitoratos N, Eleptheriadis M, Creatsas G (2006) Androgen levels in the third trimester of pregnancy in patients with preeclampsia. Eur J Obstet Gynecol Reprod Biol 126:16\u201319. https:\/\/doi.org\/10.1016\/j.ejogrb.2005.07.007","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"4031_CR2","first-page":"390","volume":"59","author":"V Ghorashi","year":"2008","unstructured":"Ghorashi V, Sheikhvatan M (2008) The relationship between serum concentration of free testosterone and pre-eclampsia. Endokrynol Pol 59:390\u2013392","journal-title":"Endokrynol Pol"},{"key":"4031_CR3","doi-asserted-by":"publisher","first-page":"E262","DOI":"10.1152\/ajpendo.90208.2008","volume":"295","author":"M Demissie","year":"2008","unstructured":"Demissie M, Lazic M, Foecking EM, Aird F, Dunaif A, Levine JE (2008) Transient prenatal androgen exposure produces metabolic syndrome in adult female rats. Am J Physiol Endocrinol Metab 295:E262\u2013E268. https:\/\/doi.org\/10.1152\/ajpendo.90208.2008","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"4031_CR4","doi-asserted-by":"publisher","first-page":"2783","DOI":"10.1210\/en.2017-00460","volume":"158","author":"M Puttabyatappa","year":"2017","unstructured":"Puttabyatappa M, Andriessen V, Mesquitta M, Zeng L, Pennathur S, Padmanabhan V (2017) Developmental programming: impact of gestational steroid and metabolic milieus on mediators of insulin sensitivity in prenatal testosterone-treated female sheep. Endocrinology 158:2783\u20132798. https:\/\/doi.org\/10.1210\/en.2017-00460","journal-title":"Endocrinology"},{"key":"4031_CR5","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1016\/S0140-6736(11)61454-2","volume":"380","author":"R Bellomo","year":"2012","unstructured":"Bellomo R, Kellum JA, Ronco C (2012) Acute kidney injury. Lancet 380:756\u2013766. https:\/\/doi.org\/10.1016\/S0140-6736(11)61454-2","journal-title":"Lancet"},{"key":"4031_CR6","unstructured":"National Kidney and Urologic Diseases Information Clearinghouse (NKUDIC): Kidney Disease Statistics for the United States, 2012 http:\/\/kidney.niddk.nih.gov\/kudiseases\/pubs\/kustats\/KU"},{"key":"4031_CR7","doi-asserted-by":"publisher","first-page":"2056","DOI":"10.1046\/j.1523-1755.1998.00217.x","volume":"54","author":"AB Chapman","year":"1998","unstructured":"Chapman AB, Abraham WT, Zamudio S, Coffin C, Merouani A, Young D, Johnson A, Osorio F, Goldberg C, Moore LG, Dahms T, Schrier RW (1998) Temporal relationships between hormonal and hemodynamic changes in early human pregnancy. Kidney Int 54:2056\u20132063. https:\/\/doi.org\/10.1046\/j.1523-1755.1998.00217.x","journal-title":"Kidney Int"},{"key":"4031_CR8","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1053\/j.semperi.2009.02.010","volume":"33","author":"L Duley","year":"2009","unstructured":"Duley L (2009) The global impact of pre-eclampsia and eclampsia. Semin Perinatol 33:130\u2013137. https:\/\/doi.org\/10.1053\/j.semperi.2009.02.010","journal-title":"Semin Perinatol"},{"key":"4031_CR9","doi-asserted-by":"publisher","first-page":"8317","DOI":"10.1161\/01.RES.0000164401.21929.CF","volume":"96","author":"Y Zhang","year":"2005","unstructured":"Zhang Y, Handy DE, Loscalzo J (2005) Adenosine-dependent induction of glutathione peroxidase 1 in human primary endothelial cells and protection against oxidative stress. Circ Res 96:8317. https:\/\/doi.org\/10.1161\/01.RES.0000164401.21929.CF","journal-title":"Circ Res"},{"key":"4031_CR10","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3109\/03009734.2013.851748","volume":"119","author":"D Patinha","year":"2014","unstructured":"Patinha D, Afonso J, Sousa T, Morato M, Albino-Teixeira A (2014) Activation of adenosine receptors improves renal antioxidant status in diabetic Wistar but not SHR rats. Upsala J Med Sci 119:10\u201318. https:\/\/doi.org\/10.3109\/03009734.2013.851748","journal-title":"Upsala J Med Sci"},{"key":"4031_CR11","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.15252\/emmm.201607066","volume":"9","author":"Y Xu","year":"2017","unstructured":"Xu Y, Wang Y, Yan S, Zhou Y, Yang Q, Pan Y, Zeng X, An X, Liu Z, Wang L, Xu J, Cao Y, Fulton DJ, Weintraub NL, Bagi Z, Hoda MN, Wang X, Li MQ, Hong X, Jiang X, Boison D, Weber C, Wu C, Huo Y (2017) Intracellular adenosine regulates epigenetic programming in endothelial cells to promote angiogenesis. EMBO Mol Med 9:1263\u20131278. https:\/\/doi.org\/10.15252\/emmm.201607066","journal-title":"EMBO Mol Med"},{"key":"4031_CR12","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1146\/annurev-physiol-021113-170343","volume":"77","author":"AK Mandal","year":"2015","unstructured":"Mandal AK, Mount DB (2015) The molecular physiology of uric acid homeostasis. Annu Rev Physiol 77:323\u2013345. https:\/\/doi.org\/10.1146\/annurev-physiol-021113-170343","journal-title":"Annu Rev Physiol"},{"key":"4031_CR13","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.freeradbiomed.2009.11.012","volume":"48","author":"EE Kelley","year":"2010","unstructured":"Kelley EE, Khoo NK, Hundley NJ, Malik UZ, Freeman BA, Tarpey MM (2010) Hydrogen peroxide is the major oxidant product of xanthine oxidase. Free Radic Biol Med 48:493\u2013498. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2009.11.012","journal-title":"Free Radic Biol Med"},{"key":"4031_CR14","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/s0002-9149(01)02155-5","volume":"89","author":"C Bickel","year":"2002","unstructured":"Bickel C, Rupprecht HJ, Blankenberg S, Rippin G, Hafner G, Daunhauer A, Hofmann KP, Meyer J (2002) Serum uric acid as an independent predictor of mortality in patients with angiographically proven coronary artery disease. Am J Cardiol 89:12\u201317. https:\/\/doi.org\/10.1016\/s0002-9149(01)02155-5","journal-title":"Am J Cardiol"},{"issue":"19","key":"4031_CR15","first-page":"3707","volume":"39","author":"ZM Mao","year":"2014","unstructured":"Mao ZM, Huang YR, Wan YG, Chen HL, Shi XM, Meng XJ, Yao J (2014) Regulative mechanisms of oxidative stress in kidney in diabetic nephropathy and interventional effects of Chinese herbal medicine. China J Chinese Nat Med 39(19):3707\u20133712","journal-title":"China J Chinese Nat Med"},{"key":"4031_CR16","doi-asserted-by":"publisher","first-page":"L163","DOI":"10.1152\/ajplung.1989.257.4.L163","volume":"257","author":"SM Deneke","year":"1989","unstructured":"Deneke SM, Fanburg BL (1989) Regulation of cellular glutathione. Am J Phys 257:L163\u2013L173. https:\/\/doi.org\/10.1152\/ajplung.1989.257.4.L163","journal-title":"Am J Phys"},{"issue":"7","key":"4031_CR17","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1007\/s00210-019-01630-5","volume":"392","author":"TO Usman","year":"2019","unstructured":"Usman TO, Badmus OO, Kim I, Olatunji LA (2019) Mineralocorticoid receptor blockade attenuates disrupted glutathione-dependent antioxidant defense and elevated endoglin in the hearts of pregnant rats exposed to testosterone. Naunyn Schmiedeberg\u2019s Arch Pharmacol 392(7):773\u2013784. https:\/\/doi.org\/10.1007\/s00210-019-01630-5","journal-title":"Naunyn Schmiedeberg\u2019s Arch Pharmacol"},{"key":"4031_CR18","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1093\/ajcn\/45.5.1243","volume":"45","author":"JH Cummings","year":"1987","unstructured":"Cummings JH, Englyst HN (1987) Fermentation in the human large intestine and the available substrates. Am J Clinic Nutr 45:1243\u20131255. https:\/\/doi.org\/10.1093\/ajcn\/45.5.1243","journal-title":"Am J Clinic Nutr"},{"key":"4031_CR19","doi-asserted-by":"publisher","first-page":"3611","DOI":"10.1038\/ncomms4611","volume":"5","author":"G Frost","year":"2014","unstructured":"Frost G, Sleeth ML, Sahuri-Arisoylu M, Lizarbe B, Cerdan S, Brody L, Anastasovska J, Ghourab S, Hankir M, Zhang S, Carling D, Swann JR, Gibson G, Viardot A, Morrison D, Louise E, Bell JD (2014) The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism. Nat Commun 5:3611. https:\/\/doi.org\/10.1038\/ncomms4611","journal-title":"Nat Commun"},{"key":"4031_CR20","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1038\/nature08530","volume":"461","author":"KM Maslowski","year":"2009","unstructured":"Maslowski KM, Vieira AT, Ng A, Kranich J, Sierro F, Yu D, Schilter HC, Rolph MS, Mackay F, Artis D, Xavier RJ, Teixeira MM, Mackay CR (2009) Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 461:1282\u20131286. https:\/\/doi.org\/10.1038\/nature08530","journal-title":"Nature"},{"key":"4031_CR21","doi-asserted-by":"publisher","first-page":"3138","DOI":"10.1007\/s11064-016-2038-2","volume":"41","author":"M Moriyama","year":"2016","unstructured":"Moriyama M, Kurebayashi R, Kawabe K, Takano K, Nakamura Y (2016) Acetate attenuates lipopolysaccharide-induced nitric oxide production through an anti-oxidative mechanism in cultured primary rat astrocytes. Neurochem Res 41:3138\u20133146. https:\/\/doi.org\/10.1007\/s11064-016-2038-2","journal-title":"Neurochem Res"},{"key":"4031_CR22","first-page":"68","volume-title":"Red cell metabolism: a manual of biochemical methods","author":"E Beutler","year":"1978","unstructured":"Beutler E (1978) Red cell metabolism: a manual of biochemical methods. Grune and Stratton, New York, p 68"},{"key":"4031_CR23","first-page":"158","volume":"70","author":"PE Paglia","year":"1967","unstructured":"Paglia PE, Valentine WN (1967) Studies on the quantitation and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70:158\u2013169","journal-title":"J Lab Clin Med"},{"issue":"3","key":"4031_CR24","first-page":"749","volume":"227","author":"JD Adams","year":"1983","unstructured":"Adams JD, Lauterburg BH, Mitchell JR (1983) Plasma glutathione and glutathione disulfide in the rat: regulation and response to oxidative stress. J Pharmacol Exp Ther 227(3):749\u2013754","journal-title":"J Pharmacol Exp Ther"},{"key":"4031_CR25","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Annals Biochem 72:248\u2013254","journal-title":"Annals Biochem"},{"key":"4031_CR26","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/s0014-2999(02)02151-9","volume":"451","author":"P Montilla-L\u00f3pez","year":"2002","unstructured":"Montilla-L\u00f3pez P, Mu\u00f1oz-Agueda MC, Feij\u00f3o L\u00f3pez M, Mu\u00f1oz-Casta\u00f1eda JR, Bujalance-Arenas I, T\u00fanez-Fi\u00f1ana I (2002) Comparison of melatonin versus vitamin C on oxidative stress and antioxidant enzyme activity in Alzheimer\u2019s disease induced by okadaic acid in neuroblastoma cells. Euro J Pharmacol 451:237\u2013243. https:\/\/doi.org\/10.1016\/s0014-2999(02)02151-9","journal-title":"Euro J Pharmacol"},{"issue":"9","key":"4031_CR27","doi-asserted-by":"publisher","first-page":"2707","DOI":"10.1523\/JNEUROSCI.06-09-02707.1986","volume":"6","author":"JD Geiger","year":"1986","unstructured":"Geiger JD, Nagy JI (1986) Distribution of adenosine deaminase activity in rat brain and spinal cord. J Neurosci 6(9):2707\u20132714","journal-title":"J Neurosci"},{"key":"4031_CR28","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1002\/ajp.20679","volume":"71","author":"DH Abbott","year":"2009","unstructured":"Abbott DH, Tarantal AF, Dumesic DA (2009) Fetal, infant, adolescent and adult phenotypes of polycystic ovary syndrome in prenatally androgenized female rhesus monkeys. Am J Primatol 71:776\u2013784. https:\/\/doi.org\/10.1002\/ajp.20679","journal-title":"Am J Primatol"},{"key":"4031_CR29","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1161\/HYPERTENSIONAHA.111.180620","volume":"59","author":"AZ Chignalia","year":"2012","unstructured":"Chignalia AZ, Schuldt EZ, Camargo LL, Montezano AC, Callera GE, Laurindo FR, Avellar MC, Carvalho MH, Fortes ZB, Tostes RC (2012) Testosterone induces vascular smooth muscle cell migration by NADPH oxidase and c-Src-dependent pathways. Hypertension 59:1263\u20131271. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.111.180620","journal-title":"Hypertension"},{"key":"4031_CR30","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1124\/jpet.112.201947","volume":"345","author":"Y Puttabyatappa","year":"2013","unstructured":"Puttabyatappa Y, Stallone JN, Ergul A, El-Remessy AB, Kumar S, Black S, Johnson M, Owen MP, White RE (2013) Peroxynitrite mediates testosterone-induced vasodilation of microvascular resistance vessels. J Pharmacol Exp Ther 345:7\u201314. https:\/\/doi.org\/10.1124\/jpet.112.201947","journal-title":"J Pharmacol Exp Ther"},{"key":"4031_CR31","doi-asserted-by":"publisher","first-page":"R1","DOI":"10.1152\/ajpregu.00392.2014","volume":"310","author":"RC Tostes","year":"2016","unstructured":"Tostes RC, Carneiro FS, Carvalho MH, Reckelhoff JF (2016) Reactive oxygen species: players in the cardiovascular effects of testosterone. Am J Physiol Regul Integr Compr Physiol 310:R1\u2013R14. https:\/\/doi.org\/10.1152\/ajpregu.00392.2014","journal-title":"Am J Physiol Regul Integr Compr Physiol"},{"key":"4031_CR32","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.gene.2013.11.081","volume":"537","author":"M Remely","year":"2014","unstructured":"Remely M, Aumueller E, Merold C, Dworzak S, Hippe B, Zanner J (2014) Effects of short chain fatty acid producing bacteria on epigenetic regulation of FFAR3 in type 2 diabetes and obesity. Gene 537:85\u201392. https:\/\/doi.org\/10.1016\/j.gene.2013.11.081","journal-title":"Gene"},{"key":"4031_CR33","doi-asserted-by":"publisher","unstructured":"Puddu A, Sanguineti A, Montecucco F, Viviani GL (2014) Evidence for the gut microbiota short-chain fatty acids as key pathophysiological molecules improving diabetes. Mediat Inflamm 162021. https:\/\/doi.org\/10.1155\/2014\/162021","DOI":"10.1155\/2014\/162021"},{"key":"4031_CR34","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1002\/jms.181","volume":"36","author":"E Pouteau","year":"2001","unstructured":"Pouteau E, Meirim I, M\u00e9tairon S, Fay LB (2001) Acetate, propionate and butyrate in plasma: determination of the concentration and isotopic enrichment by gas chromatography\/mass spectrometry with positive chemical ionization. J Mass Spectrom 36:798\u2013805. https:\/\/doi.org\/10.1002\/jms.181","journal-title":"J Mass Spectrom"},{"key":"4031_CR35","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.ejphar.2013.10.051","volume":"720","author":"SJ Sherajee","year":"2013","unstructured":"Sherajee SJ, Rafiq K, Nakano D, Mori H, Kobara H, Hitomi H (2013) Aldosterone aggravates glucose intolerance induced by high fructose. Euro J Pharmacol 720:63\u201368. https:\/\/doi.org\/10.1016\/j.ejphar.2013.10.051","journal-title":"Euro J Pharmacol"},{"key":"4031_CR36","doi-asserted-by":"publisher","unstructured":"Adeyanju OA, Michael OS, Soladoye AO, Olatunji LA (2018) Blockade of mineralocorticoid receptor ameliorates oral contraceptive-induced insulin resistance by suppressing elevated uric acid and glycogen synthase kinase-3 instead of circulating mineralocorticoid. Arch Physiol Biochem. https:\/\/doi.org\/10.1080\/13813455.2018.1509220","DOI":"10.1080\/13813455.2018.1509220"},{"key":"4031_CR37","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1080\/13813455.2017.1320681","volume":"123","author":"LA Olatunji","year":"2017","unstructured":"Olatunji LA, Usman TO, Akinade AI, Adeyanju OA, Kim IK, Soladoye AO (2017) Low-dose spironolactone ameliorates insulin resistance and suppresses elevated plasminogen activator inhibitor-1 during gestational testosterone exposure. Arch Physiol Biochem 123:286\u2013292. https:\/\/doi.org\/10.1080\/13813455.2017.1320681","journal-title":"Arch Physiol Biochem"},{"key":"4031_CR38","doi-asserted-by":"publisher","first-page":"H1485","DOI":"10.1152\/ajpheart.00809.2013","volume":"306","author":"RA Lopes","year":"2014","unstructured":"Lopes RA, Neves KB, Pestana CR, Queiroz AL, Zanotto CZ, Chignalia AZ, Valim YM, Silveira LR, Curti C, Tostes RC (2014) Testosterone induces apoptosis in vascular smooth muscle cells via extrinsic apoptotic pathway with mitochondria generated reactive oxygen species involvement. Am J Physiol Heart Circ Physiol 306:H1485\u2013H1494. https:\/\/doi.org\/10.1152\/ajpheart.00809.2013","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"4031_CR39","first-page":"56","volume":"2","author":"P Kovacic","year":"2008","unstructured":"Kovacic P, Somanathan R (2008) Unifying mechanism for eye toxicity: electron transfer, reactive oxygen species, antioxidant benefits, cell signaling and cell membranes. Cell Membr Free Radic Res 2:56\u201369","journal-title":"Cell Membr Free Radic Res"},{"key":"4031_CR40","doi-asserted-by":"publisher","first-page":"H491","DOI":"10.1152\/ajpheart.00721.2012","volume":"304","author":"PA Hecker","year":"2012","unstructured":"Hecker PA, Leopold JA, Gupte SA, Recchia FA, Stanley WC (2012) Impact of glucose-6-phosphate dehydrogenase deficiency in the pathophysiology of cardiovascular disease. Am J Physiol Heart Circ Physiol 304:H491\u2013H500. https:\/\/doi.org\/10.1152\/ajpheart.00721.2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"4031_CR41","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1177\/1470320311422581","volume":"13","author":"BS Pess\u00f4a","year":"2011","unstructured":"Pess\u00f4a BS, Peixoto EBMI, Papadimitriou A, Lopes de Faria JM, Lopes de Faria JB (2011) Spironolactone improves nephropathy by enhancing glucose-6-phosphate dehydrogenase activity and reducing oxidative stress in diabetic hypertensive rat. J RAAS 13(1):56\u201366. https:\/\/doi.org\/10.1177\/1470320311422581","journal-title":"J RAAS"},{"key":"4031_CR42","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1124\/pr.108.00802","volume":"60","author":"LA Stoddart","year":"2008","unstructured":"Stoddart LA, Smith NJ, Milligan G (2008) International union of pharmacology. LXXI. Free fatty acid receptors FFA1,-2, and -3: pharmacology and pathophysiological functions. Pharmacol Rev 60:405\u2013417. https:\/\/doi.org\/10.1124\/pr.108.00802","journal-title":"Pharmacol Rev"},{"issue":"1","key":"4031_CR43","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nrneph.2017.155","volume":"14","author":"S Agrawal","year":"2018","unstructured":"Agrawal S, Zaritsky JJ, Fornoni A, Smoyer WE (2018) Dyslipidaemia in nephrotic syndrome: mechanisms and treatment. Nat Rev Nephrol 14(1):57\u201370. https:\/\/doi.org\/10.1038\/nrneph.2017.155","journal-title":"Nat Rev Nephrol"},{"key":"4031_CR44","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1093\/clinchem\/38.7.1322","volume":"38","author":"JP Ungerer","year":"1992","unstructured":"Ungerer JP, Oosthuizen HM, Bissbort SH, Vermaak WJ (1992) Serum adenosine deaminase: isoenzymes and diagnostic application. Clin Chem 38:1322\u20131326","journal-title":"Clin Chem"},{"key":"4031_CR45","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1080\/15257770.2018.1460482","volume":"37","author":"IM Rybakowska","year":"2018","unstructured":"Rybakowska IM, Kutryb-Zaj\u0105c B, Milczarek R, \u0141ukasz B, Slominska EM, Smolenski RT (2018) Activities of purine converting enzymes in heart, liver and kidney mice LDLR\u2212\/\u2212and Apo E\u2212\/\u2212. Nucleosides Nucleotides Nucleic Acids 37:340\u2013347. https:\/\/doi.org\/10.1080\/15257770.2018.1460482","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"4031_CR46","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1542\/peds.98.1.103","volume":"98","author":"OD Saugstad","year":"1996","unstructured":"Saugstad OD (1996) Role of xanthine oxidase and its inhibitor in hypoxia: re-oxygenation injury. Pediatrics 98:103\u2013107","journal-title":"Pediatrics"},{"key":"4031_CR47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023967","volume":"6","author":"T Wang","year":"2011","unstructured":"Wang T, Qiao S, Lei S, Liu Y, Ng KF, Xu A, Lam KS, Irwin MG, Xia Z (2011) N acetyl cysteine and allopurinol synergistically enhance cardiac adiponectin content and reduce myocardial reperfusion injury in diabetic rats. PLoS One 6:e23967. https:\/\/doi.org\/10.1371\/journal.pone.0023967","journal-title":"PLoS One"},{"key":"4031_CR48","doi-asserted-by":"publisher","first-page":"4071","DOI":"10.1210\/en.2015-1159","volume":"156","author":"A Hurliman","year":"2015","unstructured":"Hurliman A, Brown JK, Maille N, Mandala M, Casson P, Osol CP (2015) Hyperandrogenism and insulin resistance, not changes in body weight, mediate the development of endothelial dysfunction in a female rat model of polycystic ovary syndrome (PCOS). Endocrinology 156:4071\u20134080. https:\/\/doi.org\/10.1210\/en.2015-1159","journal-title":"Endocrinology"},{"key":"4031_CR49","doi-asserted-by":"publisher","first-page":"11312","DOI":"10.1074\/jbc.M211609200","volume":"278","author":"AJ Brown","year":"2003","unstructured":"Brown AJ, Goldsworthy SM, Barnes AA, Eilert MM, Tcheang L, Daniels D, Muir AI, Wigglesworth MJ, Kinghorn I, Fraser NJ, Pike NB, Strum JC, Steplewski KM, Murdock PR, Holder JC, Marshall FH, Szekeres PG, Wilson S, Ignar DM, Foord SM, Wise A, Dowell SJ (2003) The orphan G-protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J Biol Chem 278:11312\u201311319. https:\/\/doi.org\/10.1074\/jbc.M211609200","journal-title":"J Biol Chem"},{"key":"4031_CR50","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1161\/circresaha.113.301071","volume":"112","author":"HA Lee","year":"2013","unstructured":"Lee HA, Lee DY, Cho HM, Kim SY, Iwasaki Y, Kim IK (2013) Histone deacetylase inhibition attenuates transcriptional activity of mineralocorticoid receptor through its acetylation and prevents development of hypertension. Circ Res 112:1004\u20131012. https:\/\/doi.org\/10.1161\/circresaha.113.301071","journal-title":"Circ Res"},{"key":"4031_CR51","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1161\/circulationaha.116.024545","volume":"135","author":"FZ Marques","year":"2017","unstructured":"Marques FZ, Nelson E, Chu PY, Horlock D, Fiedler A, Ziemann M, Tan JK, Kuruppu S, Rajapakse NW, El-Osta A, Mackay CR, Kaye DM (2017) High-fiber diet and acetate supplementation change the gut microbiota and prevent the development of hypertension and heart failure in hypertensive mice. Circulation 135:964\u2013977. https:\/\/doi.org\/10.1161\/circulationaha.116.024545","journal-title":"Circulation"},{"key":"4031_CR52","doi-asserted-by":"publisher","first-page":"365","DOI":"10.3389\/fimmu.2017.00365","volume":"8","author":"LEK Gray","year":"2017","unstructured":"Gray LEK, O\u2019Hely M, Ranganathan S, Sly PD, Vuillermin P (2017) The maternal diet, gut bacteria, and bacterial metabolites during pregnancy influence offspring asthma. Front Immunol 8:365. https:\/\/doi.org\/10.3389\/fimmu.2017.00365","journal-title":"Front Immunol"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-020-04031-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11010-020-04031-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-020-04031-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T18:27:53Z","timestamp":1670869673000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11010-020-04031-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,21]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["4031"],"URL":"https:\/\/doi.org\/10.1007\/s11010-020-04031-y","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,21]]},"assertion":[{"value":"10 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"LAO received eplerenone (PF-02845980) used in this study from Pfizer Inc. (NY, USA) via the Compound Transfer Program (CTP). TOU, OAA, EDA, OOB, IPO, KSO and AOO do not have any conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All authors gave consent for this manuscript to be published.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"This study protocol was approved by the University Ethical Review Committee (UERC), University of Ilorin, Ilorin.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}